NMR of Paramagnetic Molecules: Applications to Metallobiomolecules and Models, Second Edition is a self-contained, comprehensive reference for chemists, physicists, and life scientists whose research involves analyzing paramagnetic compounds. Since the previous edition of this book was published, there have been many advancements in the field of paramagnetic NMR spectroscopy. This completely updated and expanded edition contains the latest fundamental theory and methods for mastery of this analytical technique. Users will learn how to interpret the NMR spectra of paramagnetic molecules, improve experimental techniques, and strengthen their understanding of the underlying theory and applications. - Reflects all advances in the field in a completely updated new edition - Presents new material on self-orientation residual dipolar couplings, solid state NMR, dynamic nuclear polarization, and paramagnetic restraints for structure calculations - Includes information relevant to paramagnetic molecules, metallobiomolecules, paramagnetic compounds, and paramagnetic NMR spectroscopy - Presents specific examples of paramagnetic inorganic species and experimental techniques for structure characterization
Hereditary spastic paraplegias (HSPs) are genetically heterogeneous Mendelian disorders characterized by spastic gait with stiffness and weakness in the legs and an associated plethora of neurological or extraneurological signs in “complicated” forms. Major advances have been made during the past two decades in our understanding of their molecular bases with the identification of a large number of gene loci and the cloning of a set of them. The combined genetic and clinical information obtained has permitted a new, molecularly-driven classification and an improved diagnosis of these conditions. This represents a prerequisite for better counseling in families and more appropriate therapeutic options. However, further heterogeneity is expected and new insight into the possible mechanisms anticipated.
2019 edition ‘Lake Como’ is a name you will often hear from friends or read in travel blogs if you are planning a vacation in Italy. The third largest lake in Italy is a hit amongst vacationers, and there are plenty of reasons behind it. So, let’s underline everything that you would like to know about the area before reaching a vacation decision. Where exactly is it? Lake Como has a glacial origin and is in the region of Lombardy, Italy. Considered as one of the most beautiful lakes in Italy, Como is located between Milan and the border of Switzerland. Why is it so famous? Those who are unfamiliar with the charm of Lake Como often wonder why it garners so much attention. Why people fly from all around the world to see just a lake? Well, the answer the query is that Lake Como is not just any lake; it is marked by one of the best properties, natural beauty, mountains, picturesque villages, adventure sports options and, last but not the least, pure luxury of Lake Como holiday villas. Apart from the cultural heritage of historic villas and waterfront cottages, Lake Como area also offers plenty of scope for outdoor activities like hiking, trekking, and biking. The lake itself provides avenues of kite surfing, sailing, yachting, windsurfing, and fishing. Ladies especially fall in love with the boutiques that mark the place, and men with golfing in Lake Como area. Who visits Lake Como? The hot holiday spot is frequented by vacationers from all around the world that crave a quaint, peaceful holiday in the lap of nature. The rich and famous too chose Lake Como to spend time away from the flashlights. Celebrities like Madonna, George Clooney, Gianni Versace, Ronaldinho, Sylvester Stallone, and Richard Branson maintain holiday homes near the shores of the lake. If you too are looking forward to the similar experience, then, Lake Como Villas for rent are readily available. This guide covers the Lake Como, and the towns of Como, Bellagio, Menaggio, and Varenna, in addition to the one-day trips you can make from one of these towns to Piona, Villa Carlotta, and Villa del Balbianello. There are extensive descriptions and photos of the attractions. This guide contains links to the websites of train and navigation companies, so you can check the latest schedule and buy the tickets.
In recent years there has been enormous activity in the theory of algebraic curves. Many long-standing problems have been solved using the general techniques developed in algebraic geometry during the 1950's and 1960's. Additionally, unexpected and deep connections between algebraic curves and differential equations have been uncovered, and these in turn shed light on other classical problems in curve theory. It seems fair to say that the theory of algebraic curves looks completely different now from how it appeared 15 years ago; in particular, our current state of knowledge repre sents a significant advance beyond the legacy left by the classical geometers such as Noether, Castelnuovo, Enriques, and Severi. These books give a presentation of one of the central areas of this recent activity; namely, the study of linear series on both a fixed curve (Volume I) and on a variable curve (Volume II). Our goal is to give a comprehensive and self-contained account of the extrinsic geometry of algebraic curves, which in our opinion constitutes the main geometric core of the recent advances in curve theory. Along the way we shall, of course, discuss appli cations of the theory of linear series to a number of classical topics (e.g., the geometry of the Riemann theta divisor) as well as to some of the current research (e.g., the Kodaira dimension of the moduli space of curves).
