Dynamic Treatment Regimes: Statistical Methods for Precision Medicine provides a comprehensive introduction to statistical methodology for the evaluation and discovery of dynamic treatment regimes from data. Researchers and graduate students in statistics, data science, and related quantitative disciplines with a background in probability and statistical inference and popular statistical modeling techniques will be prepared for further study of this rapidly evolving field. A dynamic treatment regime is a set of sequential decision rules, each corresponding to a key decision point in a disease or disorder process, where each rule takes as input patient information and returns the treatment option he or she should receive. Thus, a treatment regime formalizes how a clinician synthesizes patient information and selects treatments in practice. Treatment regimes are of obvious relevance to precision medicine, which involves tailoring treatment selection to patient characteristics in an evidence-based way. Of critical importance to precision medicine is estimation of an optimal treatment regime, one that, if used to select treatments for the patient population, would lead to the most beneficial outcome on average. Key methods for estimation of an optimal treatment regime from data are motivated and described in detail. A dedicated companion website presents full accounts of application of the methods using a comprehensive R package developed by the authors. The authors’ website www.dtr-book.com includes updates, corrections, new papers, and links to useful websites.
Estuarine Ecohydrology, Second Edition, provides an ecohydrology viewpoint of an estuary as an ecosystem by focusing on its principal components, the river, the estuarine waters, the sediment, the nutrients, the wetlands, the oceanic influence, and the aquatic food web, as well as models of the health of an estuary ecosystem. Estuaries, the intersection of freshwater and coastal ecosystems, exhibit complex physical and biological processes which must be understood in order to sustain and restore them when necessary. This book demonstrates how, based on an understanding of the processes controlling estuarine ecosystem health, one can quantify its ability to cope with human stresses. The theories, models, and real-world solutions presented serve as a toolkit for designing a management plan for the ecologically sustainable development of estuaries. - Provides a sound knowledge of the physical functioning of an estuary, a critical component of understanding its ecological functioning - Ideal reference for those interested in marine biology, oceanography, coastal management, and sustainable development - Describes the essentials behind conceptual and numerical models of the health of an estuary ecosystem and how to use these models to quantify both human impacts and the value of remediation and management measures - Chapters are written in an accessible way that encourages collaboration between aquatic, marine, and wetland biologists, ecologists, oceanographers, geologists, geomorphologists, chemists, and ecosystem modelers - Covers the physical, chemical, and biological elements of estuary environments, indicating that the essence of an estuary's functioning lies in its connectivity with the adjacent catchment and the marine/coastal system
Since the concept was first proposed at the end of the 20th Century, metamaterials have been the subject of much research and discussion throughout the wave community. More than 10 years later, the number of related published articles is increasing significantly. On the one hand, this success can be attributed to dreams of new physical objects which are the consequences of the singular properties of metamaterials. Among them, we can consider the examples of perfect lensing and invisibility cloaking. On other hand, metamaterials also provide new tools for the design of well-known wave functions such as antennas for electromagnetic waves. The goal of this book is to propose an overview of the concept of metamaterials as a perspective on a new practical tool for wave study and engineering. This includes both the electromagnetic spectrum, from microwave to optics, and the field of acoustic waves. Contents 1. Overview of Microwave and Optical Metamaterial Technologies, Didier Lippens. 2. MetaLines: Transmission Line Approach for the Design of Metamaterial Devices, Bruno Sauviac. 3. Metamaterials for Non-Radiative Microwave Functions and Antennas, Divitha Seetharamdoo and Bruno Sauviac. 4. Toward New Prospects for Electromagnetic Compatibility, Divitha Seetharamdoo. 5. Dissipative Loss in Resonant Metamaterials, Philippe Tassin, Thomas Koschny, and Costas M. Soukoulis. 6. Transformation Optics and Antennas, André de Lustrac, Shah Nawaz Burokur and Paul-Henri Tichit. 7. Metamaterials for Control of Surface Electromagnetic and Liquid Waves, Sébastien Guenneau, Mohamed Farhat, Muamer Kadic, Stefan Enoch and Romain Quidant. 8. Classical Analog of Electromagnetically Induced Transparency, Philippe Tassin, Thomas Koschny and Costas M. Soukoulis.
The New Grove Dictionary of Music and Musicians is the most comprehensive and up-to-date body of musical knowledge ever gathered together. The New Grove composer biographies have been selected from the dictionary to bring the finest of the biographies to a wider audience. Each has been expanded and updated for book publication and contains a comprehensive work-list, index, and fully revised bibliography, in addition to the definitive view of the subject's life and works.
This document reports on the achievements of a project for the co-management of fisheries resources carried out by IUCN in Guinea-Bissau since 1991 (Rio Grande de Buba region). It provides a summary analysis of the approach taken by the project and its achievements, offering a set of guidelines and lessons learned which will enable replication of the project at other sites.
With historical photos and impeccable storytelling, this extraordinary book chronicles an astonishing moment in American history. Starting Christmas Day, 1941, when transport trains on the Union Pacific Railroad stopped in North Platte to refill their water tanks, the local families of North Platte, Nebraska, came together to provide love, support, food, and morale to young soldiers involved in World War II—black and white—who briefly passed through their town. Troops poured into the North Platte Depot, "The Canteen," to find homecooked meals, birthday cakes, hot coffee, cold milk, magazines, postcards, and the warmth of a grateful and loving community. The stops lasted only ten minutes, but the people of North Platte made sure that everyone in their midst was taken care of. This remarkable story will inspire readers of all ages, as The Canteen nourishes all who have the privilege to visit.
The SAGE Library in Social and Personality Psychology Methods provides students and researchers with an understanding of the methods and techniques essential to conducting cutting-edge research. Each volume within the Library explains a specific topic and has been written by an active scholar (or scholars) with expertise in that particular methodological domain. Assuming no prior knowledge of the topic, the volumes are clear and accessible for all readers. In each volume, a topic is introduced, applications are discussed, and readers are led step by step through worked examples. In addition, advice about how to interpret and prepare results for publication are presented. Social Psychophysiology for Social and Personality Psychology provides methodological and technical information to help social psychologists make valid and valuable use of peripheral neurophysiological and endocrine measures of psychological constructs.
Precision medicine seeks to use data to construct principled, i.e., evidence-based, treatment strategies that dictate where, when, and to whom treatment should be applied. This book provides an accessible yet comprehensive introduction to statistical methodology for dynamic treatment regimes"--
Dynamic Treatment Regimes: Statistical Methods for Precision Medicine provides a comprehensive introduction to statistical methodology for the evaluation and discovery of dynamic treatment regimes from data. Researchers and graduate students in statistics, data science, and related quantitative disciplines with a background in probability and statistical inference and popular statistical modeling techniques will be prepared for further study of this rapidly evolving field. A dynamic treatment regime is a set of sequential decision rules, each corresponding to a key decision point in a disease or disorder process, where each rule takes as input patient information and returns the treatment option he or she should receive. Thus, a treatment regime formalizes how a clinician synthesizes patient information and selects treatments in practice. Treatment regimes are of obvious relevance to precision medicine, which involves tailoring treatment selection to patient characteristics in an evidence-based way. Of critical importance to precision medicine is estimation of an optimal treatment regime, one that, if used to select treatments for the patient population, would lead to the most beneficial outcome on average. Key methods for estimation of an optimal treatment regime from data are motivated and described in detail. A dedicated companion website presents full accounts of application of the methods using a comprehensive R package developed by the authors. The authors’ website www.dtr-book.com includes updates, corrections, new papers, and links to useful websites.
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