Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. This popular primer provides a solid understanding of the nervous system, neurologic disorders, and treatments with drugs and other substances Nestler, Hyman, and Malenka’s Molecular Neuropharmacology, Fourth Edition covers everything you need to know about molecular neuroscience. This meticulously detailed guide provides a deep dive into the pathophysiology of neurologic and psychiatric disorders by describing neuropharmacological fundamentals of the nervous system. Packed with tables, diagrams, and figures making the intricacies of neurochemistry easy to understand, it builds a solid understanding of major disease mechanisms by reviewing the effects of drug actions (organized by drug category), and it explains the neuropharmacology of specific neural and psychiatric disorders. Concise overviews of the effects of drugs and neurologically active substances appear before the descriptions of the minute details that lead to these effects—a format designed to boost understanding and knowledge retention of critical concepts.
* The most up-to-date and comprehensive coverage of the relationship of brain function and neuroactive chemicals * Authors are world-known leaders in the field * Molecular Neuropharmacology is the hot topic in medicine
Market: Pharmacy and medical students; neuroscientists; neurologists; pharmacologists Updated edition has an attractive full-color design with more illustrations Includes numerous Fact Boxes to help reinforce learning
Cocaine produces its psychoactive & addictive effects primarily by acting on the brain¿s limbic system, a set of interconnected regions that regulate pleasure & motivation. An initial, short-term effect -- a buildup of the neurochemical dopamine -- gives rise to euphoria & a desire to take the drug again. Researchers are seeking to understand how cocaine¿s many longer term effects produce addiction¿s persistent cravings & risk of relapse. This paper focuses on the buildup of the genetic transcription factor DeltaFosB in the limbic system which correlate with addiction-like behaviors in mice & may precipitate very long-lasting changes to nerve cell structure. This is one of the first steps toward an understanding of the transition from cocaine abuse to addiction.
GAIN A COMPLETE UNDERSTANDING OF NERVOUS SYSTEM FUNCTION AND ITS RELATIONSHIP TO HUMAN NEUROLOGIC DISORDERS Molecular Neuropharmacology first reviews the fundamental biochemistry of the functioning nervous system and then describes how nerve cells communicate with one another through numerous types of neurotransmitters involving amino acids, monoamines, neuropeptides, and neurotrophic factors, among several others. The neuropharmacology and neural circuits that underlie complex behaviors as well as major neural disorders are also discussed as are the drugs used to treat those conditions. In the final section, the authors use the concepts presented in the first two sections to explainhow irregularities in the biochemistry of neuronal interactions can lead to a wide array of clinical manifestations. FEATURES NEW chapter on neuroinflammation All chemical structure illustrations have been redrawn and improved Fully updated to reflect the latest breakthroughs and new drugs The most well-written and easily understood work on the subject More than 300 full-color illustrations!
This text offers a comprehensive introduction to molecular biology, genetics, and neurobiology relevant to psychiatry. Generously illustrated chapters are organized to be read at both an introductory and a more advanced level. Both beginners and advanced professionals will benefit from this text's discussion of how psychotropic drugs work and how gene-environment interactions may contribute to the pathogenesis of psychiatric disorders. The authors demonstrate how molecular investigations in psychiatry will revolutionize the field by leading to improved diagnostic testing, to new and more effective treatments, and ultimately to the development of preventive measures for mental illness.
This text offers a comprehensive introduction to molecular biology, genetics, and neurobiology relevant to psychiatry. Generously illustrated chapters are organized to be read at both an introductory and a more advanced level. Both beginners and advanced professionals will benefit from this text's discussion of how psychotropic drugs work and how gene-environment interactions may contribute to the pathogenesis of psychiatric disorders. The authors demonstrate how molecular investigations in psychiatry will revolutionize the field by leading to improved diagnostic testing, to new and more effective treatments, and ultimately to the development of preventive measures for mental illness.
