Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. - Introduces the relevant aspects of molecular biology and biophysics - Describes the principal methods used to study channelopathies - Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function - Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype
Known for its reliable, clinically focused content, Swearingen's Manual of Medical-Surgical Nursing provides a quick reference to 125 of the most commonly encountered medical-surgical conditions. Expert authors Fran Monahan, RN, PhD, ANEF, Marianne Neighbors, EdD, RN, and Carol Green, PhD, RN, CNE make it easy to find and use the information you need to know to provide optimal patient care. Unique to this manual, outcome criteria include specific and measurable timeframes to help in establishing realistic treatment goals and evaluating the effectiveness of care. For students, it's an ideal resource for care planning and clinicals; for practitioners, it's a great clinical reference! - More than 125 common medical-surgical conditions are organized by body system for convenient use as a clinical reference. - A quick-reference, easy-to-use format includes these headings for each med-surg disorder: - Overview/Pathophysiology - Assessment - Diagnostic Tests - Collaborative Management - Nursing Diagnoses and Interventions - Patient-Family Teaching and Discharge Planning - Outcome criteria feature specific and measurable timeframes for each outcome. - Patient teaching for each disorder helps you educate patients and their families for self-care and discharge. - Clinical notes and cautions stress key points or alerts related to various disorders and conditions. - An overview of nursing considerations for the hospitalized patient includes concepts relevant to many disorders, such as perioperative care, pain, prolonged bed rest, psychosocial support, and older adult care. - Attractive two-color design highlights key information for fast reference. - A durable, water-resistant cover prolongs the life of the book. - Thorough updates provide you with the latest evidence-based practice content and clinical developments, including the newest Joint Commission standards, latest screening recommendations, revised treatment guidelines, new drugs, and lab tests. - New Burns section covers the care of burns in the medical-surgical setting. - New Immunologic Disorders unit discusses transfusion reactions, hypersensitivity, and AIDS. - New Cancer Care unit updates and expands coverage of lung cancer, nervous system tumors, GI malignancies, neoplastic diseases of the hematopoietic system, head/neck cancers, breast cancer, and GI cancer. - An emphasis on patient safety addresses preventable patient safety issues.
A psychiatrist examines how the world's four most important mind-altering substances alcohol, cocaine, nicotine, and opiateshave played a significant role throughout human history, and explains how these powerful drugs affect the brain and cause addiction. Alcohol, cocaine, nicotine, and opiates have spurred some of the greatest human pleasure and pain across time. Providing information that ranges as widely as from ancient Egypt to modern times, this book comprehensively addresses the good, the bad, and the very ugliest aspects of these substances, examining their history, their effects on the brain and body, and on civilization itself. Frances R. Frankenburg, MD, employs accessible, everyday language to explain the neurology of addiction and describe how these "brain-robbing" substances work to hijack the brain's pleasure systems to create powerful addictions. The author also provides perspective into the intertwined, inescapable, and often uneasy relationship between these substances and human culture, economics, and politicsfor example, how individuals become physically or psychologically addicted to alcohol, cocaine, nicotine, and opiates, while governments become financially "addicted" to the revenue, such as taxes, that can be collected from the sale and use of these substances.
Updated with NANDA-I Nursing Diagnoses 2018-20 The all-in-one care planning resource! Here’s the step-by-step guidance you need to develop individualized plans of care while also honing your critical-thinking and analytical skills. You’ll find about 160 care plans in all, covering acute, community, and home-care settings across the life span. Each plan features… Client assessment database for each medical condition Complete listings of nursing diagnoses organized by priority Diagnostic studies with explanations of the reason for the test and what the results mean Actions and interventions with comprehensive rationales NANDA, NIC, and NOC’s most recent guidelines and terminology Evidence-based citations Index of nursing diagnoses and their associated disorders
The Sea Survival Manual is the definitive book on the subject for anyone aboard a yacht of any size. It is aimed at the yachtsman or seafarer who is likely to proceed to sea out of the sight of land, whether for pleasure or professional reasons. Fully compliant with the IMO (International Maritime Organisation) resolutions and MCA (Maritime Coastguard Agency) regulations it embodies Sea Safety checks issued by the MCA and RNLI and is completely international in its appeal. Includes chapters on safety and survival equipment, Global Maritime Distress and Safety Systems (GMDSS), liferafts, grab bags, medical equipment and advice, first aid and emergency treatment, abandoning ship, survival in a liferaft and rescues at sea. This is the first modern book to tackle the subject from the small craft point of view.
