The phenomenon of amyloidosis has attracted the attention of numerous researchers for two main reasons: (1) it involves unexpected changes in protein conformation (without chemical intervention) and (2) has practical implications, such as elucidating the mechanisms which drive neurodegenerative diseases carries. In particular, understanding the process of amyloidosis is a fundamental prerequisite in the search for new, effective drugs and therapies targeting the key area of neurodegenerative diseases. The book proposes a model and a mechanism which explain protein misfolding. The concepts presented are based on a model originally intended to show how proteins attain their native conformations. The model is quantitative in nature and founded upon arguments derived from information theory. It facilitates prediction and simulation of the amyloid fibrillation process. It also identifies progressive changes which occur in native proteins, leading to the emergence of amyloid aggregations.
This volume of The Frederick Douglass Papers represents the first of a four-volume series of the selected correspondence of the great American abolitionist and reformer. Douglass’s correspondence was richly varied, from relatively obscure slaveholders and fugitive slaves to poets and politicians, including Horace Greeley, William H. Seward, Susan B. Anthony, and Henry Wadsworth Longfellow. The letters acquaint us with Douglass’s many roles—politician, abolitionist, diplomat, runaway slave, women’s rights advocate, and family man—and include many previously unpublished letters between Douglass and members of his family. Douglass stood at the epicenter of the political, social, intellectual, and cultural issues of antebellum America. This collection of Douglass’s early correspondence illuminates not only his growth as an activist and writer, but the larger world of the times and the abolition movement as well.
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