Enterohemorrhagic Escherichia coli (EHEC) can cause food-borne disease outbreaks associated with contaminated beef or fresh produce, resulting in diarrhea, hemorrhagic colitis, and/or hemolytic uremic syndrome: the triad of anemia, thrombocytopenia, and renal failure. Intestinally colonized cattle are a major source of human infection. Upon colonic infection, EHEC utilizes a type III secretion system to translocate into mammalian cells bacterial effector proteins that target cellular functions such as epithelial barrier integrity, vesicular transport, and cytoskeletal structure. Translocated effectors induce ‘attaching and effacing’ lesions, characterized by microvillar effacement, intimate attachment, and actin ‘pedestal’ formation beneath bound bacteria. Systemic disease relies on the production of Shiga toxin, a potent inhibitor of ribosome function that triggers cell death, inflammation, and vascular damage. Most current therapies are only supportive in nature because antibiotic treatment may increase Shiga toxin production. Therefore, outbreak prevention, early diagnosis, and the development of new therapeutic strategies are critical.
Thought about lying and perjury became increasingly practical from the end of the twelfth century in Western Europe. At this time, a distinctive way of thinking about deception and false oaths appeared in the schools of Paris and Bologna, most notably in the Summa de Sacramentis et Animae Consiliis of Peter the Chanter. This kind of thought was concerned with moral dilemmas and the application of moral rules in exceptional cases. It was a tradition which continued in pastoral writings of the thirteenth century, the practical moral questions addressed by theologians in universities in the second half of the thirteenth century, and in the Summae de Casibus Conscientiae of the late Middle Ages. Lying and Perjury in Medieval Practical Thought argues that medieval practical ethics of this sort can usefully be described as casuistry - a term for the discipline of moral theology that became famous during the Counter-Reformation. This can be seen in the origins of the concept of equivocation, an idea that was explored in medieval literature with varying degrees of moral ambiguity. From the turn of the thirteenth century, the concept was adopted by canon lawyers and theologians, as a means of exploring questions about exceptional situations in ethics. It has been assumed in the past that equivocation, and the casuistry of lying was an academic discourse invented in the sixteenth century in order to evade moral obligations. This study reveals that casuistry in the Middle Ages was developed in ecclesiastical thought as part of an effort to explain how to follow moral rules in ambiguous and perplexing cases.
Hyacinthe Dancy knows better than to get in Lord Norwood’s path, as he is well-known to be a charming rake. But when his lordship proposes to destroy the delightful village where her dearest friend lives, merely for the sake of improving his view, Hyacinthe cannot avoid confronting him. And being in his path is a decidedly dangerous place to be…for one’s heart. Regency Romance by Emily Hendrickson; originally published by Signet
This book introduces human factors engineering (HFE) principles, guidelines, and design methods for medical device design. It starts with an overview of physical, perceptual, and cognitive abilities and limitations, and their implications for design. This analysis produces a set of human factors principles that can be applied across many design challenges, which are then applied to guidelines for designing input controls, visual displays, auditory displays (alerts, alarms, warnings), and human-computer interaction. Specific challenges and solutions for various medical device domains, such as robotic surgery, laparoscopic surgery, artificial organs, wearables, continuous glucose monitors and insulin pumps, and reprocessing, are discussed. Human factors research and design methods are provided and integrated into a human factors design lifecycle, and a discussion of regulatory requirements and procedures is provided, including guidance on what human factors activities should be conducted when and how they should be documented. This hands-on professional reference is an essential introduction and resource for students and practitioners in HFE, biomedical engineering, industrial design, graphic design, user-experience design, quality engineering, product management, and regulatory affairs. Teaches readers to design medical devices that are safer, more effective, and less error prone; Explains the role and responsibilities of regulatory agencies in medical device design; Introduces analysis and research methods such as UFMEA, task analysis, heuristic evaluation, and usability testing.
