This Brief provides a concise review of chaperonopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters deal with the chaperoning system and chaperoning teams and networks, HSP-chaperone subpopulations, the locations and functions of chaperones, and chaperone genes in humans. Other chapters present the chaperonopathies in general, including their molecular features and mechanistic classification into by defect, excess, or mistake. Subsequent chapters discuss the chaperonopathies in more detail, focusing on their distinctive characteristics: primary or secondary; quantitative and/or qualitative; structural and hereditary or acquired; genetic polymorphisms; gene dysregulation; age-related; associated with cancer, chronic inflammatory conditions, and autoimmune diseases. The interconnections between the chaperoning and the immune systems in cancer development, chronic inflammation, autoimmunity, and ageing are outlined, which leads to a discussion on the future prospects of chaperonotherapy. The latter may consist of chaperone gene and protein replacement/supplementation in cases of deficiency and of gene or protein blocking when the chaperone actively promotes disease. The last chapter presents the extracellular chaperones and details on how the chaperone Hsp60 is secreted into the extracellular space and, thus, appears in the blood of cancer patients with potential to participate in carcinogenesis and chronic inflammation and autoimmunity. Chaperones as clinically useful biomarkers are mentioned when pertinent. Likewise, guidelines for clinical evaluation of chaperonopathies and for their histopathological and molecular identification are provided throughout. The book also provides extensive bibliography organized by chapter and topic with comments.
Biographical accounts by several of Titian’s contemporaries, including Giorgio Vasari, Pietro Aretino, and Raffaele Borghini, trace the fascinating and prolific life of this master of the Italian Renaissance. As the most important member of the sixteenth-century Venetian school, Titian (ca. 1488–1576) reached a level of professional success rivaled only by Raphael, Michelangelo, and, later, Rubens. He was sought after by a range of patrons from Venice as well as northern Italian princes and, eventually, the papacy. Titian’s painting methods, particularly his use of color, influenced not only painters of the Renaissance but also future generations of Western artists. This richly illustrated volume also includes comments on Titian by El Greco.
The racism and antisemitism of Fascist Italy have often been described as ‘mild’, ‘cultural’, ‘spiritual’, and essentially non-violent, especially in comparison with the racial ideology of Nazi Germany. This book challenges this simplistic interpretation with a thorough analysis of the texts and images of the magazine La Difesa della razza (Defence of the race), the principal public voice of Fascist biological racism, which appeared fortnightly between 1938 and 1943 under the editorship of Telesio Interlandi, Mussolini’s ‘unofficial mouthpiece’, with governmental financial support. A negative icon of the propaganda of Fascist racism, La Difesa della razza first appeared in August 1938 shortly before the passing of Italy’s Racial Laws, but had a long gestation. It was the expression of a Fascist cultural milieu – journalists, writers, artists, and architects – headed by Interlandi, whose racism and antisemitism dated back to the end of the First World War. By placing the magazine’s emergence in this longer timescale, and exploring the interrelationships of political action, ideological discourse, and imagery, this book also demonstrates how the project of ‘anthropological revolution’ – building the New Man – was a central element of Italian Fascism, from the very beginning to the deportation of Italian Jews. This new English edition has been thoroughly revised and updated.
This book aims to highlight the causes why the Prohibition Era led to an evolution of the New York mob from a rural, ethnic and small-scale to an urban, American and wide-scale crime. The temperance project, advocated by the WASP elite since the early nineteenth century, turned into prohibition only after the end of WWI with the enactment of the Eighteenth Amendment. By considering the success that war prohibition made to the soldiers' psychophysical condition, Congress aimed to shift this political move even to civil society. So it was that the Italian, Irish and Jewish mobs took the chance to spread their bribe system to local politics due to the lucrative alcohol bootlegging. New York became the core of the national anti-prohibition, where the smuggling from Canada and Europe merged into the legendary Manhattan nightclubs and speakeasies. With the coming of the Great Depression, the Republican Party was aware about the failure of this political measure, leading to the making of a new corporate underworld. The book is addressed to historians of New York, historians of crime and historians of modern America as well as to an audience of readers interested in the history of the Prohibition Era.
Un nuovo, letale virus sta colpendo gli utenti del peer to peer, ma non si tratta di un virus informatico. Una sindrome misteriosa, legata a un’antica leggenda e a una maledizione, sta mietendo vittime in tutta Europa a causa di un video casalingo distribuito random sul web, nel quale viene filmato l’omicidio di un’adolescente: nottetempo, chiunque abbia la sventura di osservare il filmato rimane orrendamente paralizzato, ma cosciente, fino al sopraggiungere di una morte lenta e angosciosa. Quando anche a Londra, Mae Ho e Nick Norwood vengono colpiti dal morbo misterioso, l’amico Lalo, con l’aiuto di un professore universitario e di un hacker informatico, si metterà sulle tracce della maledizione che accompagna il video. Una ricerca che lo condurrà lontano e che lo porterà a rischiare la vita pur di trovare la soluzione a questo inspiegabile rompicapo. La Fillette Triste è un thriller che unisce archeologia e informatica, azione e divertimento. La soluzione del mistero si dipanerà a poco a poco in un susseguirsi di colpi di scena che lasceranno il lettore con il fiato sospeso, in un intreccio che unisce realtà e fantasia, archeologia, mitologia, psicologia.
