This practical high-level guidebook offers an in-depth understanding of the newly emerging clinical trial designs in adaptive trial designs and master protocols. Both concise and readable without shying away from technical discussion, the book introduces the most innovative approaches in clinical trial research such as adaptive trial designs, master protocols, platform trial, basket trial, and umbrella trial designs. Featuring a revisionist history of clinical research before moving on to case-study based discussion and practical considerations from collective experience. The book enables readers to understand the strengths and limitations of these novel designs as well as their application to individual areas of research and clinical practice. Supplemented by real-world examples from the recent developments in medical research efficiency instigated by both personalized medicine and high-profile diseases like COVID-19 and cancer. The first book of its kind, it is the go-to resource for medical students and researchers working in clinical trial research.
Unlike most books, this one actually does risk assessments for you for over 110 chemicals that are confirmed or probable air toxics. All chemicals are analyzed with a scientifically sound methodology-outlined in the book-to assess public health risk associated with exposure to air toxics. Methodology will allow you to properly handle all air toxic health concerns within a practical decision-free framework. This permits the application of methodology to any new chemical. Each chemical or compound is organized by synonym, molecular weight, molecular formula, AALG, occupational limits, drinking water limits, toxicity profile and indexed by CAS number, and synonyms.
Sergeant-Major Cotton retired from the British army after long and hard service that saw him fight in numerous engagements and battles, none more memorable than his last, that of Waterloo. During the battle he was orderly to Maj-General Sir Hussey Vivian commanding 6th British cavalry brigade. Thankfully a new, less dangerous, and more lucrative trade opened up to him, that of battlefield guide. This trade still lives on in and around the battlefield, after many years Cotton knew the history of the campaign in minute detail, not however missing updating his knowledge with the books published from time to time such as Beamish’s History of the King’s German Legion and Siborne’s History. Having fought on and spent so much time in and around the battlefield steeped in the history of the epoch defining battle, Cotton stood uniquely placed to add to the blossoming Waterloo book trade and add his own incomparable story. His book is well researched, interesting and is the source for a great many of the anecdotes that have been lifted for other books on the subject. An excellent addition to the eye-witness accounts, flavoured with a lifetimes knowledge of the battlefield and the original source documents which he uses especially as indexes. Author – Sergeant-Major Edward Cotton, formerly of the 7th Hussars (1792?-1849)
This volume presents the complete correspondence between two of the most important and influential American poets of the postwar period. The almost 500 letters range widely over the poetry scene and the issues that made the period so lively and productive. But what gives the exchange its special personal and literary resonance is the sense of spiritual affinity and shared conviction about the power of the visionary imagination. Duncan and Levertov explore these matters in rich detail until, under the stress of dealing with the Vietnam War in poetry, they discover deep-seated differences in the religious and ethical convictions underlying their politics and poetic stance. The issues that drew them together and those that drove them apart create a powerful personal drama with far-reaching historical and cultural significance. The editors have provided a critical Introduction, full notes, a chronology, and a glossary of names.
The bloody and decisive two-day battle of Shiloh (April 6-7, 1862) changed the entire course of the American Civil War. The stunning Northern victory thrust Union commander Ulysses S. Grant into the national spotlight, claimed the life of Confederate commander Albert S. Johnston, and forever buried the notion that the Civil War would be a short conflict. The conflagration at Shiloh had its roots in the strong Union advance during the winter of 1861-1862 that resulted in the capture of Forts Henry and Donelson in Tennessee. The offensive collapsed General Albert S. Johnstons advanced line in Kentucky and forced him to withdraw all the way to northern Mississippi. Anxious to attack the enemy, Johnston began concentrating Southern forces at Corinth, a major railroad center just below the Tennessee border. His bold plan called for his Army of the Mississippi to march north and destroy General Grants Army of the Tennessee before it could link up with another Union army on the way to join him. On the morning of April 6, Johnston boasted to his subordinates, Tonight we will water our horses in the Tennessee! They nearly did so. Johnstons sweeping attack hit the unsuspecting Federal camps at Pittsburg Landing and routed the enemy from position after position as they fell back toward the Tennessee River. Johnstons sudden death in the Peach Orchard, however, coupled with stubborn Federal resistance, widespread confusion, and Grants dogged determination to hold the field, saved the Union army from destruction. The arrival of General Don C. Buells reinforcements that night turned the tide of battle. The next day, Grant seized the initiative and attacked the Confederates, driving them from the field. Shiloh was one of the bloodiest battles of the entire war, with nearly 24,000 men killed, wounded, and missing. Edward Cunningham, a young Ph.D. candidate studying under the legendary T. Harry Williams at Louisiana State University, researched and wrote Shiloh and the Western Campaign of 1862 in 1966. Although it remained unpublished, many Shiloh experts and park rangers consider it to be the best overall examination of the battle ever written. Indeed, Shiloh historiography is just now catching up with Cunningham, who was decades ahead of modern scholarship. Western Civil War historians Gary D. Joiner and Timothy B. Smith have resurrected Cunninghams beautifully written and deeply researched manuscript from its undeserved obscurity. Fully edited and richly annotated with updated citations and observations, original maps, and a complete order of battle and table of losses, Shiloh and the Western Campaign of 1862 will be welcomed by everyone who enjoys battle history at its finest. About the Authors: Edward Cunningham, Ph.D., studied under T. Harry Williams at Louisiana State University. He was the author of The Port Hudson Campaign: 1862-1863 (LSU, 1963). Dr. Cunningham died in 1997. Gary D. Joiner, Ph.D., is the author of One Damn Blunder from Beginning to End: The Red River Campaign of 1864, winner of the 2004 Albert Castel Award and the 2005 A. M. Pate, Jr., Award, and Through the Howling Wilderness: The 1864 Red River Campaign and Union Failure in the West. He lives in Shreveport, Louisiana. Timothy B. Smith, Ph.D., is author of Champion Hill: Decisive Battle for Vicksburg (winner of the 2004 Mississippi Institute of Arts and Letters Non-fiction Award), The Untold Story of Shiloh: The Battle and the Battlefield, and This Great Battlefield of Shiloh: History, Memory, and the Establishment of a Civil War National Military Park. A former ranger at Shiloh, Tim teaches history at the University of Tennessee.
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