Doxorubicin: Anticancer Antibiotics details the development of doxorubicin as a wide-spectrum antitumor antibiotic. The book begins by tracing the discovery and development of doxorubicin, highlighting factors such as (a) the involvement of organic chemistry at an early stage, which allowed the rapid identification of doxorubicin and ensured its prompt availability for the clinical trials; (b) the well-established, pioneering expertise in experimental chemotherapy of Professor Aurelio di Marco and his group at Istituto Nazionale Tumori, Milan; and (c) the highly motivated interest of experienced clinicians. The remaining chapters provide an overview of basic studies in the area of medicinal chemistry and related fields that have resulted from doxorubicin development. Such studies have been concerned with both biochemical and biophysical investigations at the molecular level and at different levels of biological organization. A large body of work aimed at developing synthetic procedures for the drug and for new related analogs of potential clinical usefulness has also been carried out.
Why did Italo Calvino decide to translate Les Fleurs bleues by Raymond Queneau? Was his translation just a way to pay a tribute to one of his models? This study looks at Calvino's translation from a literary and linguistic perspective: Calvino's I fiori blu is more than a rewriting and a creative translation, as it contributed to a revolution in his own literary language and style. Translating Queneau, Calvino discovered a new fictional voice and explored the potentialities of his native tongue, Italian. In fact Calvino's writings show a visible evolution of poetics and style that occurred rather abruptly in the mid 1960s; this sudden change has long been debated. The radical transformation of his style was affected by several factors: Calvino's new interests in linguistics, in translation theory, and in the act of translation. Translation as Stylistic Evolution analyses several passages in detail and scrutinizes quantitative data obtained by comparing digital versions of the original and Calvino's translation. The results of such assessment of Calvino's text-consistency suggest clear interpretations of the motives behind Calvino's radical and remarkable change of style that are tied to his notion of creative translation.
This volume is the first monograph devoted to the philosophy of Taurus of Beirut, and provides a long-awaited analysis of his texts and their first English translation. Through close examination of the extant witnesses, Petrucci gives a new account of Middle Platonism based on a fresh approach to the theological and cosmological view of Taurus. In this way, the book contributes substantially to the debate on Post-Hellenistic Platonism from the point of view of both exegetical methods and philosophical doctrines, and offers a starting point for a new understanding of many aspects of ancient thought.
Doxorubicin: Anticancer Antibiotics details the development of doxorubicin as a wide-spectrum antitumor antibiotic. The book begins by tracing the discovery and development of doxorubicin, highlighting factors such as (a) the involvement of organic chemistry at an early stage, which allowed the rapid identification of doxorubicin and ensured its prompt availability for the clinical trials; (b) the well-established, pioneering expertise in experimental chemotherapy of Professor Aurelio di Marco and his group at Istituto Nazionale Tumori, Milan; and (c) the highly motivated interest of experienced clinicians. The remaining chapters provide an overview of basic studies in the area of medicinal chemistry and related fields that have resulted from doxorubicin development. Such studies have been concerned with both biochemical and biophysical investigations at the molecular level and at different levels of biological organization. A large body of work aimed at developing synthetic procedures for the drug and for new related analogs of potential clinical usefulness has also been carried out.
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