The peripheral T-cell lymphomas (PTCLs) are a heterogenous group of rare entities. Whilst cytogenetic and molecular identifiers are being identified, accurate diagnosis remains challenging, requiring careful, expert integration of the clinical and pathological findings. The treatment of PTCL is also challenging. Protocols for the different subtypes are only just beginning to emerge, hindered by the complexities of conducting trials in such uncommon and varied conditions. While first-line treatment with conventional chemotherapy is seldom curative, patients who achieve remission may be eligible for stem cell transplantation, offering the possibility of long-term disease control if not cure. Targeted biologics are also being developed as unique cytotoxic markers are identified. 'Fast Facts: Peripheral T-Cell Lymphomas' is a new title in the Fast Facts extensive hemato-oncology library, written by experts in this emerging field. This handbook will be useful to anyone involved in the care of patients with PTCL, including haematologists, oncologists, specialist nurses and primary care providers, raising awareness of these rare lymphomas and the current – and emerging – approaches to diagnosis and treatment.
Essential for anyone who seeks to understand the contemporary gender landscape, Gender Stories defines gender as the socially constructed meanings that are assigned to bodies. The book helps readers navigate issues of gender by introducing them to the ubiquitous gender binary, the problems with much of the research on gender differences, and the variety of gender stories in popular culture. At the heart of the book is a description of the process of becoming a gendered person through crafting and performing gender stories. Because each gender performance is unique, a virtually unlimited number of genders existsnot just two, as the gender binary would have us believe. The same multiplicity that characterizes the gender landscape characterizes the individual, who typically changes gender multiple times a day and across the lifespan. In Gender Stories, personal gender performances are framed within a philosophy of choice. Readers are encouraged to become more conscious of the choices they have in constructing their gender identities and to allow others the same choice by respecting their gender performances. Readers will easily find a place for themselves in the book, regardless of their views on gender, because one perspective on gender is not presented as the right one. Gender Stories affirms and legitimizes diverse perspectives as providing more comprehensive knowledge about gender for everyone.
American society centers on individualism, celebrating personal choice even at the expense of collective progress. As part of this emphasis on agency, Americans value freedom for health decisions, and individual health professionals and consumers are held responsible for the nation’s health, often at the expense of improving the overall healthcare system. Such individualistic discourse, disseminated and reinforced through American media, has created resistance and hostility toward health policy initiatives such as the Affordable Care Act and other legislation aimed to improve American healthcare. Television and Health Responsibility in an Age of Individualism examines the relationship between entertainment and health responsibility in the United States. Through the analysis of contemporary television medical dramas, Foss explores how these media texts help shape and perpetuate ideologies that have and continue to encourage resistance to healthcare reform that shifts responsibility away from individuals to government and other institutions.
The peripheral T-cell lymphomas (PTCLs) are a heterogenous group of rare entities. Whilst cytogenetic and molecular identifiers are being identified, accurate diagnosis remains challenging, requiring careful, expert integration of the clinical and pathological findings. The treatment of PTCL is also challenging. Protocols for the different subtypes are only just beginning to emerge, hindered by the complexities of conducting trials in such uncommon and varied conditions. While first-line treatment with conventional chemotherapy is seldom curative, patients who achieve remission may be eligible for stem cell transplantation, offering the possibility of long-term disease control if not cure. Targeted biologics are also being developed as unique cytotoxic markers are identified. 'Fast Facts: Peripheral T-Cell Lymphomas' is a new title in the Fast Facts extensive hemato-oncology library, written by experts in this emerging field. This handbook will be useful to anyone involved in the care of patients with PTCL, including haematologists, oncologists, specialist nurses and primary care providers, raising awareness of these rare lymphomas and the current – and emerging – approaches to diagnosis and treatment.
The mature T and NK cell lymphomas are rare, comprising approximately 10% of all malignant lymphomas. The incidence of T-cell lymphoma is variable around the world, with a higher incidence compared to B-cell lymphomas in the Asian basin. While the overall incidence of B-cell lymphomas has begun to decline in the United States, the incidence of T-cell lymphomas continues to rise. Over the last decade, a number of novel agents have been developed which target T-cell lymphomas and studies have identified novel genes and pathways associated with lymphomagenesis in T-cells. This comprehensive volume examines the clinical and biological aspects of the T-cell lymphoproliferative disorders in adults and children. The book includes an overview of both the cutaneous and the systemic T-cell malignancies and addresses the classification of T-cell lymphomas, the clinical features of each subtype, and the relevant molecular and genetic studies. Clinical outcomes and treatment strategies are discussed with an emphasis on the development of novel biological and targeted therapies. An outstanding resource for hematologists and oncologists, this book gathers insights from experts in the field and provides the most up-to-date information on all of the T-cell lymphoma subgroups and current and emerging therapies.
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