In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis.
In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis.
The earliest known literary productions by women living in Europe were probably written by French writers. As early as the 12th century, women troubadours in the south of France were writing poems. French women continued writing through the ages, their number increasing as education became more available to women of all classes. And yet, of the great number of works by women writers who preceded the current feminist movement, very few have survived. A few writers such as Marie de France, George Sand, and Simone de Beauvoir became part of the canon. But critics, mostly male, had judged the works of only a few women writers worthy of recognition. As part of the feminist move to reclaim women writers and to rethink literary history, scholars in French literature began to take a new look at women writers who had been popular during their lifetimes but who had not been admitted into the canon. This reference book provides extensive information about French women writers and the world in which they lived. Included are several hundred alphabetically arranged entries for authors; literary genres, such as the novel, poetry, and the short story; literary movements, such as classicism, realism, and surrealism; life-cycle events particular to women, such as menstruation and menopause; events and institutions which affected women differently than men, such as revolutions, wars, and laws on marriage, divorce, and education. The volume spans French literature from the Middle Ages to the present and covers those writers who lived and worked mainly in France. The entries are written by expert contributors and each includes bibliographical information. The entries focus on each writer's awareness of how her gender shaped her outlook and opportunities, on how categorizations, structures, and terms used to describe literary works have been defined for women, and the ways in which women writers have responded to these definitions. The volume begins with a feminist history of French literature and concludes with a selected, general bibliography and a chronology of women writers.
Robust statistics is an extension of classical statistics that specifically takes into account the concept that the underlying models used to describe data are only approximate. Its basic philosophy is to produce statistical procedures which are stable when the data do not exactly match the postulated models as it is the case for example with outliers. Robust Methods in Biostatistics proposes robust alternatives to common methods used in statistics in general and in biostatistics in particular and illustrates their use on many biomedical datasets. The methods introduced include robust estimation, testing, model selection, model check and diagnostics. They are developed for the following general classes of models: Linear regression Generalized linear models Linear mixed models Marginal longitudinal data models Cox survival analysis model The methods are introduced both at a theoretical and applied level within the framework of each general class of models, with a particular emphasis put on practical data analysis. This book is of particular use for research students,applied statisticians and practitioners in the health field interested in more stable statistical techniques. An accompanying website provides R code for computing all of the methods described, as well as for analyzing all the datasets used in the book.
The interaction between color and architecture determines our perception of space, and defines the tectonic relationships. The fascinating spatial potential of color, and the multi-layered dimensions of interpretation in the experience of color are design and communication means which, however, are often not fully used – color oscillates between autonomy and functional purpose, and should be understood as a distinct "material" that can be used as part of the design. The book focuses both on the tangible aspects and design criteria of color, and on its indeterminate nature and its experience value. Using examples in art and architecture, the spatial interdependency of color is illustrated, as is its interaction with structure, light, and geometry.
An increasing number of European countries are being faced with demands for greater autonomy or independence from regional groups. The legitimacy of nation states in Europe is thus being called into question not only by the forces of globalization and Europeanization from above, but also by growing pressure to recognize the autonomous or independent status of regional groups from below. From Scotland to Catalonia, from Flanders to South Tyrol, the movements vary in their intensity and demands, yet also have many commonalities. This book constitutes a compilation of papers presented at the international Conference "States Falling Apart? Secessionist and Autonomy Movements in Europe" at the University of Fribourg in 2013 and is a timely addition to the literature on secession, autonomy and federalism. With theoretical contributions and case studies, it presents a wide range of opinions and facts on these issues.
Postwar multilateral cooperation is often viewed as an attempt to overcome the limitations of the nation-state system. However, in 1945, when the United Nations was founded, large parts of the world were still under imperial control. Building States investigates how the UN tried to manage the dissolution of European empires in the 1950s and 1960s—and helped transform the practice of international development and the meaning of state sovereignty in the process. Eva-Maria Muschik argues that the UN played a key role in the global proliferation and reinvention of the nation-state in the postwar era, as newly independent states came to rely on international assistance. Drawing on previously untapped primary sources, she traces how UN personnel—usually in close consultation with Western officials—sought to manage decolonization peacefully through international development assistance. Examining initiatives in Libya, Somaliland, Bolivia, the Congo, and New York, Muschik shows how the UN pioneered a new understanding and practice of state building, presented as a technical challenge for international experts rather than a political process. UN officials increasingly took on public-policy functions, despite the organization’s mandate not to interfere in the domestic affairs of its member states. These initiatives, Muschik suggests, had lasting effects on international development practice, peacekeeping, and post-conflict territorial administration. Casting new light on how international organizations became major players in the governance of developing countries, Building States has significant implications for the histories of decolonization, the Cold War, and international development.