Benvenuto Olivieri was a Florentine banker active in Rome during the first half of the sixteenth century. A self made man without any great family patrimony, he rose to prominence during the pontificate of Pope Paul III, becoming involved with a variety of papal enterprises which allowed him to get to the heart of the mechanisms governing the papal finances. Amassing a considerable fortune along the way, Olivieri soon built himself a role as co-ordinator of the appalti (revenue farms) and became one of the most powerful players in the complex network that connected bankers and the papal revenue. This book explores the indissoluble link that had developed between the papacy and bankers, illuminating how the Apostolic Chamber, increasingly in need of money, could not meet its debts, without farming out the rights to future income. Utilising documents from a rich corpus of unpublished sources in Florence and Rome, Guidi Bruscoli unravels the web of financial connections that bound together Florentine and Genoese bankers with the papacy, and looks at how money was raised and the appalti managed.
This issue of Dermatologic Clinics, Guest Edited by Drs. Giuseppe Micali and Francesco Lacarrubba, is devoted to Alternative Uses of Dermatoscopy. Articles in this outstanding issue include: Instruments in Dermatoscopy; Dermatoscopy of Parasitic and Infectious Disorders; Dermatoscopy of Common Inflammatory Disorders; Dermatoscopy of Granulomatous Disorders; Dermatoscopy of Lymphomas and Pseudolymphomas; Dermatoscopy of Cutaneous Vascular Lesions; Dermatoscopy of Adnexal Lesions; Trichoscopy Tips; Trichoscopy of Hair Shaft Disorders; Dermatoscopy of Nail Disorders; Dermatoscopy of Conjunctival Lesions; Dermatoscopy in Pediatric Dermatology; Dermatoscopy of Inflammatory Genital Diseases: Practical Insights; Dermatoscopy in Brown Skin; and Dermatoscopy and Reflectance Confocal Microscopy Correlations.
Manuscript Poetics explores the interrelationship between the material features of textual artifacts and the literary aspects of the medieval Italian texts they preserve. This original study is both an investigation into the material foundations of literature and a reflection on notions of textuality, writing, and media in late medieval and early modern Italy. Francesco Marco Aresu examines the book-objects of manuscripts and early printed editions, asking questions about the material conditions of production, circulation, and reception of literary works. He invites scholars to reconcile reading with seeing (and with touching) and to challenge contemporary presumptions about technological neutrality and the modes of interfacing and reading. Manuscript Poetics investigates the correspondences between textuality and materiality, content and medium, and visual-verbal messages and their physical support through readings of Dante Alighieri’s Vita nova, Giovanni Boccaccio’s Teseida, and Francesco Petrarca’s canzoniere (Rerum vulgarium fragmenta). Aresu shows that Dante, Boccaccio, and Petrarca evaluated and deployed the tools of scribal culture to shape, signal, or layer meanings beyond those they conveyed in their written texts. Medieval texts, Aresu argues, are uniquely positioned to provide this perspective, and they are foundational to the theoretical understanding of new forms and materials in our media-saturated contemporary world.
This book provides a concise and innovative history of Italian migration to Australia over the past 150 years. It focuses on crucial aspects of the migratory experience, including work and socio-economic mobility, disorientation and reorientation, gender and sexual identities, racism, sexism, family life, aged care, language, religion, politics, and ethnic media. The history of Italians in Australia is re-framed through key theoretical concepts, including transculturation, transnationalism, decoloniality, and intersectionality. This book challenges common assumptions about the Italian-Australian community, including the idea that migrants are ‘stuck’ in the past, and the tendency to assess migrants’ worth according to their socio-economic success and their alleged contribution to the Nation. It focuses instead on the complex, intense, inventive, dynamic, and resilient strategies developed by migrants within complex transcultural and transnational contexts. In doing so, this book provides a new way of rethinking and remembering the history of Italians in Australia.
