Having staked his claim as a master of epic fantasy with The Ring of Five Dragons, Eric Van Lustbader now returns to his world of Kundala to unearth new riches of wonder and excitement in this second volume of The Pearl saga. With the help of her friends, Riane, the prophesied redeemer known as the Dar Sala-at, saved Kundala from annihilation, preserving natives and V'ornn invaders alike. Together, the companions avenged terrible crimes and secured the Ring of Five Dragons, but their struggles have only just begun. The Ring averted doomsday, yet it did not open the magical Storehouse Door as expected. That sorcerous treasury remains sealed because of the spell cast by Giyan and her sister. A spell to migrate Annon Ashera's male V'ornn psyche into Riane's dying Kundalan female body. By combining them into a single being, it saved them both and fulfilled the prophecy that the Dar Sala-at would be "born at both ends of the cosmos." But the spell also breached the Abyss, releasing daemons who could wreak havoc on Kundala. The daemons were imprisoned there aeons ago by the Goddess Miina. Now the fiends must be vanquished, not only so the quest for the Pearl can continue, but to save Giyan, who has been possessed by the archdaemon Horolaggia. Their only hope is the fabled Veil of A Thousand Tears. At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.
This is the first book-length treatment of both the non-positive- and the positive-liberty strands of the republican revival in political and constitutional theory. The republican revival, pursued especially over the last few decades, has presented republicanism as an exciting alternative to the dominant tradition of liberalism. The book provides a sharply different interpretation of liberty from that found in the republican revival, and it argues that this different interpretation is not only historically more faithful to some prominent writers identified with the republican tradition, but is also normatively more attractive. The normative advantages are revealed through discussion of some central concerns relating to democracy and constitutionalism, including the justification for democracy and the interpretation of constitutional rights. The book also looks beyond republican liberty by drawing on the republican device of sortition (selection by lot). It proposes the use of large juries to decide bill-of-rights matters. This novel proposal indicates how democracy might be reconciled with constitutional review based on a bill of rights. Republicanism is not pitted against liberalism: the favoured values and institutions fit with liberal commitments.
Postcolonial Naturalism proposes an innovative periodizing schema for historicizing contemporary Anglophone fiction. Engaging and revising the materialist paradigm of the Warwick Research Collective’s concept of “world-literature,” Fredric Jameson’s mapping of modernity’s cultural periods, and Christopher L. Hill’s positing of a transnational naturalism, Eric D. Smith theorizes “postcolonial naturalism” as a structurally determined cultural logic rather than as a literary technique or style. Supported by careful, theoretically and critically sophisticated analyses of exemplary literary works, this important intervention invites us to reconsider the living history of aesthetic naturalism as well as its social and political implications for the practice of world-literature in the aftermath of anticolonial resistance.
The 2008 financial crisis was the worst since the Great Depression and many voices argued that it would transform global financial governance. But half a decade later, how much has really changed? In The Status Quo Crisis, Helleiner surveys the landscape and argues that continuity has marked global financial governance more than dramatic transformation.
Thoroughly updated, this fourth edition focuses on modern techniques used to generate synthetic three-dimensional images in a fraction of a second. With the advent of programmable shaders, a wide variety of new algorithms have arisen and evolved over the past few years. This edition discusses current, practical rendering methods used in games and other applications. It also presents a solid theoretical framework and relevant mathematics for the field of interactive computer graphics, all in an approachable style. New to this edition: new chapter on VR and AR as well as expanded coverage of Visual Appearance, Advanced Shading, Global Illumination, and Curves and Curved Surfaces.
Covers the history of this form of warfare, information on chemical agents themselves, as well as regulation, controls, and disposal policies. Scientific research on CBW, extending as far back as 1940 is organized under categories of CBW agents and their corresponding subheadings.