The Sonoran Desert, a fragile ecosystem, is under ever-increasing pressure from a burgeoning human population. This ecological atlas of the region's plants, a greatly enlarged and full revised version of the original 1972 atlas, will be an invaluable resource for plant ecologists, botanists, geographers, and other scientists, and for all with a serious interest in living with and protecting a unique natural southwestern heritage. An encyclopedia as well as an atlas, this monumental work describes the taxonomy, geographic distribution, and ecology of 339 plants, most of them common and characteristic trees, shrubs, or succulants. Also included is valuable information on natural history and ethnobotanical, commercial, and horticultural uses of these plants. The entry for each species includes a range map, an elevational profile, and a narrative account. The authors also include an extensive bibliography, referring the reader to the latest research and numerous references of historical importance, with a glossary to aid the general reader. Sonoran Desert Plants is a monumental work, unlikely to be superseded in the next generation. As the region continues to attract more people, there will be an increasingly urgent need for basic knowledge of plant species as a guide for creative and sustainable habitation of the area. This book will stand as a landmark resource for many years to come.
Refining adult-focused perspectives on medieval rulership, Emily Joan Ward exposes the problematic nature of working from the assumption that kingship equated to adult power. Children's participation and political assent could be important facets of the day-to-day activities of rule, as this study shows through an examination of royal charters, oaths to young boys, cross-kingdom diplomacy and coronation. The first comparative and thematic study of child rulership in this period, Ward analyses eight case studies across northwestern Europe from c.1050 to c.1250. The book stresses innovations and adaptations in royal government, questions the exaggeration of political disorder under a boy king, and suggests a ruler's childhood posed far less of a challenge than their adolescence and youth. Uniting social, cultural and political historical methodologies, Ward unveils how wider societal changes between the eleventh and thirteenth centuries altered children's lived experiences of royal rule and modified how people thought about child kingship.
The ladies of the Mayfair Orchid and Exotic Plant Society are known for a bit of friendly rivalry, but the backstabbing has never been literal--until now. When Hiram Filmore, an orchid hunter and supplier, is found dead in Mrs. Helena Rayburn's conservatory, Inspector Witherspoon is called in to weed out a murderer. When it comes out that Mrs. Rayburn and her flowery friend knew each other from long ago, Mrs. Jeffries begins to suspect that there's more to unearth about this case. Now she, along with the rest of Inspector Witherspoon's household and friends, will have to dig up the past to figure out which gardening gentlewoman had a grudge worth killing for..."--Page 4 of cover.
In the seventeenth century, English economic theorists lost interest in the moral status of exchange and became increasingly concerned with the roots of national prosperity. This shift marked the origins of classical political economy and provided the foundation for the contemporary discipline of economics. The seventeenth-century revolution in economic thought fundamentally reshaped the way economic processes have been interpreted and understood. In Trade and Nation, Emily Erikson brings together historical, comparative, and computational methods to explain the institutional forces that brought about this transformation. Erikson pinpoints how the rise of the company form in confluence with the political marginalization of English merchants created an opening for public argumentation over economic matters. Independent merchants, who were excluded from state institutions and vast areas of trade, confronted the power and influence of crown-endorsed chartered companies. Their distance from the halls of government drove them to take their case to the public sphere. The number of merchant-authored economic texts rose as members of this class sought to show that their preferred policies would contribute to the benefit of the state and commonwealth. In doing so, they created and disseminated a new moral framework of growth, prosperity, and wealth for evaluating economic behavior. By using computational methods to document these processes, Trade and Nation provides both compelling evidence and a prototype for how methodological innovations can help to provide new insights into large-scale social processes.
From the author of Expecting Better, The Family Firm, and The Unexpected an economist's guide to the early years of parenting. “Both refreshing and useful. With so many parenting theories driving us all a bit batty, this is the type of book that we need to help calm things down.” —LA Times “The book is jampacked with information, but it’s also a delightful read because Oster is such a good writer.” —NPR With Expecting Better, award-winning economist Emily Oster spotted a need in the pregnancy market for advice that gave women the information they needed to make the best decision for their own pregnancies. By digging into the data, Oster found that much of the conventional pregnancy wisdom was wrong. In Cribsheet, she now tackles an even greater challenge: decision-making in the early years of parenting. As any new parent knows, there is an abundance of often-conflicting advice hurled at you from doctors, family, friends, and strangers on the internet. From the earliest days, parents get the message that they must make certain choices around feeding, sleep, and schedule or all will be lost. There's a rule—or three—for everything. But the benefits of these choices can be overstated, and the trade-offs can be profound. How do you make your own best decision? Armed with the data, Oster finds that the conventional wisdom doesn't always hold up. She debunks myths around breastfeeding (not a panacea), sleep training (not so bad!), potty training (wait until they're ready or possibly bribe with M&Ms), language acquisition (early talkers aren't necessarily geniuses), and many other topics. She also shows parents how to think through freighted questions like if and how to go back to work, how to think about toddler discipline, and how to have a relationship and parent at the same time. Economics is the science of decision-making, and Cribsheet is a thinking parent's guide to the chaos and frequent misinformation of the early years. Emily Oster is a trained expert—and mom of two—who can empower us to make better, less fraught decisions—and stay sane in the years before preschool.
