Discover how the crisis of a global pandemic allowed educators to improve learning across the pre-K–adult pipeline. While acknowledging the scale of loss and difficulty the COVID pandemic engendered within the field of education, this book focuses on how sudden and forced changes to teaching and learning created “Pandemic Positives,” which can be captured and brought to scale. In particular: Part I addresses how Pandemic Positives came into being, with special attention to the presence of educator hope and creativity. Part II explores the Pandemic Positives that arose in three settings: when schools were closed, when learning turned online, and when schools re-opened. Part III provides strategies for replicating the Pandemic Positives so they become positive educational game changers. This book is grounded on trauma and mental wellness theory and includes the in-the-trenches experiences and voices of educators. The text features art created by the coauthors and shares both their professional and personal experiences, humanizing and enriching the book. Mending Education completes a trilogy composed of Breakaway Learners and Trauma Doesn’t Stop at the School Door by Karen Gross. “We have all bemoaned the COVID pandemic and its lasting negative effects, but Karen Gross and Edward Wang turn that pessimism on its head. Their extensive experience in education is augmented by the priceless data gathered through their research survey of teachers and educators. This is a must-have for educators everywhere.” —Chris Messina-Boyer, educational crisis manager/crisis communications consultant, 20Buttonwood PR Solutions LLC
The concepts in this book will provide a comprehensive overview of the current state for a broad range of nitride semiconductor devices, as well as a detailed introduction to selected materials and processing issues of general relevance for these applications. This compilation is very timely given the level of interest and the current stage of research in nitride semiconductor materials and device applications. This volume consists of chapters written by a number of leading researchers in nitride materials and device technology addressing Ohmic and Schottky contacts, AIGalnN multiple quantum well laser diodes, nitride vertical cavity emitting lasers, and ultraviolet photodetectors. This unique volume provides a comprehensive review and introduction to application and devices based on GaN and related compounds for newcomers to the field and stimulus to further advances for experienced researchers.
Generals and Scholars is the first work in English to examine fully military rule during the Koryo. Although it lasted for only a century, the period was one of dynamic change--a time of institutional development, social transformation, and the reassertion of the civil service examination and Confucian ideology coupled with the flowering of Son (Zen) Buddhism. (When confronted with fundamental matters of rule, however, Ch'oe leaders frequently opted for the status quo and in the end aligned with many traditional civil elites to preserve their power.) The traditional tension between civilians and the military was eased as both came to accept the primacy and necessity of civilian values. Koryo generals, unlike those in Japan, learned they could govern more readily by relying on civil leaders administering a strong central government than on a call to arms. Institutional innovations from this period survived well into the next and Son Buddhism continued to flourish throughout the country.
Among the most influential models in contemporary behavioral science, self-determination theory (SDT) offers a broad framework for understanding the factors that promote human motivation and psychological flourishing. In this authoritative work, SDT cofounders Richard M. Ryan and Edward L. Deci systematically review the theory's conceptual underpinnings, empirical evidence base, and practical applications across the lifespan. Ryan and Deci demonstrate that supporting people's basic needs for competence, relatedness, and autonomy is critically important for virtually all aspects of individual and societal functioning."--Jacket.
Psychology 2ed will support you to develop the skills and knowledge needed for your career in psychology and within the professional discipline of psychology. This book will be an invaluable study resource during your introductory psychology course and it will be a helpful reference throughout your studies and your future career in psychology. Psychology 2ed provides you with local ideas and examples within the context of psychology as an international discipline. Rich cultural and indigenous coverage is integrated throughout the book to help your understanding. To support your learning online study tools with revision quizzes, games and additional content have been developed with this book.
