Explores the limits of human survival and the physiological adaptations that enable us to exist under extreme conditions. The author reviews limits to human life underwater, at high altitudes, at high speeds, at micro levels, and at freezing and hot temperatures.
Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Introduces the relevant aspects of molecular biology and biophysics Describes the principal methods used to study channelopathies Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype
This is a wonderful book. Frances Ashcroft has a rare gift for making difficult subjects accessible and fascinating." —Bill Bryson, author of The Body: A Guide for Occupants What happens during a heart attack? Can someone really die of fright? What is death, anyway? How does electroshock treatment affect the brain? What is consciousness? The answers to these questions lie in the electrical signals constantly traveling through our bodies, driving our thoughts, our movements, and even the beating of our hearts. The history of how scientists discovered the role of electricity in the human body is a colorful one, filled with extraordinary personalities, fierce debates, and brilliant experiments. Moreover, present-day research on electricity and ion channels has created one of the most exciting fields in science, shedding light on conditions ranging from diabetes and allergies to cystic fibrosis, migraines, and male infertility. With inimitable wit and a clear, fresh voice, award-winning researcher Frances Ashcroft weaves together compelling real-life stories with the latest scientific findings, giving us a spectacular account of the body electric.
The challenge of scaling the highest mountain, exploring the deepest ocean, crossing the hottest desert, or swimming in near-freezing water is irresistible to many people. Here is an exploration of what happens to our bodies in these seemingly uninhabitable environments. Author Ashcroft weaves stories of extraordinary feats of endurance with historical material and the latest scientific findings as she investigates the limits of human survival and the remarkable adaptations that enable us to withstand extreme conditions.--From publisher description.
This is a wonderful book. Frances Ashcroft has a rare gift for making difficult subjects accessible and fascinating." —Bill Bryson, author of The Body: A Guide for Occupants What happens during a heart attack? Can someone really die of fright? What is death, anyway? How does electroshock treatment affect the brain? What is consciousness? The answers to these questions lie in the electrical signals constantly traveling through our bodies, driving our thoughts, our movements, and even the beating of our hearts. The history of how scientists discovered the role of electricity in the human body is a colorful one, filled with extraordinary personalities, fierce debates, and brilliant experiments. Moreover, present-day research on electricity and ion channels has created one of the most exciting fields in science, shedding light on conditions ranging from diabetes and allergies to cystic fibrosis, migraines, and male infertility. With inimitable wit and a clear, fresh voice, award-winning researcher Frances Ashcroft weaves together compelling real-life stories with the latest scientific findings, giving us a spectacular account of the body electric.
This text provides a full and clear exposition of the fundamentals of intellectual property law in the UK. It combines excerpts from cases and a broad range of secondary works with insightful commentary from the authors which will situate the law within a wider international, comparative and political context.
Boricua Pop is the first book solely devoted to Puerto Rican visibility, cultural impact, and identity formation in the U.S. and at home. Frances Negrón-Muntaner explores everything from the beloved American musical West Side Story to the phenomenon of singer/actress/ fashion designer Jennifer Lopez, from the faux historical chronicle Seva to the creation of Puerto Rican Barbie, from novelist Rosario Ferré to performer Holly Woodlawn, and from painter provocateur Andy Warhol to the seemingly overnight success story of Ricky Martin. Negrón-Muntaner traces some of the many possible itineraries of exchange between American and Puerto Rican cultures, including the commodification of Puerto Rican cultural practices such as voguing, graffiti, and the Latinization of pop music. Drawing from literature, film, painting, and popular culture, and including both the normative and the odd, the canonized authors and the misfits, the island and its diaspora, Boricua Pop is a fascinating blend of low life and high culture: a highly original, challenging, and lucid new work by one of our most talented cultural critics.
Australian Fiction as Archival Salvage examines key developments in the field of the Australian postcolonial historical novel from 1989 to the present. In parallel with this analysis, A. Frances Johnson undertakes a unique study of in-kind creativity, reflecting on how her own nascent historical fiction has been critically and imaginatively shaped and inspired by seminal experiments in the genre – by writers as diverse as Kate Grenville, Mudrooroo, Kim Scott, Peter Carey, Richard Flanagan, and Rohan Wilson. Mapping the postcolonial novel against the impact of postcolonial cultural theory and Australian writers’ intermittent embrace of literary postmodernism, this survey is also read against the post-millenial ‘history’ and ‘culture wars’ which saw politicizations of national debates around history and fierce contestation over the ways stories of Australian pasts have been written.