The Marine World is a book for everyone with an interest in the ocean, from the marine biologist or student wanting expert knowledge of a particular group to the naturalist or diver exploring the seashore and beyond. With colour illustrations, line drawings, more than 1,500 colour photographs, and with clear accessible text, this book encompasses all those organisms that live in, on and around the ocean, bringing together in a single text everything from the minuscule to the immense. It includes sections on all but the most obscure marine groups, covering invertebrate phyla from sponges to sea squirts, as well as plants, fungi, bacteria, fish, reptiles, mammals and birds. It incorporates information on identification, distribution, structure, biology, ecology, classification and conservation of each group, addressing the questions of ‘what?’, ‘where?’ and ‘how?’. Today global warming, overfishing, ocean acidification and pollution are just a few of the ever increasing number of threats and challenges faced by ocean life. Without knowledge of the animals, plants and other organisms that live in the marine world, we cannot hope to support or implement successful conservation and management measures, nor truly appreciate the incredible wealth and variety of marine life. The Marine World is the product of a lifetime spent by Frances Dipper happily observing and studying marine organisms the world over. It has been brought to colourful life by a myriad of enthusiastic underwater photographers and by Marc Dando, the renowned natural history illustrator.
This is a wonderful book. Frances Ashcroft has a rare gift for making difficult subjects accessible and fascinating." —Bill Bryson, author of The Body: A Guide for Occupants What happens during a heart attack? Can someone really die of fright? What is death, anyway? How does electroshock treatment affect the brain? What is consciousness? The answers to these questions lie in the electrical signals constantly traveling through our bodies, driving our thoughts, our movements, and even the beating of our hearts. The history of how scientists discovered the role of electricity in the human body is a colorful one, filled with extraordinary personalities, fierce debates, and brilliant experiments. Moreover, present-day research on electricity and ion channels has created one of the most exciting fields in science, shedding light on conditions ranging from diabetes and allergies to cystic fibrosis, migraines, and male infertility. With inimitable wit and a clear, fresh voice, award-winning researcher Frances Ashcroft weaves together compelling real-life stories with the latest scientific findings, giving us a spectacular account of the body electric.
A rich, poignant eBook original about two people’s struggles to overcome their demons and find happiness and love. All Niki Katona wants in life is true love with a good man. But when she finds her fiancé with another woman, she’s ready to resign herself to a life alone...until she meets paramedic Dylan Clarke. Niki falls for Dylan when she sees him jump into life-saving action to treat a man having a heart attack. But both Dylan and Niki have their own demons. Together, they work towards realizing their dreams and passions, but soon fall into old patterns. The only thing that will pull them through is finding their own self-worth through their love for each other.
