Forum on Neuroscience and Nervous System Disorders's Books

Harnessing Mobile Devices for Nervous System Disorders

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Harnessing Mobile Devices for Nervous System Disorders

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

The critical importance of using mobile technology is clear to anyone in the health professions, particularly those who treat people with central nervous system (CNS) disorders. To explore current developments and opportunities for using mobile technology to advance research and treatment of CNS disorders, the National Academies' Forum on Neuroscience and Nervous System Disorders hosted a workshop in June 5â€"6, 2018. This publication summarizes the presentations and discussions at the workshop.

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ISBN 10

030948510X

ISBN 13

9780309485104

Financial Incentives to Encourage Development of Therapies That Address Unmet Medical Needs for Nervous System Disorders

Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation,Forum on Neuroscience and Nervous System Disorders

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Financial Incentives to Encourage Development of Therapies That Address Unmet Medical Needs for Nervous System Disorders

Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation,Forum on Neuroscience and Nervous System Disorders

The Institute of Medicine (IOM) Forum on Neuroscience and Nervous System Disorders, in collaboration with the IOM Forum on Drug Discovery, Development, and Translation, convened a workshop on January 20-21, 2015, to explore policy changes that might increase private sector investment in research and development innovation that fills unmet medical needs for central nervous system (CNS) disorders. Workshop participants strategized about how to incentivize companies to fortify their CNS drug development programs, shrinking obstacles that currently deter ventures. Representatives from academia, government agencies, patient groups, and industry gathered to share information and viewpoints, and to brainstorm about budget-neutral policy changes that could help widen the pipeline toward drugs that address unmet needs for CNS disorders. This report summarizes the presentations and discussion of the workshop.

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ISBN 10

0309373263

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9780309373265

Improving the Utility and Translation of Animal Models for Nervous System Disorders

Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Improving the Utility and Translation of Animal Models for Nervous System Disorders

Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.

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National Academies Press

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ISBN 10

0309266335

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9780309266338

Harnessing Mobile Devices for Nervous System Disorders

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Harnessing Mobile Devices for Nervous System Disorders

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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030948510X

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9780309485104

Advancing Gene-Targeted Therapies for Central Nervous System Disorders

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Advancing Gene-Targeted Therapies for Central Nervous System Disorders

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

On April 23 and 24, 2019 the Forum on Neuroscience and Nervous System Disorders convened a workshop titled "Advancing Gene-Targeted Therapies for Central Nervous System Disorders" in Washington, DC. This public workshop brought together experts and key stakeholders from academia, government, industry, philanthropic foundations, and disease/patient-focused nonprofit organizations to explore approaches for advancing the development of gene-targeted therapies for central nervous system (CNS) disorders, and implications of developing these therapies. Participants explored lessons learned from both successful and unsuccessful clinical development programs; new knowledge about the genetic underpinnings of brain disorders; the current status and future potential of gene-targeted therapies for CNS disorders; challenges and potential solutions for translating preclinical findings to approved therapies; and patient and caregiver perspectives. They also discussed what will be needed to develop these therapies for common disorders such as Alzheimer's and Parkinson's disease, as well as neuropsychiatric and neurodevelopmental disorders such as schizophrenia and autism. The workshop included approaches that target both DNA and RNA, as well as gene products using viral vectors, antisense oligonucleotides, and RNA interference. This publication summarizes the presentations and discussion of the workshop.

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ISBN 10

0309495873

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9780309495875

Enabling Novel Treatments for Nervous System Disorders by Improving Methods for Traversing the Bloodâ¬"Brain Barrier

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Enabling Novel Treatments for Nervous System Disorders by Improving Methods for Traversing the Bloodâ¬"Brain Barrier

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

Despite substantial advances in developing treatments for the serious illnesses that affect people worldwide, there remains a tremendous unmet need in the treatment of complex neurologic diseases, including neuropsychiatric and neurodegenerative disorders. Chief among the challenges that have hindered the development of therapeutics for central nervous system (CNS) disorders is the bloodâ€"brain barrier (BBB). The Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop to explore the challenges associated with the BBB that have thus far stymied development of CNS drugs, examine new technologies that could address these challenges, and highlight potential opportunities for moving the field forward. This publication summarizes the presentations and discussions from the workshop.

