This is Volume 2 of a 2-part genealogy of the Harris family, tracing the lineage of Robert Harris Sr. (1702-1788). This work is part of The Families of Old Harrisburg Series, compiled and published by The Harris Depot Project. (Compact, Hardbound Edition)
View the author's companion website for more information and extra materials Whether they have full governance powers or are just there in an advisory capacity, trustees on library boards need to understand the complex issues that affect a library's ability to provide its community with materials and services that support lifelong learning, jobs, and quality of life. Authors Ellen G. Miller and Patricia H. Fisher have created a strategic guide that will help library board leaders handle important issues such as managing risk; local values and first amendment rights; leadership capable of achieving the library's ideal vision; getting and growing diverse funding sources; and becoming part of the community's leadership team. These issues are discussed in laymen's terms designed for busy trustees and directors who have only a few hours per month together to consider options and make decisions. Library Board Strategic Guide: Going to the Next Level seeks to help trustees and their directors in three broad areas: understanding complex issues and their local impact, assessing the trustee's role in addressing those issues, and reviewing experiences and best practices from other libraries. With many other uses, including use as a tool for board meeting discussions, for self-study, or as a benchmark for assessing your board's performance, this guide will help your library leaders reach that next level of community support.
How Art Works explores puzzles that have preoccupied philosophers as well as the general public: Can art be defined? How do we decide what is good art? Why do we gravitate to sadness in art? Why do we devalue a perfect fake? Could 'my kid have done that'? Does reading fiction enhance empathy? Drawing on careful observations, probing interviews, and clever experiments, Ellen Winner reveals surprising answers to these and other artistic mysteries. We may come away with a new understanding of how art works on us."--Jacket.
Thoroughly revised and updated, the New Edition of this definitive text explains how to care for neonates using the very latest methods. It maintains a clinical focus while providing state-of-the-art diagnosis and treatment techniques. Written by more than 55 specialists who are actively involved in the care of sick newborns, it serves as an authoritative reference for practitioners, a valuable preparation tool for neonatal board exams, and a useful resource for the entire neonatal care team. Focuses on diagnosis and management, describing pertinent developmental physiology and the pathogenesis of neonatal problems.Includes over 500 crisp illustrations that clarify important concepts and techniques. Features the contributions of new editor Christine Gleason, a well-known neonatologist specializing in fetal physiology and drug/alcohol effects on the brain.Discusses hot topics such as ethical decisions in the neonatal-perinatal period * maternal medical disorders of fetal significance, seizure disorders, isoimmunization, cancer and mental disorders * maternal and fetal anesthesia and analgesia * prenatal genetic diagnosis * overview of clinical evaluation of metabolic disease * neonatal pain in the 21st Century * immunology of the fetus and newborn * wonders of surfactant * long-term neurological outcomes in children with congenital heart disease * developmental biology of the hematologic system * and illustrative forms and normal values: blood, CSF, urine.Features extensive cross-referencing, making it quick and easy to navigate through the organ-related sections.Includes coverage of perinatology-providing a well-rounded, comprehensive approach to patient care.Presents case studies designed to help readers recognize and manage cases in the office setting and asses their understanding of the topic.
This book summarizes the etiology, presentation, and treatment of the complex symptoms, infections, and opportunistic cancers of people living with HIV/AIDS. Presents therapies that strike a balance between controlling and eliminating cancer and minimizing the damage to the immune system. Illustrates points with clear and easily read figures,
Fatty acid synthase (FAS) is a key lipogenic enzyme catalyzing the terminal steps in the synthesis of fatty acids. In the majority of normal tissues, FAS expression is low. In many human cancers, however, including cancer of the prostate, FAS expression and FAS activity are very high. As shown in the laboratory, overexpression of FAS in tumor cells is part of a more general and coordinate upregulation of multiple lipogenic genes caused, at least in part, by activation of sterol regulatory element binding proteins (SREBPs), transcription factors that play a key role in cellular lipid homeostasis. The mechanisms underlying the activation of the SREBP pathway and the increase in lipogenesis in tumor cells as well as the ultimate biological significance of this phenomenon remain poorly understood. Nonetheless there is evidence that overexpression of lipogenic genes occurs early in tumor development and that the degree of overexpression correlates with increasing tumor grade. Moreover, a number of studies suggest that inhibition of FAS selectively reduces proliferation of tumor cells and causes apoptosis, implying that FAS and other lipogenic enzymes may constitute interesting targets for antineoplastic therapy.
The book's contributors explore the transformative power of the arts therapies in areas stricken by conflict and discuss how and why expressive arts works. They look at the ways it can be used to engage community consciousness and improve social conditions whilst taking into account the issues that arise within different contexts and populations.
In this landmark work on early conceptual and lexical development, Ellen Markman challenges the fundamental assumptions of traditional theories of language acquisition and proposes a new notion of how children acquire categories.
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