The Royal Opera House, Covent Garden is home of two of the most famous opera and ballet companies in the world. In this official history, Frances Donaldson discusses Covent Garden's many legendary achievements - Der Rosenkavalier with Lotte Lehmann, the unparalleled partnership of Fonteyn and Nureyev, the recent Otello with Domingo. She follows the attitude of the English to opera and their Opera House, and the crusade for opera to be sung in English. She looks at the internal politics and at the often charismatic personalities who have worked at the Opera House: Thomas Beecham, George Solti, Maria Callas, Tito Gobbi, Ninette de Valois and Frederick Ashton. Underlying the story, despite the many successful seasons, are the ever-present problems of financial support and uncertainty of the future. The history is superbly well-documented from the Royal Opera House archives. Comments from journalists of the time -whose critical reviews sometimes led to singers of international acclaim refusing to return to Covent Garden - lend spice to this fine analysis of administrative and artistic management at the Garden.
A timely and nonpartisan book on voter manipulation and electoral corruption—and the importance of stimulating voter turnout and participation Though voting rights are fundamental to American democracy, felon disfranchisement, voter identification laws, and hard-to-access polling locations with limited hours are a few of the ways voter turnout is suppressed. These methods of voter suppression are pernicious, but in Five Dollars and a Pork Chop Sandwich, Dr. Mary Frances Berry focuses on forms of corruption including vote buying, vote hauling, the abuse of absentee ballots, and other illegal practices by candidates and their middlemen, often in collusion with local election officials. Vote buying—whether it’s for a few dollars, a beer, or a pack of cigarettes—is offered to individual citizens in order to ensure votes for a particular candidate, and Dr. Berry notes it occurs across party lines, with Republicans, Democrats, and independents all participating. Dr. Berry shares the compelling story of Greg Malveaux, former director of Louisiana’s Vote Fraud Division, and how this “everyman” tried to clean up elections in a state notorious for corruption. Malveaux discovered virtually every type of electoral fraud during his tenure and saw firsthand how abuses occurred in local communities—from city councils to coroners’ offices. In spite of Sisyphean persistence, he found it virtually impossible to challenge the status quo. Dr. Berry reveals how this type of electoral abuse is rampant across the country and includes myriad examples from other states, including Illinois, Texas, Florida, Kentucky, and Mississippi. Voter manipulation is rarely exposed and may be perceived as relatively innocuous, however; Dr. Berry observes that in addition to undermining basic democracy, it also leads to a profound lack of accountability and a total disconnect between politicians and their constituents, and that those in poor and minority communities are the most vulnerable. While reforming campaign finance laws are undeniably important to our democracy, being attuned to issues of structural powerlessness and poverty, and to the cycles that perpetuate them, is no less crucial. In Five Dollars and a Pork Chop Sandwich, Dr. Berry shares specific successful voting strategies that other countries have adopted and urges creativity in rewarding people for voting. She also underscores the continued importance of grassroots education, so that citizens see voting as desirable and empowering—as a tool to help create the kind of environment they deserve.
* Winner of the 2017 National Book Critics Circle Award * National Book Award Finalist * Time magazine Top 10 Nonfiction Book of the Year * New York Times Notable Book * Publishers Weekly Best Books of 2017 This “epic history” (The Boston Globe) from Pulitzer Prize-winning historian Frances FitzGerald is the first to tell the powerful, dramatic story of the Evangelical movement in America—from the Puritan era to the 2016 election. “We have long needed a fair-minded overview of this vitally important religious sensibility, and FitzGerald has now provided it” (The New York Times Book Review). The evangelical movement began in the revivals of the eighteenth and nineteenth centuries, known in America as the Great Awakenings. A populist rebellion against the established churches, it became the dominant religious force in the country. During the nineteenth century white evangelicals split apart, first North versus South, and then, modernist versus fundamentalist. After World War II, Billy Graham attracted enormous crowds and tried to gather all Protestants under his big tent, but the civil rights movement and the social revolution of the sixties drove them apart again. By the 1980s Jerry Falwell and other southern televangelists, such as Pat Robertson, had formed the Christian right. Protesting abortion and gay rights, they led the South into the Republican Party, and for thirty-five years they were the sole voice of evangelicals to be heard nationally. Eventually a younger generation proposed a broader agenda of issues, such as climate change, gender equality, and immigration reform. Evangelicals now constitute twenty-five percent of the American population, but they are no longer monolithic in their politics. They range from Tea Party supporters to social reformers. Still, with the decline of religious faith generally, FitzGerald suggests that evangelical churches must embrace ethnic minorities if they are to survive. “A well-written, thought-provoking, and deeply researched history that is impressive for its scope and level of detail” (The Wall Street Journal). Her “brilliant book could not have been more timely, more well-researched, more well-written, or more necessary” (The American Scholar).
