Personalized medicine is a medical paradigm that emphasizes systematic use of individual patient information to optimize that patient's health care, particularly in managing chronic conditions and treating cancer. In the statistical literature, sequential decision making is known as an adaptive treatment strategy (ATS) or a dynamic treatment regime (DTR). The field of DTRs emerges at the interface of statistics, machine learning, and biomedical science to provide a data-driven framework for precision medicine.? The authors provide a learning-by-seeing approach to the development of ATSs, aimed at a broad audience of health researchers. All estimation procedures used are described in sufficient heuristic and technical detail so that less quantitative readers can understand the broad principles underlying the approaches. At the same time, more quantitative readers can implement these practices. This book provides the most up-to-date summary of the current state of the statistical research in personalized medicine; contains chapters by leaders in the area from both the statistics and computer sciences fields; and also contains a range of practical advice, introductory and expository materials, and case studies.?
Statistical Methods for Dynamic Treatment Regimes shares state of the art of statistical methods developed to address questions of estimation and inference for dynamic treatment regimes, a branch of personalized medicine. This volume demonstrates these methods with their conceptual underpinnings and illustration through analysis of real and simulated data. These methods are immediately applicable to the practice of personalized medicine, which is a medical paradigm that emphasizes the systematic use of individual patient information to optimize patient health care. This is the first single source to provide an overview of methodology and results gathered from journals, proceedings, and technical reports with the goal of orienting researchers to the field. The first chapter establishes context for the statistical reader in the landscape of personalized medicine. Readers need only have familiarity with elementary calculus, linear algebra, and basic large-sample theory to use this text. Throughout the text, authors direct readers to available code or packages in different statistical languages to facilitate implementation. In cases where code does not already exist, the authors provide analytic approaches in sufficient detail that any researcher with knowledge of statistical programming could implement the methods from scratch. This will be an important volume for a wide range of researchers, including statisticians, epidemiologists, medical researchers, and machine learning researchers interested in medical applications. Advanced graduate students in statistics and biostatistics will also find material in Statistical Methods for Dynamic Treatment Regimes to be a critical part of their studies.
Taking Your iPad to the Max, iOS 5 Edition is written so that anyone can quickly get up to speed on Apple’s latest hit. As bloggers at The Unofficial Apple Weblog (TUAW.com), the authors have the happy privilege of working with Apple products every day, and they'll guide you through all of the perks of being an iPad owner with access to all the new and amazing features in iOS 5. This book takes you from selecting and buying an iPad, to connecting it to the Internet, to using the incredible power of the iPad and all its apps to enhance your life. Whether you’re using your iPad to surf the Internet, admire or edit family photos, listen to music, watch movies, create or edit movies, or read a book, this book will help guide you. Discover how your iPad can be a virtual shopping mall, opening the door to purchases of music, books, videos, and movies. This book will help you organize your daily life through the use of Calendar, Notes, and Contacts, communicate with friends and colleagues with Mail, and find your way with Maps. You'll also learn how get the most out of your iPad's two cameras, and you'll learn how iCloud keeps all of your documents and photos in sync across all your Apple devices. You'll also learn about great new iOS 5 features like Reminders, Notification Center, iMessage, Newsstand, and PC-Free updates. Taking Your iPad to the Max, iOS 5 Edition introduces the essentials of using your iPad for recreation, travel, and work—and includes the basics of Apple's iWork suite for iPad. Learn to create business or personal documents with Pages, make professional presentations with Keynote, and keep data and finances under control with Numbers. You'll also learn how to use iLife's suite of apps, including iPhoto, iMovie, and GarageBand on the iPad. No matter how you use your iPad, Taking Your iPad to the Max, iOS 5 Edition will show you how to make the most of it.
National Jewish Book Award Finalist: “A fresh and delightful portrait of Jewish renewal in Poland . . . Highly recommended.” —Choice Since the end of Communism, Jews from around the world have visited Poland to tour Holocaust-related sites. A few venture further, seeking to learn about their own Polish roots and connect with contemporary Poles. For their part, a growing number of Poles are fascinated by all things Jewish. In this book, Erica T. Lehrer explores the intersection of Polish and Jewish memory projects in the historically Jewish neighborhood of Kazimierz in Krakow. Her own journey becomes part of the story as she demonstrates that Jews and Poles use spaces, institutions, interpersonal exchanges, and cultural representations to make sense of their historical inheritances.
