Aging of the Autonomic Nervous System is the first book devoted to the aging of the autonomic nervous system. The book presents the most recent findings on topics such as general aspects of the autonomic nervous system, main neurotransmitter systems, age-dependent changes of neuroeffector mechanisms in target organs, and therapeutic perspectives. It also provides a comprehensive analysis of the possible consequences of these findings. Aging of the Autonomic Nervous System will be a useful volume for gerontologists and neuroscientists.
Territory, Time and State is a study of long term archaeological history in the remote and beautiful upland valley of Gubbio within the Umbrian Apennines of Italy. The aim of the work is well defined by the natural constraints of this mountainous region. The authors have developed a multi-disciplinary approach to study the human and physical characteristics of the valley from the paleolithic to the medieval period. They integrate the analysis of a unique text (the Iguvine Tables) with excavation, field survey and environmental reconstruction to provide a synthesis of current knowledge. They break boundaries of time and tradition which are normally compartmentalised between different scholars. Although the linkage is sometimes controversial, it is always stimulating. The book has two major focuses: the first is on the Bronze Age landscape where spectacular sites and finds have contributed very significantly to our knowledge of pre-state Italy; and the second is on the identity and character of the early city state of Gubbio and its incorporation into the Roman world.
High in the Sibillini Mountains of central Italy, famous since Roman times for their curative waters, a killer deposits his victims' bodies within the ancient local churches. An environmental fanatic, a mystical cult, a pragmatic business plan...?
Osteoimmunology pertains to the study of the relationship between the bones, particularly the bone marrow, and the immune system. This monograph pursues the best available evidence, by means of research synthesis, for the characterization of the physiological relevance and pathological implications of the inter-connectedness between the skeletal and the immune system. Research will be discussed that highlights the associated role of the circulatory, nervous and endocrine systems, as well as proteomic and genomic pathways and signatures. Emphasis is given that domain of medicine that relates to the oral cavity, its diseases and their systemic sequelae. This monograph arises from observations that have suggested that the skeletal system and the immune system are intimately intertwined. Chronic inflammatory reactions subsequent to an excessive immune reaction can damage the bones, as in rheumatoid arthritis (RA), osteoporosis, patients seropositive for the human immunodeficiency virus (HIV)-1 and with signs and symptoms of the acquired immune deficiency syndrome (AIDS), and bone cancer. Bones – in particular the bone marrow – are one of the primary locations in which cells of the immune system mature. In brief, this monograph begins to answer a range of questions, such as, what is osteoimmunology all about?, does the immune system and its components affect bone development?, how do stress hormones impact upon the pathophysiology of bone-immune interactions?, can the scientific process of research synthesis, obtain the best available evidence for treatment of diseases involving the bone-immune entity (i.e., osteo immunopathologies) means of evidence-based clinical decision-making directed at the treatment of osteoimmune pathologies?
A stark departure from traditional philology, What is Authorial Philology? is the first comprehensive treatment of authorial philology as a discipline in its own right. It provides readers with an excellent introduction to the theory and practice of editing ‘authorial texts’ alongside an exploration of authorial philology in its cultural and conceptual architecture. The originality and distinction of this work lies in its clear systematization of a discipline whose autonomous status has only recently been recognised (at least in Italy), though its roots may extend back as far as Giorgio Pasquali. This pioneering volume offers both a methodical set of instructions on how to read critical editions, and a wide range of practical examples, expanding upon the conceptual and methodological apparatus laid out in the first two chapters. By presenting a thorough account of the historical and theoretical framework through which authorial philology developed, Paola Italia and Giulia Raboni successfully reconceptualize the authorial text as an ever-changing organism, subject to alteration and modification. What is Authorial Philology? will be of great didactic value to students and researchers alike, providing readers with a fuller understanding of the rationale behind different editing practices, and addressing both traditional and newer methods such as the use of the digital medium and its implications. Spanning the whole Italian tradition from Petrarch to Carlo Emilio Gadda, this ground-breaking volume provokes us to consider important questions concerning a text’s dynamism, the extent to which an author is ‘agentive’, and, most crucially, about the very nature of what we read.
Regional integration and territorial development in Latin America / Paolo Giordano, Francesco Lanzafame, and Jörg Meyer-Stamer -- Free trade agreements and asymmetries : proposals to foster gains from trade / Inés Bustillo and José Antonio Ocampo -- Comparative integration patterns : transatlantic lessons / Raúl Hinojosa-Ojeda -- Compensating asymmetries in regional integration agreements : lessons from Mercosur / Roberto Bouzas -- Differential regional competitiveness : opportunities and constraints / Ann Markusen and Clélio Campolina Diniz -- The regional challenge : European and Latin American experiences / Francisco Xabier Albistur Marin -- Globalization and local policy implementation : the challenge to practitioners / Greg Clark -- Local economic development : what makes makes it difficult, what makes it work / Jörg Meyer-Stamer.