A fascinating and novel exploration of the transformative role played by the American West in the development of modernism in the United States Drawing extensively from various disciplines including ethnology, geography, geology, and environmental studies, this groundbreaking book addresses shifting concepts of time, history, and landscape in relation to the work of pioneering American artists during the first half of the 20th century. Paintings, watercolors, and photographs by renowned artists such as Frederic Remington, Georgia O'Keeffe, Ansel Adams, Thomas Hart Benton, Dorothea Lange, and Jackson Pollock are considered alongside American Indian ledger drawings, tempuras, and Dineh sandpaintings. Taken together, these works document the quest to create a specifically American art in the decades prior to World War II. The Modern West begins with a captivating meditation on the relationship between human culture and the physical landscape by Barry Lopez, who traveled the West in the artists' footsteps. Emily Ballew Neff then describes the evolving importance of the West for American artists working out a radically new aesthetic response to space and place, from artist-explorers on the turn-of-the-century frontier, to visionaries of a Californian arcadia, to desert luminaries who found in its stark topography a natural equivalent to abstraction. Beautifully illustrated and handsomely designed, this book is essential to anyone interested in the West and the history of modernism in American art.
Maternal Performance: Feminist Relations bridges the fields of performance, feminism, maternal studies, and ethics. It loosely follows the life course with chapters on maternal loss, pregnancy, birth, aftermath, maintenance, generations, and futures. Performance and the maternal have an affinity as both are lived through the body of the mother/artist, are played out in real time, and are concerned with creating ethical relationships with an other – be that other the child, the theatrical audience, or our wider communities. The authors contend that maternal performance takes the largely hidden, private and domestic work of mothering and makes it worthy of consideration and contemplation within the public sphere.
Mrs. Jeffries and Inspector Witherspoon should be checking off their Christmas present list but instead they're listing murder suspects in this latest entry of the beloved Victorian Mystery series. Harriet Andover had no intention of dying young like her silly siblings had. She intended to outlive them and outdo them as she always had. But Harriet discovers that the best intentions can lead to murder when she is strangled inside her mansion with a house full of holiday guests. As much as Inspector Witherspoon enjoys his job delivering justice, the last thing he wanted was a complicated murder case just a week before Christmas. He soon discovers that Harriet's own husband and grown stepchildren are not overcome with grief and neither are most of her friends. And to put the icing on the Christmas cookies, the room where Harriet's body was found was locked from the inside and she had the only key in her pocket. Mrs. Jeffries and the household have no intention of letting their inspector down and learn that Harriet's sister may have died from foul play as well. As the clues mount, this dedicated band of merry sleuths will not rest until they've delivered a stocking full of coal to a crafty killer.
From the beginning, Myrna Loy's screen image conjured mystery, a sense of something withheld. This first ever biography of the wry and sophisticated actress, best known for her role as Nora Charles in The Thin Man, offers an unprecedented picture of her life and a career that spanned six decades. Opening with Loy's rough-and-tumble upbringing in Montana, the book takes us to Los Angeles from the 1920s, through the thirties, when Loy became a top box office draw, and to her robust post-World War II career. Throughout, Emily W. Leider illuminates the actress's friendships with luminaries such as Cary Grant, Clark Gable, and Joan Crawford and her collaborations with the likes of John Barrymore, David O. Selznick, Sam Goldwyn, and William Wyler, among many others. This biography offers a fascinating slice of studio era history and gives us the first full picture of a woman who has often been overlooked.--From publisher description.
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