Cellular Internet of Things: From Massive Deployments to Critical 5G Applications, Second Edition, gives insights into the recent and rapid work performed by the 3rd Generation Partnership Project (3GPP) and the Multefire Alliance (MFA) to develop systems for the Cellular IoT. Beyond the technologies, readers will learn what the mMTC and cMTC market segments look like, deployment options and expected performance in terms of system capacity, expected battery lifetime, data throughput, access delay time and device cost, regulations for operation in unlicensed frequency bands, and how they impact system design and performance. This new edition contains updated content on the latest EC-GSM IoT, LTE-M and NB-IoT features in 3GPP Release 15, critical communication, i.e. URLLC, specified in 3GPP Release 15 for both LTE and NR, LTE-M and NB-IoT for unlicensed frequency bands specified in the Multefire Alliance (MFA), and an updated outlook of what the future holds in Industrial IoT and drone communications, amongst other topics. - Provides ubiquitous wireless connectivity for a diverse range of services and applications, describing their performance and how their specifications were developed to meet the most demanding requirements - Describes licensed and unlicensed technologies based on 2G, 4G and 5G technologies and how they have evolved towards the Cellular IoT - Presents the Narrowband Internet of Things technology and how GSM, LTE and NR have been designed to provide Cellular Internet of Things services - Provides use cases that cover ultra-low complex systems connecting billions of devices (massive MTC, mMTC), critical MTC and cMTC based on Ultra-Reliable and Low Latency Communications (URLLC) to meet strict latency and reliability requirements
Well-known for their inability to heal, articular cartilage injuries often degenerate inexorably to disastrous impairment. Multitudes of treatments have been devised for this problem, but no satisfactory long-term solutions have been established. Written by world-class experts, Articular Cartilage covers the latest research and advancements related to biology, development, pathology, clinical applications, and tissue engineering. This book is useful for rheumatologists, orthopaedic surgeons, cartilage biologists, and cartilage engineers as well as for professionals working in the orthopaedic and other musculoskeletal industries. This book also belongs in the library of primary care physicians, gerontologists, physical therapists, kinesiologists, and chiropractors. Written at a level that allows accessibility to a wide audience, it provides an interdisciplinary approach that encompasses the breadth and depth of basic science, bioengineering, translational science, and detailed methodologic approaches. The authors examine the major events and signaling molecules that lead to development of articular cartilage from precursor cells, and the changes in cartilage as it matures and ages. They focus on the epidemiology, etiopathogenesis, and therapeutic approaches for cartilage injury and the major arthritides that affect cartilage and the synovial joints such as osteoarthritis, rheumatoid arthritis, and gout. They supply an up-to-date overview of the field of tissue engineering as applied to articular cartilage repair. They examine a number of methods used to assess structure, composition, biology, and biomechanical function. Each chapter contains extensive references to enhance additional study. The book’s comprehensive focus on multiple aspects of articular cartilage sets it apart from other tissue engineering or developmental biology-based books available. It includes important discussions and perspectives on many of the remaining challenges and opportunities in the development and translation of new approaches for treating diseases of articular cartilage. It also provides detailed working protocols for many of the methods used to study articular cartilage, coverage of current treatment options, and business and regulatory aspects of the development of cartilage products. It provides a deeper understanding that will help with the development of new products and clinical applications.
This textbook for courses on function data analysis and shape data analysis describes how to define, compare, and mathematically represent shapes, with a focus on statistical modeling and inference. It is aimed at graduate students in analysis in statistics, engineering, applied mathematics, neuroscience, biology, bioinformatics, and other related areas. The interdisciplinary nature of the broad range of ideas covered—from introductory theory to algorithmic implementations and some statistical case studies—is meant to familiarize graduate students with an array of tools that are relevant in developing computational solutions for shape and related analyses. These tools, gleaned from geometry, algebra, statistics, and computational science, are traditionally scattered across different courses, departments, and disciplines; Functional and Shape Data Analysis offers a unified, comprehensive solution by integrating the registration problem into shape analysis, better preparing graduate students for handling future scientific challenges. Recently, a data-driven and application-oriented focus on shape analysis has been trending. This text offers a self-contained treatment of this new generation of methods in shape analysis of curves. Its main focus is shape analysis of functions and curves—in one, two, and higher dimensions—both closed and open. It develops elegant Riemannian frameworks that provide both quantification of shape differences and registration of curves at the same time. Additionally, these methods are used for statistically summarizing given curve data, performing dimension reduction, and modeling observed variability. It is recommended that the reader have a background in calculus, linear algebra, numerical analysis, and computation.
