In this book the authors reduce a wide variety of problems arising in system and control theory to a handful of convex and quasiconvex optimization problems that involve linear matrix inequalities. These optimization problems can be solved using recently developed numerical algorithms that not only are polynomial-time but also work very well in practice; the reduction therefore can be considered a solution to the original problems. This book opens up an important new research area in which convex optimization is combined with system and control theory, resulting in the solution of a large number of previously unsolved problems.
For this updated edition, the treatment of the mechanisms of action, pharmacology and adverse effects of the drugs used to treat bacterial, fungal, parasitic and viral infections has been expanded. This edition also includes new chapters on the fluoroquinolones and drugs used to treat AIDS.
In this update to the very popular first edition of the same name, skilled science popularizer Eric Grace helps readers understand what biotechnology is and what implications it holds for all of us. Following on the heels of the success of the first edition, this thoroughly updated version offers an in-depth and accessible review of the basics of biotechnology. Accomplished science communicator Eric Grace focuses on the ethical implications involved, the wide range of public opinions both at home and abroad, the role of the media in communicating a complicated science topic, and the formidable problems associated with patenting life itself. With an emphasis on medicine, agriculture, and the environment, Grace explores the promises and realities of biotechnology. He deals frankly with the fact that biotechnology is first and foremost a commercial activity, often driven by big business and directed by the bottom line. And as biotechnology is used more frequently in medical diagnosis and treatment, we are witness to significant setbacks and reversals, dimming hopes that were prevalent when the first edition was released. But we are also witness to the burgeoning use of the technology in forensic science where DNA analysis has become commonplace in solving crimes. Likewise, DNA analysis has been a boon to studies of human history and evolution, revealing ancient details originally thought lost to us. At the same time, new uses for genetically altered bacteria are being discovered that help us clean up the environment by breaking down or sequestering toxic chemicals. While the public remains concerned about biotechnology, there is increasing awareness of the potential benefits. This updated edition of Biotechnology Unzipped helps put the many issues in perspective and provides answers to the most important questions.
The forgotten story of the nineteenth-century freethinkers and twentieth-century humanists who tried to build their own secular religion In The Church of Saint Thomas Paine, Leigh Eric Schmidt tells the surprising story of how freethinking liberals in nineteenth-century America promoted a secular religion of humanity centered on the deistic revolutionary Thomas Paine (1737–1809) and how their descendants eventually became embroiled in the culture wars of the late twentieth century. After Paine’s remains were stolen from his grave in New Rochelle, New York, and shipped to England in 1819, the reverence of his American disciples took a material turn in a long search for his relics. Paine’s birthday was always a red-letter day for these believers in democratic cosmopolitanism and philanthropic benevolence, but they expanded their program to include a broader array of rites and ceremonies, particularly funerals free of Christian supervision. They also worked to establish their own churches and congregations in which to practice their religion of secularism. All of these activities raised serious questions about the very definition of religion and whether it included nontheistic fellowships and humanistic associations—a dispute that erupted again in the second half of the twentieth century. As right-wing Christians came to see secular humanism as the most dangerous religion imaginable, small communities of religious humanists, the heirs of Paine’s followers, were swept up in new battles about religion’s public contours and secularism’s moral perils. An engrossing account of an important but little-known chapter in American history, The Church of Saint Thomas Paine reveals why the lines between religion and secularism are often much blurrier than we imagine.
This book presents the various design methods of a state-feedback control law and of an observer. The considered systems are of continuous-time and of discrete-time nature, monovariable or multivariable, the last ones being of main consideration. Three different approaches are described: • Linear design methods, with an emphasis on decoupling strategies, and a general formula for multivariable controller or observer design; • Quadratic optimization methods: Linear Quadratic Control (LQC), optimal Kalman filtering, Linear Quadratic Gaussian (LQG) control; • Linear matrix inequalities (LMIs) to solve linear and quadratic problems. The duality between control and observation is taken to advantage and extended up to the mathematical domain. A large number of exercises, all given with their detailed solutions, mostly obtained with MATLAB, reinforce and exemplify the practical orientation of this book. The programs, created by the author for their solving, are available on the Internet sites of Springer and of MathWorks for downloading. This book is targeted at students of Engineering Schools or Universities, at the Master’s level, at engineers desiring to design and implement innovative control methods, and at researchers.