At the end of her life, Frances Osborne’s one-hundred-year-old great-grandmother Lilla was as elegant as ever–all fitted black lace and sparkling-white diamonds. To her great-grandchildren, Lilla was both an ally and a mysterious wonder. Her bedroom was filled with treasures from every exotic corner of the world. But she rarely mentioned the Japanese prison camps in which she spent much of World War II, or the elaborate cookbook she wrote to help her survive behind the barbed wire. Beneath its polished surface, Lilla’s life had been anything but effortless. Born in 1882 to English parents in the beautiful North China port city of Chefoo, Lilla was an identical twin. Growing up, she knew both great privilege and deprivation, love and its absence. But the one constant was a deep appreciation for the power of food and place. From the noodles of Shanghai to the chutney of British India and the roasts of England, good food and sensuous surroundings, Lilla was raised to believe, could carry one a long way toward happiness. Her story is brimming with the stuff of good fiction: distant locales, an improvident marriage, an evil mother-in-law, a dramatic suicide, and two world wars. Lilla’s remarkable cookbook, which she composed while on the brink of starvation, makes no mention of wartime rations, of rotten vegetables and donkey meat. In the world this magical food journal, now housed in the Imperial War Museum in London, everyone is warm and safe in their homes, and the pages are filled with cream puffs, butterscotch, and comforting soup. In its writing, Lilla was able to transform the darkest moments into scrumptious escape. Lilla’s Feast is a rich evocation of a bygone world, the inspiring story of an ordinary woman who tackled the challenges life threw in her path with an extraordinary determination.
Philadelphia heiress and amateur sleuth Martha Beale investigates the kidnapping of a society girl on the verge of marriage in Cordelia Frances Biddle’s second Martha Beale mystery Martha Beale, now the guardian of seven-year-old Ella and five-year-old Cai, has just returned to Philadelphia after summering in the country. The children have to begin school, and Martha looks forward to a reunion with Thomas Kelman, even though she isn’t sure where their relationship stands. But a string of robberies is plaguing the city and the nineteen-year-old daughter of one of Philadelphia’s wealthiest families has vanished. With no unified police force, the mayor depends on Thomas Kelman to sort out criminal matters. Martha reluctantly acts as a liaison between Thomas and the missing girl’s parents, but the investigation soon takes a darker turn. As suspicion falls on rich and poor alike, both the guilty and innocent become ensnared in a web of deception and escalating violence.
“Army intelligence work whets Pat's wits for lively, well-plotted and mystifying case with spouse stooging pleasantly.”—The Saturday Review From the Jacket: San Francisco is the locale of this fast-paced mystery by the author of The Indigo Necklace and The Man in Gray—San Francisco of the fabulously steep hills, the fog drifting in over the bay, the excellent restaurants and the exotic dives. On one of its hills, in a muffling fog, Pat and Jean Abbott, Mrs. Crane’s delightful sleuthing couple, see a car crash into a hydrant, and it's no surprise to anyone when a murdered man is found slumped behind the wheel. The dead man, however, is the estranged husband of a very good friend of the Abbotts, Nancy Leland. Because Nancy is suspected of the murder, the Abbotts are from then on involved in two more murders, mayhem and a few other slightly illegal activities. A grim chain of apparently unrelated clues leads them to the murderer, and to a solution of more than passing interest to the Federal Bureau of Narcotics.”
A life hangs in the balance of memory in this poignant, witty and “effective feminine counterpoint to . . . Philip Roth’s 2006 novel, ‘Everyman’” by the award-winning author (The Washington Post). Born on the same day as Queen Elizabeth II, Canadian Georgina Danforth Witley is one of ninety-nine lucky Commonwealth residents invited to Her Majesty’s eightieth birthday lunch at Buckingham Palace. But en route to the airport to board the plane for London, Georgina’s car slips off the road and plunges into a thickly wooded ravine. Thrown from the car, injured, and unable to move, she must rely on her full store of family memories, her no-nonsense wit, and a recitation of the names of the bones in her body—an exercise from childhood—to remind her that she is still very much alive. But what has the entirety of her life meant? As Georgina lies stranded and helpless, she reflects on her eighty years as a daughter, mother, sister, wife, and widow, on lost loves and secrets, and on painful moments of the past she struggles not to recall. With this exquisite, suspenseful, and surprising tale of the staying power of family through time and memory, “Itani exposes the richness and depth beneath the surface of one ordinary life” (The New Yorker).
