This book celebrates a number of Guadalupan sermons that serve as the fundamental source of the Mexican people's unique spiritual devotion and identity. These sermons were preached, published, and circulated among the populace of Mexico in the seventeenth and eighteenth centuries. They proclaim an unshakable conviction that the peoples of the American continent are the uniquely blessed recipients of God's, and especially Mary's, favor. In their modern sense, these sermons provide a wealth of information on Mexican theology, spirituality, and religious self-understanding at a pivotal time in a people's culture.
About two centuries after the communication by Sir Percival Pott that the "chimney sweeper disease" was a cancer and its suggestion that active compounds of soot were the causative agents, and about one century after the description of urinary bladder cancer in dye workers, an enormous number of substances have been synthesized and have probably come into contact with man. Research in cancer prevention is of primary importance, and may receive continuous support from new discoveries on cancer etiology and pathogenesis. If one accepts the multistage model of chemical carcinogenesis, one has also to accept that many events occur between the contact of carcino genic compounds and their specific targets and the development of a clinically recognizable neoplasm. Thus, animal studies become essential to elucidate the different steps by which chemical carcinogens induce neoplasia. The analysis of these steps and the comparative evaluation of experimental models is essential to an understanding of pathogenesis.
An excellent, concise, and interdisciplinary overview of different classes of emerging pollutants arising, for example, from pharmaceuticals, pesticides, personal care products, and industrial chemicals and their impact on water, soil, and air. Following an introduction to chemical pollutants, with special attention focused on organic compounds and their properties, the book goes on to describe major emerging pollutants grouped according to their applications in different sectors of industrial or economic activity. For each type of compound, the chemical structure, main properties, and source are presented, along with their fate in the environment as pollutants, the latest analytical methods for detection, possible health or ecology consequences, as well as current regulatory laws. New developments, such as nanotechnology as a pollution source, are also included. The book closes with a chapter devoted to conclusions and future perspectives.
Mammals are the so-called "pinnacle" group of vertebrates, successfully colonising virtually all terrestrial environments as well as the air (bats) and sea (especially pinnipeds and cetaceans). How mammals function and survive in these diverse environments has long fascinated mammologists, comparative physiologists and ecologists. Ecological and Environmental Physiology of Mammals explores the physiological mechanisms and evolutionary necessities that have made the spectacular adaptation of mammals possible. It summarises our current knowledge of the complex and sophisticated physiological approaches that mammals have for survival in a wide variety of ecological and environmental contexts: terrestrial, aerial, and aquatic. The authors have a strong comparative and quantitative focus in their broad approach to exploring mammal ecophysiology. As with other books in the Ecological and Environmental Physiology Series, the emphasis is on the unique physiological characteristics of mammals, their adaptations to extreme environments, and current experimental techniques and future research directions are also considered. This accessible text is suitable for graduate level students and researchers in the fields of mammalian comparative physiology and physiological ecology, including specialist courses in mammal ecology. It will also be of value and use to the many professional mammologists requiring a concise overview of the topic.
Akka solves the big problems of distributed systems, from multithreading and concurrency to scalability and failure. Learn how to use it effectively. In Akka in Action, Second Edition you will learn how to: Create basic programs with Akka Typed Work with clusters to build robust, fault-tolerant programs Use Akka with Kubernetes Build microservices with Akka Create and maintain distributed state with strong consistency guarantees Employ actor-based concurrency and parallelism Test Akka software Akka in Action, Second Edition teaches you to use Akka Typed to solve common problems of distributed systems. You’ll learn how to bring together all of Akka’s moving parts to design and implement highly scalable and maintainable software. Extensively revised by Akka contributor Francisco López-Sancho Abraham, this new edition demonstrates Akka’s complex concepts through engaging hands-on examples. Discover the power of the Actor Model, how Akka works with Kubernetes, and how to utilize Akka modules to create microservices that are reliable and fault tolerant. About the technology For large software systems, the action is in the “-ilities.” Scalability. Reliability. Maintainability. Capability. Akka, toolkit for building