The information given in this book tries to capture the essence of the sheer dynamicity of the cell along with useful tips on how to address critical rate limiting steps in the process of exploration and investigation of its capacity to regenerate, rebuild and replenish from within. The definitions of stem cells, stemness, and the niche concept continue to undergo revisions. In adult vertebrates, hematopoietic and some non-hematopoietic progenitors are synthesized within specialized niches of bone marrow. They migrate to designated tissues, and are either trans-differentiated or become quiescent and settle down. These form the stem cell niche reservoir in all tissues. Not only the primary hematopoietic tissue but all organs and tissues are also capable of generating progenitors which are either synthesized from these migrants or are direct recruits from other tissues. In the niches, the cells settle down and await their turn to either make more clones like themselves or differentiate and mobilize in an exigency. Thus progenitors are important reserves, to be multiplied and deployed or travel as important message bearing molecules via blood as circulating progenitors which can home to their allocated destinations. Upon reaching, specific integrins and selectins help them “dock” and “port” and they may be reprogrammed to induce further differentiation and help repopulate the denuded tissue. In pulmonary fibrosis and asthma, progenitors from both systemic circulation and local stem cell niches have been found to participate in the myriad ramifications of repair, replacement and regeneration of lost or diseased tissue. Whether they are lung specific or global in origin and role remain to be explored. Research tools, fundamental concepts, techniques, methodologies and standard operating protocols and animal models and human extrapolations, have been discussed in a concise way along with detailed description and discussion on the appropriate rationale to introduce the subject to the casual reader and provide valuable tactical information to the specialist in Regenerative Medicine. I sincerely hope you enjoy the work and appreciate the hard work that has gone into designing and executing elegant experiments by many researchers in the field. The branch is multi-disciplinary and I hope that the readers will not be limited to biologists alone.
“Perspectives in Inflammation Biology” outlines detailed studies using preclinical murine models in Inflammation. The book is meant for academicians, industry persons, research scholars and students alike. The detailed perspective for a beginner and the exhaustive methodologies and analyses outlined, for the veteran researcher, makes this book a unique link between someone who is thinking of embarking on a study of inflammation and one who is delving deep into this area of specialization. The book deals with asthma and allergy as specific disease areas of inflammation of the lung, aseptic peritonitis as a disease of systemic inflammation and details how each role player in its pathophysiology has a unique niche of activity. Data acquisition, sequentiality and analyses in context demonstrate how each role player is validated systematically to become a target for drug discovery. Methods and models used in the course of my work and their relevance will demonstrate to the researcher how a study can be developed from an idea. Further into a researcher’s ongoing work, this book is meant to stimulate new questions and pave ways for better dissection of a phenomenon. The highlights of this book are the detailed tables tabulating sub species of immune cells, their inflammatory recruitment indices, their translation into tissue-to-tissue traffic of the inflammatory stimulus and the delicate interplay of resident structural cells, cells recruited from circulation, their feedback poiesis in bone marrow, their instruction in the lymphoid organs and tissues as well as the non-cellular mediators synthesized from corresponding genetic instruction. The book shall definitely help students and researchers how a disease can be simplified from its complex ramifications and network of implications and put back into perspective and the whole thing falls into place without an intimate understanding of the mechanism and the compelling circumstances that causes a disease, a drug hunter cannot hope to begin her quest. To find the “Achilles’ heel” and effectively neutralize the enemy!
The present book addresses the multi-disciplinary nature of Translational Outcomes Research, which is a watershed for nearly all the disciplines of Life and Health Sciences, along with the Materials Sciences including but not limited to Zoology, Botany, Microbiology, Biochemistry, Physiology, Nanotechnology, the Medical Sciences, Bioengineering, Biophysics, Medicinal Chemistry, Structural Biology, Biostatistics and Bioinformatics. This book, for the first time, addresses the basic premises of fundamental research in facilitating drug discovery. One chapter is dedicated to a novel generation of platforms with novel camelid antibodies and their technological extensions, while another focuses on functional food and nutraceuticals. The book begins with a thorough overview of what translational outcomes research connotes and what the current status of research in the area is, and goes on to elucidate various pertinent preclinical disease models and their uses in basic and application based research in the Life Sciences. How basic approaches to screening and characterization vis-à-vis their role in amelioration of the two cardinal problems of inflammation and degeneration involved in most diseases is elucidated. The book ends with a discussion of the relevance and importance of using Bio Green technology in Translational Outcomes, addressing the need to fill the gap between academia and industry and clinics that can arise through direct or indirect collaboration between the stakeholders and emphasizing the need for an eco-friendly approach so as not to jeopardize the fine balance that holds life on earth in harmony.
During the last few years several immunotherapies have been shown to induce clinical response and/or improve the clinical outcome in a significant number of cancer patients. However, the lack of a human-centered translational approach has led to the accumulation of a multitude of disjointed clinical and basic researches with a consequent disharmonic growth of the scientific knowledge. The huge number of non-evidence-based conjectural hypotheses has competitively interacted with the few evidence-based hypotheses generated by studies conducted in humans leading to the accumulation of several clinical breakdowns and few “mysterious” successes. In the last decade, the availability of high-throughput gene expression profiling has led to the development of novel discovery-driven approaches capable of investigating the tumor/host integration in its globality. Here, we describe in detail gene expression profiling studies that have led to the formulation of a new generation of evidence-based hypotheses explaining the structural basis of the immune-mediated tumor rejection following immunotherapy.