Drug Delivery Devices and Therapeutic Systems examines the current technology and innovations moving drug delivery systems (DDS) forward. The book provides an overview on the therapeutic use of drug delivery devices, including design, applications, and a description of the design of each device. While other books focus on the therapy, the primary emphasis in this book is on current technologies for DDS applications, including microfluidics, nanotechnology, biodegradable hydrogel and microneedles, with a special emphasis on wearable DDS. As part of the Developments in Biomedical Engineering and Bioelectronics series, this book is written by experts in the field and informed with information directly from manufacturers. Pharmaceutical scientists, medical researchers, biomedical engineers and clinical professionals will find this an essential reference. - Provides essential information on the most recent drug delivery systems available - Explains current technology and its applications to drug delivery - Contains contributions from biomedical engineers, pharmaceutical scientists and manufacturers
Using as a theme the encounter between protozoan parasites and macrophages, this volume brings together cell biologists, immunologists and protozoologists to review current developments in this broad and dynamic research area. Discussed are ways protozoans establish their intracellular niche, how they activate macrophage effector functions, what th
Enemy in the Blood: Malaria, Environment, and Development in Argentina examines the dramatic yet mostly forgotten history of malaria control in northwest Argentina. Carter traces the evolution of malaria science and policy in Argentina from the disease’s emergence as a social problem in the 1890s to its effective eradication by 1950. Malaria-control proponents saw the campaign as part of a larger project of constructing a modern identity for Argentina. Insofar as development meant building a more productive, rational, and hygienic society, the perceptions of a culturally backwards and disease-ridden interior prevented Argentina from joining the ranks of “modern” nations. The path to eradication, however, was not easy due to complicated public health politics, inappropriate application of foreign malaria control strategies, and a habitual misreading of the distinctive ecology of malaria in the northwest, especially the unique characteristics of the local mosquito vector. Homegrown scientific expertise, a populist public health agenda, and an infusion of new technologies eventually brought a rapid end to malaria’s scourge, if not the cure for regional underdevelopment. Enemy in the Blood sheds light on the often neglected history of northwest Argentina’s interior, adds to critical perspectives on the history of development and public health in modern Latin America, and demonstrates the merits of integrative socialenvironmental research.
This book provides a comprehensive overview of the legal and regulatory framework for the nuclear industry from an Asian perspective. It includes information on the history of nuclear lawmaking, the key international treaties and agreements that govern the use of nuclear energy, the role of national and regional regulatory bodies, and the legal and policy issues that arise in the development and operation of nuclear power plants. The book also covers topics such as nuclear safety, security, waste management, environmental protection, and liability for nuclear accidents. Additionally, it provides insights into the legislative process and the various stakeholders involved in nuclear lawmaking, such as industry, government, and civil society organizations. The overall goal of this book is to provide a detailed and up-to-date understanding of the legal and regulatory framework for the nuclear newcomers, particularly in Asia, and to help readers navigate this complex and dynamic field. The book is also used as a guide for all nuclear energy-producing countries, lawmakers, students, researchers, or even for general readers to understand the perspectives of international nuclear energy law.
An analysis of the physics of multiantenna systems Multiple-Input Multiple-Output (MIMO) technology is one of the current hot topics in emerging wireless technologies. This book fills the important need for an authoritative reference on the merits of MIMO systems based on physics and provides a sound theoretical basis for its practical implementation. The book also addresses the important issues related to broadband adaptive processing. Written by three internationally known researchers, Physics of Multiantenna Systems and Broadband Processing: Provides a thorough discussion of the physical and mathematical principles involved in MIMO and adaptive systems Examines the electromagnetic framework of wireless communications systems Uses Maxwell's theory to provide a system-based framework for the abstract concept of channel capacity Performs various numerical simulations to observe how a typical system will behave in practice Provides a mathematical formulation for broadband adaptive processing and direction-of-arrival estimation using real antenna arrays Integrates signal processing and electromagnetics to address the performance of realistic multiantenna systems With Physics of Multiantenna Systems and Broadband Processing, communication systems engineers, graduate students, researchers, and developers will gain a thorough, scientific understanding of this important new technology.
