Ellen De Schrijver's Books

Fatty Acid Synthase

A Novel Target for Antineoplastic Therapy?

By: Ellen De Schrijver

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Fatty Acid Synthase

A Novel Target for Antineoplastic Therapy?

By: Ellen De Schrijver

Fatty acid synthase (FAS) is a key lipogenic enzyme catalyzing the terminal steps in the synthesis of fatty acids. In the majority of normal tissues, FAS expression is low. In many human cancers, however, including cancer of the prostate, FAS expression and FAS activity are very high. As shown in the laboratory, overexpression of FAS in tumor cells is part of a more general and coordinate upregulation of multiple lipogenic genes caused, at least in part, by activation of sterol regulatory element binding proteins (SREBPs), transcription factors that play a key role in cellular lipid homeostasis. The mechanisms underlying the activation of the SREBP pathway and the increase in lipogenesis in tumor cells as well as the ultimate biological significance of this phenomenon remain poorly understood. Nonetheless there is evidence that overexpression of lipogenic genes occurs early in tumor development and that the degree of overexpression correlates with increasing tumor grade. Moreover, a number of studies suggest that inhibition of FAS selectively reduces proliferation of tumor cells and causes apoptosis, implying that FAS and other lipogenic enzymes may constitute interesting targets for antineoplastic therapy.

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Page Count

158

Publisher

Leuven University Press

Published Date

ISBN 10

9058674568

ISBN 13

9789058674562

Jan Tschichold

A Life in Typography

By: Ruari McLean,Ellen Lupton,Elaine Lustig Cohen

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Jan Tschichold

A Life in Typography

By: Ruari McLean,Ellen Lupton,Elaine Lustig Cohen

Jan Tschichold: A Life in Typography offers a concise biography of this complex figure, accompanied by numerous annotated illustrations of his work. An excellent introduction for those unfamiliar with Tschichold's influential style, it also offers the experienced designer an outstanding collection of his wide-ranging designs.

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Page Count

131

Publisher

Princeton Architectural Press

Published Date

ISBN 10

1568980841

ISBN 13

9781568980843

Self-Defence against Non-State Actors

By: Mary Ellen O'Connell,Christian J. Tams,Dire Tladi

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Self-Defence against Non-State Actors

By: Mary Ellen O'Connell,Christian J. Tams,Dire Tladi

Provides a multi-perspective study of the international law on self-defence against non-State actors.

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Page Count

313

Publisher

Cambridge University Press

Published Date

ISBN 10

1107190746

ISBN 13

9781107190740

The Luminous Image

Painted Glass Roundels in the Lowlands, 1480-1560

By: Timothy Husband,Ellen Konowitz,Zsuzsanna van Ruyven-Zeman,Metropolitan Museum of Art (New York, N.Y.)

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The Luminous Image

Painted Glass Roundels in the Lowlands, 1480-1560

By: Timothy Husband,Ellen Konowitz,Zsuzsanna van Ruyven-Zeman,Metropolitan Museum of Art (New York, N.Y.)

Published in conjunction with a 1995 exhibit at The Metropolitan Museum of Art in New York, this catalog features extensive explication of a relatively unknown art, focusing on problems of style, workshop techniques, the dissemination of designs, iconographic variety, the functions of the diversity of drawings, details of specific patrons and commissions, and the leading centers of Lowlands stained-glass production--Ghent, Bruges, and Leiden. Includes 455 bandw and 22 color illustrations. Annotation copyright by Book News, Inc., Portland, OR

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Page Count

236

Publisher

Metropolitan Museum of Art

Published Date

ISBN 10

0870997483

ISBN 13

9780870997488

Book's by Ellen De Schrijver

Fatty Acid Synthase

Fatty Acid Synthase

Jan Tschichold

Jan Tschichold

Self-Defence against Non-State Actors

Self-Defence against Non-State Actors

The Luminous Image

The Luminous Image

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