Feifang Hu's Books

The Theory of Response-Adaptive Randomization in Clinical Trials

By: Feifang Hu,William F. Rosenberger

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The Theory of Response-Adaptive Randomization in Clinical Trials

By: Feifang Hu,William F. Rosenberger

Presents a firm mathematical basis for the use of response-adaptive randomization procedures in practice The Theory of Response-Adaptive Randomization in Clinical Trials is the result of the authors' ten-year collaboration as well as their collaborations with other researchers in investigating the important questions regarding response-adaptive randomization in a rigorous mathematical framework. Response-adaptive allocation has a long history in biostatistics literature; however, largely due to the disastrous ECMO trial in the early 1980s, there is a general reluctance to use these procedures. This timely book represents a mathematically rigorous subdiscipline of experimental design involving randomization and answers fundamental questions, including: How does response-adaptive randomization affect power? Can standard inferential tests be applied following response-adaptive randomization? What is the effect of delayed response? Which procedure is most appropriate and how can "most appropriate" be quantified? How can heterogeneity of the patient population be incorporated? Can response-adaptive randomization be performed with more than two treatments or with continuous responses? The answers to these questions communicate a thorough understanding of the asymptotic properties of each procedure discussed, including asymptotic normality, consistency, and asymptotic variance of the induced allocation. Topical coverage includes: The relationship between power and response-adaptive randomization The general result for determining asymptotically best procedures Procedures based on urn models Procedures based on sequential estimation Implications for the practice of clinical trials Useful for graduate students in mathematics, statistics, and biostatistics as well as researchers and industrial and academic biostatisticians, this book offers a rigorous treatment of the subject in order to find the optimal procedure to use in practice.

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Page Count

234

Publisher

John Wiley & Sons

Published Date

ISBN 10

0470055871

ISBN 13

9780470055878

Advances in Statistics

Proceedings of the Conference in Honor of Professor Zhidong Bai on His 65th Birthday, National University of Singapore, 20 July 2008

By: Zehua Chen,Jin-Ting Zhang,Feifang Hu

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Advances in Statistics

Proceedings of the Conference in Honor of Professor Zhidong Bai on His 65th Birthday, National University of Singapore, 20 July 2008

By: Zehua Chen,Jin-Ting Zhang,Feifang Hu

This book, which is split into two parts, is about Prof. Zhidong Bai's life and his contributions to statistics and probability. The first part contains an interview with Zhidong Bai conducted by Dr Atanu Biswas from the Indian Statistical Institute, and seven short articles detailing Bai's contributions. The second part is a collection of his selected seminal papers in the areas of random matrix theory, Edgeworth expansion, M-estimation, model selection, adaptive design in clinical trials, applied probability in algorithms, small area estimation, and time series, among others. This book provides an easy access to Zhidong Bai's important works, and serves as a useful reference for researchers who are working in the relevant areas.

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Page Count

397

Publisher

World Scientific

Published Date

ISBN 10

9812793089

ISBN 13

9789812793089

The Theory of Response-Adaptive Randomization in Clinical Trials

By: Feifang Hu,William F. Rosenberger

Write a review Read reviews Take a Quiz Solve Book Puzzle

The Theory of Response-Adaptive Randomization in Clinical Trials

By: Feifang Hu,William F. Rosenberger

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

234

Publisher

John Wiley & Sons

Published Date

ISBN 10

0470055871

ISBN 13

9780470055878

Book's by Feifang Hu

The Theory of Response-Adaptive Randomization in Clinical Trials

The Theory of Response-Adaptive Randomization in Clinical Trials

Advances in Statistics

Advances in Statistics

The Theory of Response-Adaptive Randomization in Clinical Trials

The Theory of Response-Adaptive Randomization in Clinical Trials

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