Two, Plus Ten Unforgettable Tales is based on true stories about unusual encounters and experiences with unforgettable people in labor and delivery, where the author, N. Frances Warner, worked as a registered nurse. Her fascination with the moon stirred intrigue; does moon-shine mysteriously reflect influence and do moon-moods-swing? Two, Plus Ten Unforgettable Tales embraces moon-phases and pampers fantasy and imagination, keeping us young at heart as we nurse the fun of wondering, 'Are the moon and stork in cahoots?
Based on a true story, The Diary is set in Walla Walla County, Washington during the Great Depression. During his 17 months of hospitalization for tuberculosis, Al Potts keeps a diary allowing the reader to experience both his private world, and the trying and changing times of the world outside the hospital.
After a body is found on a Florida fishing boat, a vacationing PI and his wife must cast a wide net . . . After Capt. Cy Martingale’s boat is docked in Key West, a passenger is left behind—not just dead drunk, but dead. Pat and Jean Abbott are in town for some rest and relaxation, but the captain is a friend and he wants their help. Unfortunately, what he wants help with is getting rid of the body, since he doesn’t really trust the local police. Pat Abbott is not about to be an accessory to murder, so he turns to another kind of captain: his friend on the force in New Orleans. They’ll have to debate their theories of the case before they can reel in the killer . . . Praise for the Pat and Jean Abbott Mysteries “One of the more interesting married teams of detectives . . . A sort of globetrotting Nick and Nora.” —Thrilling Detective “Lively and exciting.” —The New York Times “[A] well-plotted and mystifying case.” —Saturday Review
Sherwood recreates the life and times of Mary Wollstonecraft, the trailblazing English feminist. Abetted by an unruly intelligence and an unquenchable romanticism, Sherwood's Mary survives a brutal childhood to carve a courageous but always uncertain path for herself in a world of men.
The perfect pocket guide makes care planning easier. This quick-reference tool has exactly what you need to select the appropriate diagnoses to plan your patients’ care effectively. The 16th Edition features all the latest nursing diagnoses and updated interventions from NANDA-I 2021-2023. One of the best nursing school tools that I can use beyond graduation! “I only wish I found this book at the beginning of my nursing school experience and not towards the end. Finally a useful book that tells us what to do, what we can do, and prioritizes everything. I think it wouldn’t have taken me 6 hours to complete a Care Plan/Map had I found this gem sooner. I’m even going to recommend it to my school to suggest students purchase it.”—Angela D., Online Reviewer Love this Book! “I'm a nursing student, and for all y'all nursing professions, you need to have some form of this book. In semesters past, a friend of mine had a later edition, and the information was incredible. This book is really a must-have when making care plans or wanting to learn more about what interventions you can do for your patient. Reasonable for price.”—Felicia M., Online Reviewer New & Updated! The latest diagnoses and updated interventions from NANDA International Nursing Diagnoses: Definitions and Classification 2021-2023, 12th Edition, including 46 new diagnoses and 67 revised diagnoses, the most current NANDA-I terminology, and labels from NIC and NOC that link content to nursing diagnosis, and statistic data Revised! Streamlined preface that focuses on how to use the book Alphabetized listing of nursing diagnoses from NANDA-I 2021-2023, covering more than 400 diseases/disorders Actions/interventions uniquely organized by priority with selected rationales. Icons within the prioritized interventions for acute care, collaboration, community/home care/cultural considerations, diagnostic studies, medications, and lifespan considerations. NIC and NOC labels at the end of each diagnosis Defining characteristics presented subjectively and objectively. Documentation section that focuses on the other steps of the nursing process, reminding students of the importance and necessity of recording each step. Index with hundreds of diseases/disorders with prioritized associated nursing diagnoses Detachable, laminated, pocket-minder bookmark on the inside back cover
Emília and Luzia dos Santos, orphaned when they are children, grow up under the protection of their aunt in the hillside village of Taquaritinga, Brazil. Raised as seamstresses, the sisters learn how to cut, how to mend and how to conceal. Emília treasures pretty, girlish things and longs to escape from the confines of the little town. Captivated by the romances she reads in magazines, she dreams of finding love in the bustle and glamour of the city. Luzia, scarred by a childhood accident that has left her with a deformed arm, knows that for her, real life can not be romantically embroidered, and so she finds solace in her sewing and in the secret prayers to the saints she believes once saved her life. But when Luzia is abducted by a gang of rebel bandits, the sisters' lives diverge in ways they never imagined. Whilst Luzia learns to survive in the unforgiving Brazilian outland, discovering love in the most unexpected of places, Emília meets the son of a wealthy doctor who seems to offer her everything she has always desired. But for the innocent dreamer, the excitement of her escape to the city is soon overshadowed by disillusion and loneliness. As she learns how to navigate the treacherous waters of Brazilian high society, the bandits' campaign against the land-owning 'Colonels' intensifies, and when a price is placed upon Luzia's head Emília realises she must risk everything in order to save her sister.
