Farid Badria's Books

Honey and Its Products. Chemical, Biological and Therapeutic Applications

By: Farid Badria,Hassan M. Fathy,Ashraf S. Fatehe,Mohamed G. Ghazy

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Honey and Its Products. Chemical, Biological and Therapeutic Applications

By: Farid Badria,Hassan M. Fathy,Ashraf S. Fatehe,Mohamed G. Ghazy

Scientific Study from the year 2017 in the subject Medicine - Pharmacology, Pharmacy, Mansoura University (Faculty of Pharmacy), language: English, abstract: The study includes measurement of bee activity in collecting and producing honey, propolis and bee venom according to bee race, in a comparative study between Carniolan hybrid and Italian hybrid. For one year and study of some biological and chemical properties of some bee products (Honey, propolis and bee venom) and their effects on three types of cancer cells (Hep-G2, Caco-2 and MCF-7) in a comparative study with the effort of two drugs (5Fu and Cis-pt) in different concentrations. The study dealt with the following points: 1. Activity honeybee in collecting and producing honey, propolis and bee venom according to bee race. 2. Biological properties of some bee products and their effects on some cancer cells. 3. Chemical properties of some bee products. Apitherapy is the art and science of making therapeutic use of products of honey bee, including honey, bee pollen, propolis, royal jelly, bees wax and bee venom. apitherapy is defined as api, meaning bee and therapy from the greek word therapia, which literally means "curing" or "healing". apitherapy is healing by using bee products. hippocrates, the greek physician known as the "father of medicine", recognized the hialing virtues of bee venom for treating arthritis and other joint problems. Since the ancient egyptians, cultures across the ages have revered the honey bee for its healing powers. Integrative medical apitherapy is the application of bee products like honey, pollen, royal jelly and propolis in healing therapies. apitherapy is an ancient alternative healing modality dating back several thousand years and used by hippocrates, mentioned by plato, and others throughout our history.

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266

Publisher

GRIN Verlag

Published Date

ISBN 10

3346103781

ISBN 13

9783346103789

Natural Iron Chelator. Chemistry, Biology, and Therapeutic Applications

Developing New Natural Iron Chelator

By: Farid Badria

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Natural Iron Chelator. Chemistry, Biology, and Therapeutic Applications

Developing New Natural Iron Chelator

By: Farid Badria

Master's Thesis from the year 2019 in the subject Chemistry - General, grade: 4.0, Mansoura University, language: English, abstract: Iron-overload disorder (hemochromatosis) is one of the major reasons of morbidity, caused by genetic disorder of protein involved in regulation of iron absorption or due to multiple transfusion of iron in chronic anemia for example thalassemia. Resulting in initiation and propagation reactive oxygen species which attacking macromolecules of cells such as proteins, lipids, RNA and DNA and ultimately cells death. Leading to a state of oxidative stress associated with many of health problems such as heart failure, liver cirrhosis, fibrosis, gallbladder disorders, diabetes, arthritis, infertility, and cancer. The available chelators drugs can forming soluble, stable complexes with excessive iron andexcreted it in the feces and/or urine. But due to, their high cost, severe side effects, poor oralbioavailability or short plasma half-life make them suboptimal. Sixteen plant leaves were collected, authenticated and subjected to exhausted extraction by 70% methanol. The obtained leaves extracts were screened for their iron chelation activity using 2,2`- bipyridyl assay. Among the screened extracts, the Mangiferaindica leaves showed the highest iron chelation activity(69.71 ± 0.27%)comparable to positive control, EDTA(70.30 ± 0.08%). The total extract of theM. indica leaves was partitioned with different solvents (petroleum ether, methylene chloride, ethyl acetate and n-butanol). The resultingfractions were screened for their iron chelation activity using 2, 2`- bipyridyl assay.EtOAcfractionhad the significant chelating activity (123 ± 2.75%),more potent than EDTA(64.12 ± 1.48%) and total extract of M. indica leaves (69.71 ± 0.27%). The mangiferin compound was subjected to comparison with desferal® to assurance the quality of its chelating activity throughdetermine the active sites responsible of its chelating property and evaluation the effect of its iron-stable complex on its antioxidant activity. According to introduced results, through different biological analysis. We found that, the iron-overloaded rats treated with ethyl acetate fraction had significant decreases in iron accumulation within liver and spleen (the major organs affected by iron overload). We assume that, the mangiferin may protect from reactive oxygenspecies-stimulatedseveral of disordersby its iron chelatingactivity which promotes its antioxidant property.

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123

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GRIN Verlag

Published Date

ISBN 10

3346117340

ISBN 13

9783346117342

Synthesis of Nanoparticles Using Green Chemistry

Green Synthesis

By: Farid Badria,Mohamed AbouHabieb,Fatma Abdel Bar

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Synthesis of Nanoparticles Using Green Chemistry

Green Synthesis

By: Farid Badria,Mohamed AbouHabieb,Fatma Abdel Bar

Document from the year 2017 in the subject Chemistry - Bio-chemistry, Mansoura University, language: English, abstract: Forty-two medicinal plants were collected depending on their availability on Egypt. These plant were extracted and screened for their activity towards green synthesis of AgNPs. A new modified method was used in order to screen large number of extracts in short time (high throughput screening). In this method, the synthesized nanoparticles were evaluated in using 96-well plate which is transparent to facilitate the color monitoring and easy to be read spectrophotometrically using microplate reader. The green synthesis activity by the different plant extracts was monitored and evaluated by color change and UV-Vis absorption at time intervals. Out of these 42 plants, only 3 plants viz.,Pyllanthusemblicafruits, Psidium guajava leaves and Lawsoniainermisleaves, showed high AgNPs synthetic activity. The most active plant extracts were further partitioned with ethyl acetate. The results showed that the EtOAc fraction of the three active plants showed superior AgNPs green synthesis over their remaining aqueous. Thus, chromatographic columns were used to isolate the active compounds from the EtOAc fraction of each plant. Metal nanoparticles synthesis is a leading topic of research in modern material science owing to their distinctive potential applications in the field of electronic, optoelectronic, information storage and Health care. Among the all noble metal nanoparticles, silver nanoparticles are one the main products in the field of nanotechnology which has acquired limitless attention due to their unique properties such as chemical stability, good conductivity, catalytic and most important antibacterial, antiviral and antifungal activities. Nevertheless, there is still need for economic commercially viable as well as environmentally clean synthesis route to synthesize the silver nanoparticles.