How humans and technology evolve together in a creative partnership. In this book, Edward Ashford Lee makes a bold claim: that the creators of digital technology have an unsurpassed medium for creativity. Technology has advanced to the point where progress seems limited not by physical constraints but the human imagination. Writing for both literate technologists and numerate humanists, Lee makes a case for engineering—creating technology—as a deeply intellectual and fundamentally creative process. Explaining why digital technology has been so transformative and so liberating, Lee argues that the real power of technology stems from its partnership with humans. Lee explores the ways that engineers use models and abstraction to build inventive artificial worlds and to give us things that we never dreamed of—for example, the ability to carry in our pockets everything humans have ever published. But he also attempts to counter the runaway enthusiasm of some technology boosters who claim everything in the physical world is a computation—that even such complex phenomena as human cognition are software operating on digital data. Lee argues that the evidence for this is weak, and the likelihood that nature has limited itself to processes that conform to today's notion of digital computation is remote. Lee goes on to argue that artificial intelligence's goal of reproducing human cognitive functions in computers vastly underestimates the potential of computers. In his view, technology is coevolving with humans. It augments our cognitive and physical capabilities while we nurture, develop, and propagate the technology itself. Complementarity is more likely than competition.
Hydrogenation is a key reaction in both the food and petrochemical industries, where it is used to reduce carbon–carbon double bonds. Without a catalyst, hydrogenation reactions require extreme temperatures to occur, meaning catalysts are essential for the reaction to be industrially useful. During the past decade, the properties of many carbon nanomaterials that are relevant to hydrogenation catalysis have been described, including carbon nanotubes (CNTs), carbon nanofibers (CNFs), carbon nanohorns (CNHs), graphene oxide (GO), reduced graphene oxides (rGO) and fullerenes, that are relevant to hydrogenation catalysis, have been described. For many of these the production methods have advanced to the commercial stage. Numerous studies on the development of catalysts on carbon nano-supports have appeared in the scientific literature and these catalysts have shown remarkable activity and specificity. Carbon Nanomaterials in Hydrogenation Catalysis is a valuable reference for researchers and chemical engineers working on improving hydrogenation processes and those interested in applications for carbon nanomaterials. Covering their production, modification and applications as a catalyst support this book provides an in-depth review of the current state-of-the art in using carbon nanomaterials for hydrogenation reactions.
Garden visitation has been a tourism motivator for many years and can now be enjoyed in many different forms. Private garden visiting, historical garden tourism, urban gardens, and a myriad of festivals, shows and events all allow the green-fingered enthusiast to appreciate the natural world. This book traces the history of garden visitation and examines tourist motivations to visit gardens. Useful for garden managers and tourism students as well as casual readers, it also examines management and marketing of gardens for tourism purposes, before concluding with a detailed look at the form and tourism-based role of gardens in the future.
A graduate-level textbook on the astrophysics of binary star systems and their evolution Physics of Binary Star Evolution is an up-to-date textbook on the astrophysics and evolution of binary star systems. Theoretical astrophysicists Thomas Tauris and Edward van den Heuvel cover a wide range of phenomena and processes, including mass transfer and ejection, common envelopes, novae and supernovae, X-ray binaries, millisecond radio pulsars, and gravitational wave (GW) sources, and their links to stellar evolution. The authors walk through the observed properties and evolution of different types of binaries, with special emphasis on those containing compact objects (neutron stars, black holes, and white dwarfs). Attention is given to the formation mechanisms of GW sources—merging double neutron stars and black holes as well as ultra-compact GW binaries hosting white dwarfs—and to the progenitors of these sources and how they are observed with radio telescopes, X-ray satellites, and GW detectors (LIGO, Virgo, KAGRA, Einstein Telescope, Cosmic Explorer, and LISA). Supported by illustrations, equations, and exercises, Physics of Binary Star Evolution combines theory and observations to guide readers through the wonders of a field that will play a central role in modern astrophysics for decades to come. 465 equations, 47 tables, and 350+ figures More than 80 exercises (analytical, numerical, and computational) Over 2,500 extensive, up-to-date references
Explore multiple disciplines to understand the impact of psychology on health, and vice versa In the newly revised 10th edition of Health Psychology: Biopsychosocial Interactions, a team of dedicated psychologists delivers an insightful and multidisciplinary demonstration of the impact of psychology and health on one another. Relying heavily on cross-cultural data, the book offers a sweeping and inclusive picture of health psychology and includes local and global research and case studies. The authors have included boxed materials in each chapter that directs the reader’s attention to the right information at the right time. Behavioral, physiological, cognitive, and social/personality viewpoints are addressed throughout the text and a strong focus on lifespan development in health and illness pervades the material. Readers will also find: Psychological perspectives on a wide variety of health issues from various parts of the world Highlights of what works for practicing psychologists and what doesn’t when their work intersects with other fields in health Expansive treatments of topics like the effect of stress on health, the impact of adverse childhood experiences, and the interaction between religiosity and health Health Psychology: Biopsychosocial Interactions is an essential resource for undergraduate students in psychology with an interest in health. It’s also invaluable for allied health professionals, addictions counselors, dietitians and nutritionists, and social workers seeking an authoritative resource on the effect of psychology on their daily work.
