Biosimulation is an approach to biomedical research and the treatment of patients in which computer modeling goes hand in hand with experimental and clinical work. Constructed models are used to interpret experimental results and to accumulate information from experiment to experiment. This book explains the concepts used in the modeling of biological phenomena and goes on to present a series of well-documented models of the regulation of various genetic, cellular and physiological processes. The way how the use of computer models allows optimization of cancer treatment for individual patients is discussed and models of interacting nerve cells that can be used to design new treatments for patients with Parkinson's disease are explained. Furthermore this volume provides an overview on the use of models in industry, and presents the view of regulatory agencies on the topic.
Technical problems often lead to differential equations with piecewise-smooth right-hand sides. Problems in mechanical engineering, for instance, violate the requirements of smoothness if they involve collisions, finite clearances, or stick-slip phenomena. Systems of this type can display a large variety of complicated bifurcation scenarios that still lack a detailed description.This book presents some of the fascinating new phenomena that one can observe in piecewise-smooth dynamical systems. The practical significance of these phenomena is demonstrated through a series of well-documented and realistic applications to switching power converters, relay systems, and different types of pulse-width modulated control systems. Other examples are derived from mechanical engineering, digital electronics, and economic business-cycle theory.The topics considered in the book include abrupt transitions associated with modified period-doubling, saddle-node and Hopf bifurcations, the interplay between classical bifurcations and border-collision bifurcations, truncated bifurcation scenarios, period-tripling and -quadrupling bifurcations, multiple-choice bifurcations, new types of direct transitions to chaos, and torus destruction in nonsmooth systems.In spite of its orientation towards engineering problems, the book addresses theoretical and numerical problems in sufficient detail to be of interest to nonlinear scientists in general.
Through a series of examples from physics, engineering, biology and economics, this book illustrates the enormous potential for application of ideas and concepts from nonlinear dynamics and chaos theory. The overlap with examples published in other books is virtually equal to zero. The book takes the reader from detailed studies of bifurcation structures of relativity simple models to pattern formation in spatially extended systems. The book also discusses the different perspectives that nonlinear dynamics brings to different fields of science.
Interacting chaotic oscillators are of interest in many areas of physics, biology, and engineering. In the biological sciences, for instance, one of the challenging problems is to understand how a group of cells or functional units, each displaying complicated nonlinear dynamic phenomena, can interact with one another to produce a coherent response on a higher organizational level.This book is a guide to the fascinating new concept of chaotic synchronization. The topics covered range from transverse stability and riddled basins of attraction in a system of two coupled logistic maps over partial synchronization and clustering in systems of many chaotic oscillators, to noise-induced synchronization of coherence resonance oscillators. Other topics treated in the book are on-off intermittency and the role of the absorbing and mixed absorbing areas, periodic orbit threshold theory, the influence of a small parameter mismatch, and different mechanisms for chaotic phase synchronization.The biological examples include synchronization of the bursting behavior of coupled insulin-producing beta cells, chaotic phase synchronization in the pressure and flow regulation of neighboring functional units of the kidney, and homoclinic transitions to phase synchronization in microbiological reactors.
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Interacting chaotic oscillators are of interest in many areas of physics, biology, and engineering. In the biological sciences, for instance, one of the challenging problems is to understand how a group of cells or functional units, each displaying complicated nonlinear dynamic phenomena, can interact with one another to produce a coherent response on a higher organizational level.This book is a guide to the fascinating new concept of chaotic synchronization. The topics covered range from transverse stability and riddled basins of attraction in a system of two coupled logistic maps over partial synchronization and clustering in systems of many chaotic oscillators, to noise-induced synchronization of coherence resonance oscillators. Other topics treated in the book are on-off intermittency and the role of the absorbing and mixed absorbing areas, periodic orbit threshold theory, the influence of a small parameter mismatch, and different mechanisms for chaotic phase synchronization.The biological examples include synchronization of the bursting behavior of coupled insulin-producing beta cells, chaotic phase synchronization in the pressure and flow regulation of neighboring functional units of the kidney, and homoclinic transitions to phase synchronization in microbiological reactors.
Technical problems often lead to differential equations with piecewise-smooth right-hand sides. Problems in mechanical engineering, for instance, violate the requirements of smoothness if they involve collisions, finite clearances, or stick-slip phenomena. Systems of this type can display a large variety of complicated bifurcation scenarios that still lack a detailed description.This book presents some of the fascinating new phenomena that one can observe in piecewise-smooth dynamical systems. The practical significance of these phenomena is demonstrated through a series of well-documented and realistic applications to switching power converters, relay systems, and different types of pulse-width modulated control systems. Other examples are derived from mechanical engineering, digital electronics, and economic business-cycle theory.The topics considered in the book include abrupt transitions associated with modified period-doubling, saddle-node and Hopf bifurcations, the interplay between classical bifurcations and border-collision bifurcations, truncated bifurcation scenarios, period-tripling and -quadrupling bifurcations, multiple-choice bifurcations, new types of direct transitions to chaos, and torus destruction in nonsmooth systems.In spite of its orientation towards engineering problems, the book addresses theoretical and numerical problems in sufficient detail to be of interest to nonlinear scientists in general.
Through a series of examples from physics, engineering, biology and economics, this book illustrates the enormous potential for application of ideas and concepts from nonlinear dynamics and chaos theory. The overlap with examples published in other books is virtually equal to zero. The book takes the reader from detailed studies of bifurcation structures of relativity simple models to pattern formation in spatially extended systems. The book also discusses the different perspectives that nonlinear dynamics brings to different fields of science.
This essential and concise clinical reference guide serves diverse clinicians and allied health professionals who prescribe antiepileptic drugs in contemporary clinical practice. Fully updated, it features chapters on newly-approved drug brivaracetam, updated paediatric prescribing, use in particular populations including women, the elderly, and patients with cognitive impairment, as well as sections on teratogenicity, pregnancy, and lactation. In full colour throughout, the guide provides comprehensive antiepileptic drug (AED) prescribing information, covering all thirty-five AEDs in alphabetical order. Each chapter features eight coloured sections including general therapeutics, pharmacokinetics, interaction profile, adverse effects, dosing and use, special population considerations, a summary overview, and suggested reading. Perfect for quick reference use, the guide is practical and essential for all AED drug prescribers including adult and paediatric neurologists, neurosurgeons, psychiatrists, internists, geriatricians, paediatricians, family physicians, as well as allied health professionals and resident, fellow, and student trainees in all related medical fields.
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