This reference brings together all aspects of renal cell carcinoma, and provides a basis for understanding the disease's origin, progression and responses to immunotherapy.;Examining the current status of cytokine, cell-based and chemotherapeutic methods of treatment, this book: discusses the clinical presentation of advanced renal carcinoma and its therapeutic challenges; reviews prognostic factors and the management of renal cell carcinoma occurring with von Hippel-Landau syndrome; summarizes efforts to identify the tumour suppressor gene deleted from chromosome 3 in most renal cell carcinomas; explicates the role of oncogenes in the progression of renal cell cancer and the molecular correlates of responses to interferon-alpha treatment; details the latest laboratory efforts to establish gene therapy for tumour treatment by transfection of cytokine genes in murine model systems; focuses on biologic response modifier therapy in humans, including cell-mediated immune responses and adoptive immunotherapy; presents preclinical and clinical studies of interleukin-2 alone, in combination with othe cytokines, and with chemothrapeutic agents; and addresses studies on the tumour necrosis factor and low- and high-dose interferon-alpha.
This handbook is a review of radioguided surgical procedures, including sentinel node mapping and biopsy described by experts in the field. It is a practical guide for the practicing surgeon and other clinicians who will provide the majority of clinical care for breast cancer and other diseases and who therefore must be able to safely and effectively perform these procedures for their patients.
After motivating examples, this monograph gives substantial new results on the analysis and control of linear repetitive processes. These include further applications of the abstract model based stability theory which, in particular, shows the critical importance to the dynamics developed of the structure of the initial conditions at the start of each new pass, the development of stability tests and performance bounds in terms of so-called 1D and 2D Lyapunov equations. It presents the development of a major bank of results on the structure and design of control laws, including the case when there is uncertainty in the process model description, together with numerically reliable computational algorithms. Finally, the application of some of these results in the area of iterative learning control is treated --- including experimental results from a chain conveyor system and a gantry robot system.
Iterative Learning CONTROL ALGORITHMS AND EXPERIMENTAL BENCHMARKING Iterative Learning Control Algorithms and Experimental Benchmarking Presents key cutting edge research into the use of iterative learning control The book discusses the main methods of iterative learning control (ILC) and its interactions, as well as comparator performance that is so crucial to the end user. The book provides integrated coverage of the major approaches to-date in terms of basic systems, theoretic properties, design algorithms, and experimentally measured performance, as well as the links with repetitive control and other related areas. Key features: Provides comprehensive coverage of the main approaches to ILC and their relative advantages and disadvantages. Presents the leading research in the field along with experimental benchmarking results. Demonstrates how this approach can extend out from engineering to other areas and, in particular, new research into its use in healthcare systems/rehabilitation robotics. The book is essential reading for researchers and graduate students in iterative learning control, repetitive control and, more generally, control systems theory and its applications.
This new review textbook, written by residents and an experienced faculty member from Cleveland Clinic, is designed to ensure success on all sorts of standardized neurology examinations. Presented in a comprehensive question-and-answer format, with detailed rationales, Comprehensive Review in Clinical Neurology is a must-have for both aspiring and practicing neurologists and psychiatrists preparation to take the RITE, the American Board of Psychiatry and Neurology written exams, and various recertification exams.
This issue of Hematology/Oncology Clinics will feature articles such as: Anaplastic large cell lymphomaj; New agents; Transplant, Uncommon variants; ATLL, CD30+ LPD of skin; NK/T, MF/SS; and many more!
**Selected for Doody's Core Titles® 2024 with "Essential Purchase" designation in Dentistry** Little and Falace's Dental Management of the Medically Compromised Patient, 10th Edition, is thoroughly revised to provide the information needed to assess common problems and make safe dental management decisions. This new edition contains revised content on Cancer and Women's Health and includes an enhanced ebook plus patient-based practice questions with print purchase. Also, each chapter features informative illustrations and well-organized tables to provide you with in-depth details and overall summaries required for understanding and applying medical concepts in dentistry. - NEW! Thoroughly revised content provides the most current, evidence-based information you need to make dental management decisions. - UPDATED! Information correlating to the revised INBDE exam prepares you for the boards. - NEW! An ebook version is included with print purchase. The ebook allows you to access all the text, figures, and references, with the ability to search, customize content, make notes and highlights, and have content read aloud. Plus, patient-based questions are included. - UPDATED! Revised coverage of Women's Health addresses issues specific to women that can impact dental management. - NEW! Completely revised chapter on Cancer discusses essential considerations for the oral care of these patients. - NEW! Key Points at the beginning of each chapter highlight important content to guide study efforts.
