Eric Vugrin's Books

Critical Infrastructure System Security and Resiliency

By: Betty Biringer,Eric Vugrin,Drake Warren

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Critical Infrastructure System Security and Resiliency

By: Betty Biringer,Eric Vugrin,Drake Warren

Security protections for critical infrastructure nodes are intended to minimize the risks resulting from an initiating event, whether it is an intentional malevolent act or a natural hazard. With an emphasis on protecting an infrastructure's ability to perform its mission or function, Critical Infrastructure System Security and Resiliency presents a practical methodology for developing an effective protection system that can either prevent undesired events or mitigate the consequences of such events. Developed at Sandia National Labs, the authors’ analytical approach and methodology enables decision-makers and security experts to perform and utilize risk assessments in a manner that extends beyond the theoretical to practical application. These protocols leverage expertise in modeling dependencies—optimizing system resiliency for effective physical protection system design and consequence mitigation. The book begins by focusing on the design of protection strategies to enhance the robustness of the infrastructure components. The authors present risk assessment tools and necessary metrics to offer guidance to decision-makers in applying sometimes limited resources to reduce risk and ensure operational resiliency. Our critical infrastructure is vast and made up of many component parts. In many cases, it may not be practical or affordable to secure every infrastructure node. For years, experts—as a part of the risk assessment process—have tried to better identify and distinguish higher from lower risks through risk segmentation. In the second section of the book, the authors present examples to distinguish between high and low risks and corresponding protection measures. In some cases, protection measures do not prevent undesired events from occurring. In others, protection of all infrastructure components is not feasible. As such, this section describes how to evaluate and design resilience in these unique scenarios to manage costs while most effectively ensuring infrastructure system protection. With insight from the authors’ decades of experience, this book provides a high-level, practical analytical framework that public and private sector owners and operators of critical infrastructure can use to better understand and evaluate infrastructure security strategies and policies. Strengthening the entire homeland security enterprise, the book presents a significant contribution to the science of critical infrastructure protection and resilience.

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Page Count

233

Publisher

CRC Press

Published Date

ISBN 10

1466557508

ISBN 13

9781466557505

Renal Cell Carcinoma

By: Eric A. Klein

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Renal Cell Carcinoma

By: Eric A. Klein

This reference brings together all aspects of renal cell carcinoma, and provides a basis for understanding the disease's origin, progression and responses to immunotherapy.;Examining the current status of cytokine, cell-based and chemotherapeutic methods of treatment, this book: discusses the clinical presentation of advanced renal carcinoma and its therapeutic challenges; reviews prognostic factors and the management of renal cell carcinoma occurring with von Hippel-Landau syndrome; summarizes efforts to identify the tumour suppressor gene deleted from chromosome 3 in most renal cell carcinomas; explicates the role of oncogenes in the progression of renal cell cancer and the molecular correlates of responses to interferon-alpha treatment; details the latest laboratory efforts to establish gene therapy for tumour treatment by transfection of cytokine genes in murine model systems; focuses on biologic response modifier therapy in humans, including cell-mediated immune responses and adoptive immunotherapy; presents preclinical and clinical studies of interleukin-2 alone, in combination with othe cytokines, and with chemothrapeutic agents; and addresses studies on the tumour necrosis factor and low- and high-dose interferon-alpha.

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Page Count

370

Publisher

CRC Press

Published Date

ISBN 10

0824790332

ISBN 13

9780824790332

Onco-Nephrology E-Book

By: Kevin W. Finkel,Mark Anthony Perazella,Eric P Cohen

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Onco-Nephrology E-Book

By: Kevin W. Finkel,Mark Anthony Perazella,Eric P Cohen

Kidney disease and cancer are frequent comorbidities that require specialized knowledge and expertise from both the nephrologist and the oncologist. Written by three pioneers in this growing subspecialty, Onco-Nephrology provides authoritative, definitive coverage of the mechanism and management of these two life-threatening diseases. This unique, single-volume resource covers current protocols and recommends management therapies to arrest kidney failure and allow oncologic treatments to continue and succeed. - Addresses acute and chronic kidney diseases that develop from a variety of cancers. This includes direct kidney injury from the malignancy, paraneoplastic effects of the cancer, and various cancer agents used to treat the malignancy. - Discusses key issues regarding kidney disease in patients with cancer, including conventional chemotherapeutic regimens and new novel therapies (targeted agents and immunotherapies) or the malignancies themselves that may promote kidney injury; patients with chronic kidney disease who acquire cancer unrelated to renal failure; and kidney transplantation, which has been shown to carry an increased risk of cancer. - Contains dedicated chapters for each class of the conventional chemotherapeutic agents, targeted cancer agents, and cancer immunotherapies including the basic science, pathogenic mechanisms of injury, clinical manifestations, and treatment. - Includes special chapters devoted to the individual classes of chemotherapies that relate to kidney disease for quick reference. Discusses increasingly complex problems due to more numerous and specialized anti-cancer drugs, as well as increased survival rates for both cancer and renal failure requiring long-term patient care. - Covers anti-VEGF (antivascular endothelial growth factor) agents and cancer immunotherapies – treatments that are being recognized for adverse kidney effects. - Utilizes a clear, logical format based on the ASN Core Curriculum for Onco-Nephrology, making this reference an excellent tool for board review, as well as a practical resource in daily practice. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

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Page Count

498

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0323549616

ISBN 13

9780323549615

Critical Infrastructure System Security and Resiliency

By: Betty Biringer,Eric Vugrin,Drake Warren

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Critical Infrastructure System Security and Resiliency

By: Betty Biringer,Eric Vugrin,Drake Warren

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233

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CRC Press

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ISBN 10

1466557508

ISBN 13

9781466557505

Hazard-resilient Infrastructure

Analysis and Design

By: Bilal M. Ayyub

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Hazard-resilient Infrastructure

Analysis and Design

By: Bilal M. Ayyub

MOP 144 provides guidance and underlying framework for creating consistency across hazards, systems, and sectors in the design of new infrastructure systems and in enhancing the resilience of existing ones.

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Page Count

294

Published Date

ISBN 10

0784415757

ISBN 13

9780784415757

Book's by Eric Vugrin

Critical Infrastructure System Security and Resiliency

Critical Infrastructure System Security and Resiliency

Renal Cell Carcinoma

Renal Cell Carcinoma

Onco-Nephrology E-Book

Onco-Nephrology E-Book

Critical Infrastructure System Security and Resiliency

Critical Infrastructure System Security and Resiliency

Hazard-resilient Infrastructure

Hazard-resilient Infrastructure

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