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0309473071

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9780309473071

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Improving and Accelerating Therapeutic Development for Nervous System Disorders

Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

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ISBN 10

0309292492

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9780309292498

Enabling Novel Treatments for Nervous System Disorders by Improving Methods for Traversing the Bloodâ¬"Brain Barrier

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Enabling Novel Treatments for Nervous System Disorders by Improving Methods for Traversing the Bloodâ¬"Brain Barrier

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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0309473071

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9780309473071

Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System

Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System

Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.

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ISBN 10

0309212219

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9780309212212

Mental, Neurological, and Substance Use Disorders in Sub-Saharan Africa

Reducing the Treatment Gap, Improving Quality of Care: Summary of a Joint Workshop by the Institute of Medicine and the Uganda National Academy of Sciences

By: Uganda National Academy of Sciences,Forum on Health and Nutrition,Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Mental, Neurological, and Substance Use Disorders in Sub-Saharan Africa

Reducing the Treatment Gap, Improving Quality of Care: Summary of a Joint Workshop by the Institute of Medicine and the Uganda National Academy of Sciences

By: Uganda National Academy of Sciences,Forum on Health and Nutrition,Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

Millions of people in sub-Saharan Africa suffer from mental, neurological, and substance use (MNS) disorders, and most do not have the resources to obtain treatment. The Uganda National Academy of Sciences and the Institute of Medicine hosted a workshop to discuss the state of care for MNS disorders in sub-Saharan Africa.

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128

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National Academies Press

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ISBN 10

0309148804

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9780309148801

Therapeutic Development in the Absence of Predictive Animal Models of Nervous System Disorders

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Therapeutic Development in the Absence of Predictive Animal Models of Nervous System Disorders

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

Compared with other disease areas, central nervous system (CNS) disorders have had the highest failure rate for new compounds in advanced clinical trials. Most CNS drugs fail because of efficacy, and the core issue underlying these problems is a poor understanding of disease biology. Concern about the poor productivity in neuroscience drug development has gained intensity over the past decade, amplified by a retraction in investment from the pharmaceutical industry. This retreat by industry has been fueled by the high failure rate of compounds in advanced clinical trials for nervous system disorders. In response to the de-emphasis of CNS disorders in therapeutic development relative to other disease areas such as cancer, metabolism, and autoimmunity, the National Academies of Sciences, Engineering, and Medicine initiated a series of workshops in 2012 to address the challenges that have slowed drug development for nervous system disorders. Motivated by the notion that advances in genetics and other new technologies are beginning to bring forth new molecular targets and identify new biomarkers, the Academies hosted the third workshop in this series in September 2016. Participants discussed opportunities to accelerate early stages of drug development for nervous system disorders in the absence of animal models that reflect disease and predict efficacy. This publication summarizes the presentations and discussions from the workshop.

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ISBN 10

0309455162

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9780309455169

Advancing Gene-Targeted Therapies for Central Nervous System Disorders

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Advancing Gene-Targeted Therapies for Central Nervous System Disorders

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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0309495849

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9780309495844

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Improving and Accelerating Therapeutic Development for Nervous System Disorders

Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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0309292492

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9780309292498

Non-Invasive Neuromodulation of the Central Nervous System

Opportunities and Challenges: Workshop Summary

By: National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Non-Invasive Neuromodulation of the Central Nervous System

Opportunities and Challenges: Workshop Summary

By: National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

Based on advances in biotechnology and neuroscience, non-invasive neuromodulation devices are poised to gain clinical importance in the coming years and to be of increasing interest to patients, clinicians,health systems, payers, and industry. Evidence suggests that both therapeutic and non-therapeutic applications of non-invasive neuromodulation will continue to expand in coming years, particularly for indications where treatments are currently insufficient, such as drug-resistant depression. Given the growing interest in non-invasive neuromodulation technologies, the Institute of Medicine's Forum on Neuroscience and Nervous System Disorders convened a workshop, inviting a range of stakeholders - including developers of devices and new technologies, researchers, clinicians, ethicists, regulators, and payers - to explore the opportunities, challenges, and ethical questions surrounding the development, regulation, and reimbursement of these devices for the treatment of nervous system disorders as well as for non-therapeutic uses, including cognitive and functional enhancement. This report highlights the presentation and discussion of the workshop.

