This second edition adds 46 new problems, for a total of 203. The solutions to certain “old” problems have been revised for improved clarity, in response to questions and comments from our students (second-year students in the Master’s in Physics program). Each problem is given a title indicating its relation to the various areas of physics or technology. By tackling the problems presented here, students are gently introduced to advanced topics such as unipolar and homopolar motors, magnetic monopoles, radiation pressure, angular momentum of light, bulk and surface plasmons, and radiation friction. We also address a number of tricky concepts and apparent ambiguities and paradoxes encountered in the classical theory of electromagnetism, with a particular focus on conservation laws and transformation properties between different frames of reference. At the same time, the book can be used as an introduction to applications of classical electromagnetism including cutting-edge topics like plasmonics, metamaterials, and light-driven propulsion. While unnecessary mathematical complexity is avoided, the new edition also provides a few introductory examples concerning elegant and powerful solution techniques. Hopefully the second edition offers an even better teaching tool for undergraduates in physics, mathematics, and electric engineering, and a valuable reference guide for students planning to work in optics, material science, electronics, and plasma physics.
Duchenne Muscular Dystrophy, an inherited and progressive muscle wasting disease, is one of the most common single gene disorders found in the developed world. In this fourth edition of the classic monograph on the topic, Alan Emery and Francesco Muntoni are joined by Rosaline Quinlivan, Consultant in Neuromuscular Disorders, to provide a thorough update on all aspects of the disorder. Recent understanding of the nature of the genetic defect responsible for Duchenne Muscular Dystrophy and isolation of the protein dystrophin has led to the development of new theories for the disease's pathogenesis. This new edition incorporates these advances from the field of molecular biology, and describes the resultant opportunities for screening, prenatal diagnosis, genetic counselling and from recent pioneering work with anti-sense oligonucleotides, the possibility of effective RNA therapy. Although there is still no cure for the disorder, there have been significant developments concerning the gene basis, publication of standards of care guidelines, and improvements in management leading to significantly longer survival, particularly with cardio-pulmonary care. The authors also investigate other forms of pharmacological, cellular and gene therapies. Duchenne Muscular Dystrophy will be essential reading not only for scientists and clinicians, but will also appeal to therapists and other professionals involved in the care of patients with muscular dystrophy.
The Vascular Endothelium: A Holistic Approach for Oncology provides novel and integrated knowledge on the endothelial cells as a crucial component involved in the growth of different organs in both physiological and pathological conditions. By covering diverse aspects of anatomy, embryology, molecular biology and pathology, it details the important role of the endothelium for the pathogenesis of cancer and how this knowledge can improve the outcome of cancer research.The content is split in six parts: appearance and evolution of the endothelial cell, which discusses for instance comparative anatomy of the endothelium in relation to the vascular system; endothelial cell in embryology and organogenesis, covering the interaction between endothelial and hematopoietic cells; the lymphatic system, which brings information on lymphatic endothelial cell markers and molecular regulation of lymphangiogenesis; the anatomy of the endothelium in adults, showing the differences in the mature endothelial cells through the body; the physiology of the endothelial cells, with organ specific physiological activity of the endothelium; and the endothelial cells in cancer, discussing the use of endothelium as target for treatment and current therapeutic approaches.This book is a valuable resource for cancer researchers, oncologists and other members of biomedical field who are interested to learn more about the complexity of vascular endothelium and its impact on cancer and other related diseases. - Provides a holistic approach to the knowledge of endothelial cells in different organs, from early years of development to adulthood - Discusses relevant aspects of endothelial cells related to the pathogenesis of cancer to be applied to novel therapeutics - Presents an interdisciplinary view of the vascular endothelium, covering anatomy, embryology, molecular biology, pathology and clinical implications
This Brief provides a concise review of chaperonopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters deal with the chaperoning system and chaperoning teams and networks, HSP-chaperone subpopulations, the locations and functions of chaperones, and chaperone genes in humans. Other chapters present the chaperonopathies in general, including their molecular features and mechanistic classification into by defect, excess, or mistake. Subsequent chapters discuss the chaperonopathies in more detail, focusing on their distinctive characteristics: primary or secondary; quantitative and/or qualitative; structural and hereditary or acquired; genetic polymorphisms; gene dysregulation; age-related; associated with cancer, chronic inflammatory conditions, and autoimmune diseases. The interconnections between the chaperoning and the immune systems in cancer development, chronic inflammation, autoimmunity, and ageing are outlined, which leads to a discussion on the future prospects of chaperonotherapy. The latter may consist of chaperone gene and protein replacement/supplementation in cases of deficiency and of gene or protein blocking when the chaperone actively promotes disease. The last chapter presents the extracellular chaperones and details on how the chaperone Hsp60 is secreted into the extracellular space and, thus, appears in the blood of cancer patients with potential to participate in carcinogenesis and chronic inflammation and autoimmunity. Chaperones as clinically useful biomarkers are mentioned when pertinent. Likewise, guidelines for clinical evaluation of chaperonopathies and for their histopathological and molecular identification are provided throughout. The book also provides extensive bibliography organized by chapter and topic with comments.
The book describes the development and commercialization of materials with viscoelastic properties, placing particular emphasis on the scientific and technological differences between plastics and bioplastics. The authors explain how to handle each of the two types of materials and determine the comparative environmental impact of the material life-cycle. The practical values of the overlapping aspects of the two types of materials from technical properties to eco-compatibility are also discussed.
This second edition adds 46 new problems, for a total of 203. The solutions to certain “old” problems have been revised for improved clarity, in response to questions and comments from our students (second-year students in the Master’s in Physics program). Each problem is given a title indicating its relation to the various areas of physics or technology. By tackling the problems presented here, students are gently introduced to advanced topics such as unipolar and homopolar motors, magnetic monopoles, radiation pressure, angular momentum of light, bulk and surface plasmons, and radiation friction. We also address a number of tricky concepts and apparent ambiguities and paradoxes encountered in the classical theory of electromagnetism, with a particular focus on conservation laws and transformation properties between different frames of reference. At the same time, the book can be used as an introduction to applications of classical electromagnetism including cutting-edge topics like plasmonics, metamaterials, and light-driven propulsion. While unnecessary mathematical complexity is avoided, the new edition also provides a few introductory examples concerning elegant and powerful solution techniques. Hopefully the second edition offers an even better teaching tool for undergraduates in physics, mathematics, and electric engineering, and a valuable reference guide for students planning to work in optics, material science, electronics, and plasma physics.
This book contains 157 problems in classical electromagnetism, most of them new and original compared to those found in other textbooks. Each problem is presented with a title in order to highlight its inspiration in different areas of physics or technology, so that the book is also a survey of historical discoveries and applications of classical electromagnetism. The solutions are complete and include detailed discussions, which take into account typical questions and mistakes by the students. Without unnecessary mathematical complexity, the problems and related discussions introduce the student to advanced concepts such as unipolar and homopolar motors, magnetic monopoles, radiation pressure, angular momentum of light, bulk and surface plasmons, radiation friction, as well as to tricky concepts and ostensible ambiguities or paradoxes related to the classical theory of the electromagnetic field. With this approach the book is both a teaching tool for undergraduates in physics, mathematics and electric engineering, and a reference for students wishing to work in optics, material science, electronics, plasma physics.
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