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202

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GRIN Verlag

Published Date

ISBN 10

3346083454

ISBN 13

9783346083456

Cytokines Modulators in Plants. Chemical and Therapeutics Studies

By: Farid Badria,Diaaeldin M. Elimam,Fatma M. Abdel Bar,Hosam M. Zaghloul

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Cytokines Modulators in Plants. Chemical and Therapeutics Studies

By: Farid Badria,Diaaeldin M. Elimam,Fatma M. Abdel Bar,Hosam M. Zaghloul

Master's Thesis from the year 2016 in the subject Medicine - Pharmacology, Pharmacy, , language: English, abstract: The aim of the present study is (1) the screening group of plants that are traditionally used as immune-enhancers in an attempt to find the major fractions that are responsible for the activity of these plants and correlating them with already published studies. (2) The Modification of structure of the most active immunomodulatory component through semisynthetic derivatization reactions. The modifications will be made in pursuance of gaining a deeper insight of the structural requirements for immunomodulatory activity. (3) Testing the immunomodulatory activities of both natural and semisynthetic compounds. And (4) studying the mechanism of action of the active compounds as antioxidantand anti-proliferative. Immunity is the body ability to identify and resist harmful pathogen. Metaphorically, the immunity is the body’s army that enables prevention as well as fighting of infectious diseasestoprotect self-tissues and organs from damage. The immune system has a multi-layered construction with multiple defense stages. The skin is considered the first barrier of immunity. Then, physiological barriers take place, which are body physical conditions for examplepH and temperature that affordunsuitableenvironments for pathogens to live. Then, if a pathogen has escaped the first barriers and entered the body, it deals with innate immunity as well as acquired and/or adaptive immunity. Both systems consist of number of molecules and cells that interact in a complex manner to detect and eliminate any threat. Detection as well as elimination relay on bonding of immune cellular surface receptors as well as chemical binding to pathogens to trigger complex interaction of signaling of immune response.

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180

Publisher

GRIN Verlag

Published Date

ISBN 10

334609801X

ISBN 13

9783346098016

New Gingerol Derivative against Human Colorectal Carcinoma Caco-2 Cells

By: Farid Badria

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New Gingerol Derivative against Human Colorectal Carcinoma Caco-2 Cells

By: Farid Badria

Akademische Arbeit aus dem Jahr 2013 im Fachbereich Chemie - Biochemie, , Sprache: Deutsch, Abstract: In this article we report the isolation, characterization and evaluation of in vitro anti-colon cancer activity of a new gingerol derivative, namely (S,E)-5-hydroxy-1-(4-hydroxy-3- methoxyphenyl)tetradec-8-en-3-one, (N6), and a known sesquiterpene (1,2- Dihydroxybisabola-3,10-diene, N7), isolated from Zingiber officinale rhizomes for the first time, together with other five known compounds. 6-gingerol (N1), 8-gingerol (N2), 10- gingerol (N3), 4-gingerol (N4) and 4`-O-methyl-6-gingerol (N5). The isolated compounds were identified using different spectroscopic techniques (1D and 2D-NMR, MS and IR). A modified chromatographic method was established and optimized to isolate the major gingerols (N1, N2, and N3) in grams. Thereafter the cytotoxic activity of the isolated compounds was evaluated against colorectal carcinoma cell line, Caco-2. It was observed that anti-colon cancer activity of N2 was superior to that of 5-FU, the classic reference cytotoxic agent. Additionally, the length of the aliphatic chain in 8-gingerol (N2) is optimum for the anticancer activity and any decrease, as in N1 and N4, or increase, as in N3, in the side chain length leads to gradient decrease in the cytotoxic activity. Following this further, methylation of phenolic OH group (N5), leads to a dramatic decrease in the anticancer activity. Furthermore, loss of aromaticity (N7), results in complete loss of the cytotoxic activity. On the other hand, introducing a π-bond in the aliphatic side chain enhances the anti-cancer activity as depicted in N6. Taken together, the aromaticity, the side chain length as well as the presence of free phenolic group contribute significantly to the anti-colon cancer activity of gingerol and its derivatives. These results open up a new window in the rational design of gingerol-based semisynthetic drugs with improved anticolon cancer activity.

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GRIN Verlag

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ISBN 10

3346078809

ISBN 13

9783346078803

Book's by Farid Badria

Honey and Its Products. Chemical, Biological and Therapeutic Applications

Honey and Its Products. Chemical, Biological and Therapeutic Applications

Natural Iron Chelator. Chemistry, Biology, and Therapeutic Applications

Natural Iron Chelator. Chemistry, Biology, and Therapeutic Applications

Synthesis of Nanoparticles Using Green Chemistry

Synthesis of Nanoparticles Using Green Chemistry

Cytokines Modulators in Plants. Chemical and Therapeutics Studies

Cytokines Modulators in Plants. Chemical and Therapeutics Studies

New Gingerol Derivative against Human Colorectal Carcinoma Caco-2 Cells

New Gingerol Derivative against Human Colorectal Carcinoma Caco-2 Cells

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