An illuminating profile of the San Francisco Bay Area, and its regional and global influence, as seen from the focal point of San Francisco International Airport (SFO). A People's History of SFO uses the history of San Francisco International Airport (SFO) to tell a multifaceted story of development, encounter, and power in the surrounding region from the eighteenth century to the present. In lively, engaging stories, Eric Porter reveals SFO's unique role in the San Francisco Bay Area's growth as a globally connected hub of commerce, technology innovation, and political, economic, and social influence. Starting with the very land SFO was built on, A People's History of SFO sees the airport as a microcosm of the forces at work in the Bay Area—from its colonial history and early role in trade, mining, and agriculture to the economic growth, social sanctuary, and environmental transformations of the twentieth century. In ways both material and symbolic, small human acts have overlapped with evolving systems of power to create this bustling metropolis. A People's History of SFO ends by addressing the climate crisis, as sea levels rise and threaten SFO itself on the edge of San Francisco Bay.
Drugs produced by molecular biological techniques, called the 'biologics', differ from the usual chemical medications. Their optimum use, and the detection and managemenet of adverse events, pose a significant challenge to the clinician. Licences for new biologics continue to be granted for the likes of rituximab, abatacept and certocizumals pegol. Intensive research is also defining new areas in which these drugs will be used in the future, increasing the number of practitioners using biologics. As the use of these drugs increases around the world, so the level of information needed by primary care practitioners and specialist prescribers needs to be expanded The Handbook of Biological Therapy provides the practising clinician with a practica guide to the use of Tumour Necrosis Factor Blocking Therapy (TNF-blockers), and important new class of biologic therapy for rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, psoriasis, and psoriatic arthritis. It is a comprehensive distillation of the authors' clinical experience with these drugs, combined with data from diverse databases offering practical advice on their uses, specific indications, supporting clinical trial data and safety issues, with the aim of making the use of these drugs easier for the busy clinician. All of the authors have been involved from the beginnings of the clinical trial programmes with these drugs and continue to use them in daily practice.
Gain the R programming language fundamentals for doing the applied statistics useful for data exploration and analysis in data science and data mining. This book covers topics ranging from R syntax basics, descriptive statistics, and data visualizations to inferential statistics and regressions. After learning R’s syntax, you will work through data visualizations such as histograms and boxplot charting, descriptive statistics, and inferential statistics such as t-test, chi-square test, ANOVA, non-parametric test, and linear regressions. Learn R for Applied Statistics is a timely skills-migration book that equips you with the R programming fundamentals and introduces you to applied statistics for data explorations. What You Will LearnDiscover R, statistics, data science, data mining, and big data Master the fundamentals of R programming, including variables and arithmetic, vectors, lists, data frames, conditional statements, loops, and functions Work with descriptive statistics Create data visualizations, including bar charts, line charts, scatter plots, boxplots, histograms, and scatterplots Use inferential statistics including t-tests, chi-square tests, ANOVA, non-parametric tests, linear regressions, and multiple linear regressions Who This Book Is For Those who are interested in data science, in particular data exploration using applied statistics, and the use of R programming for data visualizations.
