In 1934, Gerhard Domagk discovered the healing effect of sulfonamides, the precedent of antibiotics. For this discovery, he was awarded the Nobel Prize for Medicine in 1939. In 1943, Domagk detected the first remedy against tuberculosis, a worid-wide epidemic at that time. ** "It is easier to destroy thousands of lives than to save one." (Words by Gerhard Domagk which he wrote down shortly after the outbreak of World War II when he was kept prisoner because of the Nobel Prize.)
In 1934, Gerhard Domagk discovered the healing effect of sulfonamides, the precedent of antibiotics. For this discovery, he was awarded the Nobel Prize for Medicine in 1939. In 1943, Domagk detected the first remedy against tuberculosis, a worid-wide epidemic at that time. ** "It is easier to destroy thousands of lives than to save one." (Words by Gerhard Domagk which he wrote down shortly after the outbreak of World War II when he was kept prisoner because of the Nobel Prize.)
Dieser Sammelband enthält 25 Aufsätze des Kirchengeschichtlers Ekkehard Mühlenberg. Im Zentrum steht die Zeit der Spätantike. Inhaltlicher Schwerpunkt sind die Diskussionen zwischen Philosophie und Theologie im Ringen um ein umfassendes Wirklichkeitsverständnis. Einen gewichtigen Forschungsbeitrag stellen auch die Überlegungen zur kirchengeschichtlichen Methode dar. Präsentiert werden die Aufsätze unter Kategorien wie "Was ist Kirchengeschichte?", "Philosophischer und theologischer Gottesbegriff", "Die Sprache religiöser Erfahrung und Christliche Lebensführung".
This second volume reports on the reaction patterns of lymph nodes in neoplastic and immunodeficient diseases. Based on the contents of volume 1, it presents a detailed survey of lymph node structures and their cellular components under these conditions. The patterns of nodal reactions to the development and spread of cancer have recently been investigated and discussed by several authors. Here, the immediate interactions between tumor tissue and the regional nodes have been assessed in experimental models and in human material. Using modern morphological methods such as im munohistochemistry on the light and electron microscopic level, new insights have been gained into the stepwise process of lymphogenous metastasis. Macrophages/reticulum cells were found to playa signifi cant role in this process, which is duly emphasized. Based on appro priate animal models, one chapter focuses on various subtypes of these cellular elements and their role in the two separate phases of tumor spread and the development of true metastases. The induction of fibronectin in lymph nodes is effected by tumor cells forming a special part of the extracellular matrix. The multifunctional fibronec tin molecule serves as a mediator between tumor cells and fibroblasts, furthering the formation of tumor stroma. This volume also contains a comprehensive survey of primary im munodeficiency syndromes and their nodal manifestations, reference being made to the most recent immunological knowledge.
Minimal neoplasia may be defined as a small cancer that has progressed beyond its site of primary origin into the surrounding tissue, but that has not yet reached the stage of deeper invasion or metastasization. The basic principles of this minimal cancer are presented in chapters on molecular, biological and experimental aspects, and, in particular, on the clinical manifestations in various organs: preleukemia, incipient lymphoma, and minimal carcinomas of the uterine cervix, breast, thyroid, larynx, lung, prostate, stomach and colon. A separate chapter is devoted to cryptic gliomas. The latest morphological methods including cytology, early clinical diagnostics and, in particular, radiodiagnostics, are considered. The reader can expect up-to-date information about prompt diagnosis of the very early manifestations of cancer, together with inferences on therapy, which, especially in tumors of the uterine cervix, breast and thyroid, differs considerably from the treatment of advanced neoplasia.
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