The Vascular Endothelium: A Holistic Approach for Oncology provides novel and integrated knowledge on the endothelial cells as a crucial component involved in the growth of different organs in both physiological and pathological conditions. By covering diverse aspects of anatomy, embryology, molecular biology and pathology, it details the important role of the endothelium for the pathogenesis of cancer and how this knowledge can improve the outcome of cancer research.The content is split in six parts: appearance and evolution of the endothelial cell, which discusses for instance comparative anatomy of the endothelium in relation to the vascular system; endothelial cell in embryology and organogenesis, covering the interaction between endothelial and hematopoietic cells; the lymphatic system, which brings information on lymphatic endothelial cell markers and molecular regulation of lymphangiogenesis; the anatomy of the endothelium in adults, showing the differences in the mature endothelial cells through the body; the physiology of the endothelial cells, with organ specific physiological activity of the endothelium; and the endothelial cells in cancer, discussing the use of endothelium as target for treatment and current therapeutic approaches.This book is a valuable resource for cancer researchers, oncologists and other members of biomedical field who are interested to learn more about the complexity of vascular endothelium and its impact on cancer and other related diseases. - Provides a holistic approach to the knowledge of endothelial cells in different organs, from early years of development to adulthood - Discusses relevant aspects of endothelial cells related to the pathogenesis of cancer to be applied to novel therapeutics - Presents an interdisciplinary view of the vascular endothelium, covering anatomy, embryology, molecular biology, pathology and clinical implications
The progressive ageing of the general population and the consequent increase of the number of old people has made the typical medical problems of aged people more frequently observed, and particularly the problems related to the ageing brain. This new book is an updated overview of relevant aspects of cognitive decline associated with ageing. Within the wide landscape of brain ageing the authors reconsider the role of the main predisposing factors and risk factors on the development of various form of mental decline, from mild cognitive impairment to dementia. The strength of this book is the large, updated overview of the most recent data of scientific literature regarding the role of genetic, metabolic and environmental factors on the predisposition and onset of cognitive decline. Particular attention is paid to the dietary micro- and macronutrients and to their possible role in the pathogenesis of the various form of dementigen disorders.
The first English translation of Petrarch’s Psalms and Prayers provides an intimate look at the personal devotions of the “Father of Humanism.” Throughout Petrarch’s work, there is an undercurrent of tension between the secular and the sacred. In this captivating new translation of the Psalms and the Prayers, Demetrio Yocum turns to a previously overlooked area of Petrarchan studies to open a window on the scholar’s innermost religious thoughts. Petrarch's Psalms and Prayers are intricately crafted poetic and devotional works, presented in facing Latin/English format. In his extensive introduction and commentary, Yocum situates these bold, original compositions within their historical, literary, and religious contexts, deftly drawing connections to classical texts, the Bible and the writings of the church fathers, and Petrarch’s own life, work, and poetics. This remarkable first-ever English translation of the Psalms and Prayers helps to reconcile Petrarch’s classical humanism with his devout, deeply personal Christianity.
Based on previously unexplored archival documentation, this book offers the first general overview of the history of Italian eugenics, not limited to the decades of Fascist regime, but instead ranging from the beginning of the 1900s to the first half of the 1970s. The Author discusses several fundamental themes of the comparative history of eugenics: the importance of the Latin eugenic model; the relationship between eugenics and fascism; the influence of Catholicism on the eugenic discourse and the complex links between genetics and eugenics. It examines the Liberal pre-fascist period and the post-WW2 transition from fascist and racial eugenics to medical and human genetics. As far as fascist eugenics is concerned, the book provides a refreshing analysis, considering Italian eugenics as the most important case-study in order to define Latin eugenics as an alternative model to its Anglo-American, German and Scandinavian counterparts. Analyses in detail the nature-nurture debate during the State racist campaign in fascist Italy (1938–1943) as a boundary tool in the contraposition between the different institutional, political and ideological currents of fascist racism.
Investigating water resource law in the statutory legislation codified by commune, oligarchic and seigneurial governments in Northern and Central Italy from the 13th-14th centuries, this book explores the relationship between water management norms and the local environment, and the protection of inhabited areas from the danger of flooding.
Reports on excavations at the prehistoric site Ras Al-Hamra RH-5, located in the Qurum area of Muscat. The site dates from the late 5th to the end of the 4th millennia BC and comprises an accumulation of superimposed food discards deriving from continuous and repeated subsistence activities such as fishing, collecting shells, hunting and herding.