Infectious diseases are an ever present threat to humans. In recent years, the threat of these emerging viruses has been greater than ever before in human history, due in large part to global travel by larger numbers of people, and to a lesser extent to disruptions in the interface between developed and undeveloped areas. The emergence of new deadly viruses in human populations during recent decades has confirmed this risk. They remain the third leading cause of deaths in the US and the second world-wide. Emerging Viruses in Human Populations provides a comprehensive review of viruses that are emerging or that threaten to emerge among human populations in the twenty-first century. It discusses the apprehension over emerging viruses that has intensified due to concerns about bioterrorism. * Presents the history of emerging viruses * Includes chapters on SARS, Pandemic Threat of Avian Influenza Viruses, West Nile Virus, Monkeypox Virus, Hantavirus, Nipah Virus and Hendra Virus, Japanese Encephalitis Virus, Dengue and Crimean-Congo Hemorrhagic Fever Viruses * Discusses surveillance for newly emerging diseases
The second edition of Primary Immunodeficiency Diseases presents discussions of gene identification, mutation detection, and clinical and research applications for over 100 genetic immune disorders--disorders featuring an increased susceptibility to infections and, in certain conditions, an icreased rate of malignancies and autoimmune disorders. Since the publication of the first edition, a flurry of new disease entities has been defined and new treatment regimens have been introduced, the most spectacular being successful treatment by gene therapy for two genotypes of combined immunodeficiency. The first edition marked a historic turning point in the field of immunodeficiencies, demonstrating that many of the disorders of the immune systam could be understood at a molecular level. This new edition can proudly document the tremendous pace of progress in dissecting the complex immunologic networks responsible for protecting individuals from these disorders.
Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. For more than 30 years, Perez and Brady's Principles and Practice of Radiation Oncology has been the must-have standard reference for radiation oncologists and radiation oncology residents who need a comprehensive text covering both the biological and physical science aspects of this complex field as well as disease site-specific information on the integrated, multidisciplinary management of patients with cancer. The book has established itself as the discipline’s "text-of-record," belonging on the shelf of all of those working in the field. The Seventh Edition continues this tradition of excellence with extensive updates throughout, many new chapters, and more than 1,400 full-color illustrations that highlight key concepts in tumor pathogenesis, diagnosis, and targeted radiation therapy.
Annotation. Organometallic chemistry is an interdisciplinary science which continues to grow at a rapid pace. Although there is continued interest in synthetic and structural studies the last decade has seen a growing interest in the potential of organometallic chemistry to provide answers to problems in catalysis synthetic organic chemistry and also in the development of new materials. This Specialist Periodical Report aims to reflect these current interests reviewing progress in theoretical organometallic chemistry, main group chemistry, the lanthanides and all aspects of transition metal chemistry. Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.
