It's time for the Cultural Festival--an event that could change Makoto's life for good! Makoto's father has invited the toughest critics he could find to judge his son's acting talent. If they say he has the skills to become a professional actor, Makoto will not only get out of his obligation to run the family dojo, he will also be free of his arranged fiancée, Takayo. But his big audition may be ruined when Nobuko is taken hostage by bank robbers and the Festival is cancelled... -- VIZ Media
Creepy Sakamoto is looking for a girlfriend, and he wouldn't mind dating Ito or Makoto! Then Makoto's sister Tsubaki is brought in to Sakura High--she's says it's to be a teacher, but is it actually to be a spy for Makoto's father? It looks like Makoto and Ito have a few high hurdles to jump before they see the finish line! -- VIZ Media
It's finally graduation time! Having fulfilled all of his father's conditions, Makoto no longer has to disguise himself as a woman. Unfortunately, all the trouble hasn't ended for he and Ito. Her family is having a hard time accepting her as an adult who can make her own decisions...and will they accept Makoto as a man?! This heartwarming finale to the series includes a special episode that shows what Ito and Makoto are up to a year after they graduate! -- VIZ Media
A trip to Hokkaido sends Ito into the arms of a brand new paramour. Then, Makoto's dysfunctional family secrets are revealed when his oldest sister returns home. It turns out Makoto is not the only rebel in the family! -- VIZ Media
Family ties deepen when Makoto's sister Akane invites Ito's brother Yûto to a fireworks display--could another romance be about to explode? And now, with just seven months left until graduation, Makoto's acting ambition is threatened again. His father, becoming increasingly desperate to ensure that his son return home to inherit the family dojo, enlists the aid of Makoto's arranged fiancée Takayo and her devious brother. Will they succeed in thwarting Makoto's dream? -- VIZ Media
Sixteen-year-old tomboy Ito Miura has been chosen to play Romeo in Romeo and Juliet! The problem? She doesn't want the male role! So, who will be Juliet? The favorite for the part, beautiful and vain Tsugumi, must compete with the cute new transfer student, Makoto Amano. But Makoto has a secret, and if rival Tsugumi, or anyone in the school, finds out, it could ruin Makoto's life, dragging Ito down as well! -- VIZ Media
Graduation is only months away, and keeping Makoto's gender a secret is more challenging than ever! Since Makoto's father is dead-set against his son's choice of profession, he has decided not to attend the graduation ceremony. But Ito is intent on strengthening the bond between Makoto and his father. She convinces Makoto to spend the New Year's holiday with his family in the hope that the pigheaded patriarch will change his mind. Makoto is quite confident in his acting skills, but will his persuasive abilities measure up? -- VIZ Media
At the Drama Club's summer training camp, Ito reunites with Jôtaro, a childhood friend who is the son of a well-known actor. Though he bullied Ito as a tot, Jôtaro is repentant--and Makoto suspects his affection goes beyond friendship. Three is a crowd where love is concerned, and Makoto wants Ito to tell Jôtaro she's already taken. But that task turns out to be a bit difficult... -- VIZ Media
A high school field trip to an amusement park has Ito and Makoto switching clothes just to hang out together, and their friendship is threatened when a classmate sees through the ruse. Later, back in the drama-club, cute new student Kohei is determined to win the "woman" of his dreams: Makoto! -- VIZ Media
Makoto's 18th birthday is just around the corner and Ito hopes that her present, a caramel flan, will do what her horoscope promised and capture his heart. She brings the dessert to his party as a surprise--but ends up getting some surprises there herself! More romance abounds as the relationships between Ito's brother Yûto and Makoto's sister Akane--and between their friends Yoshirô and Misaki--undergo dramatic new developments. -- VIZ Media
This book introduces readers to copula-based statistical methods for analyzing survival data involving dependent censoring. Primarily focusing on likelihood-based methods performed under copula models, it is the first book solely devoted to the problem of dependent censoring. The book demonstrates the advantages of the copula-based methods in the context of medical research, especially with regard to cancer patients’ survival data. Needless to say, the statistical methods presented here can also be applied to many other branches of science, especially in reliability, where survival analysis plays an important role. The book can be used as a textbook for graduate coursework or a short course aimed at (bio-) statisticians. To deepen readers’ understanding of copula-based approaches, the book provides an accessible introduction to basic survival analysis and explains the mathematical foundations of copula-based survival models.
