With both the growing importance of integrating studies of air-sea interaction and the interest in the general problem of global warming, the appearance of the second edition of this popular text is especially welcome. Thoroughly updated and revised, the authors have retained the accessible, comprehensive expository style that distinguished the earlier edition. Topics include the state of matter near the interface, radiation, surface wind waves, turbulent transfer near the interface, the planetary boundary layer, atmospherically-forced perturbations in the oceans, and large-scale forcing by sea surface buoyancy fluxes. This book will be welcomed by students and professionals in meteorology, physical oceanography, physics and ocean engineering.
Cartilage injuries in children and adolescents are increasingly observed, with roughly 20% of knee injuries in adolescents requiring surgery. In the US alone, costs of osteoarthritis (OA) are in excess of $65 billion per year (both medical costs and lost wages). Comorbidities are common with OA and are also costly to manage. Articular cartilage's low friction and high capacity to bear load makes it critical in the movement of one bone against another, and its lack of a sustained natural healing response has necessitated a plethora of therapies. Tissue engineering is an emerging technology at the threshold of translation to clinical use. Replacement cartilage can be constructed in the laboratory to recapitulate the functional requirements of native tissues. This book outlines the biomechanical and biochemical characteristics of articular cartilage in both normal and pathological states, through development and aging. It also provides a historical perspective of past and current cartilage treatments and previous tissue engineering efforts. Methods and standards for evaluating the function of engineered tissues are discussed, and current cartilage products are presented with an analysis on the United States Food and Drug Administration regulatory pathways that products must follow to market. This book was written to serve as a reference for researchers seeking to learn about articular cartilage, for undergraduate and graduate level courses, and as a compendium of articular cartilage tissue engineering design criteria. Table of Contents: Hyaline Articular Cartilage / Cartilage Aging and Pathology / In Vitro / Bioreactors / Future Directions
A few short years after HIV first entered the world blood supply in the late 1970s and early 1980s, over half the hemophiliacs in the United States were infected with the virus. But this was far more than just an unforeseeable public health disaster. Negligent doctors, government regulators, and Big Pharma all had a hand in this devastating epidemic. Blood on Their Hands is an inspiring, firsthand account of the legal battles fought on behalf of hemophiliacs who were unwittingly infected with tainted blood. As part of the team behind the key class action litigation filed by the infected, young New Jersey lawyer Eric Weinberg was faced with a daunting task: to prove the negligence of a powerful, well-connected global industry worth billions. Weinberg and journalist Donna Shaw tell the dramatic story of how idealistic attorneys and their heroic, mortally-ill clients fought to achieve justice and prevent further infections. A stunning exposé of one of the American medical system’s most shameful debacles, Blood on Their Hands is a rousing reminder that, through perseverance, the victims of corporate greed can sometimes achieve great victory.
This book is a practical guide to the revolutionary technique of non-invasive, dyeless OCT angiography imaging. This new diagnostic tool complements, and in part replaces, fluorescein angiography. Beginning with an introduction to the principles and interpretation of OCT angiography, the book covers operating principles, recent advances, the future of OCT, and diagnosis of vascular retinopathies. The book describes how this new technology is used to study inner and outer retina disorders, both qualitatively and quantitatively, and to classify choroidal neovascularisation (CNV) in a non-invasive manner, highlighting morphology, flow and depth. It also provides new technical and clinical information on the study of glaucoma. Presented in a step by step format, the book is highly illustrated with images obtained from Optovue’s Avanti Widefield OCT hardware platform and Angiovue OCT angiography software. Key Points Practical guide to revolutionary technique of non-invasive, dyeless OCT angiography imaging Covers principles and interpretation, operating principles, recent advances, future of OCT and diagnosis of vascular retinopathies All images obtained from Optovue’s Avanti Widefield OCT hardware platform and Angiovue OCT angiography software Highly experienced, well-recognised author team led by Prof Bruno Lumbroso
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