This work provides a full and clear exposition of the fundamentals of intellectual property law in the UK. It combines excerpts from cases and a broad range of secondary works with insightful commentary from the authors which will situate the law within a wider international, comparative and political context.
Quicksilver Chronicles" is one woman's surreal and satirical memoirs spanning about a decade, from the beginning of this new century, depicting what life throws at her family of gem-mining misfits struggling to live with a lethally polluted watershed in a forgotten western ghost town, called New Idria. As the James family copes with their systematic mercury poisoning -- the aftermath of unscrupulous mining corporations, the U.S. Department of Defense, and a reservoir-hoarding drug rehab upstream -- their hopes of environmental justice diminish with each new anti-scientific edict enacted by the state. The tiny community earnestly elects an orange tabby, a people-hating cat, as Mayor to represent their micro-nation. Told through the eyes of Georgia James, the saga details the clan's run-ins with highgraders, UFOs, "Littlefoot," the insane "War on Drugs," and the absurd politics of the Bush/Cheney years.
This is the story of the U.S. Commission on Civil Rights, through its extraordinary fifty years at the heart of the civil rights movement and the struggle for justice in America. Mary Frances Berry, the commission’s chairperson for more than a decade, author of My Face Is Black Is True (“An essential chapter in American history from a distinguished historian”—Nell Painter), tells of the commission’s founding in 1957 by President Eisenhower, in response to burgeoning civil rights protests; how it was designed to be an independent bipartisan Federal agency—made up of six members, with no more than three from one political party, free of interference from Congress and presidents—beholden to no government body, with full subpoena power, and free to decide what it would investigate and report on. Berry writes that the commission, rather than producing reports that would gather dust on the shelves, began to hold hearings even as it was under attack from Southern segregationists. She writes how the commission’s hearings and reports helped the nonviolent protest movement prick the conscience of the nation then on the road to dismantling segregation, beginning with the battles in Montgomery and Little Rock, the sit-ins and freedom rides, the March on Washington. We see how reluctant government witnesses and local citizens overcame their fear of reprisal and courageously came forward to testify before the commission; how the commission was instrumental in passing the Civil Rights Act of 1964 and the Voting Rights Act of 1965; how Congress soon added to the commission’s jurisdiction the overseeing of discriminating practices—with regard to sex, age, and disability—which helped in the enactment of the Age Discrimination Act of 1978 and the Americans With Disabilities Act of 1990. Berry writes about how the commission’s monitoring of police community relations and affirmative action was fought by various U.S. presidents, chief among them Ronald Reagan and George W. Bush, each of whom fired commissioners who disagreed with their policies, among them Dr. Berry, replacing them with commissioners who supported their ideological objectives; and how these commissioners began to downplay the need to remedy discrimination, ignoring reports of unequal access to health care and employment opportunities. Finally, Dr. Berry’s book makes clear what is needed for the future: a reconfigured commission, fully independent, with an expanded mandate to help oversee all human rights and to make good the promise of democracy—equal protection under the law regardless of race, color, sexual orientation, religion, disability, or national origin.
Published in collaboration with the Victoria & Albert Musuem, Played in Britain: Modern Theatre in 100 Plays explores the best and most influential plays from 1945 to date. Fully illustrated with photos from the V&A's collections and featuring a foreword by Richard Griffiths O.B.E., the book provides a sumptuous treat for theatre-lovers. It was awarded the 2014 David Bradby Award for research by the Theatre and Performance Research Association. Opening with J. B. Priestley's classic play from 1946, An Inspector Calls, and ending with Laura Wade's examination of class privilege and moral turpitude in Posh over sixty years later, Played in Britain offers a visual history of post-war theatre on the British stage. Arranged chronologically the featured plays illustrate and respond to a number of themes that animate post-war society: censorship and controversy; race and immigration; gender and sexuality; money and politics. An essay on each period first sets the context and explores trends, while the commentary accompanying each play illuminates the plot and themes, considers its original reception and subsequent afterlife, and finishes by suggesting other plays to explore. Photographs from the V&A's extensive collection illustrate each play, providing further insight into stage and costume designs, and include iconic images from the premieres of major plays such as Waiting for Godot and Look Back in Anger. Illustrated throughout with stage production photography, Played in Britain: Modern Theatre in 100 Plays presents a unique and visually stunning panorama of key dramatic works produced in Britain over the past seventy years. From An Inspector Calls to The Rocky Horror Show, or Abigail's Party to Waiting for Godot, fresh light is thrown on the impact, aesthetics and essence of these key plays.