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103

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0309376211

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9780309376211

Improving the Utility and Translation of Animal Models for Nervous System Disorders

Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Improving the Utility and Translation of Animal Models for Nervous System Disorders

Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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0309266335

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9780309266338

Neuroscience Trials of the Future

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Neuroscience Trials of the Future

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

On March 3-4, 2016, the National Academies of Sciences, Engineering, and Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop in Washington, DC, bringing together key stakeholders to discuss opportunities for improving the integrity, efficiency, and validity of clinical trials for nervous system disorders. Participants in the workshop represented a range of diverse perspectives, including individuals not normally associated with traditional clinical trials. The purpose of this workshop was to generate discussion about not only what is feasible now, but what may be possible with the implementation of cutting-edge technologies in the future.

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0309442583

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9780309442589

Therapeutic Development in the Absence of Predictive Animal Models of Nervous System Disorders

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Therapeutic Development in the Absence of Predictive Animal Models of Nervous System Disorders

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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0309455162

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9780309455169

Neuroscience Biomarkers and Biosignatures

Converging Technologies, Emerging Partnerships: Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Neuroscience Biomarkers and Biosignatures

Converging Technologies, Emerging Partnerships: Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

Biomarkers, or biological markers, are quantitative measurements that offer researchers and clinicians valuable insight into diagnosis, treatment and prognosis for many disorders and diseases. A major goal in neuroscience medical research is establishing biomarkers for disorders of the nervous system. Given the promising potential and necessity for neuroscience biomarkers, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened a public workshop and released the workshop summary entitled Neuroscience Biomarkers and Biosignatures: Converging Technologies, Emerging Partnerships. The workshop brought together experts from multiple areas to discuss the most promising and practical arenas in neuroscience in which biomarkers will have the greatest impact. The main objective of the workshop was to identify and discuss biomarker targets that are not currently being aggressively pursued but that could have the greatest near-term impact on the rate at which new treatments are brought forward for psychiatric and neurological disorders.

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128

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National Academies Press

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ISBN 10

0309108896

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9780309108898

Biomarkers of Neuroinflammation

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Biomarkers of Neuroinflammation

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases. The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from neuroinflammatory diseases such as multiple sclerosis (MS) to neuropsychiatric disorders such as depression. This publication summarizes the presentations and discussions from the workshop.

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0309463653

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9780309463652

Developing a 21st Century Neuroscience Workforce

Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Developing a 21st Century Neuroscience Workforce

Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

From its very beginning, neuroscience has been fundamentally interdisciplinary. As a result of rapid technological advances and the advent of large collaborative projects, however, neuroscience is expanding well beyond traditional subdisciplines and intellectual boundaries to rely on expertise from many other fields, such as engineering, computer science, and applied mathematics. This raises important questions about to how to develop and train the next generation of neuroscientists to ensure innovation in research and technology in the neurosciences. In addition, the advent of new types of data and the growing importance of large datasets raise additional questions about how to train students in approaches to data analysis and sharing. These concerns dovetail with the need to teach improved scientific practices ranging from experimental design (e.g., powering of studies and appropriate blinding) to improved sophistication in statistics. Of equal importance is the increasing need not only for basic researchers and teams that will develop the next generation of tools, but also for investigators who are able to bridge the translational gap between basic and clinical neuroscience. Developing a 21st Century Neuroscience Workforce is the summary of a workshop convened by the Institute of Medicine's Forum on Neuroscience and Nervous System Disorders on October 28 and 29,2014, in Washington, DC, to explore future workforce needs and how these needs should inform training programs. Workshop participants considered what new subdisciplines and collaborations might be needed, including an examination of opportunities for cross-training of neuroscience research programs with other areas. In addition, current and new components of training programs were discussed to identify methods for enhancing data handling and analysis capabilities, increasing scientific accuracy, and improving research practices. This report highlights the presentation and discussion of the workshop.

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114

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ISBN 10

0309368774

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9780309368773

Developing Multimodal Therapies for Brain Disorders

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Developing Multimodal Therapies for Brain Disorders

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

Multimodal therapy approaches that combine interventions aimed at different aspects of disease are emerging as potentialâ€"and perhaps essentialâ€"ways to enhance clinical outcomes for patients with psychiatric and neurological disorders. In order to examine the general principles underlying multimodal therapies and to explore challenges, potential barriers, and opportunities for their development, the National Academies of Sciences, Engineering, and Medicine convened a workshop in June 2016. Participants explored scientific, clinical, regulatory, and reimbursement issues related to multimodal approaches and potential opportunities to enhance clinical outcomes for individuals with nervous system disorders. This publication summarizes the presentations and discussions from the workshop.

