As a young and impetuous gradate student, I thought that sorting out the phylogeny of crustaceans would simply take but a little time and concerted effort to eventually reveal the truth. Everyone could then agree and further research would proceed apace. How naïve I was. First of all, I had never heard of Kurt Gödel's incompleteness theorems and hence the impossibility of achieving such an end. But even so, what progress we might have made turned out to take longer than anyone could have imagined, and the effort would be immense involving many people and a number of laboratories-and that task still continues. What no one could foresee in the 1960s was that the focus of everyone's attentions would completely transform. Traditional pure anatomy would be augmented with more sophisticated developmental genetic work. Concurrent with that effort molecular sequencing would become a remarkably effective tool. And with these new sources of data, the concept of "crustaceans" would yield to a new construct-Pancrustacea-within which the arthropods that we referred to by the name of "Crustacea" became a series of monophyletic smaller groups that mark a paraphyletic transition from a mandibulate ancestor all the way up to a crown group that few in the 1960s expected-Hexapoda emerged within the pancrustaceans"--
Pain is a subject of significant scientific and clinical interest. This has resulted both from realistic rodent models, and the publication of imaging, psychological and pharmacological studies in humans. Investigators studying rodents refer to anatomical and physiological studies in non-human primates to make their results relevant to humans. Psychophysical and pharmacological studies in humans are interpreted in terms of anatomical and physiological studies in animals; primarily evidence from rodents and cats. There are significant differences in pain mechanisms between these species and primates. Over 20 years of imaging studies have demonstrated the activation of human cortical and subcortical structures in response to painful stimuli. Interpretation of these results relies upon an understanding of the anatomy and physiology of these structures in primates. Jones, Lenz, Casey and Willis review the anatomy and physiology of nociception in monkeys and humans, and provide a firm basis for interpreting studies in humans.
By detailing experimental and basic research, from premalignancy to fully invasive tumors, this book has wide applicability to all human carcinomas. No other group of human cancers is better positioned for the application of recently developed novel and targeted therapies, and this book uniquely presents the unusual opportunities tumors of the head and neck provide for clinical, translational, and basic science research. Cutting-edge and experimental treatment approaches are presented, along with future strategies and an evaluation of emerging technologies. - Presents a multi-disciplinary perspective from authorities in diverse fields - Addresses state-of-the art approaches in cancer research as well as other scientific opportunities in this field - Provides comprehensive yet easily comprehendible source of information
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