Unleash your iPhone and take it to the limit using powerful tips and techniques from tech consultant Steve Sande and gadget hacker Erica Sadun. Fast and fun to read, Taking Your iPhone 4 to the Max shows you how to get the most out of Apple's iPhone 4. You'll find all the best undocumented tricks as well as the most efficient and enjoyable introduction to the iPhone available. Starting with an introduction to iPhone basics, you'll quickly move on to discover the iPhone's hidden potential, like how to connect to a TV, use Voice Control, have video chats with FaceTime, and call friends overseas with low-cost VoIP. From the unified email inbox and surfing the Web with Mobile Safari, exploring the world of social networking, using the multitasking capabilities of iOS 4, taking and editing photos, shopping for apps, media, and books, or just managing phone callsPQZ-21723you'll find it all in this book. You'll even learn tips on where to get the best iPhone accessories. Get ready to take iPhone 4 to the max!
Fast and fun to read, this book gives you all the tips, tricks and hidden techniques that you would love to try out on your iPod Touch. It starts by getting everyone up to speed on the basics. Then quickly moves into the fun stuff, like connecting to a TV, and even how to hack so that you can run applications over the iPod Touch and a whole lot more. If you can do it on the iPod Touch, you will find it here. So whether you just want to be able to use it for music and do emails or web surfing, or you want to take it to the Max, this is the book to show you how.
It looks different. It acts different. There's no right way to hold it. It responds to the touch of your fingertips. It's the Internet in your lap. It connects to the world, yet it is as personal as a well-worn book. Taking Your iPad to the Max is written so that anyone, from a computer-savvy teenager to a 92-year-old great-grandmother, can quickly get up to speed on Apple's latest hit. As bloggers at The Unofficial Apple Weblog (tuaw.com), we have the happy privilege of working with Apple products every day. The iPad is so different from any computer you've ever used, and we realize many people could use a helping hand, to feel comfortable buying and using an iPad. We take you from selecting and buying an iPad, to connecting it to the Internet, and then demonstrate just how to use the incredible power of the iPad and all its apps to enhance your life. Whether you're using your iPad to surf the Internet, admire family photos, listen to music, watch movies, or read a book, we're here to guide you. We show you how your iPad can be a virtual shopping mall, opening the door to purchases of music, books, videos, and movies. We help you organize your daily life through the use of Calendar, Notes, and Contacts, communicate with friends and colleagues with Mail, and find your way with Maps. The iPad is more than the ultimate leisure device; it's also a work tool. Taking Your iPad to the Max guides you through the basics of Apple's iWork suite for iPad. Learn to create business or personal documents with Pages, make professional presentations with Keynote, and keep data and finances under control with Numbers.
Unleash your iPod touch and take it to the limit using secret tips and techniques. Fast and fun to read, Taking Your iPod touch 5 to the Max will help you get the most out of iOS 5 on your iPod touch. You’ll find all the best undocumented tricks, as well as the most efficient and enjoyable introduction to the iPod touch available. Starting with the basics, you’ll quickly move on to discover the iPod touch's hidden potential, like how to connect to a TV and get contract-free VoIP. From e-mail and surfing the Web, to using iTunes, iBooks, games, photos, ripping DVDs and getting free VoIP with Skype or FaceTime—whether you have a new iPod touch, or an older iPod touch with iOS 5, you'll find it all in this book. You’ll even learn tips on where to get the best and cheapest iPod touch accessories. Get ready to take iPod touch to the max!
Unleash your iPhone and take it to the limit using secret tips and techniques from gadget hacker Erica Sadun. Fast and fun to read, Taking Your iPhone to the Max details the best, and undocumented, tricks and offers an efficient and enjoyable introduction to the iPhone. It begins with iPhone basics and then uncovers the iPhone’s hidden potential, detailing such topics as how to connect to a TV, get contract-free VOIP, and hack OS X so it will run applications on the iPhone. Taking Your iPhone to the Max even offers tips on where to get the best and cheapest iPhone accessories.
