Fred Saad's Books

Money and Totality

A Macro-Monetary Interpretation of Marx's Logic in Capital and the End of the 'Transformation Problem'

By: Fred Moseley

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Money and Totality

A Macro-Monetary Interpretation of Marx's Logic in Capital and the End of the 'Transformation Problem'

By: Fred Moseley

This ambitious book presents a comprehensive new 'macro-monetary' interpretation of Marx’s logical method in Capital, based on substantial textual evidence, which emphasises two main points: (1) Marx’s theory is primarily a macroeconomic theory of the total surplus-value produced in the economy as a whole; and (2) Marx’s theory is a monetary theory from beginning to end and the circuit of money capital – M - C - M’ – is the logical framework of Marx’s theory. It follows from this 'macro-monetary' interpretation that, contrary to the prevailing view, there is no 'transformation problem' in Marx’s theory; i.e., Marx did not 'fail to transform the inputs of constant capital and variable capital' in his theory of prices of production in Part 2 of Volume III.

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Page Count

433

Publisher

BRILL

Published Date

ISBN 10

9004301933

ISBN 13

9789004301931

Children Of Ham

Freed Slaves And Fugitive Slaves On The Kenya Coast, 1873 To 1907

By: Fred Morton

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Children Of Ham

Freed Slaves And Fugitive Slaves On The Kenya Coast, 1873 To 1907

By: Fred Morton

Children of Ham: Freed Slaves and Fugitives Slaves on the Kenya Coast,I 873 to 1907 is a chronological account of the repeated bids for freedom made by slaves and ex-slaves on the Kenya coast and of the obstacles placed in their way by the British, the Busaidi Arabs, and the peoples of the coast. Efforts to escape slavery are as old as slavery itself on the Kenya coast, but the principal story begins in 1873, when Britain pressured the sultan of Zanzibar to abolish the ocean-going slave trade. Thereafter, political and military conflict intensified on the coast, while opportunities for slaves to escape increased accordingly. This period, ending roughly with the abolition of the legal status of slavery in 1907, corresponds to the imperial scramble from its earliest stages to the effective establishment of European rule.

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268

Publisher

Routledge

Published Date

ISBN 10

0429714491

ISBN 13

9780429714498

Burning Money

The Material Spirit of the Chinese Lifeworld

By: C. Fred Blake

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Burning Money

The Material Spirit of the Chinese Lifeworld

By: C. Fred Blake

For a thousand years across the length and breadth of China and beyond, people have burned paper replicas of valuable things—most often money—for the spirits of deceased family members, ancestors, and myriads of demons and divinities. Although frequently denigrated as wasteful and vulgar and at times prohibited by governing elites, today this venerable custom is as popular as ever. Burning Money explores the cultural logic of this common practice while addressing larger anthropological questions concerning the nature of value. The heart of the work integrates Chinese and Western thought and analytics to develop a theoretical framework that the author calls a “materialist aesthetics.” This includes consideration of how the burning of paper money meshes with other customs in China and around the world. The work examines the custom in contemporary everyday life, its origins in folklore and history, as well as its role in common rituals, in the social formations of dynastic and modern times, and as a “sacrifice” in the act of consecrating the paper money before burning it. Here the author suggests a great divide between the modern means of cultural reproduction through ideology and reification, with its emphasis on nature and realism, and previous pre-capitalist means through ritual and mystification, with its emphasis on authenticity. The final chapters consider how the burning money custom has survived its encounter with the modern global system and internet technology. Innovative and original in its interpretation of a common ritual in Chinese popular religion, Burning Money will be welcomed by scholars and students of Chinese religion as well as comparative religion specialists and anthropologists interested in contemporary social theory.

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290

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University of Hawaii Press

Published Date

ISBN 10

0824860101

ISBN 13

9780824860103

Bifurcation Analysis of Fluid Flows

By: Henk A. Dijkstra,Fred W. Wubs

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Bifurcation Analysis of Fluid Flows

By: Henk A. Dijkstra,Fred W. Wubs

A guide to computing bifurcation diagrams for fluid flows, including relevant code, with broad applicability to industrial, environmental, astrophysical flows.

