Virus as Composition, Complexity, Quasispecies, Dynamics, and Biological Implications, Second Edition, explains the fundamental concepts surrounding viruses as complex populations during replication in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, and the probability to be transmitted or respond to treatment all depend on virus population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, and new antiviral strategies are included. The book's main concepts are framed by recent observations on general virus diversity derived from metagenomic studies and current views on the origin and role of viruses in the evolution of the biosphere. - Features current views on key steps in the origin of life and origins of viruses - Includes examples relating ancestral features of viruses with their current adaptive capacity - Explains complex phenomena in an organized and coherent fashion that is easy to comprehend and enjoyable to read - Considers quasispecies as a framework to understand virus adaptability and disease processes
This book is a first reader in Philippine dance, observed through forty-five years of viewing, reviewing, and doing. It is one observer's understanding of what, where, or how is dance, and who makes it and why we dance. It attempts to answer these questions, aware that more questions ought to be further asked."--BOOK JACKET.
The context of business has been changing for companies in recent years, and following numerous corporate and accounting scandals, many countries have increased the number of national and international regulations designed to ensure transparency and compliance with the law. Because of the existence of these new regulations, the level of control, the severity of sanctions by governments, and the amount of the fines for noncompliance have increased dramatically. In parallel, with the technological revolution in communications, business management has become more transparent, and any negative event is uploaded to social networks and shared with an indeterminate number of people. This change in the regulatory, sanctioning and technological context has forced large companies to rethink risks, investments and budgets to deal in this more complex environment. To transition to this change, some companies have included ethics and compliance programs in their corporate agenda, along with marketing and sales plans, strategies, growth targets, investment plans and/or talent acquisition. While each industry has its particular risks, in this book, the author describes the essential elements that any effective ethics and compliance program should contain. This book is a source of information that connects yesterday with today. The author shares observations and lessons of the past to suggest corporate leaders implement effective ethics and compliance programs to protect their organizations and themselves. The book covers theories of ethics but with an eye focused on practical application. Risks, ethics, and compliance are analyzed with an overall vision, connected to the reality of business life, without getting bogged down in abstract thinking or in technical and regulatory details. Ethics and compliance are disciplines that have increasingly achieved greater recognition in organizations. Thus, due to the importance of risk management in the business world and the necessary involvement of the CEO and the board of directors, it seems appropriate that executives get access to a book about risks, ethics, compliance and human resources directed not only to compliance experts but also to any organizational leader. This book is a wake-up call that allows business leaders to understand the benefits of implementing an effective ethics and compliance program that will help members of organizations to make the right decisions and act within the law. If they do, they can better prevent and react to the difficult obstacle course of risks, dangers and threats that organizations face and that may jeopardize the sustainability, resilience, and survival of companies.
The function of dance in Latin/o American culture is the focus of the essays collected in Everynight Life. The contributors interpret how Latin/o culture expresses itself through dance, approaching the material from the varying perspectives of literary, cultural, dance, performance, queer, and feminist studies. Viewing dance as privileged sites of identity formation and cultural resistance in Latin/o America, Everynight Life translates the motion of bodies into speech, and the gestures of dance into a provocative socio-political grammar. This anthology looks at many modes of dance--including salsa, merengue, cumbia, rumba, mambo, tango, samba, and norteño--as models for the interplay of cultural memory and regional conflict. Barbara Browning's essay on capoeira, for instance, demonstrates how dance has been used as a literal form of resistance, while José Piedra explores the meanings conveyed by women of color dancing the rumba. Pieces such as Gustavo Perez Fírmat's "I Came, I Saw, I Conga'd" and Jorge Salessi's "Medics, Crooks, and Tango Queens" illustrate the lively scope of this volume's subject matter. Contributors. Barbara Browning, Celeste Fraser Delgado, Jane C. Desmond, Mayra Santos Febres, Juan Carlos Quintero Herencia, Josh Kun, Ana M. López, José Esteban Muñoz, José Piedra, Gustavo Perez Fírmat, Augusto C. Puleo, David Román, Jorge Salessi, Alberto Sandoval