The nineteenth century was one of the most fascinating and volatile periods in Christian history. It was during this time that Christianity evolved into a truly global religion, which led to an ever greater variety of ways for Christians to express and profess their faith. Frances Knight addresses the crucial question of how Christianity contributed to individual identity in a context of widespread urbanisation and modernisation. She explores important topics such as the Evangelical revival led by the likes of the founder of the Christian Mission - later the Salvation Army - William Booth; the Oxford Movement under Newman, Keble and Pusey; Mormonism and Protestant revivalism in the USA; socialism and the impacts of Karl Marx and anarchism; continuing theological divisions between Protestants and Catholics; and the development of pilgrimage and devotion at places like Lourdes and Knock. Her book also examines the most significant intellectual trends, such as the rise of critical approaches to the Bible, and the different directions that these took in Britain and America. The author's unique emphasis on the 'ordinary' experience of Christians worldwide makes her volume indispensable for students and general readers who will be fascinated by this sensitive twenty-first century perspective on the nineteenth century.
At her dying mother's plea, fourteen-year-old Lulie flees Missouri to escape her lecherous Pa. It's 1847 and she joins a wagon train bound for Oregon. Pa joins a following wagon train, intending to taunt her for 2,000 miles, before ultimately claiming her. Lulie's fellow travelers become her family and vow to help her however they legally can, but Lulie knows the only way to be free of him is to kill him. Does she have the skill, courage and resolve to do so?
The Damned Fraternitie': Constructing Gypsy Identity in Early Modern England, 1500–1700 examines the construction of gypsy identity in England between the early sixteenth century and the end of the seventeenth century. Drawing upon previous historiography, a wealth of printed primary sources (including government documents, pamphlets, rogue literature, and plays), and archival material (quarter sessions and assize cases, parish records and constables's accounts), the book argues that the construction of gypsy identity was part of a wider discourse concerning the increasing vagabond population, and was further informed by the religious reformations and political insecurities of the time. The developing narrative of a fraternity of dangerous vagrants resulted in the gypsy population being designated as a special category of rogues and vagabonds by both the state and popular culture. The alleged Egyptian origin of the group and the practice of fortune-telling by palmistry contributed elements of the exotic, which contributed to the concept of the mysterious alien. However, as this book reveals, a close examination of the first gypsies that are known by name shows that they were more likely Scottish and English vagrants, employing the ambiguous and mysterious reputation of the newly emerging category of gypsy. This challenges the theory that sixteenth-century gypsies were migrants from India and/or early predecessors to the later Roma population, as proposed by nineteenth-century gypsiologists. The book argues that the fluid identity of gypsies, whose origins and ethnicity were (and still are) ambiguous, allowed for the group to become a prime candidate for the 'other', thus a useful tool for reinforcing the parameters of orthodox social behaviour.
