The blood-brain barrier (BBB) creates and maintains the highly regulated extracellular environment of the CNS through three 'lines of defense'. (1) a physical barrier formed by tight junctions between endothelial cells of the brain capillaries and epithelial cells of both the choroid plexus and the arachnoid membrane. (2) transporters that mediate the efflux of compounds from brain to blood. And (3) an enzymatic barrier conferred by an enrichment of degradative enzymes in these endothelial and epithelial cells. The goal of this book is to provide readers with a comprehensive review of the state-of-the-art of efflux transport across the blood-brain barrier and to provide detailed 'food-for-thought' which will hopefully stimulate more research in this area in both the academic and industrial research communities.
A fresh look at the response to domestic violence in the United States today. This new edition of the bestselling Responding to Domestic Violence explores the response to domestic violence today, not only by the criminal justice system, but also by public and non-profit social service and health care agencies. After providing a brief theoretical overview of the causes of domestic violence and its prevalence in our society, the authors cover such key topics as barriers to intervention, variations in arrest practices, the role of state and federal legislation, and case prosecution. Focusing on both victims and offenders, the book includes unique chapters on models for judicial intervention, domestic violence and health, and children and domestic violence. In addition, this edition provides an in-depth discussion of the concept of coercive control in domestic violence and its importance in understanding victim needs. Finally, this volume includes international perspectives in order to broaden the reader′s understanding of alternative responses to the problem of domestic violence.
In Authoritarian Containment, Marie-Eve Reny examines why local public security bureaus tolerate unregistered Protestant churches in urban China--an officially atheist country where religious practice is controlled by the state--when the central government considers them illegal. She argues that local states tolerate these churches to contain the underground practice of Protestantism. Containment necessitates a bargain between informal religious organizations and the state. Even though they are not regulated, unregistered churches are allowed to operate conditionally, so long as church leaders keep a low profile, share information as needed with local authorities, and agree that the state will not grant them formal institutional recognition. Reny also considers authoritarian regimes other than China that employ a similar strategy to control informal religious communities. She focuses on two Middle East cases-President Sadat's control of the Muslim Brotherhood in 1970s Egypt and the Jordanian monarchy's containment of jihadi Salafists after 2006. By reducing the incentives for local religious leaders to politicize and inducing such leaders to willingly provide inside information, governments can avoid the heavy hand of coercion and forceful co-optation. Based on extensive fieldwork, Authoritarian Containment offers insight into the way authoritarian regimes neutralize underground religious leaders and discourage opposition to the state.
Female philanthropy was at the heart of transformative thinking about society and the role of individuals in the interwar period. In Britain, in the aftermath of the First World War, professionalization; the authority of the social sciences; mass democracy; internationalism; and new media sounded the future and, for many, the death knell of elite practices of benevolence. Eve Colpus tells a new story about a world in which female philanthropists reshaped personal models of charity for modern projects of social connectedness, and new forms of cultural and political encounter. Centering the stories of four remarkable British-born women - Evangeline Booth; Lettice Fisher; Emily Kinnaird; and Muriel Paget - Colpus recaptures the breadth of the social, cultural and political influence of women's philanthropy upon practices of social activism. Female Philanthropy in the Interwar World is not only a new history of women's civic agency in the interwar period, but also a study of how female philanthropists explored approaches to identification and cultural difference that emphasized friendship in relation to interwar modernity. Richly detailed, the book's perspective on women's social interventionism offers a new reading of the centrality of personal relationships to philanthropy that can inform alternative models of giving today.
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.