distributed message-driven applications, delivers on the “ilities.” And recent innovations, including Akka Typed, ensure that this amazing platform will remain the best way to build and deploy distributed Java and Scala applications for years to come. About the book Akka in Action, Second Edition is your guide to building message-centric distributed applications systems. This new edition covers all features of Akka, including Akka Typed. You’ll learn to create microservices using Akka’s powerful suite of tools, Akka Sharding, Persistence, Streams, Persistence Query, Projections, and gRPC. Practical examples taken directly from industry guide you through clustering, deploying to Kubernetes, and taking full advantage of Akka’s Actors-based approach to concurrency. What's inside Work with clusters to build robust, fault-tolerant programs Maintain distributed systems with strong consistency guarantees Utilize concurrency and parallelism Test Akka software About the reader For readers comfortable with Java and Scala. About the author Francisco Lopez Sancho-Abraham is a senior consultant at Lightbend, and a principal engineer on the Akka Team. Raymond Roestenburg, Rob Bakker, and Rob Williams are the authors of the first edition of Akka in Action. Table of Contents 1 Introducing Akka 2 Up and running 3 One actor is no actor 4 Akka test kit 5 Fault tolerance 6 Discovery and routing 7 Configuration 8 Clustering 9 Sharding and persistence 10 Streams, persistence queries, and projections 11 Akka ports 12 Real-world example: An Akka betting house 13 Clustering, part 2 14 Connecting to systems with Alpakka 15 Akka betting house, part 2 16 Akka Streams, part 2
Supporting the Workplace Learning of Vocational and Further Education Teachers is written to help people understand the arrangements in a workplace that enable and constrain teacher learning – and then to do something about it. It provides an accessible, research based, and practical guide to making changes in the workplace to enable teacher learning. The book illustrates approaches to supporting workplace learning through the extensive use of vignettes from real teachers and real teaching workplaces. With a focus on mentoring as an important component of teacher learning, it introduces the concept of a trellis of practices together with approaches for developing arrangements in the workplace that support teacher learning. It also examines the spaces between the personal and the professional and how these can become Communicative Learning Spaces where professional learning occurs. The strategies and ideas provided in this book can be implemented at a whole-of-organisation, teaching department, small team, or individual level. An essential resource for Vocational Education and Training (VET) and Further Education (FE) teachers and managers, as well as others who support teacher learning in the workplace, this book is written to help make a difference.
This book presents the characteristics and limitations of geological units, Cenozoic and geochronological concepts. It studies landscape aspects developed from research in areas with proved Cenozoic tectonic activity, such as the Potiguar basin, located between the states of Ceara and Rio Grande do Sul in Brazil. The analytical focus involves the relationship between tectonics and landscapes in different scales, in hills or karsts, or regional, in basins, and massifs.
Examines new research on the role of cholesterol in regulating ion channels and receptors and its effect on health Drawing together and analyzing all the latest research findings, this book explores the role of cholesterol in the regulation of ion channels and receptors, including its pathological effects. It is the first book to comprehensively describe the complex mechanisms by which cholesterol regulates two major classes of membrane proteins. Moreover, it sheds new light on how cholesterol affects essential cellular functions such as the contraction of the heart, propagation of nerve impulses, and regulation of blood pressure and kidney function. Written and edited by leading pioneers in the field, Cholesterol Regulation of Ion Channels and Receptors is divided into three parts: Part I, Cholesterol Regulation of Membrane Properties, introduces the heterogeneity of cholesterol distribution in biological membranes and the physical and biological implications of the formation of cholesterol-rich membrane domains. Part II, Cholesterol Regulation of Ion Channels, examines the mechanisms underlying cholesterol sensitivities of ion channels, including the regulation of ion channels by cholesterol as a boundary lipid. Part III, Cholesterol Regulation of Receptors, explores the latest discoveries concerning how cholesterol regulates distinct types of receptors, including G-protein coupled receptors, LDL and scavenger receptors, and innate immune system receptors. Increased levels of cholesterol represent a major health risk. Understanding cholesterol regulation of ion channels and receptors is essential for facilitating the development of new therapeutic strategies to alleviate the impact of pathological cholesterol conditions. With this book as their guide, readers have access to the most current knowledge in the field.