This book tells the curious story of an unexpected finding that sheds light on a crucial moment in the development of physics: the discovery of artificial radioactivity induced by neutrons. The finding in question is a notebook, clearly written in Fermi's handwriting, which records the frenzied days and nights that Fermi spent experimenting alone, driven by his theoretical ideas on beta decay. The notebook was found by the authors while browsing through documents left by Oscar D'Agostino, the chemist among Fermi's group. From Fermi's notes, they reconstruct with skill and expertise the detailed timeline of the critical days leading up to his vital discovery. While much is already known about the road that led Fermi to his important result, this is the first time that it has been possible to reconstruct precisely when and how the initial evidence of neutron-induced decay was obtained. In relating this fascinating story, the book will be of great interest not only to those with a passion for the history of science but also to a wider audience.
This atlas provides valuable information on crucial aspects of sperm examination as well numerous meaningful color illustrations. It discusses successful evaluation of the sperm morphology and the cellular elements other than spermatozoa, enabling readers to unambiguously interpret seminal cytologic images and compare reports for diagnostic, therapeutic and prognostic purposes. With its extensive collection of colored images, the book is intended as a reference resource for students and technicians in the field of andrology as well as practitioners and clinicians in andrology, urology, pathology, IVF and other ART programs
The globalization of financial markets worldwide has progressively pushed toward simultaneous globalization of accounting information. Thus, during the last 50 years, categories of preparers, users, and regulators have devoted their efforts to support the global comparability of financial reporting aiming at favoring the comparison of corporates’ financial performances at a cross-country level. In the same vein, IASB, national standard setters, and jurisdictions have participated in and given momentum to this process. At the same time, academic research has followed this process and tried to build a theoretical framework to address the related issues, to assess the impact on preparers, users, and regulators, while defining hindrances and obstacles to the comparability of financial reporting especially in an IFRS environment. In this context, this book reviews research studies on the comparability of financial reporting at a global level as well as highlights empirical analyses that demonstrate the extent to which global comparability has been achieved, and how it enhances value relevance of earnings across countries. It also looks at the cross-country investors’ perspectives by shaping the empirical analysis to provide further insights on the role of the "Big Four" auditing services in enhancing the comparability of earnings. The book provides an original contribution to the current debate about the comparability of financial reporting under IFRS and will be useful for researchers in the field.
First Published in 1989, this book offers a full, comprehensive guide into the role of Dopamine in the Periphery. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for Students of Medicine, and other practitioners in their respective fields.
Whether as excavators and re-enactors, or co-organising research campaigns and outreach activities, the participation of the general public in archaeology has become a well-represented practice, but the impact remains underexplored. Evaluating participation can influence fieldwork practice and enrich the academic discussion on public archaeology.
Unter dem Siegel der Nekropole 5 Andrew Chugg The Lost Tombs of the Last Pharaohs. The purpose of this fresh article is to present new evidence that connects the sarcophagus of the last 30th Dynasty pharaoh, Nectanebo II, currently displayed in the British Museum, with a fragment of Macedonian funerary sculpture from the middle of the Ptolemaic period, which is now in Venice. The context of this connection is the search for the missing tombs (there were at least three in Egypt) of Alexander the Great. Michael E. Habicht Meta-database of cranial measurements from Ancient Egypt and Nubia. The study presents a complex and extended database of the morphology of skulls and (partly) also for the body proportion in Ancient Egypt through all periods. The database covers the Predynastic time to the Roman period, males and females. In addition, available data on the Royal families are added. Unter dem Siegel der Nekropole 6 Cicero Moraes, Michael Habicht, Francesco M. Galassi, Elena Varotto & F. Donald Pate Facial reconstruction of the mummy Cairo CG 61076 from the Royal Mummies Cachette DB 320. A princess from the late 18th Dynasty? In this paper we investigate the anthropological aspects of the ancient Egyptian mummy Cairo CG 61076 found in the royal cachette of Deir el-Bahari (DB 320) and labelled as Baqt by reassessing the published literature and photographs and producing a facial reconstruction for the first time. South American mummies: an Overview. This preliminary overview of scientific studies on mummies in South America collects all information available in Europe on the topic. The core of the study is the geographical overview of mummies in different countries and various cultures (from pre-Columbian to Modern Age mummies). Updated edition
In the Biden multipolar era, Western Democracies face a dilemma: Should they keep marching behind the free market band, or should they engage the Asia new powers in a collegial governance of the common goods? This book looks for precedents that may guide deliberation. When the first age of globalization collapsed into WWI, Carl Polanyi wrote: "While the various shades of anti-democrats each have their own story of the world catastrophe, the democrat has yet to produce his own" (Polanyi 2018, 177). The interwar period is described through the eyes of five witnesses: J.M. Keynes recalls the surreal Versailles conference; E. Canetti, K. Polanyi, and G. Ferrero reflect on the relationship among power, markets, and the people. In the opposite field, F. von Hayek argues for a supranational agency which may ensure global free trade, bypassing the distortions national democracies procure to global markets. For a few years in the 1990s the WTO embodied von Hayek's utopia. This book contends that globalization is an intermittent event. To support that position, two main episodes of globalization are compared: the English textile revolution and the Silicon Valley information age. Each moved through four similar phases: Industry cluster; global infrastructure; regional monopolies; transfer of global leadership. To prevent a repeat of the WWI collapse, Western democracies should promote a concerted governance of environmental issues and other common goods, rather than relying on the free market mechanism.