The new edition of this definitive textbook reflects the continuing reintegration of psychiatry into the mainstream of biomedical science. The research tools that are transforming other branches of medicine - epidemiology, genetics, molecular biology, imaging, and medicinal chemistry - are also transforming psychiatry. The field stands poised to make dramatic advances in defining disease pathogenesis, developing diagnostic methods capable of identifying specific and valid disease entities, discovering novel and more effective treatments, and ultimately preventing psychiatric disorders. The Neurobiology of Mental Illness is written by world-renowned experts in basic neuroscience and the pathophysiology and treatment of psychiatric disorders. It begins with a succint overview of the basic neurosciences followed by and evaluation of the tools that are available for the study of mental disorders in humans. The core of the book is a series of consistently organized sections on the major psychiatric disorders that cover their diagnostic classification, molecular genetics, functional neuroanatomy, neurochemistry and pharmacology, neuroimaging, and principles of pharmacotherapy. Chapters are written in a clear style that is easily accessible to practicing psychiatrists, and yet they are detailed enough to interest researchers and academics. For this second edition, every section has been thoroughly updated, and 13 new chapters have been added in areas where significant advances have been made, including functional genomics and animal models of illness; epidemiology; cognitive neuroscience; postmortem investigation of human brain; drug discovery methods for psychiatric disorders; the neurobiology of schizophrenia; animal models of anxiety disorders; neuroimaging studies of anxiety disorders; developmental neurobiology and childhood onset of psychiatric disorders; the neurobiology of mental retardation; the interface between neurological and psychiatric disorders; the neurobiology of circadian rhythms; and the neurobiology of sleep disorders. Both as a textbook and a reference work, Neurobiology of Mental Illness represents a uniquely valuable resource for psychiatrists, neuroscientists, and their students or trainees.
Cocaine produces its psychoactive & addictive effects primarily by acting on the brain¿s limbic system, a set of interconnected regions that regulate pleasure & motivation. An initial, short-term effect -- a buildup of the neurochemical dopamine -- gives rise to euphoria & a desire to take the drug again. Researchers are seeking to understand how cocaine¿s many longer term effects produce addiction¿s persistent cravings & risk of relapse. This paper focuses on the buildup of the genetic transcription factor DeltaFosB in the limbic system which correlate with addiction-like behaviors in mice & may precipitate very long-lasting changes to nerve cell structure. This is one of the first steps toward an understanding of the transition from cocaine abuse to addiction.
This is a new edition of the first comprehensive text to show how the advances in molecular and cellular biology and in the basic neurosciences have brought the revolution in molecular medicine to the field of psychiatry. The book begins with a review of basic neuroscience and methods for studying neurobiology in human patients then proceeds to discussions of all major psychiatric syndromes with respect to knowledge of their etiology, pathophysiology, and treatment. Emphasis is placed on synthesizing information across numerous levels of analysis, including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, and behavior, and in translating information from the basic laboratory to the clinical laboratory and finally to clinical treatment. Editors Dennis Charney and Eric Nestle, along with their six section editors and over 150 contributors, have revised and updated all 80 chapters from the previous edition and have added new chapters on topics relating to, for example, genetics, experimental therapeutics, and late-life mood disorders. Both a textbook and a reference book, Neurobiology of Mental Illness is intended for psychiatrists, neuroscientists, and upper level students.
