Top-selling, concise guide to PET and PET/CT imaging from distinguished radiologists, now in a new edition! PET and PET/CT have been increasingly used as effective imaging modalities in the management of patients with cancer, neurologic disease, musculoskeletal disease, and cardiac disease. PET and PET/CT: A Clinical Guide, Third Edition by world renowned molecular imaging pioneer Abass Alavi and esteemed diagnostic and nuclear radiologist Eugene Lin features the latest advances in PET technology in an easy-to-read format. The book lays a solid foundation with opening chapters on scanner physics, radionuclide basics, study interpretation, patient preparation, quantitative whole-body PET/CT imaging, normal variants, benign findings, and clinical applications. Key Highlights Oncology-related chapters include the use of PET for rare and common cancers — from brain neoplasms and musculoskeletal tumors — to breast and colorectal cancers Updated with the latest scientific literature and guidelines Specialized topics include Gadolinium-68 imaging techniques, pediatric PET/CT, utilization for radiation therapy planning and infection and inflammation evaluations, and neurological and cardiac applications A state-of-the-chapter on PET/MRI More than 500 high-quality images, including many in full color Succinct yet comprehensive, this state-of-the-art book will enable clinicians to master a highly complex imaging discipline at an accelerated pace. Residents and veteran practitioners in the fields of nuclear medicine, radiology, oncology, radiation oncology, and nuclear medicine technology will benefit from reading this resource.
The second edition of Chitin underscores the important factors for standardizing chitin processing and characterization. It captures the essential interplay between chitin's assets and limitations as a biomaterial, placing the past promises of chitin in perspective, addressing its present realities and offering insight into what is required to realize chitin's destiny (including its derivative, chitosan) as a biomaterial of the twenty-first century. This book is an ideal guide for both industrialists and researchers with a vested interest in commercializing chitin. - An update on the research since 2001 as it pertains to the biomaterials and biomedical applications of chitin and chitosan - An expanded discussion on positioning chitin and chitosan for biomedical applications - Presents regulatory aspects of chitin and chitosan
Synthesizes the current knowledge in the field and provides new insights into medical applications Metalloproteomics is the large-scale study of metal-binding proteins. These proteins, which represent about one quarter of all the proteins in the Protein Data Bank, play important roles in all biological systems and all biological processes. Metalloproteomics provides the latest information on all major families of metal-binding proteins, including their structural, physico-chemical, and functional properties, enabling readers to better understand these proteins. Moreover, the book demonstrates how understanding the structures, properties, and functions of intracellular and extracellular metal-binding proteins may unlock the key to drug development for the treatment of a myriad of diseases. Written by Eugene Permyakov, an international expert and pioneer in the structural analysis of metal-binding proteins, the book offers Theoretical introduction to cation binding Broad range of methods for investigating the binding of different cations to proteins Characteristics of interactions of physiologically important cations of Ca, Mg, Zn, Fe, Mn, Co, Cu, Ni, Mo, W, Na, and K with proteins Detailed considerations of structural and physico-chemical properties of the metal-binding proteins Interactions of all other metal cations with proteins Interactions of different types of cations with nucleic acids Throughout the text, the author integrates principles of proteomics. In addition, detailed examples underscore the role metal-binding proteins play in health and medicine. Bringing together and analyzing all the latest findings, Metalloproteomics' scope and level of insight are unparalleled. It is recommended for biophysicists, biochemists, enzymologists, cell and molecular biologists, protein and peptide scientists, organic and bioinorganic chemists, and chemical biologists.
