Frederic Lawrence Holmes's Books

Investigative Pathways

Patterns and Stages in the Careers of Experimental Scientists

By: Frederic Lawrence Holmes

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Investigative Pathways

Patterns and Stages in the Careers of Experimental Scientists

By: Frederic Lawrence Holmes

This fascinating book is an investigation of scientific creativity. Following the research pathways of outstanding scientists over the past three centuries, it finds common features in their careers and their landmark discoveries and sheds light on the nature of long-term experimental research. Frederic Lawrence Holmes begins by discussing various approaches to the historical study of scientific practice. He then explains three kinds of analysis of the individual scientific life: broad-scale, which examines the phases of a scientist's career - apprenticeship, mastery, distinction, and maturity - over a lifetime; middle-scale, which explores the episodes within such a career; and fine-scale, which scrutinises laboratory notebooks and other data to focus on the daily interplay between thought and operation. Using these analyses, Holmes presents rich examples from his studies of six preeminent scientists: Antoine-Laurent Lavoisier, Claude Bernard, Hans Krebs, Matthew Meselson, Franklin Stahl, and Seymour Benzer. The similar themes that he finds in their work and careers lead him to valuable insights into enduring issues and problems in understanding the scientific process.

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Page Count

225

Published Date

ISBN 10

0300100752

ISBN 13

9780300100754

Meselson, Stahl, and the Replication of DNA

A History of "The Most Beautiful Experiment in Biology"

By: Frederic Lawrence Holmes

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Meselson, Stahl, and the Replication of DNA

A History of "The Most Beautiful Experiment in Biology"

By: Frederic Lawrence Holmes

In 1957 two young scientists, Matthew Meselson and Frank Stahl, produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a “most beautiful” experiment whose beauty was tied to its simplicity. Yet the investigative path that led to the experiment was anything but simple, Frederic L. Holmes shows in this masterful account of Meselson and Stahl’s quest. This book vividly reconstructs the complex route that led to the Meselson-Stahl experiment and provides an inside view of day-to-day scientific research--its unpredictability, excitement, intellectual challenge, and serendipitous windfalls, as well as its frustrations, unexpected diversions away from original plans, and chronic uncertainty. Holmes uses research logs, experimental films, correspondence, and interviews with the participants to record the history of Meselson and Stahl’s research, from their first thinking about the problem through the publication of their dramatic results. Holmes also reviews the scientific community’s reception of the experiment, the experiment’s influence on later investigations, and the reasons for its reputation as an exceptionally beautiful experiment.

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Page Count

516

Publisher

Yale University Press

Published Date

ISBN 10

0300129661

ISBN 13

9780300129663

Investigative Pathways

Patterns and Stages in the Careers of Experimental Scientists

By: Frederic Lawrence Holmes

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Investigative Pathways

Patterns and Stages in the Careers of Experimental Scientists

By: Frederic Lawrence Holmes

This fascinating book is an investigation of scientific creativity. Following the research pathways of outstanding scientists over the past three centuries, it finds common features in their careers and their landmark discoveries and sheds light on the nature of long-term experimental research. Frederic Lawrence Holmes begins by discussing various approaches to the historical study of scientific practice. He then explains three kinds of analysis of the individual scientific life: broad-scale, which examines the phases of a scientist’s career—apprenticeship, mastery, distinction, and maturity—over a lifetime; middle-scale, which explores the episodes within such a career; and fine-scale, which scrutinizes laboratory notebooks and other data to focus on the daily interplay between thought and operation. Using these analyses, Holmes presents rich examples from his studies of six preeminent scientists: Antoine-Laurent Lavoisier, Claude Bernard, Hans Krebs, Matthew Meselson, Franklin Stahl, and Seymour Benzer. The similar themes that he finds in their work and careers lead him to valuable insights into enduring issues and problems in understanding the scientific process.