Love lasts forever in this value-priced paranormal romance collection featuring eight couples who discover that eternal happiness is the key to conquering evil. The Demigod’s Legacy: Demigod cougar shifter Tito Perez couldn’t protect his family in pre-colonial Tenochtitlan, so he won’t risk endangering another in modern New Mexico. But when December Farmer shows up to collect child support for a daughter he never knew about, danger of all sorts finds them. This immortal shapeshifter may have no choice but to cast aside his precious humanity and become the unflinching warrior he’s never wanted to be. Immortal Flame: After a horrific accident, Peter Blackstone arrives in Allison La Croix’s ER and heals himself before her eyes. Peter traded his soul to save his wife, and now he will hunt criminals forever. Can Allison find a way to unlock his forgotten, passionate spirit? Of Eternal Life: Dr. Abilene Miller is shocked when a dead man jerks back to life in her arms and infuriated when he kidnaps her. He thinks she’s part of a conspiracy; she thinks he’s insane. Only together can they find out the truth—and brave the risks they run in loving each other. The Nymph’s Labyrinth: Shapeshifting nymph Ariadne Papadakis must keep the truth of the nymphs’ existence far out of reach from American archeologist Beau Morris. But will the task force her to sacrifice her own happiness? Secrets of the Sky: Sparrow Reed might look like an angel, but she’s actually a witch who can change into a songbird. When her best friend’s problems drop Sparrow in an underworld fraught with threats, Rowen Aerion of the Knights of the Fog has his hands full trying to keep her alive—and his love may be her biggest danger of all. Embrace the Desire: Destroyer Payne can’t believe his good luck when his father, the lord of the underworld, orders him to take the lovely Chanta Timbers through her transition from human to half-goddess. Chanta is both drawn to and frightened by the beast that lurks under his skin. But only by defying the gods to pursue this attraction do they stand a chance in the coming war. Immortal Love: Bécquer is handsome, well-read, poetic, and … an immortal literary agent who exists on human blood. Not that it matters since his relationships are strictly business—until he crosses paths with Carla, who rewrites his script. The Gettysburg Vampire: College student Abby Potter takes advantage of ghosts’ popularity in Gettysburg, Pennsylvania, by inventing a vampire folktale for the annual holiday production. Problem is, her leading man—a history professor at the college and a renowned Civil War reenactor—is a little too convincing in the role. Sensuality Level: Sensual
Clean air, land, and oceans are critical for human health and nutrition and underpin much of the world's economy. Yet they suffer from degradation, poor management, and overuse due to government subsidies. 'Detox Development: Repurposing Environmentally Harmful Subsidies' examines the impact of subsidies on these foundational natural assets. Explicit and implicit subsidies--estimated to exceed US$7 trillion per year--not only promote inefficiencies but also cause much environmental harm. Poor air quality is responsible for approximately 1 in 5 deaths globally. And as the new analyses in this report show, a significant number of these deaths can be attributed to fossil fuel subsidies. Agriculture is the largest user of land worldwide, feeding the world and employing 1 billion people, including 78 percent of the world's poor. But it is subsidized in ways that promote inefficiency, inequity, and unsustainability. Subsidies are shown to drive the deterioration of water quality and increase water scarcity by incentivizing overextraction. In addition, they are responsible for 14 percent of annual deforestation, incentivizing the production of crops that are cultivated near forests. These subsidies are also implicated in the spread of zoonotic and vector-borne diseases, especially malaria. Finally, oceans support the world's fisheries and supply about 3 billion people with almost 20 percent of their protein intake from animals. Yet they are in a collective state of crisis, with more than 34 percent of fisheries overfished, exacerbated by open-access regimes and capacity-increasing subsidies. Although the literature on subsidies is large, this report fills significant knowledge gaps using new data and methods. In doing so, it enhances understanding of the scale and impact of subsidies and offers solutions to reform or repurpose them in efficient and equitable ways. The aim is to enhance understanding of the magnitude, consequences, and drivers of policy successes and failures in order to render reforms more achievable.