Hiding the Audience examines how the development of Canadian prairie arts institutions in the context of an implicitly Euro- or Anglo-Canadian audience clashed with the creation of regional arts that needed to acknowledge a Native Canadian presence to flourish. It looks in detail at the regional versus international strains in the history of the Banff Centre, at the development of the Glenbow Museum and the controversy over the "Spirit Sings" exhibition, at the two decades of contention regarding statues of Louis Riel in Regina and Winnipeg, and at the contrasts in audience participation in two of 25th Street Theatre's productions, one about farmers and the other about Metis people. Primarily a work of cultural history, this study uses archival sources, post-colonial theory, and the theories implied in the fiction of Cherokee author Thomas King to probe the ways in which the whitestream assumptions of the individuals who institutionalized the arts on the Prairies hid both a Native audience and the kinds of issues and presentations such an audience might reasonably expect to see--and that might help make the settler audience understand the responsibilities of becoming native to this place. The interdisciplinary nature of the book makes it useful to scholars in Native Studies, Museum Studies, Art History, Theatre, and English, as well as to arts administrators and patrons, art lovers, and artists.
Mark is fighting to save the life of a traffic accident victim. It is only when he has time to check the paper work that he is shocked to find that his comotosed patient is his estranged best friend . As he nurses Matty memories of their hilarious exploits come flooding back. Frances Wright has drawn on her first-hand experiences to create a vivid account of working in hospital. She has written a book that makes you laugh out loud and is also a deeply touching account of the friendship between two young men.
This book provides a full and clear exposition of the fundamentals of intellectual property law in the UK. It combines excerpts from cases and a broad range of secondary works with insightful commentary from the authors which will situate the law within a wider international context.
This book is both a novel and essays about work life. In the novel, David is a young man intent on moving up in the company, Protech, which designs security systems. To do this, he steals an idea for a new product from a junior employee and sells it to senior management as his own. The idea takes off but David has to constantly having to do questionable things to keep his status as golden boy. He spies on another colleague for fear of an idea which might overtake his; he demands his boss' job to keep control of his project; and he browbeats his team into saying the product is ready for release when it is clearly not. He twists and turns to stay on top.The parallel stories are of Becky, David's mother, who walks away at the end of her career to pursue a lifelong dream and of Gord, David's father, who is a brilliant but difficult employee who has never fit into organizational life.Throughout the book, there are hyperlinks to essays which discuss aspects of the story and how they might apply to the reader's life. For example, one essay discusses how David gets caught up in the office politics and whether you have to do it, too. Similarly, another essay asks whether always being honest at work, such as Gord maintains he is, is good or bad for your career and psyche. Becky's essays largely deal with whether and how you can work at what you are really passionate about rather than just put food on the table. The essays can be read as the novel is being read or after. All of them pose questions about how to deal with the dark side of work.
The life of the painter and designer Duncan Grant spanned great changes in society and art, from Edwardian Britain to the 1970s, from Alma-Tadema to Gilbert and George. This authoritive biography combines an engrossing narrative with an invaluable assessment of Grant's individual achievement and his place within Bloomsbury and in the wider development of British art. 'Spalding's skill is to sketch out the intricate emotional web against the bright bold untouchable figure of the artist. . . Her achievement is to let that sense of a man living with his craft shine through on every page: the result is an exceptionally honest and warm portrait. ' Financial Times
Explaining the principles underlying legal practice, this essential guide for students on the Legal Practice Course includes topical examples and scenarios to illustrate key points, worked examples to aid understanding, and checkpoints and summaries to test comprehension of the core material.
Explaining the principles underlying legal practice, this essential guide for students on the Legal Practice Course includes topical examples and scenarios to illustrate key points, worked examples to aid understanding, and checkpoints and summaries to test comprehension of the core material.
The Allegheny Mountains constantly challenged early settlers to use their creativity and skills to conquer what seemed an almost insurmountable barrier. The founding fathers recognized potential in the area both as a resort and as a thriving town that would attract industry. Through hard work and innovation, an all-rail route over the mountains was established, linking the area with important industrial and trade centers. Many people came to Cresson to enjoy the health and recreational benefits of its natural springs, and the area's "pike" afforded the first stage link between Philadelphia and Pittsburgh. When the Pennsylvania Railroad established headquarters here, with a roundhouse, machine shops, and branch lines, the area entered an era of industrial prosperity. I n this remarkable volume, over 200 rare images are combines with informative and insightful text. Early views of the famous Horseshoe Curve, the Gallitzin Tunnels, and the Mountain House are delightfully intertwined with photographs of homes, workplaces, churches, and the people who made the area prosper and grow. Readers visit Loretto, a town founded by "A Prince-Priest, Demetrius A. Gallitzin, Apostle of the Alleghenies" and they are transported to Portage and Lilly, areas of woodlands that gave rise to numerous sawmills.
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