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343

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Cambridge University Press

Published Date

ISBN 10

1108495818

ISBN 13

9781108495813

Nation and Religion

By: Fred Halliday

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Nation and Religion

By: Fred Halliday

The Middle East is a complex region where religion, culture and politi are deeply intertwined in a powerful relationship. From the early days of the Arab nationalist experiment to the emergence of Islamic fundamentalism in the early part of this century and beyond, the region's political movements have become a salient feature of its modern history and continue to be the subject of much heated debate and speculation. This collection of essays addresses these timely issues by providing both a general analysis of the region and more focused country-by-country examples. Among the many themes, nationalism and Islamism are re-examined to demonstrate their ongoing relevance and relationship to the presentday Arab context and identity. This is followed by a closer look at Islamist movements in Turkey, Iran, and Tunisia and how these forces may either come to erode the secular state (in the case of Turkey and Tunisia) or bolster the Islamic one (in the case of Iran). The author also examines the fate of the eight remaining monarchies of the Arab world and the conditions of their emergence, consolidation and continuation. By means of a thorough analysis of these important themes, along with country-specific case studies, the author provides a wealth of information that helps towards a comprehensive understanding of the region. 'An absorbing collection of essays ... Halliday's range allows him to make many penetrating cross-cultural comparisons.' New Statesman 'Nation and Religion in the Middle East provides a wealth of information that helps towards a comprehensive understanding of the region.' The Middle East 'A formidable collection.' Times Literary Supplement 'Halliday has proven one of the most wide-ranging and sophisticated analysts of the Middle East, and this collection of essays shows both those traits.' CHOICE

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240

Publisher

Saqi

Published Date

ISBN 10

0863567193

ISBN 13

9780863567193

Rosen's Breast Pathology

By: Syed A. Hoda,Edi Brogi,Fred Koerner,Paul Peter Rosen

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Rosen's Breast Pathology

By: Syed A. Hoda,Edi Brogi,Fred Koerner,Paul Peter Rosen

For three editions, Rosen’s Breast Pathology has been widely recognized as the “gold standard” reference. Now in its Fourth Edition, this classic text continues its legacy of being the leading reference work on the pathology of the breast. Precise pathological diagnosis of breast disease is the most critical factor in determining treatment and establishing prognosis. The Fourth Edition of Rosen’s Breast Pathology provides the most comprehensive, updated information on diseases of the breast. Intended primarily for pathologists, the book will be an indispensible reference for all surgeons, oncologists, radiologists, radiation oncologists, as well as other physicians and medical personnel who require a thorough knowledge of breast pathology to provide optimal care for their patients. Discussions of most disease entities include clinical and radiological presentation, epidemiology, gross pathology, microscopic pathology, treatment, and prognosis. Surgical and oncological aspects of the various diseases are addressed wherever appropriate. Numerous images, a large proportion of which are new, complement the encyclopedic descriptions of the surgical pathology and cytology of diseases of the breast.

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4660

Publisher

Lippincott Williams & Wilkins

Published Date

ISBN 10

1469870703

ISBN 13

9781469870700

Trade Is Not a Four-Letter Word

How Six Everyday Products Make the Case for Trade

By: Fred P. Hochberg

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Trade Is Not a Four-Letter Word