An exposé of the controversial friendship between Nobel-prize winning author Gabriel Garcia Marquez and Fidel Castro. Few contemporary writers are more revered by Americans than Gabriel Garcia Marquez, the Nobel prize-winning author of Love in the Time of Cholera and One Hundred Years of Solitude. And few political leaders are more reviled than Fidel Castro. Yet these two seemingly disparate men are close friends. What could possibly unite these two men in friendship? In Fidel and Gabo, Márquez scholars Ángel Esteban and Stéphanie Panichelli examine this strange, intimate, and incredibly controversial friendship between the beloved author and Cuban dictator, exposing facets of their personalities never before revealed to the greater public. For years, Márquez, long fascinated with power, solicited and flattered Castro in hopes of a personal audience, for he viewed Castro’s Cuba as the model on which Latin American would one day build its own brand of socialism. Upon their first meeting, Castro quickly came to regard Márquez as a genius and still calls him his closest friend and confidant. To this day, Márquez still gives Castro “first look” at all his manuscripts and craves his approval. Fidel and Gabo is a vivid and in-depth look at two of the most influential men of the modern era, their worlds, and the effect this friendship has had on their life and works.
This advanced textbook explores small area estimation techniques, covers the underlying mathematical and statistical theory and offers hands-on support with their implementation. It presents the theory in a rigorous way and compares and contrasts various statistical methodologies, helping readers understand how to develop new methodologies for small area estimation. It also includes numerous sample applications of small area estimation techniques. The underlying R code is provided in the text and applied to four datasets that mimic data from labor markets and living conditions surveys, where the socioeconomic indicators include the small area estimation of total unemployment, unemployment rates, average annual household incomes and poverty indicators. Given its scope, the book will be useful for master and PhD students, and for official and other applied statisticians.
Un joven de raza afro-americana, indigente. Semi-dormia en la banca de un parque, fue testigo de una venta de droga y descubierto por los individuos. Luego de ser atrapado y golpeado. Se involucra en la mafia llegando a ser "el papa de los papas" y ser el hombre invisible y mas buscado del mundo.
United States-Cuban Relations breaks new ground in its treatment of this long and tumultuous relationship. The overall approach, mirroring the political science background of both authors, does not focus on historical detail that has been provided by many other works, but rather on a broad analysis of trends and patterns that have marked the long relationship between the two countries. Dominguez and Prevost argue that U.S. policy toward Cuba is driven in significant measure by developments on the ground in Cuba. From the U.S. intervention at the time of the Cuban Independence War to the most recent revisions of U.S. policy in the wake of the Powell Commission, the authors demonstrate how U.S. policy adjusts to developments and perceived reality on the island. The final chapters of the book focus on the contemporary period, with particular emphasis on the changing dynamic toward Cuba from U.S. civil society. Dominguez and Prevost describe how the U.S. business community, fearful of being isolated from Cuba's reinsertion in the world's capitalist markets, have united with long-standing opponents of the U.S. embargo to win the right to sell food and medicines to Cuba over the last four years. Ultimately, the authors are realists about the possibility of better relations between the U.S. and Cuba, pointing out that, short of the collapse of Cuba's current political and economic system, fundamental change in U.S. policy toward the island is unlikely in the immediate future.
The interplay of ideas and policies is central to understanding the historical evolution of economies. Ideas shape economic institutions and real economic constraints are the source of new economic ideas. The history of economic ideas, both those that are fairly recent and those that are considerably older, may provide a fertile ground for new approaches to Latin American and Caribbean economic development. However, the history of economic ideas and their intricate relation to economic policies remains a relatively unexplored field in Latin American and Caribbean studies. This book is a valuable new contribution to this emerging literature.
Social spending is a powerful tool to reduce poverty, achieve higher equality and better life conditions for the inhabitants of a country. In "Social Expenditure in Central America, Panama and the Dominican Republic: 2007-2013", a characterization of the different variables that have taken social expenditure to its current position is performed. During the economic crisis period, many governments of the region confront this situation with an increase in social expenditures. However, part of the increase was centered on inflexible items, particularly wages, which facilitated the increase in fiscal deficits and, consequently, on public debt. Thus, after the financial crisis, the fiscal situation has reduced governments' buffers to respond to economic shocks, which imply that we need to examine the fiscal policy given its rigidity, the scarcity of public resources and the institutional contract. The study of wage bill increases provides more information related to the causes of this dynamic, and allow us to offer recommendations to improve spending management without threatening public finances. A better use of resources could contribute to define a more efficient and equitable agenda for the countries in the region. Finally, something that was not deeply explored, as of today, is the institutional complexity and how this could facilitate, or hinder, the government's ability to express its fiscal policy, including the effectiveness in the use of public resources.