In the US medical environment where medical mistakes, over-diagnosis, and over-treatment have become the third leading cause of death, leadership consultant and long-time charity CEO Edward Morgan argues that protecting yourself with medical wisdom can add 10-15 years to your life. We're a nation on meds, where 60% of adults are now diagnosed with some chronic condition. We're listening to unwise advice and becoming permanent patients. Longevity is declining in America, even though medical costs in the US are twice that of other developed nations. Don't get caught in medical misadventures that escalate into permanent conditions, screenings that cascade into fear-driven decisions, prescriptions that simply suppress symptoms, or worst of all, end up dying in an ICU in the vain hope for a few more days. Smart is not the same as wise. Medical wisdom and discernment will extend your life. Taking today's aggressive, profit-driven advice will quite possibly shorten it. Living to see your grandchildren grow up is your responsibility, not your doctor's. This is a must read for anyone already feeling like a patient for life. With courage and wisdom you can become a well person again and live out your full lifespan.
Build a solid foundation of knowledge based on the fundamentals and employ step-by-step instruction from Spine Surgery. Edited by Edward C. Benzel, this best-selling medical reference explores the full spectrum of surgical techniques used in spine surgery and delivers the comprehensive, cutting-edge guidance you need to achieve successful outcomes. Online access, thorough updates, contributions by leading international authorities, an abundance of detailed illustrations, and procedural video clips provide everything you need to avoid and manage complex problems. Glean essential, up-to-date, need-to-know information in one comprehensive reference that explores the full spectrum of surgical techniques used in spine surgery. Hone your surgical skills and technique with intraoperative videos and more than 800 outstanding illustrations demonstrating each technique step by step. Grasp and apply the latest knowledge from more than 25 brand-new chapters, as well as extensive revisions or total rewrites to the majority of existing chapters to present all of the most up-to-date information available on every aspect of spine surgery including motion preservation technologies, endovascular management, back pain and psychosocial interactions, biomechanics, and more. Consult with the best. Renowned neurosurgery authority Edward C. Benzel leads an international team of accomplished neurosurgeons and orthopedic surgeons - many new to this edition - who provide dependable guidance and share innovative approaches to surgical techniques and complications management. Equip yourself to address increasing occurrences of pain among aging and physically active patients. Access the information you need, where you need it on your laptop or mobile device via expertconsult.com, with fully searchable text, a wealth of procedural videos, online updates from the experts, downloadable image gallery and links to PubMed.
In published papers H A Bethe and G E Brown worked out the collapse of large stars and supernova explosions. They went on to evolve binaries of compact stars, finding that in the standard scenario the first formed neutron star always went into a black hole in common envelope evolution. C-H Lee joined them in the study of black hole binaries and gamma ray bursts. They found the black holes to be the fossils of the gamma ray bursts. From their properties they could reconstruct features of the burst and of the accompanying hypernova explosions. This invaluable book contains 23 papers on astrophysics, chiefly on compact objects, written over 23 years. The papers are accompanied by illuminating commentary. In addition there is an appendix on kaon condensation which the editors believe to be relevant to the equation of state in neutron stars, and to explain why black holes are formed at relatively low masses.
PROFILES POTENTIAL TREATMENT APPROACHES FOR CARDIAC ARRHYTHMIAS Cardiac arrhythmias of ventricular origin are responsible for the deaths of nearly half a million Americans each year while atrial fibrillation accounts for about 2.3 million cases per year, a rate that is projected to increase 2.5 fold over the next half century. Effectively managing these cardiac rhythm disorders remains a major challenge for both caregivers and the pharmaceutical industry. Filling a gap in the current literature, Novel Therapeutic Targets for Antiarrhythmic Drugs presents the latest treatments for cardiac arrhythmias alongside comprehensive presentations of basic cardiac physiology and pharmacology. Written by leading experts in their research areas, this invaluable resource offers both practitioners and researchers a one-stop guide that brings together previously dispersed information. The text consists of four sections: Section One comprehensively reviews basic cardiac electrophysiology, the mechanisms responsible for arrhythmias in the setting of ischemia, and basic pharmacology of antiarrhythmic drugs. Section Two addresses safety pharmacology, including the concept of "repolarization reserve," safety challenges, and regulatory issues for the development of novel antiarrhythmic drugs. Section Three describes several novel pharmacological targets for antiarrhythmic drugs, including both ion channel and non-ion channel targets. Section Four describes promising non-pharmacological antiarrhythmic interventions including selective cardiac neural disruption or nerve stimulation, aerobic exercise training, and diet (omega-3 fatty acids). Offering an unparalleled look at the current state and future direction of cardiac arrhythmia treatment, Novel Therapeutic Targets for Antiarrhythmic Drugs provides an important resource to advanced students, working researchers, and busy professionals alike.