This guide covers a one-day visit to Como, and to the Brunate funicular on Lake Como. Como - The Cathedral Begun in 1396, the Cathedral of Como is the last of the Gothic cathedrals built in Lombardy. In the three and a half centuries it took on its definitive realization that appealed even if the dominant styles is the original late Gothic-Renaissance. Basilica San Fedele The magnificent Romanesque Basilica of San Fedele in Como, built around 1120 on early medieval foundation, stands the charming Piazza San Fedele was medieval commercial center and home of citizens of the grain market. The church contains fragments of frescoes from the fourteenth century and paintings of the sixteenth and seventeenth century. There are extensive descriptions and photos of the attractions to use during your visit. The guide is ideal for use on your smart phone or your tablet, it contain active links to the web sites of train companies.
This thesis covers several theoretical aspects of WIMP (weakly interacting massive particles) dark matter searches, with a particular emphasis on colliders. It mainly focuses on the use of effective field theories as a tool for Large Hadron Collider (LHC) searches, discussing in detail the issue of their validity, and on simplified dark matter models, which are receiving a growing attention from the physics community. It highlights the theoretical consistency of simplified models, which is essential in order to correctly exploit their potential and for them to be a common reference when comparing results from different experiments. This thesis is of interest to researchers (both theorists and experimentalists) in the field of dark matter searches, and offers a comprehensive introduction to dark matter and to WIMP searches for students and non-experts.
(Amadeus). Drawing on the personal recollections of the Caruso brothers, archival material preserved by the family, and extensive research, this book is a rare tribute to to the man and his vocal legacy. This abridged edition includes the full original text covering Caruso's life and death, plus a current discography.
This book is a guide to Milan for a visit lasting two, three, or more days. There are extensive descriptions and photos of the attractions: museums, churches, nightlife, and other attractions. In addition, it includes descriptions of how to get to Milan, driving, parking in the city, and helpful info to stay there. The guide includes sections on day trips from Milan to visit Lake Como, Lake Maggiore, Portofino, and the art cities of Pavia, Bergamo Alta, and Vigevano. In addition, the guide contains sections covering single days or half days, so you can combine several areas depending on the length of your stay and your preference of what to see.
To most Italians, Milan is the unofficial capital of Italy and arguably the most interesting city in the country, where old and new meet in an ever-changing relationship. For all the places I list, I give you the URL of the website where you find more detailed information. Google gives you in the most relevant positions the websites of the companies spending more on advertising with them, not necessarily the ones that have the correct information. If you search for the opening hours of a certain basilica, for example, you could get something saying that they highly recommend a reservation, while entrance to the basilica is, in fact, always FREE. It's the website of a tour operator that invests in Google advertising to gain visibility. I give you unbiased, ad-free, accurate information. Milan is Italy's powerhouse, where the money is made. Money brings people, people create vibe and energy: Milan is the place where "things happen". Milan is internationally famous for its fashion and design, of course.
It is no mistake that Bellagio is called the "pearl" of Lake Como. It is undoubtedly the most famous resort on the lake. For centuries, Bellagio's scenic location has enchanted artists and writers, not only from Italy but also from abroad. It is situated on the tip of a headland that divides the lake into the two legs of Como and Lecco. The town stretches along the coast, and part of it goes up the slopes of the peninsula. Because of its location Bellagio has a great variety of views; indeed, it offers a good view of the whole lake. On the northern horizon, one can see the Pre-Alps. Some of the best views can be seen from the top of Monte San Primo and from the park of Villa Serbelloni. On a particularly bright day, one can make out the Alps, from Mont Blanc to the Ortles, and the Madonnina on top of the Duomo of Milan. Both the historic center situated at a higher level dominated by the Romanesque Basilica Of San Giacomo (enlarged in the Baroque Age) and the more recent arcade lake-front are all preserved intact. Among the aristocratic villas let's remember Villa Serbelloni, first castle, then country residence and transformed into a villa at the end of the 15th century. Later once again restructured in the 17th and turned into a hotel during the last decade of the 19th century, it is presently appointed headquarters of conventions and study tours. This guide covers Bellagio on Lake Como, from Lecco – Varenna, or, in an alternative, via Como. It covers also day trips with public transportation with the boats to towns and attractions on the lake. There are extensive descriptions and photos of the attractions. This guide contains many reviews for the best-recommended restaurants that are at walking distance from the boat pier or the train station. P { margin-bottom: 0.08in; }
This book discusses regular powers and symbolic powers of ideals from three perspectives– algebra, combinatorics and geometry – and examines the interactions between them. It invites readers to explore the evolution of the set of associated primes of higher and higher powers of an ideal and explains the evolution of ideals associated with combinatorial objects like graphs or hypergraphs in terms of the original combinatorial objects. It also addresses similar questions concerning our understanding of the Castelnuovo-Mumford regularity of powers of combinatorially defined ideals in terms of the associated combinatorial data. From a more geometric point of view, the book considers how the relations between symbolic and regular powers can be interpreted in geometrical terms. Other topics covered include aspects of Waring type problems, symbolic powers of an ideal and their invariants (e.g., the Waldschmidt constant, the resurgence), and the persistence of associated primes.