How Six Everyday Products Make the Case for Trade

By: Fred P. Hochberg

“A sprightly and clear-eyed testimonial to the value of globalization” (The Wall Street Journal) as seen through six surprising everyday goods—the taco salad, the Honda Odyssey, the banana, the iPhone, the college degree, and the blockbuster HBO series Game of Thrones. Trade allows us to sell what we produce at home and purchase what we don’t. It lowers prices and gives us greater variety and innovation. Yet understanding our place in the global trade network is rarely simple. Trade has become an easy excuse for struggling economies, a scapegoat for our failures to adapt to a changing world, and—for many Americans on both the right and the left—nothing short of a four-letter word. But as Fred P. Hochberg reminds us, trade is easier to understand than we commonly think. In Trade Is Not a Four-Letter Word, you’ll learn how NAFTA became a populist punching bag on both sides of the aisle. You’ll learn how Americans can avoid the grim specter of the $10 banana. And you’ll finally discover the truth about whether or not, as President Trump has famously tweeted, “trade wars are good and easy to win.” (Spoiler alert—they aren’t.) Hochberg debunks common trade myths by pulling back the curtain on six everyday products, each with a surprising story to tell: the taco salad, the Honda Odyssey, the banana, the iPhone, the college degree, and the smash hit HBO series Game of Thrones. Behind these six examples are stories that help explain not only how trade has shaped our lives so far but also how we can use trade to build a better future for our own families, for America, and for the world. Trade Is Not a Four-Letter Word is the antidote to today’s acronym-laden trade jargon pitched to voters with simple promises that rarely play out so one-dimensionally. Packed with colorful examples and highly digestible explanations, Trade Is Not a Four-Letter Word is “an accessible, necessary book that will increase our understanding of trade and economic policies and the ways in which they impact our daily lives” (Library Journal, starred review).

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336

Publisher

Avid Reader Press / Simon & Schuster

Published Date

ISBN 10

1982127376

ISBN 13

9781982127374

Merchant of Words

The Life of Robert St. John

By: Terry Fred Horowitz

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Merchant of Words

The Life of Robert St. John

By: Terry Fred Horowitz

During World War II, Robert St. John of NBC, broadcast from London opposite CBS's Edward R. Murrow. Afterward, St. John would become a noted writer and commentator on world affairs, as well as a prominent and vocal supporter of the state of Israel. In Merchant of Words: The Life of Robert St. John, Terry Fred Horowitz not only documents St. John’s accomplishments and adventures but takes readers behind the scenes with St. John, who, for over three quarters of a century, served as a firsthand witness to history as it was being made in Europe, Africa, and the Middle East. From his auspicious beginnings when lying about his age in order to join the U.S. Navy during World War I to his final days as a well-established author and “righteous gentile,” St. John was both a participant and critical observer of American and world history. He became the youngest newspaper editor-publisher in the United States, breaking a story on prostitution in Cicero, Illinois, that resulted in his beating by Al Capone’s mob. When World War II began he became a war correspondent for the Associated Press, later escaping from the Nazis when they invaded Yugoslavia, he was wounded by a Messerschmitt’s strafing. He subsequently wrote From the Land of Silent People, the first full account of the fall of Yugoslavia and Greece during the war. Shortly afterward, he was hired by NBC as a radio broadcaster, covering the Blitz in London and D-Day and becoming the first commentator to announce the end of the war in Japan. During the McCarthy era, he was “pinklisted” and his passport was confiscated for a year, stranding him in Switzerland. During its War of Independence he started his lifelong love affair with Israel, becoming the only foreign correspondent to cover, in person, all of its wars, including the Israel-Lebanon War of 1982, during which he was known as the “dean of correspondents.” In addition to working as a regular contributor for the World Book Encyclopedia, St. John eventually wrote twenty-three books, many of them about Israel and the Middle East. These included well-received biographies of David Ben-Gurion (Builder of Israel), Eliezer Ben-Yehudah (Tongue of the Prophets), Abba Eban (Eban), and Gamal Abdul Nasser (The Boss: The Story of Gamel Abdal Nasser). Merchant of Words is a must-read for anyone interested in the history of journalism and the adventures of recognized war correspondent. For historians and history buffs it offers unique details from a journalist’s perspective on World War II, the Cold War, the Red Scare, Vietnam and the history of Israel and the Middle East.