Build a tower defense game and earn delectable C# treats by baking cupcakes and fighting fearsome sweet-toothed pandas About This Book Build a complete and exciting 2D Tower Defense game from scratch. Understand and learn to perform each phase of the game development pipeline Homework and exercises to improve your skills and take them to the next level Who This Book Is For If you are looking forward to get started with 2D game development, either if you are a newcomer to this world, or you came from 3D games or other game engines, this book is for you. Although there are many references to other resources throughout the book, it is assumed that you have a general understanding of C# and its syntax and structure. What You Will Learn Import and set up assets for 2D game development Design and implement dynamic and responsive User Interfaces Create and handle complex animation systems Unlock all the potentiality of the physics engine Implement Artificial Intelligence algorithms to give intelligence to your NPCs Script gameplay and overall bring your ideas to life In Detail Want to get started in the world of 2D game development with Unity? This book will take your hand and guide you through this amazing journey to let you know exactly what you need to build the games you want to build, without sacrificing quality. You will build a solid understanding of Unity 5.x, by focusing with the embedded tools to develop 2D games. In learning about these, along with accurate explanations and practical examples, you will design, develop, learn how to market and publish a delectable Tower Defense game about cupcakes versus pandas. Each chapter in this book is structured to give you a full understanding on a specific aspect of the workflow pipeline. Each of these aspects are essential for developing games in Unity. In a step-by-step approach, you will learn about each of the following phases: Game Design, Asset Importing, Scripting, User Interfaces, Animations, Physics, Artificial Intelligence, Gameplay Programming, Polishing and Improving, Marketing, Publishing and much more. This book provides you with exercises and homework at the end of each chapter so that you can level up your skills as a Unity game developer. In addition, each of these parts are centered on a common point of discussion with other learners just like you. Therefore, by sharing your ideas with other people you will not only develop your skills but you will also build a network. Style and approach This is a fun step-by-step approach in the whole pipeline of 2D game development in Unity, which is explained in a conversational and easy-to-follow style. Each topic is explained sequentially, allowing you to experience both basics and advanced features of Unity. By doing this, the book is able to provide you with a solid grasp on each of the topics. In this way, by engaging with the book's content, exploring the additional references to further readings and completing the homework sections, you are able to challenge yourself and apply what you know in a variety of ways. Once you have finished reading this book, you will be well on your way to developing games from start to finish!
Sono le parti più intime della nostra anima che ci rendono diversi dagli altri. Il ricordo e la speranza creano la nostra coscienza che dà vita ad ogni nostro giorno, ad ogni nostro attimo, facendoci vivere l'attesa di un futuro sempre nuovo, sempre imprevedibile, che muta nella nostra percezione.I sentimenti sono solo una piccola impressione di tutto ciò che viviamo, piccoli frammenti di una sensazione che tentiamo di immortalare, in parole, in immagini, ma è solo grazie al ricordo che noi riusciamo a rievocarle.Le parole per me sono quel ricordo, di incubi, di sogni, di illusioni, ma di un passato che ha creato chi sono ora.Una piccola raccolta di 86 impressioni e quattro diapositive, attraverso le quali eccitare la memoria nel ricordo.
These memories, handwritten by Elmo Cermaria (Nonno Peppe) for his grandson Checco (Francesco Nicolini), tell of when, as a young man of 20, he found himself hurled into the inferno of the First World War. In those days, you could cry your heart out for a bread roll denied, then miraculously regained thanks to the compassion of a German soldier, “the hated enemy”. These recollections are terse, without a trace of rhetoric and devoid of recriminations. Nonno Peppe tells the facts just as he experienced them first hand, without expressing any condemnation of those responsible for them, even though an awareness of the large-scale massacre he witnessed transpires from his account. When Nonno Peppe delivered the manuscript to his grandson on his wedding day, he asked him to make a promise: “Let the President of the Republic know what we did for Italy.” A hundred years ago, whole generations of young Italian men were stripped of human honor and dignity. Only a few of these young men would live on and become our grandfathers; and only a few of us would be fortunate enough to become “grandchildren of the Great War” and bear witness to their ordeal.
In Dante's Journey to Polyphony, Francesco Ciabattoni's erudite analysis sheds light on Dante's use of music in the Divine Comedy. Following the work's musical evolution, Ciabattoni moves from the cacophony of Inferno through the monophony of Purgatory, to the polyphony of Paradise and argues that Dante's use of sacred songs constitutes a thoroughly planned system. Particular types of music accompany the pilgrim's itinerary and reflect medieval theories regarding sound and the sacred. Combining musicological and philological scholarship, this book analyzes Dante's use of music in conjunction with the form and content of his verse, resulting in a cross-discipline analysis also touching on Italian Studies, Medieval Studies, and Cultural History. After moving from infernal din to heavenly harmony, Ciabattoni's final section addresses the music of the spheres, a theory that enjoyed great diffusion among the early middle ages, inspiring poets and philosophers for centuries.
This special issue of Cinéma & Cie analyses the logic and processes of re-intermediation emerging in the contemporary European media industry landscape, providing an opportunity to bring questions of availability, text circulation and gatekeeping to the centre of scholarly debates and investigations. Through contributions showcasing a wide array of methodological and theoretical approaches, the volume illustrates and analyses the presence of new gatekeepers, their impact in shaping texts and their consumption in different European contexts. Its case studies include file sharing, Curzon Home Cinema, VOD services and the problematic implementation of the Digital Single Market policy.
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