In Configurations of Rape in the Hebrew Bible, Frank M. Yamada explores the compelling similarity among three rape narratives found in the Hebrew Scriptures. These three stories the rape of Dinah (Genesis 34), the rape of an unnamed concubine (Judges 19), and the rape of Tamar, daughter of David (2 Samuel 13) move through the same plot progression: an initial sexual violation of a woman leads to escalating violence among men, resulting in some form of social fragmentation. In this intriguing study, Yamada draws from the disciplines of literary and narrative criticism, feminist biblical interpretation, and cultural anthropology to argue for a family resemblance among these three stories about rape.
Endoscopic ultrasound (EUS) is now considered one of the most essential and cost-effective techniques in the assessment of a wide range of gastrointestinal diseases. A remarkably versatile, minimally invasive procedure, it also calls for a high level of anatomic knowledge and technical prowess. This lavishly illustrated volume -- a textbook and atlas in one -- offers medical professionals the most comprehensive overview of EUS available, as well as a wealth of valuable insights from diverse leaders in the field. Features: More than 900 up-to-date, superior-quality images Clear, step-by-step instructions for all current procedures and techniques Logical, easy-to-use structure throughout, including the requisite anatomy and pathology Strategies for selecting patients and procedures, including hygiene requirements, informed consent, patient positioning and monitoring, and more Precise clinical descriptions and valuable tips and techniques for diagnosis and treatment Guidance on the successful handling of needling and catheters Insightful discussions of the uses and limitations of evolving techniques Chapters on contrast-enhanced EUS techniques and SonoElastography Designed specifically for specialists and trainees in gastroenterology, pneumology, and surgery, Endoscopic Ultrasound -- with its broad scope and up-to-date information -- is also essential reading for anyone wishing to explore and exploit the potential of state-of-the-art EUS.
With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. • Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs • Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines • Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan • Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain
This book provides an account of the structure and properties of crystalline binary adducts. Such crystals are perhaps better known as molecular compounds and complexes and are estimated to make up one quarter of the world's crystals. More than 600 figures, 200 tables and 3500 references are included in the book.
This book covers topics from a wide variety of disciplines including cell biology, developmental biology, ecology, endocrinology, genetics, molecular biology, neurobiology, and pharmacology. There is a focus on circadian (daily), tidal, seasonal, and annual rhythms, as well as other biological rhythms. Rhythms are placed within the context of the functional significance of these rhythms for the health and well-being of relevant organisms and include genetic and molecular mechanisms of biological timekeeping, melatonin and pineal gland rhythms, as well as on the chronobiology and chronotherapy of cardiovascular, pulmonary, ulcer, and other diseases.
Reviews the origins of molecular oncology, including technologies for cancer analysis, key pathways in human malignancies, and available pharmacologic therapies.
Through seven successful editions, Sabiston & Spencer Surgery of the Chest has set the standard in cardiothoracic surgery references. Now, the new 8th Edition, edited by Frank W. Sellke, MD, Pedro J. del Nido, MD, and Scott J. Swanson, MD, carries on this tradition with updated coverage of today's essential clinical knowledge from leaders worldwide. Guidance divided into three major sections—Adult Cardiac Surgery, Congenital Heart Surgery, and Thoracic Surgery—lets you quickly find what you need, while new and revised chapters reflect all of the important changes within this rapidly evolving specialty. Expert Consult functionality—new to this edition—enables you to access the complete contents of the 2-volume set from anyplace with an Internet connection for convenient consultation where and when you need it. This is an ideal source for mastering all of the most important current knowledge and techniques in cardiac and thoracic surgery—whether for specialty board review or day-to-day practice. Features short, focused chapters that help you find exactly what you need. Presents the work of international contributors who offer a global view of the entire specialty. Covers thoracic surgery as well as adult and pediatric cardiac surgery for a practical and powerful single source. Includes nearly 1,100 illustrations that help to clarify key concepts. Features online access to the complete contents of the 2-volume text at expertconsult.com for convenient anytime, anywhere reference. Covers the hottest topics shaping today's practice, including the latest theory and surgical techniques for mitral valve disease, advances in the treatment of congenital heart disease, minimally invasive surgical approaches to the treatment of adult and congenital cardiac disease and thoracic disease, stent grafting for aortic disease, and cell-based therapies. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
Ultrasound is the backbone of modern obstetric and gynecology practice. Recent technological breakthroughs in diagnostic ultrasound, including the advent of color Doppler, power Doppler, three-dimensional and four dimensional imaging, have led ultrasound to surpass the expectations of Ian Donald, its visionary father. The text is divided into three parts general aspects, obstetrics, and gynecology. The first and second textbooks were successful in this endeavor, but with the explosion of knowledge, it was clear that an expanded and updated third edition would be invaluable. Section one deals with a variety of topics that lay the foundation for the rest of the book. Section two addresses the myriad subtopics in obstetric ultrasound that optimize the care of pregnant women and fetal patients. The last section addresses the essential role that ultrasound plays in the many dimensions of clinical gynecology.
