Florian Sedlmeier's Books

The Postethnic Literary

Reading Paratexts and Transpositions around 2000

By: Florian Sedlmeier

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The Postethnic Literary

Reading Paratexts and Transpositions around 2000

By: Florian Sedlmeier

The book explores the discursive and theoretical conditions for conceptualizing the postethnic literary. It historicizes US multicultural and postcolonial studies as institutionalized discursive formations, which constitute a paratext that regulates the reception of literary texts according to the paradigm of representativeness. Rather than following that paradigm, the study offers an alternative framework by rereading contemporary literary texts for their investment in literary form. By means of self-reflective intermedial transpositions, the writings of Sherman Alexie, Chang-rae Lee, and Jamaica Kincaid insist upon a differentiation between the representation of cultural sign systems or subject positions and the dramatization of individual gestures of authorship. As such, they form a postethnic literary constellation, further probed in the epilogue of the study focused on Dave Eggers.

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Page Count

242

Publisher

Walter de Gruyter GmbH & Co KG

Published Date

ISBN 10

311036848X

ISBN 13

9783110368482

Synthetic cannabinoids in drug discovery. Design, synthesis and evaluation of modified coumarins as CB receptor ligands

By: Florian Mohr

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Synthetic cannabinoids in drug discovery. Design, synthesis and evaluation of modified coumarins as CB receptor ligands

By: Florian Mohr

The endocannabinoid system represents a highly complex lipid-based (neuro-) transmitter system and can be found in nearly all animals. Since the discovery of the two main cannabinoid receptors CB1 and CB2 in the early '90, intensive research reviled a substantial influence of this system on many physiological and pathophysiological processes. Direct and selective targeting of the system bears a huge potential for the development of novel therapeutic approaches, especially for the treatment of chronical pain, inflammation or other neurological disorders. Therefore, the endocannabinoid system is a promising target in drug development. In the presented thesis, the design, syntheses and pharmacologic evaluation of substituted coumarins as potential new drug candidates as selective synthetic cannabinoids were investigated. In a combinatorial synthetic approach, several new libraries of new ligands were synthesised and subsequently pharmacological tested. Additionally, in a second project, novel reversible monoacylglycerol lipase (MAGL) inhibitors have been synthesized and pharmacologically evaluated. Thereby, several important structure-activity relationships for high potency or selectivity were found. Nearly all potencies of the developed inhibitors were determined in the nanomolar regions.

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Page Count

354

Publisher

Logos Verlag Berlin GmbH

Published Date

ISBN 10

3832551034

ISBN 13

9783832551032

Revisiting the Sixties

Interdisciplinary Perspectives on America's Longest Decade

By: Laura Bieger,Christian Lammert

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Revisiting the Sixties

Interdisciplinary Perspectives on America's Longest Decade

By: Laura Bieger,Christian Lammert

Kubakrise und Vietnamkrieg, Bürgerrechtsbewegung und "Great Society", Woodstock und Mondlandung - die "Sixties" zählen in der Geschichte der USA zu den ereignisreichsten Jahrzehnten überhaupt. Wie aber kam es zu den politischen, sozialen und kulturellen Umwälzungen dieser Dekade und welche Konflikte sind noch heute virulent? Drücken sie dem "American Way of Life" des 21. Jahrhunderts immer noch ihren Stempel auf? Die Autorinnen und Autoren spüren diesen Fragen nach - genau 50 Jahre, nachdem John F. Kennedy 1963 den Schüssen von Dallas zum Opfer fiel.

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Page Count

345

Publisher

Campus Verlag

Published Date

ISBN 10

3593421283

ISBN 13

9783593421285

The Postethnic Literary

Reading Paratexts and Transpositions around 2000

By: Florian Sedlmeier

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The Postethnic Literary

Reading Paratexts and Transpositions around 2000

By: Florian Sedlmeier

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Page Count

320

Publisher

Walter de Gruyter GmbH & Co KG

Published Date

ISBN 10

3110409119

ISBN 13

9783110409116

Book's by Florian Sedlmeier

The Postethnic Literary

The Postethnic Literary

Synthetic cannabinoids in drug discovery. Design, synthesis and evaluation of modified coumarins as CB receptor ligands

Synthetic cannabinoids in drug discovery. Design, synthesis and evaluation of modified coumarins as CB receptor ligands

Revisiting the Sixties

Revisiting the Sixties

The Postethnic Literary

The Postethnic Literary

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