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Page Count

268

Publisher

Yale University Press

Published Date

ISBN 10

0300129688

ISBN 13

9780300129687

Hans Krebs

By: Frederic Lawrence Holmes

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Hans Krebs

By: Frederic Lawrence Holmes

This comprehensive volume completes Frederic Holmes' notable and detailed biography of Hans Krebs, from the investigator's early development through the major phase of his groundbreaking investigation, which lay the foundations upon which the modern structure of intermediary metabolism is built. With access to Krebs' research notebooks as well as to Krebs himself through more than five years of personal interviews, the author provides an insightful analysis of Hans Krebs and of the scientific process as a whole. The first volume, published in 1991, covered Krebs' formative years in Germany, his work with Otto Warburg, and his discovery of the urea cycle in 1932. This second volume reconstructs the investigative pathway and the professional and personal life of Hans Krebs, from the time of his arrival in England in 1933 until 1937, when he made the discovery for which he is best known--the formulation of the citric acid cycle. Holmes portrays Krebs' activity at the intimate level of daily interactions of thought and action, from which the characteristic patterns of scientific creativity can best be seen. Holmes' fascinating portrait of Krebs integrates the great scientist's investigative pathways with his personal life. The result is an illuminating analysis of both man and scientist that will be of interest to biochemists and historians of science.

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Page Count

498

Publisher

Oxford University Press

Published Date

ISBN 10

0195360389

ISBN 13

9780195360387

Meselson, Stahl, and the Replication of DNA

A History of "The Most Beautiful Experiment in Biology"

By: Frederic Lawrence Holmes

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Meselson, Stahl, and the Replication of DNA

A History of "The Most Beautiful Experiment in Biology"

By: Frederic Lawrence Holmes

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516

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Yale University Press

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ISBN 10

0300129661

ISBN 13

9780300129663

Lavoisier and the Chemistry of Life

An Exploration of Scientific Creativity

By: Frederic Lawrence Holmes

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Lavoisier and the Chemistry of Life

An Exploration of Scientific Creativity

By: Frederic Lawrence Holmes

Drawing on Lavoisier's daily laboratory records, unpublished notes, and successive drafts of articles, Holmes explores the interaction between this creative scientist's theories and practice, the experimental problems he encountered and his response to them, the apparently intuitive understanding that guided his choice of experiments, and the gradual refinement of his hypotheses. This thorough and comprehensive exposition of Lavoisier's scientific style forms the basis for general reflections on the nature of creative scientific imagination that will interest historians of science and biology, philosophers of science, cognitive psychologists, and all who are intrigued by the drama of pioneering scientific discovery.

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Page Count

596

Publisher

Univ of Wisconsin Press

Published Date

ISBN 10

0299099849

ISBN 13

9780299099848

Hans Krebs

By: Frederic Laurence Holmes

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Hans Krebs

By: Frederic Laurence Holmes

This is the first volume of a comprehensive scientific biography of Hans Krebs, one of the world's foremost biochemists. It treats his childhood, his medical education and scientific apprenticeship under Otto Warburg, his emergence as an independent investigator, and his discovery of the urea cycle in 1932. This early achievement, and his discovery of the citric acid cycle, are viewed as foundations for the modern structure of intermediary metabolism. During the writing of this fascinating history, the author had access to a complete set of Krebs' laboratory notebooks that reveal the daily dimensions of scientific creativity. Based in addition on many personal interviews with its subject, the Krebs biography is certain to interest and intrigue biochemists and historians of science alike. Volume 2: Hans Krebs: Architect of Intermediary Metabolism 1933-37, will appear in spring, 1993.

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Page Count

512

Publisher

Oxford University Press

Published Date

ISBN 10

0195361288

ISBN 13

9780195361285

Reconceiving the Gene

Seymour Benzer's Adventures in Phage Genetics

By: Frederic Lawrence Holmes

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Reconceiving the Gene

Seymour Benzer's Adventures in Phage Genetics

By: Frederic Lawrence Holmes

This book relates how, between 1954 and 1961, the biologist Seymour Benzer mapped the fine structure of the rII region of the genome of the bacterial virus known as phage T4. Benzer’s accomplishments are widely recognized as a tipping point in mid-twentieth-century molecular biology when the nature of the gene was recast in molecular terms. More often than any other individual, he is considered to have led geneticists from the classical gene into the molecular age. Drawing on Benzer’s remarkably complete record of his experiments, his correspondence, and published sources, this book reconstructs how the former physicist initiated his work in phage biology and achieved his landmark investigation. The account of Benzer’s creativity as a researcher is a fascinating story that also reveals intriguing aspects common to the scientific enterprise.