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446

Publisher

Rowman & Littlefield

Published Date

ISBN 10

0810889072

ISBN 13

9780810889071

Ecotoxicology of Soil Organisms

By: Herman Eijsackers,Fred Heimbach,Marianne H. Donker

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Ecotoxicology of Soil Organisms

By: Herman Eijsackers,Fred Heimbach,Marianne H. Donker

This book provides a comprehensive examination of all aspects of the ecotoxicology of soil organisms. The book explains how contaminants reach the soil, traces their transport through the soil, and then moves on to examine the effects of contaminants on different groups of soil organisms (e.g., microorganisms, micro- and mesofauna, larger soil animals including vertebrates). The book also considers food chain transfer and discusses risk assessment procedures that are specific to soil conditions. Ecotoxicology of Soil Organisms is the only book to take such a sweeping approach toward soil ecotoxicology.

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496

Publisher

CRC Press

Published Date

ISBN 10

0873715306

ISBN 13

9780873715300

The Middle East in International Relations

Power, Politics and Ideology

By: Fred Halliday

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The Middle East in International Relations

Power, Politics and Ideology

By: Fred Halliday

The international relations of the Middle East have long been dominated by uncertainty and conflict. External intervention, interstate war, political upheaval and interethnic violence are compounded by the vagaries of oil prices and the claims of military, nationalist and religious movements. The purpose of this book is to set this region and its conflicts in context, providing on the one hand a historical introduction to its character and problems, and on the other a reasoned analysis of its politics. In an engagement with both the study of the Middle East and the theoretical analysis of international relations, the author, who is one of the best known and most authoritative scholars writing on the region today, offers a compelling and original interpretation. Written in a clear, accessible and interactive style, the book is designed for students, policymakers, and the general reader.

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390

Publisher

Cambridge University Press

Published Date

ISBN 10

1139443194

ISBN 13

9781139443197

The Arab Israeli Dilemma

Third Edition

By: Fred J. Khouri

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The Arab Israeli Dilemma

Third Edition

By: Fred J. Khouri

This updated, and greatly expanded edition makes Khouri's work the best currently available study of the complex Arab-Israeli conflict. Here are several new chapters providing a thorough, well-documented examination of the critical events which have developed since 1976, as well as a detailed analysis of the views, actions, and policies of the contending parties and the Big Powers. A completely new index to the entire work is provided. The Arab-Israeli Dilemma is of major interest to policy makers, to scholars and students dealing with Middle Eastern affairs and international relations, to historians, and to all who are concerned with the issues of war and peace.

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628

Publisher

Syracuse University Press

Published Date

ISBN 10

0815623402

ISBN 13

9780815623403

Border Crossings

Toward a Comparative Political Theory

By: Fred Dallmayr

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Border Crossings

Toward a Comparative Political Theory

By: Fred Dallmayr

Comparative political theory is at best an embryonic and marginalized endeavor. As practiced in most Western universities, the study of political theory generally involves a rehearsal of the canon of Western political thought from Plato to Marx. Only rarely are practitioners of political thought willing (and professionally encouraged) to transgress the canon and thereby the cultural boundaries of North America and Europe in the direction of genuine comparative investigation. Border Crossings presents an effort to remedy this situation, fully launching a new era in political theory. Thirteen scholars from around the world examine the various political traditions of West, South, and East Asia and engage in a reflective cross-cultural discussion that belies the assumptions of an Asian 'essence' and of an unbridgeable gulf between West and non-West. The denial of essential differences does not, however, amount to an endorsement of essential sameness. As viewed and as practiced by contributors to this ground-breaking volume, comparative political theorizing must steer a course between uniformity and radical separation—this is the path of 'border crossings.