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0309450268

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9780309450263

Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

Chronic pain is one of the most prevalent, costly, and disabling health conditions in the United States. Estimates show that more than 11 percent of the American population suffer from chronic pain, yet the federal pain research investment has been minimal. In parallel with a gradual increased recognition of the problems of treating chronic pain, the opioid epidemic has emerged as a growing public health emergency. The intersection of these two crises lies in the fact that an unintended consequence of treating pain has been an increasing number of opioid prescriptions and diversion of drugs for illicit purposes. In May 2017, the National Institutes of Health (NIH), and the National Institute on Drug Abuse announced a publicâ€"private partnership to develop solutions to the opioid crisis and cut in half the time it takes to develop non-addictive analgesics. To advance the planning of NIH's anticipated publicâ€"private partnerships, the National Academies' Forum on Neuroscience and Nervous Systems Disorders hosted a public workshop that brought together a diverse group of stakeholders from academia, federal agencies, advocacy organizations and companies developing therapeutics for pain and opioid use disorders. Participants discussed potential strategies to accelerate development of non-addictive pain medications and treatments for opioid use disorders. This publication summarizes the presentations and discussions from the workshop.

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National Academies Press

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ISBN 10

0309473993

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9780309473996

From Molecules to Minds

Challenges for the 21st Century: Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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From Molecules to Minds

Challenges for the 21st Century: Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

Neuroscience has made phenomenal advances over the past 50 years and the pace of discovery continues to accelerate. On June 25, 2008, the Institute of Medicine (IOM) Forum on Neuroscience and Nervous System Disorders hosted more than 70 of the leading neuroscientists in the world, for a workshop titled "From Molecules to Minds: Challenges for the 21st Century." The objective of the workshop was to explore a set of common goals or "Grand Challenges" posed by participants that could inspire and rally both the scientific community and the public to consider the possibilities for neuroscience in the 21st century. The progress of the past in combination with new tools and techniques, such as neuroimaging and molecular biology, has positioned neuroscience on the cusp of even greater transformational progress in our understanding of the brain and how its inner workings result in mental activity. This workshop summary highlights the important issues and challenges facing the field of neuroscience as presented to those in attendance at the workshop, as well as the subsequent discussion that resulted. As a result, three overarching Grand Challenges emerged: How does the brain work and produce mental activity? How does physical activity in the brain give rise to thought, emotion, and behavior? How does the interplay of biology and experience shape our brains and make us who we are today? How do we keep our brains healthy? How do we protect, restore, or enhance the functioning of our brains as we age?

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ISBN 10

0309120926

ISBN 13

9780309120920

Neuroscience Data in the Cloud

Opportunities and Challenges: Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Neuroscience Data in the Cloud

Opportunities and Challenges: Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

The cloud model of data sharing has led to a vast increase in the quantity and complexity of data and expanded access to these data, which has attracted many more researchers, enabled multi-national neuroscience collaborations, and facilitated the development of many new tools. Yet, the cloud model has also produced new challenges related to data storage, organization, and protection. Merely switching the technical infrastructure from local repositories to cloud repositories is not enough to optimize data use. To explore the burgeoning use of cloud computing in neuroscience, the National Academies Forum on Neuroscience and Nervous System Disorders hosted a workshop on September 24, 2019. A broad range of stakeholders involved in cloud-based neuroscience initiatives and research explored the use of cloud technology to advance neuroscience research and shared approaches to address current barriers. This publication summarizes the presentation and discussion of the workshop.

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ISBN 10

0309670586

ISBN 13

9780309670586

Alzheimer's Diagnostic Guideline Validation

Exploration of Next Steps: Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous Systems Disorders

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Alzheimer's Diagnostic Guideline Validation

Exploration of Next Steps: Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous Systems Disorders

Scientific advances during the last decade now indicate that Alzheimer's disease is a continuous, progressive cognitive disease, most likely beginning many years before dementia is apparent. To discuss the next steps in validating new diagnostic guidelines for Alzheimer's disease, the IOM Forum on Neuroscience and Nervous System Disorders hosted a public workshop session at the Alzheimer's Association International Conference.

