The growing use of prescription drugs is a global health concern. A “pill-popping culture”, where many life issues are seen as problems that can be treated with medication, is becoming more common worldwide. Simultaneously, there are increasing concerns about the nonmedical use of prescription drugs (NMUPD) such as sedatives, opi-oid-based pain relief medication and prescription stimu-lants. Nevertheless, this trend has received limited atten-tion in scientific research in Belgium, and in Europe more broadly. The YOUTH-PUMED study described in this book aims at a better understanding of this phenomenon among young adults, and of their perceptions about their own nonmedical use of prescription drugs and associated harms. This book shows that the young adults were using one or more psychoactive medication (sedatives, analgesics or stimulants) in different contexts, and their use patterns and motives for use varied. It ends with helpful insights to prevent and reduce NMUPD.