A new novel in New York Times best seller Eric Flint's science fiction Jao Empire series. It has become clear to both the Jao and their human and Lleix partners that if they are going to defeat the Ekhat who have been terrorizing the galaxy for eons, they need more allies. To that end, Preceptor Ronz, guardian of Earth and greatest living strategist of the Jao, has harnessed the energy of Earth's humans to create and send out an exploration fleet under the command of Caitlin Kralik. But after a long search, all the expedition has found are dead worlds and now-extinct intelligent species slaughtered by the genocidal Ekhat. Do they continue to search down the galactic arm in which Earth and the Jao worlds lie, or do they make an astounding leap in another direction? With friends like Gabe Tully, Tamt, Wrot and Caewithe Miller supporting her, Caitlin makes her decision. Meanwhile, the Ekhat, as murderous and destructive as they have always been, have a new generation of leaders growing into power who are even more implacable than those who have gone before them. The Ekhat have not forgotten the Jao, nor the damage they have done over the years to the Ekhat purpose. It's up to the Jao-human-Lleix confederation and the new allies they make to survive the onslaught and turn the tables on the Ekhat. At the publisher's request, this title is sold without DRM (Digital Rights Management). About Jao Empire series entry #2 The Course of Empire by Eric Flint & K.D. Wentworth: “The action is fast and furious . . . a trimphant story . . . ”—The Midwest Book Review “Building to an exhilarating conclusion, this book cries out for a sequel.”—Publishers Weekly About Eric Flint’s best-selling Ring of Fire series: “…reads like a technothriller set in the age of the Medicis …”—Publishers Weekly “…each new entry appears better than the previous one, a seemingly impossible feat…terrific.”—Midwest Book Review “[C]ombines accurate historical research with bold leaps of the imagination.”—Library Journal The Jao Empire Series The Course of Empire The Crucible of Empire The Span of Empire
Pain management is an essential part of clinical practice for all healthcare providers from trainees, physician assistants and nurse practitioners through to practising physicians. Problem-Based Pain Management is a collaboration between experts in anesthesiology, geriatric medicine, neurology, psychiatry and rehabilitation which presents a multidisciplinary management strategy. Over 60 chapters follow a standard, easy-to-read, quick access format on: clinical presentation, signs and symptoms, lab tests, imaging studies, differential diagnosis, pharmacotherapy, non-pharmacologic approach, interventional procedure, follow-up and prognosis. The broad spectrum of topics include headache, neck and back pain, bursitis, phantom limb pain, sickle cell disease and palliative care. Unlike other large, cumbersome texts currently available, this book serves as a quick, concise and pertinent reference in the diagnosis and management of common pain syndromes.
This book was originally published in 1990 and was the first text to consider the definitive fundamental science of landfill biotechnology. Since then, major research initiatives, particularly in the U.K. and South Africa, have resulted in considerable advancement in our knowledge of landfill microbiology. The Second Edition details this progress. Text considers the latest findings in landfill leachate treatment, co-disposal and fundamental microbiology. It brings together the expertise of the immediate complementary, but often disparate disciplines of soil science, environmental engineering, applied mathematics, and land reclamation and focuses on the common goal of the scientific design and management of landfill sites. The book also includes effective laboratory models and selected approaches.
Generalized trust – faith in people you do not know who are likely to be different from you – is a value that leads to many positive outcomes for a society. Yet some scholars now argue that trust is lower when we are surrounded by people who are different from us. Eric M. Uslaner challenges this view and argues that residential segregation, rather than diversity, leads to lower levels of trust. Integrated and diverse neighborhoods will lead to higher levels of trust, but only if people also have diverse social networks. Professor Uslaner examines the theoretical and measurement differences between segregation and diversity and summarizes results on how integrated neighborhoods with diverse social networks increase trust in the United States, Canada, the United Kingdom, Sweden and Australia. He also shows how different immigration and integration policies toward minorities shape both social ties and trust.
Through case studies of newspaper carriers, rural route mail couriers, personal care workers, and freelance editors - four groups who have led pioneering efforts to organize - the authors provide a window into the ways political and economic conditions interact with class, ethnicity, and gender to shape the meaning and strategies of working men and women and show how these strategies have changed over time. They argue that the experiences of these workers demonstrate a pressing need to expand collective bargaining rights to include them.