He aquí a Unamuno, Baroja, don Ramón del Valle-Inclán, Benavente y los hermanos Machado, entre muchos otros. He aquí su ingente labor literaria, sus inesperadas, sus deslumbrantes frases y actitudes. He aquí la atractiva sugestión de sus discursos, sus voces caudalosas que desbordan y enriquecen la realidad, porque la obra de la generación del 98 no sólo fue escrita, sino que fue también oral. Y esta última, por su misma libertad discursiva, por su fugacidad, resulta más personal, más reveladora de sus propias personalidades. Sí, esta obra pasajera, anecdótica, que saltaba en el arco de la ruidosa tertulia, en la discusión ateneísta, en la rabia de un momento de acaloramiento, es de singular significado para conocer a los hombres que nos la ofrecen. Alfonso Reyes escribió en cierta ocasión que «hay que interesarse por las anécdotas», y se refería con esto a que la anécdota es, por esencia, reveladora. Y muestra en primer plano la psicología de sus autores, su perspicacia, su rapidez de respuesta, sus trasfondos, sus certeros diagnósticos ante una situación determinada. También su agudeza y capacidad de respuesta; además de la finura espiritual, el ingenio y el talento literario en una palabra. José Esteban. (Sigüenza, Guadalajara, 1936) ha repartido su vocación literaria entre la edición, la investigación, la crítica y la novela. Como escritor ha cultivado numerosos géneros y en el catálogo de Renacimiento y Espuela de Plata pueden encontrarse una buena muestra de sus trabajos con libros como Vituperio (y algún elogio) de la errata (2002), Judas... ¡Hi... de puta! Insultos y animadversión entre españoles (2003), Las mil y una palabras de casa de putas (2005) o El epigrama español (2008). Su labor como librero y editor de Turner fue fundamental para animar la cultura española durante el postfranquismo y la transición. Desde entonces ha sido responsable y asesor de un sinfín de ediciones, sobre todo de autores bohemios o finiseculares, y actualmente dirige para esta editorial la colección Biblioteca de Rescate, donde han aparecido ediciones suyas de Isidoro López Lapuya, Ciro Bayo o Manuel Ciges Aparicio.
Modeling and Control of Infectious Diseases in the Host: With MATLAB and R provides a holistic understanding of health and disease by presenting topics on quantitative decision-making that influence the development of drugs. The book presents modeling advances in different viral infections, dissecting detailed contributions of key players, along with their respective interactions. By combining tailored in vivo experiments and mathematical modeling approaches, the book clarifies the relative contributions of different underlying mechanisms within hosts of the most lethal viral infections, including HIV, influenza and Ebola. Illustrative examples for parameter fitting, modeling and control applications are explained using MATLAB and R. - Provides a multi-scale framework to link within-host infection dynamics (individual level) to between-host transmission fitness (epidemiological level) in viral infectious diseases - Includes PK/PD modeling and simulation approaches to improve efficiency and decision-making at preclinical development phases - Presents a theoretic approach to schedule drug treatments
Gypsum is a type of habitat widely spread throughout the world, especially in arid climates (Somalia, Australia, Middle East, USA, circum-Mediterranean region, etc.). The vegetation present on this type of habitat has long attracted the attention of specialists in the study of flora adapted to special substrates, since gypsum represents an important barrier to the growth of most plants. These ecosystems are little known in comparison to other habitats present on special substrates, even though representing natural laboratories of evolution and ecology. In this context, the Gypworld project has been developed, as a global initiative to understand the ecology of gypsum ecosystems, comes under the European Horizon 2020 research program, and which brings together researchers specialists in the study of gypsum ecosystems, from five continents. Under the umbrella of this project, different scientific meetings have been taking place, being the one held in Almeria, the third of the four that will take place, with the name of 3rd Gypworld Workshop. Thus, this monograph presents the most recent advances in the research of these special ecosystems.