William Lloyd Garrison and Giuseppe Mazzini, two of the foremost radicals of the nineteenth century, lived during a time of profound economic, social, and political transformation in America and Europe. Both born in 1805, but into dissimilar family backgrounds, the American Garrison and Italian Mazzini led entirely different lives -- one as a citizen of a democratic republic, the other as an exile proscribed by most European monarchies. Using a comparative analysis, Enrico Dal Lago suggests that Garrison and Mazzini nonetheless represent a connection between the egalitarian ideologies of American abolitionism and Italian democratic nationalism. Focusing on Garrison's and Mazzini's activities and transnational links within their own milieus and in the wider international arena, Dal Lago shows why two nineteenth-century progressives and revolutionaries considered liberation from enslavement and liberation from national oppression as two sides of the same coin. At different points in their lives, both Garrison and Mazzini demonstrated this belief by concurrently supporting the abolition of slavery in the United States and the national revolutions in Italy. The two meetings Garrison and Mazzini had, in 1846 and in 1867, served to reinforce their sense that they somehow worked together toward the achievement of liberty not just in the United States and Italy, but also in the Atlantic and Euro-American world as a whole. In the end, the abolition of American slavery led to Garrison's consecration, while the new Italian kingdom forced Mazzini into exile. Despite these different outcomes, Garrison and Mazzini both attracted legions of devoted followers who believed these men personified the radical causes of the nations to which they belonged.
This is a guide to a multi-days trip in the Alsp and lakes of Northern Italy. It starts from Turin, then it goes to Aosta, Courmayeur and the Aosta Valley. It goes then to the lakes region, touching Orta Lake, Stresa on Lake Maggiore, driving on the west coast of the lake with a visit to Villa Taranto, to continue to Lugano and the Como and Lake Como: Villa Carlotta, Menaggio, Bellagio, Varenna and Lecco. The itinerary ends with a visit to Milan. There are extensive descriptions and color photos of the attractions. It is ideal for use on your smart phone, it contains active links to the web sites of many reviews for the best recommended restaurants that are at the location described. There are active links to the review pages, you can use them if you have an active Internet connection, but, if you don’t, you have the basic information ready: the name, address and telephone number are included in the guide.
This is a guide to a multi-days trip in the Alsp and lakes of Northern Italy. It starts from Turin, then it goes to Aosta, Courmayeur and the Aosta Valley. It goes then to the lakes region, touching Orta Lake, Stresa on Lake Maggiore, driving on the west coast of the lake with a visit to Villa Taranto, to continue to Lugano and the Como and Lake Como: Villa Carlotta, Menaggio, Bellagio, Varenna and Lecco. The itinerary ends with a visit to Milan. There are extensive descriptions and color photos of the attractions. It contains many reviews for the best recommended restaurants that are at the location described. You have the basic information ready: the name, address and telephone number are included in the guide together with the review.
This is a guide to a multi-days trip in the lakes of Northern Italy. It starts from Novara then it goes to the lakes region, touching Orta Lake, Stresa on Lake Maggiore, driving on the west coast of the lake with a visit to Villa Taranto, to continue to Lugano and the Como and Lake Como: Villa Carlotta, Menaggio, Bellagio, Varenna and Lecco. The itinerary ends at Milan. There are extensive descriptions and photos of the attractions. It contains many reviews for the best recommended restaurants that are at the location described, you have the basic information ready: the name, address and telephone number are included in the guide together with the review.