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ISBN 10

0309225574

ISBN 13

9780309225571

Assessing the Impact of Applications of Digital Health Records on Alzheimer's Disease Research

Workshop Summary

By: National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Assessing the Impact of Applications of Digital Health Records on Alzheimer's Disease Research

Workshop Summary

By: National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

Health information technology is providing patients, clinicians, and researchers with access to data that will enable novel approaches to science and medicine. Digital health records (DHRs) are capable of being shared across different health care settings for the examination of possible trends and long-term changes in a patient's disease progression or status as well as the effectiveness of the health care delivery system. While prevalence of paper records remains high, there has been a rapid trend toward the digitalization of medical and health records in many countries. DHRs are widely viewed as essential for improving health, reducing medical errors, and lowering costs. However, given that these databases have the potential to house the complete medical and health information of individuals, the potential misuse, de-identification or breaching of this data may have serious implications. On July 20, 2015, the Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a public session at the 2015 Alzheimer's Association International Conference to assess the impact of DHRs on Alzheimer's disease (AD) research. An estimated 46.8 million people worldwide are currently living with dementia, and the prevalence is expected to double every year for the next 20 years. Given the few therapies currently available to treat the symptoms of AD, compared to other central nervous system disorders, participants explored how DHRs may be used to help improve clinical trial design and methodology for AD research. This report summarizes the presentations and discussions from this workshop.

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ISBN 10

030937975X

ISBN 13

9780309379755

Future Opportunities to Leverage the Alzheimer's Disease Neuroimaging Initiative

Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Future Opportunities to Leverage the Alzheimer's Disease Neuroimaging Initiative

Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

Nearly 5.3 million Americans are living with Alzheimer's disease, and 26.6 million people are affected worldwide. The Alzheimer's Disease Neuroimaging Initiative (ADNI), a public-private partnership, provides a publicly available, international database of clinical and imaging data to foster research and collaboration on Alzheimer's research worldwide. The Institute of Medicine held a workshop on July 12, 2010, to explore opportunities to use information from and partnerships formed because of ADNI to continue to improve the understanding and treatment of Alzheimer's disease.

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ISBN 10

0309186889

ISBN 13

9780309186889

Sex Differences and Implications for Translational Neuroscience Research

Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Sex Differences and Implications for Translational Neuroscience Research

Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

Biological differences between the sexes influence not only individual health but also public health, biomedical research, and health care. The Institute of Medicine held a workshop March 8-9, 2010, to discuss sex differences and their implications for translational neuroscience research, which bridges the gap between scientific discovery and application.

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110

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National Academies Press

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ISBN 10

030916124X

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9780309161244

Mental, Neurological, and Substance Use Disorders in Sub-Saharan Africa

Reducing the Treatment Gap, Improving Quality of Care: Summary of a Joint Workshop by the Institute of Medicine and the Uganda National Academy of Sciences

By: Uganda National Academy of Sciences,Forum on Health and Nutrition,Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Mental, Neurological, and Substance Use Disorders in Sub-Saharan Africa

Reducing the Treatment Gap, Improving Quality of Care: Summary of a Joint Workshop by the Institute of Medicine and the Uganda National Academy of Sciences

By: Uganda National Academy of Sciences,Forum on Health and Nutrition,Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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128

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National Academies Press

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ISBN 10

0309148804

ISBN 13

9780309148801

Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System

Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System

Workshop Summary

By: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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ISBN 10

0309212219

ISBN 13

9780309212212

Transgenic Neuroscience Research

Exploring the Scientific Opportunities Afforded by New Nonhuman Primate Models: Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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Transgenic Neuroscience Research

Exploring the Scientific Opportunities Afforded by New Nonhuman Primate Models: Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

To examine the promise, concerns, and challenges related to neuroscience research using genetically modified nonhuman primates, the National Academies of Sciences, Engineering, and Medicine hosted a public workshop on October 4, 2018, bringing together an international group of experts and stakeholders representing academia, industry, laboratory animal management, disease-focused foundations, and federal agencies. The workshop was designed to explore the current state and future promise of research using genetically modified nonhuman primate models of disease to understand the complex functions of the brain that control behavior, movement, and cognition in both health and disease states. This publication summarizes the presentations and discussions from the workshop.

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ISBN 10

0309488761

ISBN 13

9780309488761

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