Progress in space safety lies in the acceptance of safety design and engineering as an integral part of the design and implementation process for new space systems. Safety must be seen as the principle design driver of utmost importance from the outset of the design process, which is only achieved through a culture change that moves all stakeholders toward front-end loaded safety concepts. This approach entails a common understanding and mastering of basic principles of safety design for space systems at all levels of the program organisation. Fully supported by the International Association for the Advancement of Space Safety (IAASS), written by the leading figures in the industry, with frontline experience from projects ranging from the Apollo missions, Skylab, the Space Shuttle and the International Space Station, this book provides a comprehensive reference for aerospace engineers in industry. It addresses each of the key elements that impact on space systems safety, including: the space environment (natural and induced); human physiology in space; human rating factors; emergency capabilities; launch propellants and oxidizer systems; life support systems; battery and fuel cell safety; nuclear power generators (NPG) safety; habitat activities; fire protection; safety-critical software development; collision avoidance systems design; operations and on-orbit maintenance. - The only comprehensive space systems safety reference, its must-have status within space agencies and suppliers, technical and aerospace libraries is practically guaranteed - Written by the leading figures in the industry from NASA, ESA, JAXA, (et cetera), with frontline experience from projects ranging from the Apollo missions, Skylab, the Space Shuttle, small and large satellite systems, and the International Space Station - Superb quality information for engineers, programme managers, suppliers and aerospace technologists; fully supported by the IAASS (International Association for the Advancement of Space Safety)
This book examines an important paradigm shift in biology: Plants and animals, traditionally viewed as individuals, are now considered to be complex systems and host to a plethora of microorganisms. After first presenting historical aspects of microbiota research, bacterial compositions of individual microbiomes and the critical analysis of current methods, the book discusses how microbial communities inside the human body are profoundly affected by numerous factors, such as macro- and micro-nutrients, physical exercise, antibiotics, gender and age. As described by current research, the author highlights how microbiomes contribute to the fitness of the host by providing nutrients, inhibiting pathogens, aiding in the storage of fat during pregnancy, and contributing to development and behavior. The author not only focusses on prokaryotic components in microbiomes, but also addresses single-cell eukaryotes and viruses. This follow-up to the successful book The Hologenome Concept: Human, Animal and Plant Microbiota, published in 2013, provides a contemporary overview of microbiomes. It appeals to anyone working in the life sciences and biomedicine.
In order to model neuronal behavior or to interpret the results of modeling studies, neuroscientists must call upon methods of nonlinear dynamics. This book offers an introduction to nonlinear dynamical systems theory for researchers and graduate students in neuroscience. It also provides an overview of neuroscience for mathematicians who want to learn the basic facts of electrophysiology. Dynamical Systems in Neuroscience presents a systematic study of the relationship of electrophysiology, nonlinear dynamics, and computational properties of neurons. It emphasizes that information processing in the brain depends not only on the electrophysiological properties of neurons but also on their dynamical properties. The book introduces dynamical systems, starting with one- and two-dimensional Hodgkin-Huxley-type models and continuing to a description of bursting systems. Each chapter proceeds from the simple to the complex, and provides sample problems at the end. The book explains all necessary mathematical concepts using geometrical intuition; it includes many figures and few equations, making it especially suitable for non-mathematicians. Each concept is presented in terms of both neuroscience and mathematics, providing a link between the two disciplines. Nonlinear dynamical systems theory is at the core of computational neuroscience research, but it is not a standard part of the graduate neuroscience curriculum—or taught by math or physics department in a way that is suitable for students of biology. This book offers neuroscience students and researchers a comprehensive account of concepts and methods increasingly used in computational neuroscience. An additional chapter on synchronization, with more advanced material, can be found at the author's website, www.izhikevich.com.
The discovery of novel drugs that fill unmet medical needs is important for the health and well-being of people everywhere. However, the general public knows too little about the pathways through which basic research discoveries are translated into products that protect or restore human health. In the second edition of Hallelujah Moments, Eugene H. Cordes reveals the processes and pitfalls on the route from the laboratory bench to the bedside. These are adventure stories in which wit and grit created several of the most important drugs in human medicine. This new edition adds four new tales of drug discovery: for therapy of cancer, hepatitis C, HIV/AIDS, and for weight control. The stories emphasize the integration of basic research in academe and applied research in the pharmaceutical industry and introduce the key scientists. In each case, success resulted from imagination, risk-taking, problem solving, and perseverance. Cordes shares his firsthand knowledge of the drug-discovery world, having spent a long and distinguished career in both academic and industrial settings. The eleven drug discovery tales take the reader from concept to clinic for some of the most important drugs in human health including the statins, ACE inhibitors, antibiotics, avermectins, Januvia, and Taxol. These stories offer exciting insights into the fascinating world of drug discovery.
