In the 1970s, Dr. Alan Scott sought to selectively weaken eye muscles to treat strabismus (when one or both eyes are misaligned) without surgery. After failed attempts with other agents, Scott developed a method to stabilize the bacteria that causes botulism, culminating in a drug that eventually became known as Botox. In Death to Beauty, Eugene M. Helveston, MD, follows the unlikely story of botulism's 1817 discovery in contaminated German sausages, to its use in military and research facilities, to Scott, an ophthalmologist who aimed to safely use the drug in humans. Scott struggled alone as an unknown in the pharmaceutical industry, searching for clinical trial financing and FDA approval, which he achieved at a fraction of the billions big pharma usually spends to bring a drug to market. Eventually, the company Allergan bought him out, capitalizing on the possibilities for cosmetic uses. Scott's formula was renamed "Botox" and reached annual sales in the billions. After the sale, Scott received no further compensation from Botox sales and remained the same unassuming man. A fascinating walk through the intricate history of how the world's deadliest toxin starting as a treatment for crossed eyes became a routine tool for the cosmetic industry, Death to Beauty will make you rethink success, beauty, and deadly bacteria.
A vivid description of Colorado's beginnings This is the first single-volume history of the Colorado territory, encompassing the entire territorial period from the beginning of the Civil War to 1876, when Colorado became a state. The Rise of the Centennial State traces the growth of the territory as new technologies increased mining profits and as new modes of transportation--especially the Union Pacific and Kansas Pacific railroads--opened the territory to eastern markets, bringing waves of settlers to farm, ranch, and establish new communities. Eugene H. Berwanger's history is packed with colorful characters and portraits of sprawling, brawling frontier and mining towns from Denver to Central City. He presents a multifaceted discussion of Colorado's resurgence after the war, with rich discussions of the role of minorities in the territory's development: Indian-white relations (including discussions of now forgotten battles of Beecher's Island and Summit Springs, which destroyed the Indians' hold on the Colorado Plains); the social segregation of blacks in Denver; and Mexican Americans' displeasure at being separated from the Hispano culture of New Mexico. Berwanger also demonstrates the decisive role of Colorado's admission to statehood in swinging the disputed presidential election of 1876 to the Republican candidate, Rutherford B. Hayes.
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.