There is a puppy who sits in a dark toy factory far away from a place he dreams of calling home. All around him are other stuffed animals, which could not talk to him, because they do not have a heart like his. He sat in this toy factory day after day, night after night wondering if anyone would ever find him. One night he sees a big beautiful star, makes a wish. He believes with all his heart that he will soon be taken out of this dark and lonely place. The very next day his wish comes true, bu
Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. - Introduces the relevant aspects of molecular biology and biophysics - Describes the principal methods used to study channelopathies - Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function - Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype
This book addresses the crucial question for innovative prospector companies of how to bridge the gap between exploration and exploitation. Whereas exploration deals with the search for new ideas and opportunities, exploitation is about incrementally moving the performance bar a little bit higher. Finding the right balance between exploration and exploitation is essential for the long term survival in today’s highly dynamic business environments. In a cross-industry study of ten large, multinational prospector companies, which are world leaders in their respective industries, it was discovered that the 'industry clockspeed', the length between the subsequent product generations, plays an essential role in bridging this gap. The product generation life cycle (PGLC) typically ranged from just several months in short life cycle industries (SLCIs), such as electronics and the mobile phone industry, to (more than) 10 years in long life cycle industries (LLCIs), such as aerospace and pharmaceutics. Our data indicate that companies operating in SLCIs face major problems in maintaining the long term knowledge base of their firms, whereas companies in LLCIs tend to have problems in aligning their innovation strategy to the short term business needs. To investigate the dynamics of strategic alignment, in one of the LLCI companies, a multinational supplier of industrial components, a six-year longitudinal study was conducted. Here our data indicate that finding a funding structure that effectively balances exploration and exploitation, combined with regular structured feedback between the exploration and exploitation function is needed to maintain long term strategic alignment. CTOs and innovation managers can use this book by first establishing the industry clockspeed(s) in their respective industries or product range(s) and then benchmark their innovation processes to those of the first class (SLCI or LLCI) prospector companies included in this book.
This book provides a full and clear exposition of the fundamentals of intellectual property law in the UK. It combines excerpts from cases and a broad range of secondary works with insightful commentary from the authors which will situate the law within a wider international context.
The second edition of Women and Crime is a carefully revised version of what has become the standard text on this subject. It provides a comprehensive review of findings about female criminality, women and criminal justice, and the treatment of female offenders. It also offers a clear analysis of theoretical perspectives, of images of deviant women and women's experiences of social control. A new section reviews developments during the past decade and outlines the shifts in social research and crime concerns. The bibliography has been thoroughly revised and updated.
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