This book explores our changing relationship with meat as food. Half storytelling and half historic work, it analyzes the way in which humans have dealt with the idea of eating animals in the Western world, from 1900 to the present. The story part of the book follows the rise and fall of meat, and illustrates how this type of food has become a problem in a more emotional way. The historical component informs and offers readers key data. The author draws on theories of circular societies, smart cities and smart countries to explain how and why forms of meat production that were common in the past have since all but disappeared. Both components, however, explain why meat has been important and why it has now become a problem. In tracing the fall of meat, the author identifies a host of dilemmas. These include fossil energy, pollution, illnesses caused by eating meat, factory farming, and processed foods. Lastly, the book offers a possible solution. The answer focuses on new forms of meat obtained without killing animals and in a sense resembles renewable energy. Overall, this unique cultural history offers revealing insights into how meat affects social relations, interpersonal relationships, and humanity as a whole.
Discover how TypeScript allows you to build modern client-rich applications, thanks to its object-oriented capabilities and third-party tools like Angular and Web APIs Key FeaturesMake a seamless transition to using TypeScript 3.1 in your development stackWork with TypeScript 3.1 in your ASP.NET Core projects to build rich applications that are easy to maintainBuild, test, and integrate your own TypeScript library in real-world projectsBook Description Writing clean, object-oriented code in JavaScript gets trickier and complex as the size of the project grows. This is where Typescript comes into the picture; it lets you write pure object-oriented code with ease, giving it the upper hand over JavaScript. This book introduces you to basic TypeScript concepts by gradually modifying standard JavaScript code, which makes learning TypeScript easy for C# ASP.NET developers. As you progress through the chapters, you'll cover object programming concepts, such as classes, interfaces, and generics, and understand how they are related to, and similar in, both ES6 and C#. You will also learn how to use bundlers like WebPack to package your code and other resources. The book explains all concepts using practical examples of ASP.NET Core projects, and reusable TypeScript libraries. Finally, you'll explore the features that TypeScript inherits from either ES6 or C#, or both of them, such as Symbols, Iterables, Promises, and Decorators. By the end of the book, you'll be able to apply all TypeScript concepts to understand the Angular framework better, and you'll have become comfortable with the way in which modules, components, and services are defined and used in Angular. You'll also have gained a good understanding of all the features included in the Angular/ASP.NET Core Visual Studio project template. What you will learnOrganize, test, and package large TypeScript code baseAdd TypeScript to projects using TypeScript declaration filesPerform DOM manipulation with TypeScriptDevelop Angular projects with the Visual Studio Angular project templateDefine and use inheritance, abstract classes, and methodsLeverage TypeScript-type compatibility rulesUse WebPack to bundle JavaScript and other resources such as CSS to improve performanceBuild custom directives and attributes, and learn about animationsWho this book is for If you’re a C# or .NET developer looking for an easy accessible way of learning TypeScript, this book is for you.
In Dante's Journey to Polyphony, Francesco Ciabattoni's erudite analysis sheds light on Dante's use of music in the Divine Comedy. Following the work's musical evolution, Ciabattoni moves from the cacophony of Inferno through the monophony of Purgatory, to the polyphony of Paradise and argues that Dante's use of sacred songs constitutes a thoroughly planned system. Particular types of music accompany the pilgrim's itinerary and reflect medieval theories regarding sound and the sacred. Combining musicological and philological scholarship, this book analyzes Dante's use of music in conjunction with the form and content of his verse, resulting in a cross-discipline analysis also touching on Italian Studies, Medieval Studies, and Cultural History. After moving from infernal din to heavenly harmony, Ciabattoni's final section addresses the music of the spheres, a theory that enjoyed great diffusion among the early middle ages, inspiring poets and philosophers for centuries.
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