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323

Publisher

Lexington Books

Published Date

ISBN 10

0739152548

ISBN 13

9780739152546

The New Poverty Row

Independent Filmmakers as Distributors

By: Fred Olen Ray

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The New Poverty Row

Independent Filmmakers as Distributors

By: Fred Olen Ray

Since cinema's earliest beginnings, there has been friction between producers and directors. Shady accounting practices, which favored the distributors at the expense of the filmmakers, were all too common, causing many filmmakers to form independent companies to make and distribute their own product. This book examines six such low-budget exploitation companies--Associated Distributors Productions, Filmgroup, Hemisphere Pictures, American General Pictures, Independent-International Pictures, Dimension Pictures, and the author's own American-Independent Productions. A brief history of each company, laced with quotes from the company's principals, is presented, followed by a filmography that lists all known credits for that company.

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248

Publisher

McFarland

Published Date

ISBN 10

0899506283

ISBN 13

9780899506289

Heptinstall's Pathology of the Kidney

By: J. Charles Jennette,Vivette D. D'Agati,Jean L. Olson,Fred G. Silva

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Heptinstall's Pathology of the Kidney

By: J. Charles Jennette,Vivette D. D'Agati,Jean L. Olson,Fred G. Silva

If you’re looking to deepen your understanding of kidney disease, look no further than Heptinstall’s Pathology of the Kidney, 7th Edition. Authored by the world’s most accomplished renal pathologists, this image-rich text conveys the intricacies and comprehensiveness of renal disease, offering powerful diagnostic and treatment recommendations from decades of clinical research. Stay up to date on the cutting edge of kidney research and treatment and offer your patients the best therapeutic options and preventative measures available today.

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4413

Publisher

Lippincott Williams & Wilkins

Published Date

ISBN 10

146988755X

ISBN 13

9781469887555

Why Syria Goes to War

Thirty Years of Confrontation

By: Fred H. Lawson

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Why Syria Goes to War

Thirty Years of Confrontation

By: Fred H. Lawson

Rejecting conventional explanations for Syrian foreign policy, which emphasize the personalities and attitudes of leaders, cultural factors peculiar to Arab societies, or the machinations of the great powers, Fred H. Lawson describes key shifts in Damascus's response to regional adversaries in terms of changes in the intensity of political struggles at home. Periodic eruptions of domestic conflict have inspired Syria's ruling coalition to adopt a wide range of programs designed to buy off domestic rivals and perpetuate the predominance of individual coalition members. These programs have undermined the unity of the Ba'thi regime, increasing the chances that opponents will overturn the established order. Challenges to the Ba'thi regime become most threatening whenever crises of accumulation shake the domestic political economy, Lawson contends. Opposition forces gain strength when the state cannot sustain new investment or when competition increases between public and private enterprises. Political and economic trends inside Syria have determined why Damascus has since 1963 alternately escalated tensions with regional rivals and adopted more accommodating postures. Lawson traces this dynamic through five major episodes: the 1967 war with Israel; limited intervention in Jordan in 1970; the widening conflict in Lebanon in 1976; the defusing of conflict with Iraq in 1982; and the rapprochement with Turkey over Kurdish separatism in 1994. These patterns, Lawson suggests, may be characteristic of nations changing from one domestic economic system to a radically different one, as Syria has in the transition from state socialism to a privatized political economy.