THE NEW YORK TIMES BESTSELLER "A powerful story that proves how love itself requires courage." --Delia Owens, author of Where the Crawdads Sing Spanning World War II and the sweep of the twentieth century, We Must Be Brave explores the fierce love that we feel for our children and the power of that love to endure. Beyond distance, beyond time, beyond life itself. A woman. A war. The child who changed everything. December 1940. As German bombs fall on Southampton, England during World War II, the city's residents flee to the surrounding villages. In Upton village, amid the chaos, newly married Ellen Parr finds a girl asleep, unclaimed at the back of an empty bus. Little Pamela, it seems, is entirely alone. Ellen has always believed she does not want children, but when she takes Pamela into her home, the child cracks open the past Ellen thought she had escaped and the future she and her husband Selwyn had dreamed for themselves. As the war rages on, love grows where it was least expected, surprising them all. But with the end of the fighting comes the realization that Pamela was never theirs to keep. Spanning the sweep of the twentieth century, We Must Be Brave explores the fierce love that we feel for our children and the power of that love to endure. Beyond distance, beyond time, beyond life itself.
Assistive technology is essential in today's world to enable people who are blind or visually impaired to participate fully in school, work, and life. But which assistive technology tools are right for your students? This comprehensive handbook is the essential resource for teachers of students with visual impairments, administrators, technology professionals, and anyone who needs to keep up with the ever-changing world of technology. Assistive Technology For Students Who Are Blind or Visually Impaired: A Guide to Assessment contains a wealth of technical information translated into clear, user-friendly terms, including: - An overview of the full range of assistive technology that students can use to manage information in print or electronic formats-whether they use vision, touch or hearing to access information - How to select appropriate tools and strategies - A structured process for conducting a technology assessment - Detailed assessment forms that can be used to determine students' technology needs and solutions to address them - Advice on writing up program recommendations based on assessment results - Reproducible, blank assessment forms
An innocent girl is taken. The killer confesses. But that’s not the whole story. That’s not even the beginning... It’s 1985 and the disappearance of twelve-year-old Lisa Cook shocks the nation. Her best friend, Kirsty, traumatised and fearful, gives evidence that helps to put the Cook family’s lodger behind bars. …But what if Kirsty made a mistake? Now, decades later, Kirsty leaves a life she loves to move back to the hometown she hates – tortured by her memories, she’s determined to finally uncover the truth about what happened to Lisa that day. But someone is waiting for her there, someone close to her family. Someone who is hoping to finish off a job that was started years ago… An absolutely gripping emotional drama for fans of The Couple Next Door, Whisper Me This and Laura Elliot. What everyone's saying about Two Little Girls: ‘Ohhhhh my goodness!! Frances Vick is truly a master storyteller! I was hook, line, and sinker from the first page… This novel made the hair on the back of my head stand up and gave the chills more times than I can count, the twists and turns were perfectly timed! I highly recommend all thriller fans 1-click this 5-star read!’ Steph and Chris’s Book Review, 5 stars ‘Thrilling! Just when you think you have figured out who the real culprit of the story is, think again! This is a well-crafted psychological thriller to keep you reading well into the night.’ Once Upon a Time Book Reviews ‘It was a thrilling read, a fast-paced thriller. I enjoyed the author's writing style. It kept me flipping the pages just want to find out what happened. It could be your favourite spring read.’ Goodreads Reviewer, 5 stars ‘Well-written, fast-paced, and thrilling. A very engaging book.’ Goodreads reviewer ‘…Compelling psychological thriller which contains many unpredictable twists… believable and compelling.’ Goodreads reviewer ‘A fast-paced psychological thriller that will have you guessing up until the final pages. A thirty year old mystery will be revisited, and the answers that result are anything but predictable… the manipulation of childhood memories at the core, the author crafts a diabolical tale that will fully engage the reader.’ Goodreads reviewer ‘This is a well-written, gripping and pacey crime thriller with well-laid and engaging characters.’ Goodreads reviewer, 5 stars
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