The only reference available that synthesizes this vast subspecialty into a single trustworthy resource, Cornea, 5th Edition, provides state-of-the-art coverage of the expanding range of contemporary corneal surgery, new diagnostic and imaging technologies, and medical management of corneal and external disease as well as ocular surface disease. Drs. Mark J. Mannis, Edward J. Holland, and a team of more than 200 global experts keep you up to date with both common and more obscure diseases and disorders and the best route to effective treatment and management, making this two-volume text a must-have resource for residents and fellows, general ophthalmologists, and seasoned cornea specialists. Features more than 2,300 exceptionally clear illustrations, diagnostic images, and step-by-step surgical photographs that offer superb visual guidance. Contains 14 new chapters, including Nanothin DSAEK, Aqueous Deficiency Dry Eye Syndrome, Evaluation of Recurrent Corneal Erosions, Evaluation of the Corneal Ulcer, Contemporary Approaches to the Biosynthetic Cornea, and Topography Guided Photorefractive Keratectomy, and more. Includes more than 80 video clips of current corneal surgery techniques, including new clips of the application of cryopreserved amniotic membrane in the treatment of acute stevens , penetrating keratoplasty, DM rupture management in STALK and in the keratonconus patient, and KAMRA corneal inlay implantation. Covers the latest developments in ocular surface transplantation, including new chapters on Conjunctival Limbal Autograft (CLAU); Living Related Conjunctival Limbal Allograft (Lr-CLAL); Keratolimbal Allograft; Cultivated Limbal Epithelial Transplantation; Simple Limbal Epithelial Transplantation; and Outcomes of Ocular Surface Transplantation. Provides key point overviews in each chapter that offer easier access to crucial information.
Cardiac Cellular Electrophysiology is intended for the clinical cardiologist who wishes to refresh or deepen his understanding of the cellular basis of cardiac electrophysiology, for researchers interested in the basis of the electrical activity of the heart, such as clinical investigators, physiologists or pharmacologists, for teachers in physiology, pharmacology and other biomedical studies, and for medical students from graduate to postgraduate level. Cardiac Cellular Electrophysiology starts with a primer of basic electrophysiology, the cardiac action potential and the physiological basis of the electrocardiogram. Our second aim after having introduced the basic concepts was to continue with giving an overview of the properties of the most important ionic currents in the heart, and to treat their modulation, in order to deal with the mechanisms underlying cardiac ischaemia, arrhythmias and remodelling. Edward Carmeliet and Johan Vereecke, Katholieke University Leuven, Belgium, have collaborated for over 30 years in cardiac electrophysiology research. Their studies include the genesis of the normal action potential, its changes in ischaemia, the effect of drugs, and the mechanism of arrhythmias, using techniques from the classic potential registration with intracellular microelectrodes to whole cell clamp and single channel measurements.
This unique reference presents in-depth coverage of the latest methods and applications of digital image processing describing various computer architectures ideal for satisfying specific image processing demands.