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239

Publisher

Cornell University Press

Published Date

ISBN 10

1501731866

ISBN 13

9781501731860

Border Crossings

Toward a Comparative Political Theory

By: Fred Reinhard Dallmayr

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Border Crossings

Toward a Comparative Political Theory

By: Fred Reinhard Dallmayr

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342

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Lexington Books

Published Date

ISBN 10

0739100432

ISBN 13

9780739100431

Arabia Without Sultans

By: Fred Halliday

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Arabia Without Sultans

By: Fred Halliday

Fred Halliday writes: 'The Arab Middle East is probably the most misunderstood of all regions; the one with the longest history of contact with the west; yet it is probably the one least understood. Part of the misunderstanding is due to the romantic mythology that has long appeared to shroud the deserts of the peninsula. Where old myths have broken down, new ones have absorbed them or taken their place. Now the Sheikh of Arabia has stepped down from his camel. Instead, through the delusive lens of the 'energy crisis' he is seen to be riding a Cadillac and squeezing the powerless Western consumer of oil.' First published in the 1970s, Arabia Without Sultans retains its validity for the present as it analyses the Arabian peninsula and Iran within the global context of western post-colonial strategy and the political economy of oil. Halliday offers a thorough study of the history, the politi and the economi of this region in an ambitious, encompassing and entertaining manner. This classic work remains indispensable for students, academi, and all those who wish to have a greater understanding of the Arabian peninsula. 'A well-documented work, written by an author who knows the language of the area.' Maxime Rodinson 'Halliday provides an unusual view-point and a well-documented description of the history of these states.' Middle East International 'Anyone interested in this area will want to read this.' International Affairs 'A most valuable account of the developments which have taken place in the Arab Gulf over the last hundred years.' Tariq Ali

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281

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Saqi

Published Date

ISBN 10

0863567142

ISBN 13

9780863567148

Two Hours that Shook the World

September 11, 2001: Causes and Consequences

By: Fred Halliday

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Two Hours that Shook the World

September 11, 2001: Causes and Consequences

By: Fred Halliday

As the dust settled around the devastation of the World Trade Centre and the Pentagon on 11 September 2001, a host of questions emerged surrounding the attacks, the motives behind them and their future implications. In Two Hours that Shook the World Fred Halliday expands on the many socio-cultural, religious and political problems that have plagued the Middle East and Central Asia in the last half-century. Much has been written about 'global terrorism' and the need to eliminate it but also about the divide between East and West, the 'clash of civilisations'. Halliday dispels the idea that the Muslim and non-Muslim worlds are poised for conflict. He explains the causes and rise of Islamic fundamentalism, how terror became an instrument of political and military conflict, and why seemingly well-educated and sane individuals are taking drastic actions to voice their desperation. The burden of history is also invoked, as with the Palestinian-Israeli situation, the festering malaise at the heart of Middle Eastern consciousness and identity. While Halliday's book examines the causes of what has happened, it also provides a reasoned approach as to what the future may hold. 'By far the best book on the catastrophe of 11 September.' The Observer 'Cuts the proverbial ice.' The Daily Star 'Sober and balanced.' John Gray, New Statesman 'To understand 11 September we need a broader context and Halliday is up to the task ... He reveals his true calibre.' Ziauddin Sardar, Independent

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220

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Saqi

Published Date

ISBN 10

0863567290

ISBN 13

9780863567292

Asian Labor Migration

Pipeline To The Middle East

By: Fred Arnold

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Asian Labor Migration

Pipeline To The Middle East

By: Fred Arnold

Labor migration from Asia to the oil-exporting countries in the Middle East has burgeoned in the last decade to a current level of over two million workers. Because foreign labor contracts have become a potent source of foreign exchange to the sending countries in Asia as well as a safety valve for high unemployment, the export of labor has become

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227

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Routledge

Published Date

ISBN 10

0429711719

ISBN 13

9780429711718

Diterpenes of Flowering Plants

Compositae (Asteraceae)

By: Fred Seaman,Ferdinand Bohlmann,Christa Zdero,Tom J. Mabry

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Diterpenes of Flowering Plants

Compositae (Asteraceae)