Inborn errors of metabolism may impact on muscle and peripheral nerve. Abnormalities involve mitochondria and other subcellular organelles such as peroxisomes and lysosomes related to the turnover and recycling of cellular compartments. Treatable causes are β-oxidation defects producing progressive neuropathy; pyruvate dehydrogenase deficiency, porphyria, or vitamin B12 deficiency causing recurrent episodes of neuropathy or acute motor deficit mimicking Guillain–Barré syndrome. On the other hand, lysosomal (mucopolysaccharidosis, Gaucher and Fabry diseases), mitochondriopathic (mitochondrial or nuclear mutations or mDNA depletion), peroxisomal (adrenomyeloneuropathy, Refsum disease, sterol carrier protein-2 deficiency, cerebrotendinous xanthomatosis, α-methylacyl racemase deficiency) diseases are multisystemic disorders involving also the heart, liver, brain, retina, and kidney. Pathophysiology of most metabolic myopathies is related to the impairment of energy production or to abnormal production of reactive oxygen species (ROS). Main symptoms are excercise intolerance with myalgias, cramps and recurrent myoglobinuria or limb weakness associated with elevation of serum creatine kinase. Carnitine palmitoyl transferase deficiency, followed by acid maltase deficiency, and lipin deficiency, are the most common cause of isolated rhabdomyolysis. Metabolic myopathies are frequently associated to extra-neuromuscular disorders particularly involving the heart, liver, brain, retina, skin, and kidney.
This book summarises the results of field research—including historical, historico-religious and papyrological studies—conducted on the archaeological site of Bakchias, located in the north-eastern part of the Fayyūm region. The book provides a clear and comprehensive overview of the rise and fall of the kome of Bakchias.
Joubert syndrome (JS) is a rare autosomal recessive condition characterized by a peculiar midbrain-hindbrain malformation, known as the molar tooth sign (MTS). The neurological presentation of JS includes hypotonia that evolves into ataxia, developmental delay, abnormal eye movements, and neonatal breathing abnormalities. This picture is often associated with variable multiorgan involvement, mainly of the retina, kidneys, and liver, defining a group of conditions termed Joubert syndrome and related disorders (JSRDs), that share the MTS. To date, 16 causative genes have been identified, all encoding for proteins expressed in the primary cilium or its apparatus. Indeed, JSRD present clinical and genetic overlap with a growing field of disorders due to mutations in ciliary proteins, that are collectively known as “ciliopathies.” These include isolated nephronophthisis, Senior–Løken syndrome, Bardet–Biedl syndrome and, in particular, Meckel syndrome, which is allelic at JSRD at seven distinct loci. Significant genotype-phenotype correlates are emerging between specific clinical presentations and mutations in JSRD genes, with relevant implications in terms of molecular diagnosis, clinical follow-up, and management of mutated patients. Moreover, the identification of mutations allows early prenatal diagnosis in couples at risk, while fetal neuroimaging may remain uninformative until the late second trimester of pregnancy.
This is a guide to Milan, for a visit lasting two, three or more days. It includes two sections on the lakes near Milan: Lake Como and Lake Maggiore. This guide covers the Lake Como, and the towns of Como, Bellagio, Menaggio and Varenna, in addition to the one-day trips you can make from one of these towns to Piona, Villa Carlotta and Villa del Balbianello. This guide covers the Lake Maggiore, and the town of Stresa in addition to the one-day trips you can make from one of these towns to the Borromean Islands, the Angera castle, Locarno, Mottarone, Villa Taranto and the Centovalli railway. There are extensive descriptions and photos of the attractions: museums, churches, nightlife and other attractions. There are descriptions on how to get to Milan, on driving and parking in the city, useful info to stay there. There are reviews of several restaurants.
NMR of Paramagnetic Molecules: Applications to Metallobiomolecules and Models, Second Edition is a self-contained, comprehensive reference for chemists, physicists, and life scientists whose research involves analyzing paramagnetic compounds. Since the previous edition of this book was published, there have been many advancements in the field of paramagnetic NMR spectroscopy. This completely updated and expanded edition contains the latest fundamental theory and methods for mastery of this analytical technique. Users will learn how to interpret the NMR spectra of paramagnetic molecules, improve experimental techniques, and strengthen their understanding of the underlying theory and applications. - Reflects all advances in the field in a completely updated new edition - Presents new material on self-orientation residual dipolar couplings, solid state NMR, dynamic nuclear polarization, and paramagnetic restraints for structure calculations - Includes information relevant to paramagnetic molecules, metallobiomolecules, paramagnetic compounds, and paramagnetic NMR spectroscopy - Presents specific examples of paramagnetic inorganic species and experimental techniques for structure characterization
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