**American Journal of Nursing (AJN) Book of the Year Awards, 1st Place in Critical Care- Emergency Nursing, 2023** **Selected for Doody's Core Titles® 2024 in Emergency Care** Sheehy's Manual of Emergency Care, 8th Edition offers complete, up-to-date coverage of the essentials emergency nurses need to know. Each condition commonly seen in the emergency setting is thoroughly addressed, from signs and symptoms, to diagnosis, treatment, developmental considerations, patient education, and more. Updated material and easy-to-reference contents make this resource a must-have for current practice. - Quick-reference format is ideal for updating emergency nursing knowledge and improving patient care. - Detailed discussions for each condition include signs and symptoms, diagnosis/diagnostic testing, treatment/interventions, age/developmental considerations, and patient/family education/discharge instructions. - Authorship from the Emergency Nurses Association for more than 30 years ensures this book is a mainstay for best practices in emergency nursing. - Content presented in a bulleted format provides quick and easy access to vital information. - Practice points highlighted in special boxes offer quick reference to important content. - NEW! Restructured table of contents presents anatomically related medical and trauma chapters sequentially for quick reference. - NEW! Considerations for critical care in the ED. - NEW! Considerations for the transgender patient. - NEW! Section on human trafficking in the Interpersonal Violence and Abuse chapter. - NEW! Section on violent risk assessment in the Workplace Violence chapter. - NEW! Color photos insert visually highlights and clarifies key content. - EXPANDED! Substance Abuse and Addiction Emergencies chapter covers methamphetamines, bath salts, marijuana edibles, opioid abuse/prescription drug abuse, heroin/Narcan, and substance abuse disorder. - EXPANDED! Chapter on end-of-life includes information on palliative care considerations. - UPDATED! Infectious Diseases chapter addresses coronavirus 19 (COVID-19), Ebola, and vector-borne malaria.
An analytic and historical perspective of literary texts to understand the position of domestic workers in South Africa More than a million black South African women are domestic workers. Precariously situated between urban and rural areas, rich and poor, white and black, these women are at once intimately connected and at a distant remove from the families they serve. Ena Jansen shows that domestic worker relations in South Africa were shaped by the institution of slavery, establishing social hierarchies and patterns of behavior that persist today. To support her argument, Jansen examines the representation of domestic workers in a diverse range of texts in English and Afrikaans. Authors include André Brink, JM Coetzee, Imraan Coovadia, Nadine Gordimer, Elsa Joubert, Antjie Krog, Sindiwe Magona, Kopano Matlwa, Es'kia Mphahlele, Sisonke Msimang, Zukiswa Wanner and Zoë Wicomb. Like Family is an updated version of the award-winning Soos familie (2015) and the highly-acclaimed 2016 Dutch translation, Bijna familie.
This groundbreaking volume is an extraordinarily compelling and superbly well-annotated depiction of the birth of the Abolition Movement in North America in one extraordinary community: Germantown and its environs in Southeastern Pennsylvania, from the Colonial Period through the Civil War. The author presents a rich tapestry of vignettes, exhaustively researched, to illustrate the contributions of abolitionists whose agency fueled Abolitionism.
Presenting real-life case studies of child sexual abuse in the Caribbean as a basis for discussing interventions and models of practice that are relevant for a wide range of cultural and social settings, this multi-disciplinary text will be of interest to scholars, professionals and practitioners alike. Contributors to this volume demonstrate how sexual abuse is never just a problem of the individual: structures of inequality and the intersection of the factors they give rise to help to explain why some children are more at risk of abuse than others. Furthermore, the sub-systems in which lives are lived can compound risk and vulnerability or alternatively, can be sources of support and change. This book draws on these ideas to discuss practice across a range of service users: children, adolescent girls, teenage mothers, children with learning disabilities, fathers, mothers, women who abuse, juvenile sex offenders and children in residential care. p>
This book discusses the mechanisms leading to immune-mediated tissue rejection following the hypothesis that independent of the disease process the final effector mechanism is shared by most (but not all) pathologies and it is relatively simple. The book covers evidence gathered to support the thesis by studies performed in humans during rejection or in experimental models and will focus particularly (but not exclusively) on the analysis of the rejected tissue rather than the systemic circulation. Several disease processes are discussed including example of chronic inflammatory process without resolution of the pathologic process and acute one with resolution of the pathologic process (clearance of pathogen, rejection of tumor) or unwanted tissue destruction (allograft rejection, autoimmunity).
Proceedings of the 20th annual conference for the Australasian Association for Engineering Education, held at the University of Adelaide in December 2009. Papers were presented by Australian and international delegates. The conference was focused on the engineering curriculum in higher education.
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