By: Fred Seaman,Ferdinand Bohlmann,Christa Zdero,Tom J. Mabry

More than 1200 diterpenes have been identified from approximately 550 Compo sitae taxa (Figure 1 [pp. 219-384], Tables 1-3 [pp. 7-218]). The annual output of such reports rose sharply during the past several years, a trend that was also reflected by other major lipophilic constituents of the Compositae: acetylenes (63, 465), sesquiterpene lactones (266, 458), and benzofurans and chromenes (429). Unlike these other natural products, no review of the diterpene chemistry of the Compositae has been published. Given the bulk of data currently on hand, a review of this topic is clearly overdue. Several major goals influenced the preparation of this review. The first was to provide a useful reference to guide terpenoid chemists to the literature of known compounds. The published reports for 1200 structures provide a sizable body of spectroscopic data applicable to the investigation of new compounds. The study of diterpenes has been hampered by the absence of an all-inclusive nomenclature and classification system for the various skeletal types. Conse quently, a second goal was to organize structural data into a classification scheme designed to group compounds by biogenetic homology, and to standardize such features as diterpene nomenclature and numbering. Pursuant to this goal, the published names (Table 1) and numbering systems (Table 2) for all compounds are included.

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643

Publisher

Springer Science & Business Media

Published Date

ISBN 10

1461232740

ISBN 13

9781461232742

New Protein Foods in Human Health

Nutrition, Prevention, and Therapy

By: Fred H. Steinke,Doyle H. Waggle,Michel N. Volgarev

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New Protein Foods in Human Health

Nutrition, Prevention, and Therapy

By: Fred H. Steinke,Doyle H. Waggle,Michel N. Volgarev

This book is a compilation of recent research on the use of new food proteins to improve the economics, nutrition, and health of foods. The book places particular emphasis on the use of new plant protein sources in the diet, the development of new foods, and the modification of existing foods to improve human health. It also reviews potential sources of new protein foods, the use of soy proteins in foods, and new low-fat protein foods that can help prevent obesity and heart disease in people of all ages. The book is unique in its presentation of both western and Soviet research in protein foods. New Protein Foods in Human Health: Nutrition, Prevention, and Therapy is an important book for anyone involved in protein food research.

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232

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CRC Press

Published Date

ISBN 10

0849369045

ISBN 13

9780849369049

Cancer Genomics

Chapter 14. Prostate Cancer Genomics as a Driver of Personalized Medicine

By: Michael Fraser,Alejandro Berlin,Veronique Ouellet,Fred Saad,Robert G. Bristow

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Cancer Genomics

Chapter 14. Prostate Cancer Genomics as a Driver of Personalized Medicine

By: Michael Fraser,Alejandro Berlin,Veronique Ouellet,Fred Saad,Robert G. Bristow

Prostate cancer (CaP) is the most commonly diagnosed malignancy in men in the Western world. In North America, more than 275000 men are diagnosed annually whereby approximately 1 in 6 men will be diagnosed with CaP in their lifetime, and 1 in 34 men will die from castrate-resistant metastatic disease. Unfortunately, current clinical prognostic factors explain only a proportion of the observed variation in clinical outcome from patient to patient. Furthermore, over-treatment of indolent and low-risk cancers leads to inappropriate morbidity following radiotherapy or surgery. As such, better predictors of individualized prognosis and treatment response are urgently needed to triage patients to customized and intensified CaP treatment. Recent developments in next-generation sequencing have made it possible to identify prognostic and predictive signatures based on genomic profiles. Herein, we review the recent genetic data pertaining to prostate cancer carcinogenesis, progression, castrate-resistance and metastases. We discuss the genetic basis of CaP progression from localized to systemic disease (e.g. point mutations, copy number alterations and structural variants) and important considerations for CaP biology including intra- and inter-prostatic heterogeneity, multifocality and multiclonality, TMPRSS2–ERG and other ETS-family gene fusions and the role of the tumor microenvironment (e.g. hypoxia and the contribution of caner-associated stroma). Finally, we focus on the use of genomic markers as prognostic factors for local failure and for systemic disease, as novel risk stratification tools, in triaging patients to existing treatment options and, ultimately, the potential of genomics for the identification of molecular targets for CaP therapy. We conclude by summarizing selected outstanding questions in CaP biology that can be addressed effectively through international cooperation between genome sequencing projects such as The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC).

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Elsevier Inc. Chapters

Published Date

ISBN 10

0128061111

ISBN 13

9780128061114

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