Crónicas de América Latina: narrativa de no-ficción es la primera edición de una novedosa antología de crónicas diseñada para la enseñanza de español avanzado. Los textos, fascinantes y accesibles, permiten que los estudiantes se adentren en la compleja realidad contemporánea, tanto política como social y cultural, de América Latina, mientras refuerzan la lectura, la redacción y la conversación. Los ejercicios, todos ellos diseñados a partir de los propios textos, pretenden repasar problemas gramaticales y léxicos tradicionales, con especial énfasis en aquellos que atañen a las variedades dialectales del español americano: por ejemplo, el uso del pronombre ‘vos’. Este libro es un excelente material de lectura que puede usarse en clases de español como segunda lengua o en clases de español para hablantes de herencia, tanto en clases de lengua (gramática o conversación) como de contenido (cultura). Dividido en nueve capítulos, el material abarca temas cruciales tales como política, identidad, raza, género, inmigración, violencia, exilio, medio ambiente, gastronomía, fútbol y música. Cada texto puede leerse de forma independiente, lo que permite que los profesores seleccionen las lecturas según las particularidades de cada curso. Pensado en un principio para estudiantes de español, esta antología es sobre todo una lectura indispensable para cualquier persona interesada en la zona que concentra el mayor número de hispanohablantes en el mundo.
In 2001, the consequences of almost three decades of neoliberalismo made Argentina collapse. Out of the ashes of the ensuing social convulsion arose many different attempts by people to take the future into their own hands. Among them were the workers who started to put bankrupt, abandoned factories to work again in spite of the skepticism of politicians and part of society. Their successful stories surprised those who had expected them to fail and encouraged others to follow their example. In 2003, Esteban Magnani worked for Avi Lewis and Naomi Klein on a documentary on the phenomenon called The Take and wrote a book on recovered factories which is now being reprinted with an update for English speakers.
The incredibe story of Roger Tur Pallier, the honorary consul of France in Zaragoza from the pre-war period to the nineteen-seventies. Based on true events the story recounts his involvement spying on the Nazis in Spain before, during and after the Second World War and ending with his unfortunate death at the hands of left-wing terrorists shortly before he was due to retire.
South American ecosystems suffered one of the greatest biogeographical events, after the establishment of the Panamian land bridge, called the “Great American Biotic Interchange” (GABI). This refers to the exchange, in several phases, of land mammals between the Americas; this event started during the late Miocene with the appearance of the Holartic Procyonidae (Huayquerian Age) in South America and continues today. The major phases of mammalian dispersal occurred from the Latest Pliocene (Marplatan Age) to the Late Pleistocene (Lujanian Age). The most important and richest localities of Late Miocene-Holocene fossil vertebrates of South America are those of the Pampean region of Argentina. There are also several Late Miocene and Pliocene localities in western Argentina and Bolivia. Other important fossils have been collected in localities of Pleistocene age outside Argentina: Tarija (Bolivia), karstic caves of Lagoa Santa and the recently explored caves of Tocantins (Brasil), Talara (Perú), La Carolina (Ecuador), Muaco (Venezuela), and Cueva del Milodon (Chile), among others. The book discusses basic information for interpreting the GABI such as taxonomic composition (incorporating the latest revisions) at classical and new localities for each stage addressing climate, environments, and time boundaries for each stage. It includes the chronology and dynamics of the GABI, the integration of South American mammalian faunas through time, the Quaternary mammalian extinctions and the composition of recent mammalian fauna of the continent.
Your go-to resource for effective, efficient board study! The 2nd Edition of Comprehensive Review in Clinical Neurology offers clear explanations of complex concepts in an easily understandable format – all while helping you digest large amounts of information quickly and easily. Retaining the popular format of the first edition, this updated guide features more than 1,000 comprehensive, multiple-choice questions covering every area of neurology you need to master. A combined perspective from residents and faculty, plus revisions to conform to the current exam blueprint, ensure that you’ll make the most of your study time and will face no surprises on exam day.
This impressive study contains five sections on poisonous plants from the tropics. Three of the sections are devoted to plants that provoke skin allergies. Contains 13 color plates.
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