This book highlights the rapidly emerging field of solution-processed halide perovskite lasers. These amazing materials not only possess exceptional photovoltaic properties, but are also outstanding optical gain media. Halide perovskites are the latest member of solution-processed optical gain media, joining organics and traditional semiconductor colloidal quantum dots. Amplified spontaneous emission and lasing have been demonstrated in various halide perovskite configurations and nanostructures with wavelengths tunable over the visible and infrared wavelengths (400–1000 nm). This book provides comprehensive information on perovskite lasing, starting with some fundamentals of lasers and their basic operating principles. Unambiguous methods for identifying lasing light emission are presented, while the basic optoelectronic properties of perovskite materials are also discussed, with an emphasis on their photophysics, using ultrafast optical spectroscopy techniques. The viability of perovskites as a gain media within a suitable resonator, as well as the characterization methods for optical gain, are highlighted. The book closes with a discussion on the remaining challenges (such as electrical driven lasing and material stabilities) that need to be tackled, and the future of this new family of lasers.
Progresses from theoretical issues to applications. Contains a historical overview, in-depth considerations of various scenarios of silica adsorption, and results from the latest research. Invaluable for broad coverage of the expanding field of silica research.
Now in its 4th edition, Kirklin/Barratt-Boyes Cardiac Surgery remains your indispensable source for definitive, state-of-the-art answers on every aspect of adult and pediatric cardiac surgery. This dynamic medical reference thoroughly and systematically covers the full range of new and classic surgical procedures—including the latest alternate and minimally invasive surgical techniques—and presents the up-to-date clinical evidence you need to make effective management decisions. - Be certain with expert, dependable, accurate answers for every stage of your career from the most comprehensive, definitive text in the field! - Get comprehensive coverage of all areas of cardiac surgery, including ischemic, valvular, and congenital heart disease; cardiac tumors; constrictive pericarditis; thoracic aortic surgery; cardiac transplantation; coronary artery disease; aortic valve disease; cardiac rhythm disturbances; heart failure and transplantation; disease of the thoracic aorta; tetralogy of Fallot; anesthesia; and postoperative care. - Stay current with the latest advancements and practices. Comprehensive updates throughout include new information on endovascular management of thoracic aorta disease; new data on clinical outcomes; the most recent minimally invasive procedures; non-invasive CT angiography; new alternative surgical approaches to mitral valve surgery; and many other hot topics! - Make the most well-informed decisions and achieve optimal outcomes by exploring each condition's natural history; diagnostic criteria; indications for surgery; operative techniques; and follow-up care. - Reference information quickly thanks to a new, streamlined format. - Visually grasp and better understand critical information with the aid of a new, full-color design that includes an abundance of detailed charts and graphs. - Stay current with the latest advancements and practices. Comprehensive updates throughout include new information on endovascular management of thoracic aorta disease; new data on clinical outcomes; the most recent minimally invasive procedures; non-invasive CT angiography; new alternative surgical approaches to mitral valve surgery; and many other hot topics! - Reference information quickly thanks to a new, streamlined format and easily searchable online access to the complete text, downloadable image library, reference links, and more at www.expertconsult.com.