The Thirteenth Edition of Health & Wellness explores the many facets of personal health and self-responsibility, while focusing on the basic principles of physical, mental, and spiritual health. It provides students with the tools they need to make informed health decisions that promote lifelong wellness. Written in a personal and engaging style, the Thirteen Edition of this best-selling text, encourages readers to be responsible for their own health-related behaviors and outlines how to improve overall health through nutrition, fitness, stress management, and maintaining an overall healthy lifestyle.
Highly readable, well illustrated, and easy to understand, Obstetrics: Normal and Problem Pregnancies remains your go-to choice for authoritative guidance on managing today’s obstetric patient. Reflecting the expertise of internationally recognized authorities, this bestselling obstetrics reference has been thoroughly revised to bring you up to date on everything from ultrasound assessment of fetal anatomy and growth, to medical complications in pregnancy, to fetal therapy...and much more! Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Benefit from the knowledge and experience of international experts in obstetrics. Gain a new perspective on a wide range of today’s key issues - all evidence based and easy to read. Stay current with new coverage of fetal origins of adult disease, evidence-based medicine, quality assessment, nutrition, and global obstetric practices. Find the information you need quickly with bolded key statements, additional tables, flow diagrams, and bulleted lists for easy reference. Zero in on "Key Points" in every chapter - now made more useful than ever with the inclusion of related statistics. View new ultrasound nomograms in the Normal Values in Pregnancy appendix.
This document reports on the achievements of a project for the co-management of fisheries resources carried out by IUCN in Guinea-Bissau since 1991 (Rio Grande de Buba region). It provides a summary analysis of the approach taken by the project and its achievements, offering a set of guidelines and lessons learned which will enable replication of the project at other sites.
At the core of many engineering problems is the solution of sets of equa tions and inequalities, and the optimization of cost functions. Unfortunately, except in special cases, such as when a set of equations is linear in its un knowns or when a convex cost function has to be minimized under convex constraints, the results obtained by conventional numerical methods are only local and cannot be guaranteed. This means, for example, that the actual global minimum of a cost function may not be reached, or that some global minimizers of this cost function may escape detection. By contrast, interval analysis makes it possible to obtain guaranteed approximations of the set of all the actual solutions of the problem being considered. This, together with the lack of books presenting interval techniques in such a way that they could become part of any engineering numerical tool kit, motivated the writing of this book. The adventure started in 1991 with the preparation by Luc Jaulin of his PhD thesis, under Eric Walter's supervision. It continued with their joint supervision of Olivier Didrit's and Michel Kieffer's PhD theses. More than two years ago, when we presented our book project to Springer, we naively thought that redaction would be a simple matter, given what had already been achieved . . .
Tumor ablation is the most high profile procedure currently in interventional radiology. This guide sets the standard and is one of the first comprehensive references on the subject. The editors, world-renowned in the field, have assembled recognized international authorities. The book is organized into six main sections: Introduction to Ablation, Operations, Imaging, Methods, Organ System Tumor Ablation, and Perspectives. This breadth is coupled with an easy-to-read format that facilitates the application of new techniques. Practitioners in specialties other than radiology, including internal medicine, oncology, anesthesiology, and surgery, add valuable insights. In addition, a chapter depicting the cancer journey by patients and their families provides a unique perspective. More than 380 photographs and diagrams illustrate key concepts. The skillful combination of depth and practicality makes this text essential for anyone who is involved with and wants to expand their knowledge in the ablation field.