The new edition of this definitive textbook reflects the continuing reintegration of psychiatry into the mainstream of biomedical science. The research tools that are transforming other branches of medicine - epidemiology, genetics, molecular biology, imaging, and medicinal chemistry - are also transforming psychiatry. The field stands poised to make dramatic advances in defining disease pathogenesis, developing diagnostic methods capable of identifying specific and valid disease entities, discovering novel and more effective treatments, and ultimately preventing psychiatric disorders. The Neurobiology of Mental Illness is written by world-renowned experts in basic neuroscience and the pathophysiology and treatment of psychiatric disorders. It begins with a succint overview of the basic neurosciences followed by and evaluation of the tools that are available for the study of mental disorders in humans. The core of the book is a series of consistently organized sections on the major psychiatric disorders that cover their diagnostic classification, molecular genetics, functional neuroanatomy, neurochemistry and pharmacology, neuroimaging, and principles of pharmacotherapy. Chapters are written in a clear style that is easily accessible to practicing psychiatrists, and yet they are detailed enough to interest researchers and academics. For this second edition, every section has been thoroughly updated, and 13 new chapters have been added in areas where significant advances have been made, including functional genomics and animal models of illness; epidemiology; cognitive neuroscience; postmortem investigation of human brain; drug discovery methods for psychiatric disorders; the neurobiology of schizophrenia; animal models of anxiety disorders; neuroimaging studies of anxiety disorders; developmental neurobiology and childhood onset of psychiatric disorders; the neurobiology of mental retardation; the interface between neurological and psychiatric disorders; the neurobiology of circadian rhythms; and the neurobiology of sleep disorders. Both as a textbook and a reference work, Neurobiology of Mental Illness represents a uniquely valuable resource for psychiatrists, neuroscientists, and their students or trainees.
Despite the enormous diversity and complexity of financial instruments, the current taxation of hybrid financial instruments and the remuneration derived therefrom are characterized by a neat division into dividend-generating equity and interest-generating debt as well as by a coexistence of source- and residence-based taxation. This book provides a comparative analysis of the classification of hybrid financial instruments in the national tax rules currently applied by Australia, Germany, Italy and the Netherlands as well as in the relevant tax treaties and EU Directives. Moreover, based on selected hybrid financial instruments, mismatches in these tax classifications, which lead to tax planning opportunities and risks and thus are in conflict with the single tax principle, are identified. To address these issues, the author provides reform options that are in line with the dichotomous debt-equity framework, as he/she suggests the coordination of either tax classifications or tax treatments.
Widely regarded as the authoritative text on development geography, this volume examines the nature and causes of global inequality and critically analyzes contemporary approaches to economic development across the third world. Students gain a deeper understanding of the interacting dynamics of culture, gender, race, and class; biophysical factors, such as climate, population, and natural resources; and economic and political processes—all of which have led to the present-day disparities between the first and third worlds. Numerous examples, sidebars, and figures illustrate how people in the Global South are experiencing and contesting the forces of globalization.
Imaging in Rheumatology: A Clinical Approach is ideal for radiologists and rheumatologists—as well as orthopedic surgeons and others interested in applying imaging to rheumatologic diseases—and stresses conventional radiography as the most effective imaging assessment technique to help diagnose various diseases and conditions. Greenspan and Gershwin—a radiologist and rheumatologist, respectively—focus on practical, everyday use, so you can apply knowledge you learn in any clinical setting.
This book addresses two of the most important trends in political economy during the last two decades - globalization and decentralization - in the context of the world's most rapidly growing economic power, China. The intent is to provide a better understanding of how local political and economic institutions shape the ability of Chinese state-owned firms to utilize foreign direct investment (FDI) to remake themselves in the transition from inefficient and technologically backward firms into powerful national champions. In a global economy, the author argues, local governments are increasingly the agents of industrial transformation at the level of the firm. Local institutions are durable over time, and they have important economic consequences. Through an analysis of five Chinese regions, the treatment seeks to specify the opportunities and constraints that alternative institutional structures create, how they change over time, and ultimately, how they prepare Chinese firms for the challenge of global competition.
This textbook on Healthcare Management provides a systematic and comprehensive overview of the organisational forms and management instruments implemented in managed care. Within the international discussion on the structure of healthcare systems, managed care is an increasingly important topic. Over more than twenty years managed care approaches have fundamentally influenced healthcare systems in terms of patient orientation, efficiency, and quality. Experts assume that up to 20% of healthcare expenses can be saved by applying high-quality managed care approaches. By using suitable organisational forms and management principles, not only can costs be reduced, but the quality of medical service provision can be augmented. Managed care is therefore much more than a cost-cutting strategy. Advocates consider managed care to be a logical and necessary developmental step in modern healthcare systems. An increase in quality and at the same time a reduction of costs is not seen as contradictory but rather as consistent. Therefore, managed care is a response to changed challenges in the provision of healthcare.