Now in its 4th edition, Kirklin/Barratt-Boyes Cardiac Surgery remains your indispensable source for definitive, state-of-the-art answers on every aspect of adult and pediatric cardiac surgery. This dynamic medical reference thoroughly and systematically covers the full range of new and classic surgical procedures-including the latest alternate and minimally invasive surgical techniques-and presents the up-to-date clinical evidence you need to make effective management decisions. Be certain with expert, dependable, accurate answers for every stage of your career from the most comprehensive, definitive text in the field! Get comprehensive coverage of all areas of cardiac surgery, including ischemic, valvular, and congenital heart disease; cardiac tumors; constrictive pericarditis; thoracic aortic surgery; cardiac transplantation; coronary artery disease; aortic valve disease; cardiac rhythm disturbances; heart failure and transplantation; disease of the thoracic aorta; tetralogy of Fallot; anesthesia; and postoperative care. Stay current with the latest advancements and practices. Comprehensive updates throughout include new information on endovascular management of thoracic aorta disease; new data on clinical outcomes; the most recent minimally invasive procedures; non-invasive CT angiography; new alternative surgical approaches to mitral valve surgery; and many other hot topics! Make the most well-informed decisions and achieve optimal outcomes by exploring each condition's natural history; diagnostic criteria; indications for surgery; operative techniques; and follow-up care. Reference information quickly thanks to a new, streamlined format and easily searchable online access to the complete text, downloadable image library, reference links, and more at expertconsult.com. Visually grasp and better understand critical information with the aid of a new, full-color design that includes an abundance of detailed charts and graphs. Stay current with the latest advancements and practices. Comprehensive updates throughout include new information on endovascular management of thoracic aorta disease; new data on clinical outcomes; the most recent minimally invasive procedures; non-invasive CT angiography; new alternative surgical approaches to mitral valve surgery; and many other hot topics! Reference information quickly thanks to a new, streamlined format and easily searchable online access to the complete text, downloadable image library, reference links, and more at www.expertconsult.com.
Here is the new edition of this classic technical guide which clearly presents in-depth information on this wide ranging subject. It has been fully revised and updated to cover the relentless advance in TV and VCR technology. Because it functions both as an introduction to the subject and as a general guide, the Newnes Guide to TV and Video Technology is an ideal text for students, technicians and enthusiasts alike. The new edition of this comprehensive and detailed manual encompasses all aspects of TV and video technology ranging from the camera lens, via videotape signal processing and deck management, to the latest TV screen technology, space satellites, microcomputers and the practicalities of video recorder servicing and maintenance.
This book begins with an account of the author's ancestral roots in Norway, Denmark and Great Britain and ends which his retirement in Happy Valley, Oregon, where he served as its Mayor from 1998 to 2006. His ancestors emigrated to America and fought and died in its wars, pioneered newly acquired territories and states, eventually reaching Eugene, Oregon, for which the author was named. His history includes surviving his oftentimes grim childhood in a dysfunctional family beset with serious domestic abuse and mental illness. The author describes his joy of discovering the stories of his ancestors' triumphs and tragedies. Their stories have all the drama of murder, suicide, war, crime, persecution, poverty, addiction, illicit affairs, abandonment, arson, insanity, domestic abuse, and other tragedies but also many triumphs. The sublime and spiritual contrasts with the carnal and depraved. It includes the sad story of the expanding frontier experience of American pioneers displacing native Americans and enslaving Blacks. The heart of this book is the creation of the author's immediate family and struggling to be successful as a prominent Oregon lawyer, local politician, local Mormon religious leader, and most importantly a father and husband. In part this is a religious autobiography. It is like biblical stories, an accounting and evaluation of being in the World but not of the World, an acknowledgement of how he has seen God's hand in the details of his life, the story of his religious conversion and path of discipleship through this veil of tears, seeking salvation. His story, therefore, ends with his evaluation, for the reader's benefit, of his lessons learned. His hope is that these lessons will help the reader appreciate his perspective and hopefully avoid his mistakes not the least of which were his conflicts, especially with political and religious extremists who increasingly bedeviled him during the highly polarized first two decades of the 21st century. This is also his intellectual and political autobiography. His faith was not one of withdrawal from the world into monastic simplicity, but rather one of enthusiastically engaging a complex world by gaining a higher education and using his knowledge and values to help the City of Happy Valley become a thriving and attractive community for likeminded families. It includes the story of how he led Happy in becoming Oregon's fastest growing city. It is also the story of his interaction with the leaders of Clackamas County and all its cities, including both allies and opponents. Lastly, this book includes the story of his legal career. He was fortunate to play a significant role in two leading law firms and his 40-year career helped shape the built environment of the City of Portland, the Metro Region, and the State of Oregon. He worked with many prominent and interesting Oregonians in the process. His legal career was completed by serving for almost two years as a senior legal missionary for his church in the Pacific Area including Australia, New Zealand, and the South Pacific islands.
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