Mucosal Health in Aquaculture is an essential reference on mucosal health for the diverse aquaculture community. Rich in explanatory figures and schematics, the book includes important concepts such as structural and cellular composition of mucosal surfaces in fish and shellfish, known functional roles of molecular and cellular actors during pathogen invasion, impacts of nutrition on the mucosal barriers, impacts of chemical treatments on mucosal surfaces, mucosal vaccines and vaccination strategies, and more. The health of cultured aquaculture species is critical in establishing the sustainable growth of the aquaculture industry worldwide, and mucosal health is of particular interest to those working in aquaculture because mucosal surfaces (skin, gill, intestine, reproductive tissues) constitute the first line of defense against pathogen invasion. Mucosal Health in Aquaculture captures the latest research on mucosal barriers in aquaculture species and their impacts on nutrition and immunity to ensure sustainable aquaculture development. - Includes research case studies to exhibit the importance of various integrated approaches to mucosal health - Examines the latest scientific methods and technologies to maximize efficiencies for healthy fish production for farming - Brings together the latest knowledge and research on mucosal barriers and mechanisms from world-wide experts in mucosal health - Utilizes detailed diagrams and figures to enhance comprehension
Well-known for their inability to heal, articular cartilage injuries often degenerate inexorably to disastrous impairment. Multitudes of treatments have been devised for this problem, but no satisfactory long-term solutions have been established. Written by world-class experts, Articular Cartilage covers the latest research and advancements related to biology, development, pathology, clinical applications, and tissue engineering. This book is useful for rheumatologists, orthopaedic surgeons, cartilage biologists, and cartilage engineers as well as for professionals working in the orthopaedic and other musculoskeletal industries. This book also belongs in the library of primary care physicians, gerontologists, physical therapists, kinesiologists, and chiropractors. Written at a level that allows accessibility to a wide audience, it provides an interdisciplinary approach that encompasses the breadth and depth of basic science, bioengineering, translational science, and detailed methodologic approaches. The authors examine the major events and signaling molecules that lead to development of articular cartilage from precursor cells, and the changes in cartilage as it matures and ages. They focus on the epidemiology, etiopathogenesis, and therapeutic approaches for cartilage injury and the major arthritides that affect cartilage and the synovial joints such as osteoarthritis, rheumatoid arthritis, and gout. They supply an up-to-date overview of the field of tissue engineering as applied to articular cartilage repair. They examine a number of methods used to assess structure, composition, biology, and biomechanical function. Each chapter contains extensive references to enhance additional study. The book’s comprehensive focus on multiple aspects of articular cartilage sets it apart from other tissue engineering or developmental biology-based books available. It includes important discussions and perspectives on many of the remaining challenges and opportunities in the development and translation of new approaches for treating diseases of articular cartilage. It also provides detailed working protocols for many of the methods used to study articular cartilage, coverage of current treatment options, and business and regulatory aspects of the development of cartilage products. It provides a deeper understanding that will help with the development of new products and clinical applications.
Written by experts in the field, the Tarascon Gastroenterology Pocketbook is a convenient reference guide that provides a comprehensive review of major gastroenterology topics along with a succinct presentation of pathophysiology and diagnostic and management strategies in gastroenterology. Topics include: -Evaluation and characterization of acute abdominal pain -Chronic inflammatory diseases including ulcerative colitis, Chron's disease, and primary biliary cirrhosis -Diagnosis and management of Gastroesophageal Reflux Disease (GERD) -Ordering radiologic studies for GI conditions The Tarascon Gastroenterology Pocketbook is a comprehensive, evidenced-based resource, and is a must-have tool for gastroenterologists, primary care physicians, nurses, fellows, and other health care providers in the field of gastroenterology.
Statistics: Unlocking the Power of Data, 2nd Edition continues to utilize these intuitive methods like randomization and bootstrap intervals to introduce the fundamental idea of statistical inference. These methods are brought to life through authentically relevant examples, enabled through easy to use statistical software, and are accessible at very early stages of a course. The program includes the more traditional methods like t-tests, chi-square texts, etc. but only after students have developed a strong intuitive understanding of inference through randomization methods. The focus throughout is on data analysis and the primary goal is to enable students to effectively collect data, analyze data, and interpret conclusions drawn from data. The program is driven by real data and real applications.
This is a new edition of the first comprehensive text to show how the advances in molecular and cellular biology and in the basic neurosciences have brought the revolution in molecular medicine to the field of psychiatry. The book begins with a review of basic neuroscience and methods for studying neurobiology in human patients then proceeds to discussions of all major psychiatric syndromes with respect to knowledge of their etiology, pathophysiology, and treatment. Emphasis is placed on synthesizing information across numerous levels of analysis, including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, and behavior, and in translating information from the basic laboratory to the clinical laboratory and finally to clinical treatment. Editors Dennis Charney and Eric Nestle, along with their six section editors and over 150 contributors, have revised and updated all 80 chapters from the previous edition and have added new chapters on topics relating to, for example, genetics, experimental therapeutics, and late-life mood disorders. Both a textbook and a reference book, Neurobiology of Mental Illness is intended for psychiatrists, neuroscientists, and upper level students.