Pharmacology of Pain provides a complete review of the pharmacology of pain, including mechanisms of drug actions, clinical aspects of drug usage, and new developments. This authoritative book describes the different systems involved in the perception, transmission, and modulation of pain and discusses the available options for pharmacological treatment of pain. Who should buy this book? Pharmacology of Pain is a particularly useful resource for: Basic researchers and clinicians, including physicians, dentists, pharmacists, nurses, and physical therapists Other professionals in the field of pain research and treatment Students and trainees
Macrocyclic molecules contain rings made up of seven or more atoms. They are interesting because they provide building blocks for synthesizing precise two or three dimensional structures – an important goal in nanotechnology. For example, they can be used to develop nanosized reaction vessels, cages, switches and shuttles, and have potential as components in molecular computers. They also have applications as catalysts and sensors. Macrocycles: Construction, Chemistry and Nanotechnology Applications is an essential introduction this important class of molecules and describes how to synthesise them, their chemistry, how they can be used as nanotechnology building blocks, and their applications. A wide range of structures synthesised over the past few decades are covered, from the simpler cyclophanes and multi-ring aromatic structures to vases, bowls, cages and more complex multi-ring systems and 3D architectures such as “pumpkins”, interlocking chains and knots. Topics covered include: principles of macrocycle synthesis simple ring compounds multi-ring aromatic structures porphyrins and phthalocanines cyclophanes crown ethers, cryptands and spherands calixarenes, resorcinarenes, cavitands, carcerands, and heterocalixarenes cyclodextrins cucurbiturils cyclotriveratylenes rotaxanes catenanes complex 3D architectures, including trefoils and knots Macrocycles: Construction, Chemistry and Nanotechnology Applications distills the essence of this important topic for undergraduate and postgraduate students, and for researchers in other fields interested in getting a general insight into this increasingly important class of molecules.
Learn to master a highly specialized form of animal surgery. Oral and Maxillofacial Surgery in Dogs and Cats, 2nd Edition offers a unique, detailed, comprehensive and highly illustrated account of surgical procedures that will improve outcomes for all surgical and dental specialists. The second edition of this text is a collaborative effort from both human and veterinary oral surgeons – each considered an expert in their field. With in-depth clinical photos, and illustrations, this indispensable resource is perfect for both general practitioners and students alike. - An authoritative collaboration between human and animal surgeons includes over 30 international contributors whorepresent the peak of professional expertise in the field. - UNIQUE! Only book on the market devoted to a surgical specialty of growing relevance provides you with a look at a highly specialized practice. - High-quality illustrations combined with step-by-step textual guidance give you a clear understanding of the material. - In-depth descriptions of surgical conditions provide you with detailed explanations of surgical procedures. - NEW! Expert Consult site provides you with digital access to the full textbook. - NEW! Additional chapters on the latest discoveries and techniques cover Diagnostic imaging in oral and maxillofacial surgery, Piezosurgery, Temporomandibular ankyloses and pseudoankylosis, and Regenerative techniques in maxillofacial surgery.
The new edition covers 285 conditions, disorders, and diseases routinely seen by orthopaedic surgeons, orthopaedists, primary care physicians, and physical therapists. Topics presents disease or condition history, epidemiology, assessing the patient, diagnosis, treatment, therapy, and other important information. Illustrations are embedded throughout, and provide much-needed visual context to the written content.
This Second Edition is the premier name resource in the field. It provides a handy resource for navigating the web of named reactions and reagents. Reactions and reagents are listed alphabetically, followed by relevant mechanisms, experimental data (including yields where available), and references to the primary literature. The text also includes three indices based on reagents and reactions, starting materials, and desired products. Organic chemistry professors, graduate students, and undergraduates, as well as chemists working in industrial, government, and other laboratories, will all find this book to be an invaluable reference.
Provides a high level reference source for scientists engaged in any aspect of plant research - chemistry, biochemistry or physiology - with primary focus on the chemistry of phosphorus-containing compounds that occur naturally in the plant kingdom, and specifically in the higher plants (Plantae). The book is comprehensive with respect to nomenclature, physical properties, and distribution worldwide. There are many tables of actual data on phosphorus compounds occurring in whole plants and parts of plants. The tables provide detailed data that is needed by the food industry, agriculture, etc as many of the phosphorus compounds are common to both plants and animals. Two appendices cover other aspects including changes in phosphorus-containing compounds during germination and their accumulation during growth and senescence. The final sections of the book comprise separate indexes of plants, compounds and authors. - Comprehensive examination of phosphorus compounds found in plants - Extensive tables listing types of compounds and their occurrence in plants including: Nomenclature; Occurrence; Physical Properties; Synthesis; Hydrolysis; Phosphorylation; Extraction; Separation and Analysis - Easy to use indexes of plants, compounds and authors
In March 1979, a prototype of a ‘Compact Disc (CD) digital audio system’ was publicly presented and demonstrated to an audience of about 300 journalists at Philips in Eindhoven, The Netherlands. This milestone effectively marked the beginning of the digital entertainment era. In the years to follow, the CD-audio system became an astonishing worldwide success, and was followed by successful derivatives such as CD-ROM, CD-RW, DVD, and recently Blu-ray Disc. Today, around the thirtieth anniversary of the milestone, it is taken for granted that media content is stored and distributed digitally, and the analog era seems long gone. This book retraces the origins of the CD system and the subsequent evolution of digital optical storage, with a focus on the contributions of Philips to this field. The book contains perspectives on the history and evolution of optical storage, along with reproductions of key technical contributions of Philips to the field.
In Configurations of Rape in the Hebrew Bible, Frank M. Yamada explores the compelling similarity among three rape narratives found in the Hebrew Scriptures. These three stories the rape of Dinah (Genesis 34), the rape of an unnamed concubine (Judges 19), and the rape of Tamar, daughter of David (2 Samuel 13) move through the same plot progression: an initial sexual violation of a woman leads to escalating violence among men, resulting in some form of social fragmentation. In this intriguing study, Yamada draws from the disciplines of literary and narrative criticism, feminist biblical interpretation, and cultural anthropology to argue for a family resemblance among these three stories about rape.
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