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Macrolides

Properties, Synthesis and Applications

By: Biljana Arsic,Predrag Novak,Goran Kragol,Jill Barber,Maria Grazia Rimoli,Federica Sodano

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Macrolides

Properties, Synthesis and Applications

By: Biljana Arsic,Predrag Novak,Goran Kragol,Jill Barber,Maria Grazia Rimoli,Federica Sodano

Macrolide antibiotics represent a class of natural macrocyclic products, one of the most clinically important antibiotics. Unfortunately, the production and development of new macrolide antibiotics are not represented enough in the pharmaceutical industry today. The intention of the book is therefore not only to be a teaching tool for students and experts, but also to draw the attention of the general public to this extremely useful, cheap and relatively unharmful effective anti-macrobials, and potential anti-malarials. The authors introduce the different classes of macrolides and their derivatives, principles of their biological activity, their structure and interactions with biological targets as well as synthetic methods to produce new macrolide antibiotics of similar or improved properties. Special emphasis was put on conjugates of macrolides with nucleobases or nucleosides with numerous applications; among them the most important remains the attempt to overcome bacterial resistance.

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Page Count

112

Publisher

Walter de Gruyter GmbH & Co KG

Published Date

ISBN 10

311051575X

ISBN 13

9783110515756

Macrolides

Properties, Synthesis and Applications

By: Biljana Arsic,Predrag Novak,Goran Kragol,Jill Barber,Maria Grazia Rimoli,Federica Sodano

Write a review Read reviews Take a Quiz Solve Book Puzzle

Macrolides

Properties, Synthesis and Applications

By: Biljana Arsic,Predrag Novak,Goran Kragol,Jill Barber,Maria Grazia Rimoli,Federica Sodano

Macrolide antibiotics represent a class of natural macrocyclic products, one of the most clinically important antibiotics. Unfortunately, the production and development of new macrolide antibiotics are not represented enough in the pharmaceutical industry today. The intention of the book is therefore not only to be a teaching tool for students and experts, but also to draw the attention of the general public to this extremely useful, cheap and relatively unharmful effective anti-macrobials, and potential anti-malarials. The authors introduce the different classes of macrolides and their derivatives, principles of their biological activity, their structure and interactions with biological targets as well as synthetic methods to produce new macrolide antibiotics of similar or improved properties. Special emphasis was put on conjugates of macrolides with nucleobases or nucleosides with numerous applications; among them the most important remains the attempt to overcome bacterial resistance.

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Page Count

192

Publisher

Walter de Gruyter GmbH & Co KG

Published Date

ISBN 10

3110515040

ISBN 13

9783110515046