The Pragmatics of Executive Coaching is the first linguistic monograph on executive coaching, a recent, not fully professionalized, yet booming helping professional format in the organizational realm. The book is positioned at the interface between applied linguistic analysis and the activity of coaching, coupled with its structuring professional theory. It presents the Basic Activity Model of coaching, a model for the qualitative analysis and description of the discursive co-construction of coaching by coach and client within and across individual coaching sessions and whole processes. The analysis is based on 150 hours of authentic data from the coaching approach Emotionally Intelligent Coaching and presents coaching as hybrid and interdiscursive helping professional format. The gained insights into the discursive layout of coaching interactions advance our linguistic understanding of helping professions as such, contribute to the theoretical and methodological underpinning of coaching and help promote the coaching practice.
Die 1859 als Kind deutscher Eltern in Zürich geborene Ottilie W. Roederstein gehörte zu Lebzeiten zu den führenden Malerinnen im deutschsprachigen Raum. Früh genoss sie auch Anerkennung in Paris. Wie nur wenige Frauen ihrer Zeit widmete sie ihr ganzes Leben erfolgreich der Kunst und führte zusammen mit ihrer Lebenspartnerin, der Gynäkologin Elisabeth H. Winterhalter, in Deutschland ein unkonventionelles, aber angesehenes Dasein. Während sich Roedersteins Frühwerk innerhalb der kunstakademischen Konventionen bewegte, öffnete sich die Malerin in ihrem reiferen Werk zunehmend anderen Strömungen, um in den 1920er-Jahren zu einer sachlich-nüchternen Bildsprache zu finden. Trotz ihrer einst internationalen Wertschätzung als Porträtistin und Malerin von Stillleben geriet Roederstein fast unmittelbar nach ihrem Tod 1937 in Vergessenheit. Nach mehreren Jahrzehnten widmen das Kunsthaus Zürich und das Städel Museum in Frankfurt am Main ihr die erste monografische Werkschau, die dieser umfassende Katalog begleitet.
The building shell is the interface with the outside world, it offers protection and at the same time represents its owners or occupants. But what are the criteria for choosing a specific shell? Why is a particular material used on a particular undercoat? The fifth volume of the SCALE series, Enclose | Build, is not about the curtain, the dressing of the facade that surrounds a building, but rather on a causal level about the exterior termination of a building, the wall, the facade, which can be made of various materials, surfaces, and achieves different design effects. It shows the conditions under which certain constructions can be employed and why; what criteria such as construction costs, issues of sustainability, of energy efficiency, of assembly or of insulation or protection against moisture can also influence the choice of a system. In addition to classical constructions, Enclose | Build offers a look at future developments. How will the facade evolve as an interface for information? What do viable concepts for environmentally active, energy-efficient building shells look like? Enclose | Build is an indispensable tool for every architect and planner.
′This volume is the most comprehensive overview to date of sociologically orientated approaches to text and discourse analysis and is worth reading even for those who are interested only in purely linguistiv approaches to text and discourse. Its main merit, I think, is that it intorduces approaches which up to now have hardley been admitted into the universe of scientific discourse′ - Discourse Studies Methods of Text and Discourse Analysis provides the most comprehensive overview currently available of linguistic and sociological approaches to text and discourse analysis. Among the 10 linguistic and sociological models surveyed in this book some of the more important are Grounded Theory, Content Analysis, Conversation Analysis and Critical Discourse Analysis. The book presents each approach according to a standardised format, which allows for direct systematic comparisons. The fully annotated lists of sources provide readers with an additional means of evaluation of the competing analytical methods. Interdisciplinary and international in its aims, Methods of Text and Discourse Analysis suggests the benefits both linguists and sociologists will derive from a more intimate knowledge of each others′ methods and procedures.
How do the victims and perpetrators of the Argentinian dictatorship experience transitional justice on their own terms? Grounded in phenomenological anthropology and the anthropology of emotion, Phenomenal Justice establishes a new theoretical basis that is faithful to the uncertainties of justice and truth in the aftermath of human rights violations.
Quick and easy to consult, the principal features of interest are described in the main Sights From A To Z section, with each entry cross-referenced to the large folded map that completes this handy map and guide pack. Detailed background information sets the scene: facts and figures about the people, religion, climate and economy, its culture and history, plus a round-up of associated famous people. Special features, colour photographs, superb colour maps and plans are found throughout the book and the well-organised Practical Information section ensures you can make the most of your stay.
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