Practical resource covering applications of crystallization principles with methodologies, case studies, and numerous industrial examples for emphasis Based on the authors' hands-on experiences as process engineers, through the use of case studies and examples of crystallization processes, ranging from laboratory development through manufacturing scale-up, Crystallization of Organic Compounds guides readers through the practical applications of crystallization and emphasizes strategies that have proven to be successful, enabling readers to avoid common pitfalls that can render standard procedures unsuccessful. Most chapters feature multiple examples that guide readers, step by step, through the crystallization of active pharmaceutical ingredients (APIs), including an analysis of the major methods of carrying out crystallization operations, their strengths and potential issues, as well as numerous examples of crystallization processes from development through manufacturing scale. Advancements in the field of crystallization have been integrated throughout the book in the newly revised Second Edition to ensure the content adequately reflects current state-of-the-art industrial know-hows and practice. The new edition also adds chapters addressing downstream operations after the crystallization, including filtration/washing and drying, together with industrial use cases. Crystallization of Organic Compounds includes detailed information on: Solubility and solid behavior, covering phase rule, polymorph, salt/coccrystals, chiral resolution and in-silico solubility prediction; and kinetics, covering seed, supersaturation, nucleation, crystal growth and model-based experimental design Critical issues in the crystallization practice, covering oiling out, seeding/wet-milling, agglomeration/aggregation, mixing scale-up and quality-by-design principles. Cooling, anti-solvent, evaporation and reactive crystallization process design, covering batch and continuous operations with industrial examples. Special applications, covering crystallization with ultrasound and computation fluid dynamics, and solid dispersion. With highly practical coverage of the subject, Crystallization of Organic Compounds is an essential resource for engineers and chemists involved with the development, scaling, or operation of crystallization process in the pharmaceutical and fine chemical industries, particularly those with degrees in chemical engineering and chemistry.
A research teams reports on its efforts to develop and implement DNA fingerprinting techniques to characterize and differentiate the parvus species of protozoal parasite that is ubiquitous in rivers and lakes, is relatively resistant to chlorine disinfection at commonly used concentrations, and can prove fatal for immune compromised people who become infected. They evaluate fingerprinting methods based on polymerase chain reaction, determine which method is most suitable for determining strains or isolates within a species, implement the most appropriate molecular method for determining whether the isolates can be differentiated based on its animal or human host or geographical source, and determine the particular source of the protozoa contamination in source water. The report is not indexed. c. Book News Inc.
Written by world-class experts in clinical cancer therapeutics, Physicians’ Cancer Chemotherapy Drug Manual 2019 provides a complete, easy-to-use catalog of over 100 drugs and commonly used drug regimens—both on- and off-label—for the treatment of all the major cancers.
This thesis makes significant advances in the use of microspheres in optical traps as highly precise sensing platforms. While optically trapped microspheres have recently proven their dominance in aqueous and vacuum environments, achieving state-of-the-art measurements of miniscule forces and torques, their sensitivity to perturbations in air has remained relatively unexplored. This thesis shows that, by uniquely operating in air and measuring its thermally-fluctuating instantaneous velocity, an optically trapped microsphere is an ultra-sensitive probe of both mass and sound. The mass of the microsphere is determined with similar accuracy to competitive methods but in a fraction of the measurement time and all while maintaining thermal equilibrium, unlike alternative methods. As an acoustic transducer, the air-based microsphere is uniquely sensitive to the velocity of sound, as opposed to the pressure measured by a traditional microphone. By comparison to state-of-the-art commercially-available velocity and pressure sensors, including the world’s smallest measurement microphone, the microsphere sensing modality is shown to be both accurate and to have superior sensitivity at high frequencies. Applications for such high-frequency acoustic sensing include dosage monitoring in proton therapy for cancer and event discrimination in bubble chamber searches for dark matter. In addition to reporting these scientific results, the thesis is pedagogically organized to present the relevant history, theory, and technology in a straightforward way.