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Page Count

348

Publisher

Yale University Press

Published Date

ISBN 10

030012970X

ISBN 13

9780300129700

The Investigative Enterprise

Experimental Physiology in Nineteenth-Century Medicine

By: William Coleman,Frederic L. Holmes

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The Investigative Enterprise

Experimental Physiology in Nineteenth-Century Medicine

By: William Coleman,Frederic L. Holmes

The seven distinguished contributors to this volume illuminate not only the history of the biological and medical sciences but also the relationship between institutes and ideas which characterized the explosion of scientific investigation, especially in Germany. Besides William Coleman and Frederic L. Holmes, they include Robert G. Frank, Jr., Timothy Lenoir, John E. Lesch, Kathryn M. Olesko, and Arlene M. Tuchman. Scientific investigation was not new to the nineteenth century, but it was during that period that it began to be carried out on a scale large enough to become crucial to the welfare of nations. Much remains to be learned about how the forms of organization characteristic of the modern investigative enterprise originated. This book explores such questions in relation to one of the dominant experimental sciences of the century, physiology. Each author shows, through the examination of a specific institute or a specific subject, that the interplay between research, pedagogy, personal vision, and state or public interests can be studied to particular advantage in localized settings. This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1988.

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350

Publisher

Univ of California Press

Published Date

ISBN 10

0520310357

ISBN 13

9780520310353

Antoine Lavoisier: The Next Crucial Year

Or, The Sources of His Quantitative Method in Chemistry

By: Frederic Lawrence Holmes

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Antoine Lavoisier: The Next Crucial Year

Or, The Sources of His Quantitative Method in Chemistry

By: Frederic Lawrence Holmes

Through his development of quantitative experimental methods, the chemist Antoine Lavoisier (1743-1794) implemented a principle that many regard as the cornerstone of modern science: in every operation there is an equal quantity of material before and after the operation. The origin of Lavoisier's methods, however, has remained a missing piece in this remarkable episode of scientific history, perhaps because the talented young scientist himself was not prepared for the journey his discoveries would set before him. In this book, Frederic Holmes suggests that Lavoisier gradually came to understand the nature and power of his quantitative method during the year 1773, when he began to carry out a research program on the fixation and release of airs. Drawing upon Lavoisier's surviving laboratory notebooks, Holmes presents an engaging portrait of a scientist still seeking the way that would lead him to become the leader of one of the great upheavals in the history of science. Holmes follows Lavoisier day-by-day at work in his laboratory over a course of several months. The scientist's resourcefulness and imagination spring to life in this account, as does his propensity to make mistakes, which taught him as much as his successes. During the course of this odyssey, Lavoisier saw his early theory of combustion collapse under the weight of his own efforts to provide experimental evidence to support it. In compensation, he acquired a method and the hard-won experience on which he would later construct a more enduring theoretical structure. Originally published in 1997. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

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Page Count

193

Publisher

Princeton University Press

Published Date

ISBN 10

1400864658

ISBN 13

9781400864652

Book's by Frederic Lawrence Holmes

Investigative Pathways

Investigative Pathways

Meselson, Stahl, and the Replication of DNA

Meselson, Stahl, and the Replication of DNA

Investigative Pathways

Investigative Pathways

Hans Krebs

Hans Krebs

Meselson, Stahl, and the Replication of DNA

Meselson, Stahl, and the Replication of DNA

Lavoisier and the Chemistry of Life

Lavoisier and the Chemistry of Life

Hans Krebs

Hans Krebs

Reconceiving the Gene

Reconceiving the Gene

The Investigative Enterprise

The Investigative Enterprise

Antoine Lavoisier: The Next Crucial Year

Antoine Lavoisier: The Next Crucial Year

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