Theory of Drug Development presents a formal quantitative framework for understanding drug development that goes beyond simply describing the properties of the statistics in individual studies. It examines the drug development process from the perspectives of drug companies and regulatory agencies. By quantifying various ideas underlying drug development, the book shows how to systematically address problems, such as: Sizing a phase 2 trial and choosing the range of p-values that will trigger a follow-up phase 3 trial Deciding whether a drug should receive marketing approval based on its phase 2/3 development program and recent experience with other drugs in the same clinical area Determining the impact of adaptive designs on the quality of drugs that receive marketing approval Designing a phase 3 pivotal study that permits the data-driven adjustment of the treatment effect estimate Knowing when enough information has been gathered to show that a drug improves the survival time for the whole patient population Drawing on his extensive work as a statistician in the pharmaceutical industry, the author focuses on the efficient development of drugs and the quantification of evidence in drug development. He provides a rationale for underpowered phase 2 trials based on the notion of efficiency, which leads to the identification of an admissible family of phase 2 designs. He also develops a framework for evaluating the strength of evidence generated by clinical trials. This approach is based on the ratio of power to type 1 error and transcends typical Bayesian and frequentist statistical analyses.
In this wide-ranging history of modern Britain, Eric Evans surveys every aspect of the period in which Britain was transformed into the world's first industrial power. By the end of the nineteenth century, Britain was still ruled by wealthy landowners, but the world over which they presided had been utterly transformed. It was an era of revolutionary change unparalleled in Britain - yet that change was achieved without political revolution. Ranging across the developing empire, and dealing with such central institutions as the church, education, health, finance and rural and urban life, The Shaping of Modern Britain provides an unparallelled account of Britain's rise to superpower status. Particular attention is given to the Great Reform Act of 1832, and the implications of the 1867 Reform Act are assessed. The book discusses: - the growing role of the central state in domestic policy making - the emergence of the Labour party - the Great Depression - the acquisition of a vast territorial empire Comprehensive, informed and engagingly written, The Shaping of Modern Britain will be an invaluable introduction for students of this key period of British history.
Fluid dynamics plays a crucial role in many cellular processes, including the locomotion of cells such as bacteria and spermatozoa. These organisms possess flagella, slender organelles whose time periodic motion in a fluid environment gives rise to motility. Sitting at the intersection of applied mathematics, physics and biology, the fluid dynamics of cell motility is one of the most successful applications of mathematical tools to the understanding of the biological world. Based on courses taught over several years, it details the mathematical modelling necessary to understand cell motility in fluids, covering phenomena ranging from single-cell motion to instabilities in cell populations. Each chapter introduces mathematical models to rationalise experiments, uses physical intuition to interpret mathematical results, highlights the history of the field and discusses notable current research questions. All mathematical derivations are included for students new to the field, and end-of-chapter exercises help consolidate understanding and practise applying the concepts.
This book is a comprehensive treatment of inference for hidden Markov models, including both algorithms and statistical theory. Topics range from filtering and smoothing of the hidden Markov chain to parameter estimation, Bayesian methods and estimation of the number of states. In a unified way the book covers both models with finite state spaces and models with continuous state spaces (also called state-space models) requiring approximate simulation-based algorithms that are also described in detail. Many examples illustrate the algorithms and theory. This book builds on recent developments to present a self-contained view.
Now in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field’s Virology: RNA Viruses, Seventh Edition covers the latest information on RNA viruses, how they cause disease, how they can cause epidemics and pandemics, new therapeutics and vaccine approaches, as provided in new or extensively revised chapters that reflect these advances in this dynamic field. Bundled with the eBook, which will be updated regularly as new information about each virus is available, this text serves as the authoritative, up-to-date reference book for virologists, infectious disease specialists, microbiologists, and physicians, as well as medical students pursuing a career in infectious diseases.
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