Because of the ever-increasing number of pathogenic organisms and their rapid mutation rates, the humoral immune system must have the ability to adapt and change along with evolving pathogens. The ability to rearrange germline antibody receptors during B-cell development and then modify these receptors in germinal centers is a means of ensuring that the antibody repertoire diversifies to be able to expunge a broad range of pathogens. However, the randomness of the mechanisms involved in diversifying the antibody repertoire can also generate specificities that attack the host. Because of this, strict regulation of B-cell development and activation is utilized to maintain humoral self tolerance. In this chapter, we broadly overview B-cell biology and the mechanisms used to introduce diversity into the antibody repertoire. We also discuss checkpoints that occur during development that ensure maintenance of self-tolerance. Finally, we discuss the special role that the inhibitory Fc receptor, FcγRIIB, plays in maintaining humoral tolerance.
Realize the potential of quality questioning for student thinking and learning Jackie Walsh and Beth Sattes present quality questioning as a process that begins with the preparation of questions to engage all students in thinking and culminates in the facilitation of dialogue that takes learning deeper. This new edition of the bestseller organizes questioning practices around the 6Ps framework, composed of Prepare and Present the Question, Prompt Student Thinking, Process Student Responses, Polish Questioning Practices, and Partner with Students. It extends and expands on timeless principles while adding significant new research-based practices and insights derived from the authors’ own learning with and from classroom teachers. Designed for immediate classroom use, this guide includes: Graphics, tools, and strategies to develop student skills and create a classroom culture that nurtures thinking and learning QR codes that link to more than twenty new videos depicting students and teachers from elementary through high school Tools and strategies to support teacher engagement in personal reflection, classroom observations, and collaborative dialogue that improve personal practice This exciting new book demonstrates how to seamlessly integrate effective questioning strategies into daily practice, thereby energizing teaching and learning. "Questions are the most important tool in a teacher’s toolbox. Walsh and Sattes teach us how to sharpen those tools and use the right ones to maximize learning. They understand that questioning isn’t interrogation, but rather frames dialogic instruction. You can see this come to life in the videos throughout this book! Quality Questioning belongs on every thoughtful educator’s bookshelf." —Nancy Frey, Professor, Department of Educational Leadership San Diego State University, CA "If you’re ready to shift your purpose for questioning from answer-getting to provoking higher-order thinking, this book is a must-read. Never again will you take questioning for granted." —Connie Hamilton, EdS, Curriculum Director Saranac (Michigan) Community Schools "Reading this book is like chatting with an amazing professional friend and mentor. It’s a joy to read, to ponder, and to use as a constant resource. —Susan Hudson, Educational Consultant and Former Exemplary Educator Tennessee Department of Education "A must-read for all teachers who continually strive to improve their practice to better impact student learning." —Betsy Rogers, EdD, 2003 National Teacher of the Year & Associate Professor and Department Chair, Curriculum and Instruction Samford University, Birmingham, AL
There's no such thing as an easy divorce. On top of the emotional turmoil, there are also numerous other concerns – from organising finances and splitting property, to breaking the news to children, and picking the best lawyer. This comprehensive guide shows that, with a clear-head and straight-talking advice, divorce can be swifter and easier than expected, letting you make a clean break and move on with confidence. Divorce For Dummies includes the most up-to-date information on: What to Do First When Things Start to Go Wrong Separation: A Healthy Breather or a Prelude to Divorce? Helping Your Children Get Through Your Divorce Pre-marital Agreements Same-sex and DIY divorces About the author Elizabeth Walsh is a legal expert and the Editor of Family Law, recently voted ‘Legal Journal of the Year’. Thelma Fisher is a former chair of the UK College of Family Mediators and has been involved in mediation for over twenty years.
What is the world like for todayÆs children? How do they construct meaning in it? Answering these key questions, Studying Children in Context explains the art and science of doing qualitative research involving children. Authors M. Elizabeth Graue and Daniel J. Walsh carefully discuss the research process, dealing succinctly with generic research issues yet emphasizing where work with children presents its own particular challenges. They look across the research enterprise in the first part of the book, conceptualizing it as a holistic activity. They next focus on fieldwork, and in the final section examine the interpreting and reporting aspects of qualitative research. In addition to presenting their own considerable experiences in fieldwork with children, Graue and Walsh also present the contributions of numerous researchers with their own insights on key issues. Studying Children in Context will be an invaluable addition to the libraries of teachers and researchers interested in qualitative research methods in general and in doing fieldwork with children in particular.
Issue framing is the way that people, especially politicians, get other people to view a particular problem or issue. By framing the issue in a particular way, the goal is to get people to think about the issue, to believe that an action is required and, most importantly, to believe that a particular action (the one being proposed by the framer) is the right one. The use of language and imagery is an essential part of issue framing and has been an integral part of the presidency since our nation’s founding, but it has become particularly important since Theodore Roosevelt began to take his message directly to the people. This work examines a selected speech delivered by every president from Roosevelt through Barack Obama to show how language has been instrumental in directing policy. Each chapter will examine the situation or background for the problem, include a transcript of the speech the president delivered, and conclude with an analysis of the speech in terms of the particular frame that the speech utilized and the eventual outcome, or policy direction, inspired by the speech.
Instantly diagnose 100 of the most commonly seen symptoms in adults and children! "This is a book of lists to help inexperienced healthcare providers hone their skill at progressing from symptoms to a differential diagnosis to treatment decisions. This is a necessary step in a student's development and this book goes a long way in assisting in this process. 3 Stars."--Doody's Review Service The Common Symptom Guide is the most trusted and easy-to-use reference for quickly and accurately evaluating and treating patients based on presenting symptoms. The Guide includes lists of pertinent questions, physical findings, and differential diagnosis for more than 100 of the most common adult and pediatric symptoms so you can instantly diagnose and treat the complaint. Turn to The Common Symptom Guide for important guidelines on: Patient and family history Physical examination Diagnostic considerations Medications Environmental history Plus... Outstanding indexing and cross-referencing to help you quickly arrive at a diagnosis Increased number of evidence-based medicine references Updated medical information throughout More references to key websites Additional information on the author's website (www.howsyourhealth.org) that provides valuable patient education material
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