Makoto's doting sister Tsubaki finds out that Makoto hasn't kept his secret from Ito! She threatens to tell Makoto's father unless Makoto and Ito's homeroom can win a school competition. Then Makoto accompanies the entire Miura household to their ancestral home to meet Ito's eccentric, sharp-witted grandmother. Little does Ito know that her past will catch up with her there...literally! -- VIZ Media
This book introduces readers to statistical methodologies used to analyze doubly truncated data. The first book exclusively dedicated to the topic, it provides likelihood-based methods, Bayesian methods, non-parametric methods, and linear regression methods. These procedures can be used to effectively analyze continuous data, especially survival data arising in biostatistics and economics. Because truncation is a phenomenon that is often encountered in non-experimental studies, the methods presented here can be applied to many branches of science. The book provides R codes for most of the statistical methods, to help readers analyze their data. Given its scope, the book is ideally suited as a textbook for students of statistics, mathematics, econometrics, and other fields.
Makoto's father is trying to force Akane into an arranged marriage, and to help Makoto, she's willing to do it! But can Makoto allow his sister to marry a man she doesn't even know so that he can get a chance to make a life for himself as an actor? And who is that handsome man who is always there to come to Akane's rescue? Then, Tsugumi invites Ito to the beach, and the whole gang comes along for an adventure so bizarre, it must be a dream. Or is it? -- VIZ Media
This book introduces readers to advanced statistical methods for analyzing survival data involving correlated endpoints. In particular, it describes statistical methods for applying Cox regression to two correlated endpoints by accounting for dependence between the endpoints with the aid of copulas. The practical advantages of employing copula-based models in medical research are explained on the basis of case studies. In addition, the book focuses on clustered survival data, especially data arising from meta-analysis and multicenter analysis. Consequently, the statistical approaches presented here employ a frailty term for heterogeneity modeling. This brings the joint frailty-copula model, which incorporates a frailty term and a copula, into a statistical model. The book also discusses advanced techniques for dealing with high-dimensional gene expressions and developing personalized dynamic prediction tools under the joint frailty-copula model. To help readers apply the statistical methods to real-world data, the book provides case studies using the authors’ original R software package (freely available in CRAN). The emphasis is on clinical survival data, involving time-to-tumor progression and overall survival, collected on cancer patients. Hence, the book offers an essential reference guide for medical statisticians and provides researchers with advanced, innovative statistical tools. The book also provides a concise introduction to basic multivariate survival models.
Makoto has a fever, and his closest friends' concern over his sickness may be the very thing that reveals Makoto's secret to his classmates--forcing him to give up his dreams and return home! Then Ito is caught on the grounds of the Narita residence by Makoto's father, and her life is in the hands of fate! Even if Makoto is able to make it to the scene in time, can he stop the very man who taught him to fight from attacking the woman he loves?! -- VIZ Media
This book provides statistical methodologies for time series data, focusing on copula-based Markov chain models for serially correlated time series. It also includes data examples from economics, engineering, finance, sport and other disciplines to illustrate the methods presented. An accessible textbook for students in the fields of economics, management, mathematics, statistics, and related fields wanting to gain insights into the statistical analysis of time series data using copulas, the book also features stand-alone chapters to appeal to researchers. As the subtitle suggests, the book highlights parametric models based on normal distribution, t-distribution, normal mixture distribution, Poisson distribution, and others. Presenting likelihood-based methods as the main statistical tools for fitting the models, the book details the development of computing techniques to find the maximum likelihood estimator. It also addresses statistical process control, as well as Bayesian and regression methods. Lastly, to help readers analyze their data, it provides computer codes (R codes) for most of the statistical methods.
Makato must spend the last two years of high school posing as a girl in order to fulfill his dream of becoming an actor, which confuses things with a good friend at school when she finds out.
It's finally graduation time! Having fulfilled all of his father's conditions, Makoto no longer has to disguise himself as a woman. Unfortunately, all the trouble hasn't ended for he and Ito. Her family is having a hard time accepting her as an adult who can make her own decisions ... and will they accept Makoto as a man?! This heartwarming finale to the series includes a special episode that shows what Ito and Makoto are up to a year after they graduate!
This book introduces readers to advanced statistical methods for analyzing survival data involving correlated endpoints. In particular, it describes statistical methods for applying Cox regression to two correlated endpoints by accounting for dependence between the endpoints with the aid of copulas. The practical advantages of employing copula-based models in medical research are explained on the basis of case studies. In addition, the book focuses on clustered survival data, especially data arising from meta-analysis and multicenter analysis. Consequently, the statistical approaches presented here employ a frailty term for heterogeneity modeling. This brings the joint frailty-copula model, which incorporates a frailty term and a copula, into a statistical model. The book also discusses advanced techniques for dealing with high-dimensional gene expressions and developing personalized dynamic prediction tools under the joint frailty-copula model. To help readers apply the statistical methods to real-world data, the book provides case studies using the authors' original R software package (freely available in CRAN). The emphasis is on clinical survival data, involving time-to-tumor progression and overall survival, collected on cancer patients. Hence, the book offers an essential reference guide for medical statisticians and provides researchers with advanced, innovative statistical tools. The book also provides a concise introduction to basic multivariate survival models.
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