As the definitive reference for clinical chemistry, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition offers the most current and authoritative guidance on selecting, performing, and evaluating results of new and established laboratory tests. Up-to-date encyclopedic coverage details everything you need to know, including: analytical criteria for the medical usefulness of laboratory procedures; new approaches for establishing reference ranges; variables that affect tests and results; the impact of modern analytical tools on lab management and costs; and applications of statistical methods. In addition to updated content throughout, this two-color edition also features a new chapter on hemostasis and the latest advances in molecular diagnostics. Section on Molecular Diagnostics and Genetics contains nine expanded chapters that focus on emerging issues and techniques, written by experts in field, including Y.M. Dennis Lo, Rossa W.K. Chiu, Carl Wittwer, Noriko Kusukawa, Cindy Vnencak-Jones, Thomas Williams, Victor Weedn, Malek Kamoun, Howard Baum, Angela Caliendo, Aaron Bossler, Gwendolyn McMillin, and Kojo S.J. Elenitoba-Johnson. Highly-respected author team includes three editors who are well known in the clinical chemistry world. Reference values in the appendix give you one location for comparing and evaluating test results. NEW! Two-color design throughout highlights important features, illustrations, and content for a quick reference. NEW! Chapter on hemostasis provides you with all the information you need to accurately conduct this type of clinical testing. NEW! Six associate editors lend even more expertise and insight to the reference. NEW! Reorganized chapters ensure that only the most current information is included.
Small angle solution scattering (SAS) is increasingly being applied to biological problems. It is a complementary technique that, when applied in appropriate circumstances with carefully structured questions, can provide unique information not available from other techniques. While small angle solution scattering has been around for some time, a confluence of recent developments has dramatically enhanced its power. Intense third generation X-ray sources, low noise detectors, development of new algorithms and the computational power to take advantage of these have all matured, and use of free-electron x-ray laser sources is on the horizon. Whole new classes of experiments and analyses have been created as a result. These include the generation of molecular envelopes, the ability to do time-resolved studies, and the ability to account for structural changes using modelling based on the SAS data. The technical improvements have also reduced the amount of time and material needed to carry out an experiment. Beamtime at synchrotron sources is in demand, workshops on the subject are popular and researchers adopting the technique as part of their repertoire are growing. With these in mind, this book was written to guide structural biologists who may wish to adopt the technique, understand its strengths and weaknesses or just have a general interest in its potential.
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. Provides a comprehensive and valuable working handbook for scientists and students in medicinal chemistry Includes expanded coverage of pharmacokinetics fundamentals and effects Contains updates throughout, including the authors’ recent work in the importance of solubility in drug development; new and currently used property methods, with a reduction of seldom-used methods; and exploration of computational modeling methods
New emerging diseases, new diagnostic modalities for resource-poor settings, new vaccine schedules ... all significant, recent developments in the fast-changing field of tropical medicine. Hunter’s Tropical Medicine and Emerging Infectious Diseases, 10th Edition, keeps you up to date with everything from infectious diseases and environmental issues through poisoning and toxicology, animal injuries, and nutritional and micronutrient deficiencies that result from traveling to tropical or subtropical regions. This comprehensive resource provides authoritative clinical guidance, useful statistics, and chapters covering organs, skills, and services, as well as traditional pathogen-based content. You’ll get a full understanding of how to recognize and treat these unique health issues, no matter how widespread or difficult to control. Includes important updates on malaria, leishmaniasis, tuberculosis and HIV, as well as coverage of Ebola, Zika virus, Chikungunya, and other emerging pathogens. Provides new vaccine schedules and information on implementation. Features five all-new chapters: Neglected Tropical Diseases: Public Health Control Programs and Mass Drug Administration; Health System and Health Care Delivery; Zika; Medical Entomology; and Vector Control – as well as 250 new images throughout. Presents the common characteristics and methods of transmission for each tropical disease, as well as the applicable diagnosis, treatment, control, and disease prevention techniques. Contains skills-based chapters such as dentistry, neonatal pediatrics and ICMI, and surgery in the tropics, and service-based chapters such as transfusion in resource-poor settings, microbiology, and imaging. Discusses maladies such as delusional parasitosis that are often seen in returning travelers, including those making international adoptions, transplant patients, medical tourists, and more.
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