Drug Delivery Devices and Therapeutic Systems examines the current technology and innovations moving drug delivery systems (DDS) forward. The book provides an overview on the therapeutic use of drug delivery devices, including design, applications, and a description of the design of each device. While other books focus on the therapy, the primary emphasis in this book is on current technologies for DDS applications, including microfluidics, nanotechnology, biodegradable hydrogel and microneedles, with a special emphasis on wearable DDS. As part of the Developments in Biomedical Engineering and Bioelectronics series, this book is written by experts in the field and informed with information directly from manufacturers. Pharmaceutical scientists, medical researchers, biomedical engineers and clinical professionals will find this an essential reference. - Provides essential information on the most recent drug delivery systems available - Explains current technology and its applications to drug delivery - Contains contributions from biomedical engineers, pharmaceutical scientists and manufacturers
NEW YORK TIMES BESTSELLER “Metaxas is a scrupulous chronicler and has an eye for a good story. . . . full, instructive, and pacey.” —The Washington Post From #1 New York Times bestselling author Eric Metaxas comes a brilliant and inspiring biography of the most influential man in modern history, Martin Luther, in time for the 500th anniversary of the Reformation On All Hallow’s Eve in 1517, a young monk named Martin Luther posted a document he hoped would spark an academic debate, but that instead ignited a conflagration that would forever destroy the world he knew. Five hundred years after Luther’s now famous Ninety-five Theses appeared, Eric Metaxas, acclaimed biographer of the bestselling Bonhoeffer: Pastor, Martyr, Prophet, Spy and Amazing Grace: William Wilberforce and the Heroic Campaign to End Slavery, paints a startling portrait of the wild figure whose adamantine faith cracked the edifice of Western Christendom and dragged medieval Europe into the future. Written in riveting prose and impeccably researched, Martin Luther tells the searing tale of a humble man who, by bringing ugly truths to the highest seats of power, caused the explosion whose sound is still ringing in our ears. Luther’s monumental faith and courage gave birth to the ideals of liberty, equality, and individualism that today lie at the heart of all modern life.
The new edition of this definitive textbook reflects the continuing reintegration of psychiatry into the mainstream of biomedical science. The research tools that are transforming other branches of medicine - epidemiology, genetics, molecular biology, imaging, and medicinal chemistry - are also transforming psychiatry. The field stands poised to make dramatic advances in defining disease pathogenesis, developing diagnostic methods capable of identifying specific and valid disease entities, discovering novel and more effective treatments, and ultimately preventing psychiatric disorders. The Neurobiology of Mental Illness is written by world-renowned experts in basic neuroscience and the pathophysiology and treatment of psychiatric disorders. It begins with a succint overview of the basic neurosciences followed by and evaluation of the tools that are available for the study of mental disorders in humans. The core of the book is a series of consistently organized sections on the major psychiatric disorders that cover their diagnostic classification, molecular genetics, functional neuroanatomy, neurochemistry and pharmacology, neuroimaging, and principles of pharmacotherapy. Chapters are written in a clear style that is easily accessible to practicing psychiatrists, and yet they are detailed enough to interest researchers and academics. For this second edition, every section has been thoroughly updated, and 13 new chapters have been added in areas where significant advances have been made, including functional genomics and animal models of illness; epidemiology; cognitive neuroscience; postmortem investigation of human brain; drug discovery methods for psychiatric disorders; the neurobiology of schizophrenia; animal models of anxiety disorders; neuroimaging studies of anxiety disorders; developmental neurobiology and childhood onset of psychiatric disorders; the neurobiology of mental retardation; the interface between neurological and psychiatric disorders; the neurobiology of circadian rhythms; and the neurobiology of sleep disorders. Both as a textbook and a reference work, Neurobiology of Mental Illness represents a uniquely valuable resource for psychiatrists, neuroscientists, and their students or trainees.
Focusing on allergy triggers, "Allergy-Free Naturally" offers hundreds of effective, non-drug treatments and easy-to-follow action plans for hay fever, asthma, food allergy, pet allergy, and other allergy-related conditions for both children and adults. Photos and illustrations.
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