Brought together for the first time in a single volume, these eight important and fascinating essays by Nobel Prize-winning psychiatrist Eric Kandel provide a breakthrough perspective on how biology has influenced modern psychiatric thought. Complete with commentaries by experts in the field, Psychiatry, Psychoanalysis, and the New Biology of Mind reflects the author's evolving view of how biology has revolutionized psychiatry and psychology and how potentially could alter modern psychoanalytic thought. The author's unique perspective on both psychoanalysis and biological research has led to breakthroughs in our thinking about neurobiology, psychiatry, and psychoanalysis -- all driven by the central idea that a fuller understanding of the biological processes of learning and memory can illuminate our understanding of behavior and its disorders. These wonderful essays cover the mechanisms of psychotherapy and medications, showing that both work at the same level of neural circuits and synapses, and the implications of neurobiological research for psychotherapy; the ability to detect functional changes in the brain after psychotherapy, which enables us, for the first time, to objectively evaluate the effects of psychotherapy on individual patients; the need for animal models of mental disorders; for example, learned fear, to show how molecules and cellular mechanisms for learning and memory can be combined in various ways to produce a range of adaptive and maladaptive behaviors; the unification of behavioral psychology, cognitive psychology, neuroscience, and molecular biology into the new science of the mind, charted in two seminal reports on neurobiology and molecular biology given in 1983 and 2000; the critical role of synapses and synaptic strength in both short- and long-term learning; the biological and social implications of the mapping of the human genome for medicine in general and for psychiatry and mental health in particular; The author concludes by calling for a revolution in psychiatry, one that can use the power of biology and cognitive psychology to treat the many mentally ill persons who do not benefit from drug therapy. Fascinating reading for psychiatrists, psychoanalysts, social workers, residents in psychiatry, and trainees in psychoanalysis, Psychiatry, Psychoanalysis, and the New Biology of Mind records with elegant precision the monumental changes taking place in psychiatric thinking. It is an invaluable reference work and a treasured resource for thinking about the future.
The gold standard of neuroscience texts―updated with hundreds of brand-new images and fully revised content in every chapter Doody's Core Titles for 2023! For more than 40 years, Principles of Neural Science has helped readers understand the link between the human brain and behavior. As the renowned text has shown, all behavior is an expression of neural activity and the future of both clinical neurology and psychiatry is dependent on the progress of neural science. Fully updated, this sixth edition of the landmark reference reflects the latest research, clinical perspectives, and advances in the field. It offers an unparalleled perspective on the the current state and future of neural science. This new edition features: Unmatched coverage of how the nerves, brain, and mind function NEW chapters on: - The Computational Bases of Neural Circuits that Mediate Behavior - Brain-Machine Interfaces - Decision-Making and Consciousness NEW section on the neuroscientific principles underlying the disorders of the nervous system Expanded coverage of the different forms of human memory Highly detailed chapters on stroke, Parkinson’s disease, and multiple sclerosis 2,200 images, including 300 new color illustrations, diagrams, radiology studies, and PET scans Principles of Neural Science, Sixth Edition benefits from a cohesive organization, beginning with an insightful overview of the interrelationships between the brain, nervous system, genes, and behavior. The text is divided into nine sections: Part I: Overall Perspective provides an overview of the broad themes of neural science, including the basic anatomical organization of the nervous system and the genetic bases of nervous system function and behavior. Part II: Cell and Molecular Biology of Cells of the Nervous System examines the basic properties of nerve cells, including the generation and conduction of propagated signaling. Part III: Synaptic Transmission focuses on the electrophysiological and molecular mechanism of synaptic transmission with chapters on neuronal excitability, neurotransmitters, and transmitter release. Part IV: Perception discusses the various aspects of sensory perception, including how information from the primary organs of sensation is transmitted to and processed by the central nervous system. Part V: Movement considers the neural mechanisms underlying movement and examines a new treatment that addresses how the basal ganglia regulate the selection of motor actions and instantiate reinforcement learning. Part VI: The Biology of Emotion, Motivation and Homeostasis examines the neural mechanisms by which subcortical areas mediate homeostatic control mechanisms, emotions, and motivation. Part VII: Development and the Emergence of Behavior looks at the nervous system from early embryonic differentiation to the formation and elimination of synapses. Part VIII: Learning, Memory, Language and Cognition expands on the previous section, examining the cellular mechanisms of implicit and explicit memory storage, as well as decision-making and consciousness. Part IX: explores the neural mechanisms underlying diseases and disorders of the nervous system, including autism spectrum disorder, epilepsy, schizophrenia, and anxiety.
