The book considers Thomas More’s early life-choices. An early letter is cited by biographers but most miss More’s reference to the market place. More’s great-grandson, Cresacre, a Londoner, understood it correctly, and that gives reason to trust him on other aspects of More’s youth. This study is based on early testimonies, those of Erasmus, Roper, Harpsfield, Stapleton and Cresacre More, as well as More’s early writings, the Pageant Verses, and his additions / omissions to the Life of Pico; evidence drawn from authors he recommended, like Hilton and Gerson; and finally, his epitaph. Attention is given to his lectures on St Augustine’s City of God, and to St John Chrysostom. It is argued More studied Chrysostom’s Homilies on the Gospel of St Matthew,/i> from a Greek manuscript. Chrysostom, in the introductory homily, spoke of the city and the market place, as the setting in which Christians practice the teaching of Christ. More practiced law and taught it. He was attracted to becoming a Christian humanist alongside Grocyn, Colet, Linacre, and Lily. With them he studied Greek, the classics and Fathers of the Church. Helped by them he became a man of prayer, aware of the need to seek holiness in the midst of the world as a layman. Faced with the dilemma of the humanist in choosing between the contemplative life of the philosopher and an active life of engagement with the world, he deliberately chose the active life in service to society, and the contemplative life of the Christian as a married man. This awareness and choice is what is called vocation, implying determination to persevere throughout life: More saw his life as a pilgrimage towards heaven as described in the last chapter focusing on More’s last work, De tristitia, tedio, pavore, et oratione christi ante captionem eius.
The book considers Thomas More’s early life-choices. An early letter is cited by biographers but most miss More’s reference to the market place. More’s great-grandson, Cresacre, a Londoner, understood it correctly, and that gives reason to trust him on other aspects of More’s youth. This study is based on early testimonies, those of Erasmus, Roper, Harpsfield, Stapleton and Cresacre More, as well as More’s early writings, the Pageant Verses, and his additions / omissions to the Life of Pico; evidence drawn from authors he recommended, like Hilton and Gerson; and finally, his epitaph. Attention is given to his lectures on St Augustine’s City of God, and to St John Chrysostom. It is argued More studied Chrysostom’s Homilies on the Gospel of St Matthew,/i> from a Greek manuscript. Chrysostom, in the introductory homily, spoke of the city and the market place, as the setting in which Christians practice the teaching of Christ. More practiced law and taught it. He was attracted to becoming a Christian humanist alongside Grocyn, Colet, Linacre, and Lily. With them he studied Greek, the classics and Fathers of the Church. Helped by them he became a man of prayer, aware of the need to seek holiness in the midst of the world as a layman. Faced with the dilemma of the humanist in choosing between the contemplative life of the philosopher and an active life of engagement with the world, he deliberately chose the active life in service to society, and the contemplative life of the Christian as a married man. This awareness and choice is what is called vocation, implying determination to persevere throughout life: More saw his life as a pilgrimage towards heaven as described in the last chapter focusing on More’s last work, De tristitia, tedio, pavore, et oratione christi ante captionem eius.
For any advanced club player (Elo 1800 - 2300) one thing remains true: if you want to win more games, nothing works better than training your combination skills. After all, studying the endgame will not help you if you are defeated by a deadly tactic long before the ending is reached. In this follow-up to his acclaimed 1001 Chess Exercise for Club Players, FIDE Master Frank Erwich teaches you how to reach the next level of identifying weak spots in the position of your opponent, recognizing patterns of combinations, visualizing tricks and calculating effectively. Erwich repeats the themes of his previous book, focusing on exercises in which the key move is less obvious. He also introduces new, more sophisticated tactical weapons. They are geared towards the reality of the advanced club player: it is not enough to spot simple combinations, at this level you must be able to resist your reflexes and look deeper. Being able to take a piece of your opponent, doesn’t mean you have to. If one of your pieces is attacked you should first research what happens if you don’t move it away. In variations that look forcing you will always search for that deadly Zwischenzug. Quiet moves in general should be your new best friends. In short: an advanced club player should expect the unexpected. One of the celebrated elements of Erwich’s previous book, neglected in other books on tactics, is back: defence! You will also learn how to defend against tactics, as well as how to use tactical weapons when you are under heavy pressure. 1001 Chess Exercises for Advanced Club Players is a complete and structured course, and not just a collection of freewheeling puzzles. Erwich starts every chapter with an instructive explanation of the tactical concept and has carefully selected the most didactically productive exercises.
Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently, the second edition of Principles of Toxicology Testing starts with basic toxicological principles, including absorption, distribution, metabolism, and elimination of toxins, including chemicals and drugs. The book then continues with animal (in vivo) and in vitro toxicology testing methods associated with toxicological analysis and preclinical drug development. As in the first edition, the book begins with an introduction into the fundamentals of toxicology (Section I) to prepare readers for the subsequent topics and continues through with a discussion of toxicokinetics and human risk assessment. This introductory material is useful in understanding the applications of toxicology testing. Section II describes the fundamental principles of toxicology testing in animals in greater detail. This section describes acute toxicity studies as well as subchronic and chronic studies performed on animals. Special emphasis is placed on study design and determination of classical indicators for acute and chronic testing, such as the LD50. The book examines other short- and long-term animal toxicity testing methodologies, including dermal, ocular, and reproductive toxicity testing. In addition, mutagenicity and carcinogenicity studies are also discussed in separate chapters. Section III introduces and discusses in vitro alternatives to animal toxicology tests. This section emphasizes cell culture methodology and cellular methods for acute systemic toxicity, target organ toxicity, and local toxicity. The contributors present the advantages and disadvantages of alternative methods. They also describe the use of high-throughput screening and its applications, the concepts of standardization and validation of in vitro techniques (especially large, organized validation efforts currently supported by US and EU regulatory agencies), and the theories supporting the development of in vitro methodologies. This second edition is a must-read for undergraduate and graduate toxicology students. Industrial and academic research centers will also find the text useful for establishing a toxicology testing laboratory.
For complete, authoritative coverage of every aspect of thoracic and cardiac surgery, turn to the unparalleled guidance found in Sabiston and Spencer Surgery of the Chest, 9th Edition. Now in full-color for the first time, Drs. Frank W. Sellke, Pedro J. del Nido, and Scott J. Swanson's standard-setting set is meticulously organized so that you can quickly find expert information on open and endoscopic surgical techniques performed in the operating room. With its comprehensive coverage of thoracic as well as adult and pediatric cardiac surgery, this 9th Edition is an essential resource not only for all thoracic surgeons, but also for physicians, residents, and students concerned with diseases of the chest. - Find what you need quickly with short, focused chapters divided into three major sections: Adult Cardiac Surgery, Pediatric Cardiac Surgery, and Thoracic Surgery. - Benefit from the knowledge and expertise of global experts who provide a comprehensive view of the entire specialty. - Master all of the most important current knowledge and techniques in cardiac and thoracic surgery—whether for specialty board review or day-to-day surgical practice. - Visualize challenging surgical techniques and procedures and navigate the text more efficiently thanks to an all-new, full-color design. - Stay up to date with revised or all-new chapters including Critical Care for War-related Thoracic Surgery; Neuromonitoring and Neurodevelopment Outcomes in Congenital Heart Surgery; and Quality Improvement: Surgical Performance. - Keep abreast of cutting-edge topics such as endovascular stenting and cell-based therapies, as well as the latest innovations in imaging and diagnosis, minimally invasive cardiothoracic surgery, and percutaneous devices. - Sharpen your surgical skills with access to 21 procedural videos online, including 3 new videos covering Surgical Technique-VATS Sympathetic Block; Open pneumothorax; and Extent II repair of thoracoabdominal aortic aneurysm.
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