In recent years, a great number of publications have explored the use of genetic algorithms as a tool for designing fuzzy systems. Genetic Fuzzy Systems explores and discusses this symbiosis of evolutionary computation and fuzzy logic. The book summarizes and analyzes the novel field of genetic fuzzy systems, paying special attention to genetic algorithms that adapt and learn the knowledge base of a fuzzy-rule-based system. It introduces the general concepts, foundations and design principles of genetic fuzzy systems and covers the topic of genetic tuning of fuzzy systems. It also introduces the three fundamental approaches to genetic learning processes in fuzzy systems: the Michigan, Pittsburgh and Iterative-learning methods. Finally, it explores hybrid genetic fuzzy systems such as genetic fuzzy clustering or genetic neuro-fuzzy systems and describes a number of applications from different areas.Genetic Fuzzy System represents a comprehensive treatise on the design of the fuzzy-rule-based systems using genetic algorithms, both from a theoretical and a practical perspective. It is a valuable compendium for scientists and engineers concerned with research and applications in the domain of fuzzy systems and genetic algorithms.
Environmental issues are a growing concern for our society, and should deserve increased attention, given the extremely negative climate changes which have been taking place. Emissions of greenhouse gases, excessive dependence on fossil fuels, growing consumption of power energy, and exacerbated consumption of materials are some of the problems that need to be addressed urgently. Some of these problems can be overcome through ingenious solutions based on automation. This book aims to make a contribution precisely in this sense, criticizing the current state of society in general and providing some solutions that can be used as a basis for the development of more environmentally friendly systems.
Ecological Impacts of Toxic Chemicals presents a comprehensive, yet readable account of the known disturbances caused by all kinds of toxic chemicals on both aquatic and terrestrial ecosystems. Topics cover the sources of toxicants, their fate and distribution through the planet, their impacts on specific ecosystems, and their remediation by natural systems. Each chapter is written by well-known specialists in those areas, for the general public, students, and even scientists from outside this field. The book intends to raise awareness of the dangers of chemical pollution in a world dominated by industry and globalization of resources. Because the problems are widespread and far reaching, it is hoped that confronting the facts may prompt better management practices at industrial, agricultural and all levels of management, from local to governmental, so as to reduce the negative impacts of chemical contaminants on our planet.
This book is the latest and most comprehensive reference to the regional geography of Spain, taking into account emergent issues such as biodiversity, climate change and nationalism. It appeals to scientists as well as to students and instructors and all fields of geography, regional, environmental and cultural studies, and business related disciplines. It covers the whole range of topics from the physical to the human geography of Spain and provides detailed insights into all 17 autonomous communities. Dozens of GIS maps and hundreds of photographs and images including remote sensing imagery make this volume a must have for every geography department.
Psychocutaneous Medicine offers an overview of diseases in psychosomatic dermatology and creates a bridge between cutaneous and emotional disorders using extraordinary illustrations and clinical images of psychosomatic dermatology. It covers both common and rare diseases and helps doctors and psychologists recognize and deal with psychosocial features in dermatology and venerology. This superbly illustrated clinical atlas with concise text passages follows the American diagnosis classification DSM-V and current evidence-based guidelines. It allows rapid recognition of masked emotional disorders and thus administration of the most effective and efficient treatment as early as possible. Hone your diagnostic vision for psychosomatic disorders. Treat your patients efficiently and effectively. Psychocutaneous Medicine is a picture atlas and textbook that is indispensable for dermatologists, psychologists, pediatricians and general practitioners.
Advanced Techniques in Musculoskeletal Medicine & Physiotherapy is a brand new, highly illustrated guide to the diagnosis and treatment of musculoskeletal disorders. It demonstrates how to safely and effectively use selected minimally invasive therapies in practice. In addition to more well-established techniques such as acupuncture or dry needling, this ground-breaking resource also covers techniques including intratissue percutaneous electrolysis, mesotherapy, percutaneous needle tenotomy, and high volume image guided injections. Other featured chapters include those on specific musculoskeletal ultrasound such as sonoanatomy and ultrasound-guided procedures. Each chapter describes the principles, indications and contraindications, mechanisms of action and detailed outlines of techniques with an emphasis throughout on accessible practical information. Additionally, methodologies, research results and summaries of studies for particular minimally invasive therapies are presented. The book is also supported by a companion website – www.advancedtechniquesonline.com – containing procedural video clips, a full colour image library and interactive multiple choice questions (MCQs). - skills-based and clinically-oriented – reinforced by the latest contemporary scientific medical research - chapters on outcomes in clinical practice - indications and contraindications discussed - clinical cases, key terms and key points boxes used throughout - companion website – www.advancedtechniquesonline.com – containing procedural video clips, full colour image bank and interactive MCQs
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