A Nobel Prize–winning neuroscientist’s probing investigation of what brain disorders can tell us about human nature Eric R. Kandel, the winner of the Nobel Prize in Physiology or Medicine for his foundational research into memory storage in the brain, is one of the pioneers of modern brain science. His work continues to shape our understanding of how learning and memory work and to break down age-old barriers between the sciences and the arts. In his seminal new book, The Disordered Mind, Kandel draws on a lifetime of pathbreaking research and the work of many other leading neuroscientists to take us on an unusual tour of the brain. He confronts one of the most difficult questions we face: How does our mind, our individual sense of self, emerge from the physical matter of the brain? The brain’s 86 billion neurons communicate with one another through very precise connections. But sometimes those connections are disrupted. The brain processes that give rise to our mind can become disordered, resulting in diseases such as autism, depression, schizophrenia, Parkinson’s, addiction, and post-traumatic stress disorder. While these disruptions bring great suffering, they can also reveal the mysteries of how the brain produces our most fundamental experiences and capabilities—the very nature of what it means to be human. Studies of autism illuminate the neurological foundations of our social instincts; research into depression offers important insights on emotions and the integrity of the self; and paradigm-shifting work on addiction has led to a new understanding of the relationship between pleasure and willpower. By studying disruptions to typical brain functioning and exploring their potential treatments, we will deepen our understanding of thought, feeling, behavior, memory, and creativity. Only then can we grapple with the big question of how billions of neurons generate consciousness itself.
Rutter’s Child and Adolescent Psychiatry has become an established and accepted textbook of child psychiatry. Now completely revised and updated, the fifth edition provides a coherent appraisal of the current state of the field to help trainee and practising clinicians in their daily work. It is distinctive in being both interdisciplinary and international, in its integration of science and clinical practice, and in its practical discussion of how researchers and practitioners need to think about conflicting or uncertain findings. This new edition now offers an entirely new section on conceptual approaches, and several new chapters, including: neurochemistry and basic pharmacology brain imaging health economics psychopathology in refugees and asylum seekers bipolar disorder attachment disorders statistical methods for clinicians This leading textbook provides an accurate and comprehensive account of current knowledge, through the integration of empirical findings with clinical experience and practice, and is essential reading for professionals working in the field of child and adolescent mental health, and clinicians working in general practice and community pediatric settings.
Eric Rentschler's new book, The Use and Abuse of Cinema, takes readers on a series of enthralling excursions through the fraught history of German cinema, from the Weimar and Nazi eras to the postwar and postwall epochs and into the new millennium. These journeys afford rich panoramas and nuanced close-ups from a nation's production of fantasies and spectacles, traversing the different ways in which the film medium has figured in Germany, both as a site of creative and critical enterprise and as a locus of destructive and regressive endeavor. Each of the chapters provides a stirring minidrama; the cast includes prominent critics such as Siegfried Kracauer and Rudolf Arnheim; postwar directors like Wolfgang Staudte, Rainer Werner Fassbinder, Wim Wenders, and Alexander Kluge; representatives of the so-called Berlin School; and exponents of mountain epics, early sound musicals, rubble films, and recent heritage features. A film history that is both original and unconventional, Rentschler's colorful tapestry weaves together figures, motifs, and stories in exciting, unexpected, and even novelistic ways.
New edition of this effective toolbox for treating trauma survivors is even more comprehensive This popular, practical resource for clinicians caring for trauma survivors has been fully updated and expanded. It remains a key toolkit of cognitive behavioral somatic therapy (CBST) techniques for clinicians who want to enhance their skills in treating trauma. Baranowsky and Gentry help practitioners find the right tools to guide trauma survivors toward growth and healing. Reinforcing this powerful intervention is the addition of a deeper emphasis on the preparatory phase for therapists, including the therapists' own ability to self-regulate their autonomic system during client encounters. Throughout the acclaimed book, an effective tri-phasic model for trauma treatment is constructed (safety and stabilization; working through trauma; reconnection with a meaningful life) as guiding principle, enabling a phased delivery that is fitted to the survivor's relational and processing style. The authors present, clearly and in detail, an array of techniques, protocols, and interventions for treating trauma survivors (cognitive, behavioral, somatic, and emotional/relational). These include popular and effective CBST techniques, approaches inspired by research on neuroplasticity, and interventions informed by polyvagal theory. Many techniques include links to video or audio material demonstrating how to carry-out the intervention. Further sections are devoted to forward-facing trauma therapy, a safe, effective, and accelerated method of treating trauma, and to clinician self-care. Over 40 video and audio demonstrations of many of the techniques are available for download. There are also 36 handouts for clients that can be downloaded and printed for clinical use.