Unleash the power of your new iPhone 4S or other iOS 5-driven iPhone and take it to the limit using powerful tips and techniques from the Apple experts at TUAW, Erica Sadun, Steve Sande, and Michael Grothaus. Fast and fun to read, Taking Your iPhone 4S to the Max shows you how to get the most out of your iPhone using Apple’s new iOS 5. Whether you're using the new iPhone 4S or earlier iPhone that runs the new iOS 5, you’ll find all the best undocumented tricks, as well as the most efficient and enjoyable introduction to the iPhone available. Starting with an introduction to iPhone basics, you’ll quickly discover the iPhone’s hidden potential, like how to connect to a TV, use Voice Control using Siri, have video chats with FaceTime, and call friends overseas with low-cost VoIP. From the unified e-mail inbox and surfing the Web with Mobile Safari, exploring the world of social networking, using the multitasking capabilities of iOS 5, taking and editing photos, shopping for apps, media, and books, or just managing phone calls—you’ll find it all in this book. You’ll even learn tips on where to get the best iPhone accessories. Get ready to take your iPhone 4S and earlier running the new iOS 5 to the max!
iPad 2: It looks different. It acts different. It connects to the world, yet it is as personal as a well-worn book. And now it has two cameras! Taking Your iPad 2 to the Max is written so that anyone can quickly get up to speed on Apple’s latest hit. As bloggers at The Unofficial Apple Weblog (TUAW.com), the authors have the happy privilege of working with Apple products every day, and they'll guide you through all of the perks of being an iPad 2 owner. This book takes you from selecting and buying an iPad, to connecting it to the Internet, to using the incredible power of the iPad and all its apps to enhance your life. Whether you’re using your iPad to surf the Internet, admire family photos, listen to music, watch movies, create or edit movies, or read a book, this book will help guide you. Discover how your iPad 2 can be a virtual shopping mall, opening the door to purchases of music, books, videos, and movies. This book will help you organize your daily life through the use of Calendar, Notes, and Contacts, communicate with friends and colleagues with Mail, and find your way with Maps. You'll also learn how get the most out of your iPad's two cameras. Taking Your iPad 2 to the Max introduces the essentials of using your iPad 2 for recreation, travel, and work—and includes the basics of Apple's iWork suite for iPad. Learn to create business or personal documents with Pages, make professional presentations with Keynote, and keep data and finances under control with Numbers.
Cape Town in South Africa is one of the great wine capitals of the world and gateway to the internationally renowned Cape winelands with its breathtaking scenery and legendary wines. From historic gabled manor houses to contemporary wineries, quirky family-run farms to iconic estates, country picnics to world-class fine dining restaurants, the Cape winelands offer a wide diversity of visitor experiences, all within an easy hour's drive of the city. But how do you choose where to go, what to taste and what to do in the winelands when time is limited and options are vast? Wineries of the Cape is an informative and richly photographed guidebook, complete with handy regional maps, which shares a wealth of practical information ensuring that you experience the very best of the winelands, whether you are a local or first-time visitor. Lindsaye McGregor - a long-time contributor to 14 editions of Platter's South African Wine Guide and a regular writer in the world of wine - simplifies this choice by sharing her intimate industry knowledge, profiling 56 of the Cape's must-visit wineries.
Statistical Methods for Dynamic Treatment Regimes shares state of the art of statistical methods developed to address questions of estimation and inference for dynamic treatment regimes, a branch of personalized medicine. This volume demonstrates these methods with their conceptual underpinnings and illustration through analysis of real and simulated data. These methods are immediately applicable to the practice of personalized medicine, which is a medical paradigm that emphasizes the systematic use of individual patient information to optimize patient health care. This is the first single source to provide an overview of methodology and results gathered from journals, proceedings, and technical reports with the goal of orienting researchers to the field. The first chapter establishes context for the statistical reader in the landscape of personalized medicine. Readers need only have familiarity with elementary calculus, linear algebra, and basic large-sample theory to use this text. Throughout the text, authors direct readers to available code or packages in different statistical languages to facilitate implementation. In cases where code does not already exist, the authors provide analytic approaches in sufficient detail that any researcher with knowledge of statistical programming could implement the methods from scratch. This will be an important volume for a wide range of researchers, including statisticians, epidemiologists, medical researchers, and machine learning researchers interested in medical applications. Advanced graduate students in statistics and biostatistics will also find material in Statistical Methods for Dynamic Treatment Regimes to be a critical part of their studies.
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