The book is organized into four chapters. The first three treat distinct types of design variables, and the fourth presents a built-up structure formulation that combines the other three. The first chapter treats finite-dimensional problems, in which the state variable is a finite-dimensional vector of structure displacements and the design parameters. The structual state equations are matrix equations for static response, vibration, and buckling of structures and matrix differential equations for transient dynamic response of structures, which design variables appearing in the coefficient matrices.
The second edition of Primary Immunodeficiency Diseases presents discussions of gene identification, mutation detection, and clinical and research applications for over 100 genetic immune disorders--disorders featuring an increased susceptibility to infections and, in certain conditions, an icreased rate of malignancies and autoimmune disorders. Since the publication of the first edition, a flurry of new disease entities has been defined and new treatment regimens have been introduced, the most spectacular being successful treatment by gene therapy for two genotypes of combined immunodeficiency. The first edition marked a historic turning point in the field of immunodeficiencies, demonstrating that many of the disorders of the immune systam could be understood at a molecular level. This new edition can proudly document the tremendous pace of progress in dissecting the complex immunologic networks responsible for protecting individuals from these disorders.
This new handbook fills the need for in-depth coverage of concrete construction engineering and technology. It features discussions on what design engineers and contractors need to know about concrete materials and systems - one of the most versatile materials available. The Concrete Construction Engineering Handbook focuses on these important topics:
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