Today environmental problems of unprecedented magnitude confront planet earth. The sobering fact is that a whole range of human activities is affecting our global environment as profoundly as the billions of years of evolution that preceded our tenure on Earth. The pressure on vital natural resources in the developing world and elsewhere is intense, and the destruction of tropical forests, wildlife habitat, and other irreplaceable resources, is alarming. Climate change, ozone depletion, loss of genetic diversity, and marine pollution are critical global environmental concerns. Their cumulative impact threatens to destroy the planet's natural resources. The need to address this situation is urgent. More than at any previous moment in history, nature and ecological systems are in human hands, dependent on human efforts. The earth is an interconnected and interdependent global ecosystem, and change in one part of the system often causes unexpected change in other parts. Atmospheric, oceanic, wetland, terrestrial and other ecological systems have a finite capacity to absorb the environmental degradation caused by human behavior. The need for an environmentally sound, sustainable economy to ease this degradation is evident and urgent. Policies designed to stimulate economic development by foregoing pollution controls both destroy the long-term economy and ravage the environment. Over the years, we have sometimes drawn artificial distinctions between the health of individuals and the health of ecosystems. But in the real world, those distinctions do not exist.
In an unparalleled collaboration, two leading global thinkers in technology and foreign affairs give us their widely anticipated, transformational vision of the future: a world where everyone is connected—a world full of challenges and benefits that are ours to meet and to harness. Eric Schmidt is one of Silicon Valley’s great leaders, having taken Google from a small startup to one of the world’s most influential companies. Jared Cohen is the director of Google Ideas and a former adviser to secretaries of state Condoleezza Rice and Hillary Clinton. With their combined knowledge and experiences, the authors are uniquely positioned to take on some of the toughest questions about our future: Who will be more powerful in the future, the citizen or the state? Will technology make terrorism easier or harder to carry out? What is the relationship between privacy and security, and how much will we have to give up to be part of the new digital age? In this groundbreaking book, Schmidt and Cohen combine observation and insight to outline the promise and peril awaiting us in the coming decades. At once pragmatic and inspirational, this is a forward-thinking account of where our world is headed and what this means for people, states and businesses. With the confidence and clarity of visionaries, Schmidt and Cohen illustrate just how much we have to look forward to—and beware of—as the greatest information and technology revolution in human history continues to evolve. On individual, community and state levels, across every geographical and socioeconomic spectrum, they reveal the dramatic developments—good and bad—that will transform both our everyday lives and our understanding of self and society, as technology advances and our virtual identities become more and more fundamentally real. As Schmidt and Cohen’s nuanced vision of the near future unfolds, an urban professional takes his driverless car to work, attends meetings via hologram and dispenses housekeeping robots by voice; a Congolese fisherwoman uses her smart phone to monitor market demand and coordinate sales (saving on costly refrigeration and preventing overfishing); the potential arises for “virtual statehood” and “Internet asylum” to liberate political dissidents and oppressed minorities, but also for tech-savvy autocracies (and perhaps democracies) to exploit their citizens’ mobile devices for ever more ubiquitous surveillance. Along the way, we meet a cadre of international figures—including Julian Assange—who explain their own visions of our technology-saturated future. Inspiring, provocative and absorbing, The New Digital Age is a brilliant analysis of how our hyper-connected world will soon look, from two of our most prescient and informed public thinkers.
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