A relatable early reader that taps into important life lessons about friendship, grief, and talking through feelings. "Debut author Oliveira’s lush prose brings the Portugal setting to life and portrays Amelia’s grief with realism. Her struggle to manage her emotions, as well as the deeper understanding she reaches of herself and the people around her, is endearing and rewarding. Balezza’s b&w pencil illustrations appear throughout, adding nuance to Amelia’s heightened feelings." —Publishers Weekly Ten-year-old Amelia has always had Calvin, her chinchilla friend, to talk to about her problems. But Calvin is no longer in his cage, and her parents just say he’s in a “better place.” When Amelia and her best friend, Camila, have an argument, and Amelia later misses the school talent show, she doesn’t know what to do. Without Calvin, who does she talk to about her disappointments at school? And who does she talk to about missing Calvin? Just when Amelia thinks she’s completely alone, a new student arrives, and they begin to sort things out together. Amelia learns that it’s always possible to make new friends, that expressing yourself can happen in different ways, and that it all starts with talking it out. MORE PRAISE FOR CALVIN AND THE SUGAR APPLES “A sensitive and rich children’s novel—a thoughtful, warm reflection on overcoming loss and embracing change.” —Foreword Reviews “Ten-year-old Amelia is sometimes awkward, often tongue-tied, and ALWAYS a bright shining star, even when she doesn’t know it. Readers will adore her!” —Lauren Myracle, author of best-selling books, ttyl, ttfn, and l8r, g8r
Major depression is a highly prevalent disorder that poses a significant social burden in society nowadays. The pathophysiology of this disease is still poorly understood but growing evidence suggests that impaired neuron and glial plasticity may be a key underlying mechanism for the precipitation of the disorder. One of the most surprising findings in this field was the involvement of glial cells in the pathophysiology of major depression and in the action of antidepressants, namely in mechanisms related with adult neurogenesis imbalances or dendritic arborization impairments. In particular, several works refer to alterations in the morphology and numbers of astrocytes, microglia and oligodendrocytes in the context of depression in human patients or animal models of depression. These observations were linked to functional evidences and suggested to underlie the pathophysiology of depression. Among others, these include impairments in the cross-talk between glia and neurons, changes in the level of neurotransmitter or immunoactive substances, myelination status, synapse formation, maintenance, or elimination. In addition to the implication of glia in the pathophysiology of depression, a number of studies is ascribing glia pathways to classically accepted antidepressant mechanisms. Therefore, it is noteworthy to elucidate the role of glia in the effect provided by antidepressant treatment in order to better understand secondary effects and elucidate alternative targets for treatment.
O Gato Que Salvou o Trem e Outras Histórias traz 32 narrativas, algumas já publicadas nas revistas Insight, Guide Junior, Our Little Friend, Nosso Amiguinho e Revista Adventista. São histórias sobre a natureza, heroísmo, amor, dedicação e honestidade. Todas com uma aplicação prática. Lembram, sobretudo, que vale a pena viver honestamente, fazer o bem e confiar em Deus.
In the oral cavity, materials (including our natural teeth) are exposed to a complex environment, which results in simultaneous mechanical, electrochemical, and microbiological solicitations. Therefore, bio-tribocorrosion is an important cause of degradation of dental materials leading to functional and/or biological detrimental effects due to an increased release of metallic ions and wear debris. This chapter describes the main bio-tribocorrosion phenomena that occur in the oral environment, and discuss the main parameters related to both the materials and the environment affecting bio-tribocorrosion in dental applications.
This book is focused on Sertoli cell physiology and its role in the spermatogenic event. These cells, known as “nurse cells”, are essential for the normal development of germ cells by offering not only physical support and creating an immune-privileged environment, but also for providing nutritional support. The presence of Sertoli cells promotes the establishment of the appropriate microenvironment so that spermatogenesis may occur. Spermatogenesis maintenance in vivo is highly dependent on the metabolic cooperation established between Sertoli cells and developing germ cells. For many years this metabolic cooperation between testicular cells has been disregarded, but recent advances have highlighted the relevance of these processes for male fertility. Thus, the understanding of the functioning and regulation of these metabolic processes is a crucial step to identify key mechanisms associated with Sertoli cell (dys)function and to enlighten their influence on male fertility.
The study of alternative reproductive tactics (the behavioural strategies used by individuals to increase their reproductive success) is an evolutionary puzzle, and one of great interest to researchers. For instance, why do some males guard both nest and eggs, while others sneak into nests while pairs are spawning and fertilise those eggs? The field offers a special opportunity to study the evolution and functional causes of phenotypic variation, which is a general problem in the field of evolutionary biology. By integrating both mechanistic (psychological) and evolutionary (behavioural ecology) perspectives and by covering a great diversity of species, Alternative Reproductive Tactics addresses this integrated topic of longstanding interest, bringing together a multitude of otherwise scattered information in an accessible form that is ideal for graduate students and researchers.
This book contains twelve chapters detailing significant advances and applications in fluid dynamics modeling with focus on biomedical, bioengineering, chemical, civil and environmental engineering, aeronautics, astronautics, and automotive. We hope this book can be a useful resource to scientists and engineers who are interested in fundamentals and applications of fluid dynamics.
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