The names of James Watson and Francis Crick are bound together forever because the scientific discovery they made was truly a joint enterprise. As Edward Edelson reveals in this intriguing biography, Watson and Crick were the first to describe the structure of deoxyribonucleic acid, or DNA, the molecule that carries our genes and determines everything from the color of our eyes to the shape of our fingernails. Even though Watson and Crick's collaboration lasted only a few years, their achievement was enough to tie their names together forever in the history of science and to establish a firm footing for what was then a radical new branch of science: molecular biology. In doing so, they paved the way for the early detection of genetic diseases such as sickle-cell anemia, and for new scientific leaps such as animal cloning.
William E. Nelson's first volume of the four-volume The Common Law of Colonial America (2008) established a new benchmark for study of colonial era legal history. Drawing from both a rich archival base and existing scholarship on the topic, the first volume demonstrated how the legal systems of Britain's thirteen North American colonies-each of which had unique economies, political structures, and religious institutions -slowly converged into a common law order that differed substantially from English common law. The first volume focused on how the legal systems of the Chesapeake colonies--Virginia and Maryland--contrasted with those of the New England colonies and traced these dissimilarities from the initial settlement of America until approximately 1660. In this new volume, Nelson brings the discussion forward, covering the years from 1660, which saw the Restoration of the British monarchy, to 1730. In particular, he analyzes the impact that an increasingly powerful British government had on the evolution of the common law in the New World. As the reach of the Crown extended, Britain imposed far more restrictions than before on the new colonies it had chartered in the Carolinas and the middle Atlantic region. The government's intent was to ensure that colonies' laws would align more tightly with British law. Nelson examines how the newfound coherence in British colonial policy led these new colonies to develop common law systems that corresponded more closely with one another, eliminating much of the variation that socio-economic differences had created in the earliest colonies. As this volume reveals, these trends in governance ultimately resulted in a tension between top-down pressures from Britain for a more uniform system of laws and bottom-up pressures from colonists to develop their own common law norms and preserve their own distinctive societies. Authoritative and deeply researched, the volumes in The Common Law of Colonial America will become the foundational resource for anyone interested the history of American law before the Revolution.
More than a century has passed since Sigmund Freud began his groundbreaking work in psychoanalysis yet there is no consensus about his legacy; instead there is persistent disagreement not only about Freud's reputation and place in history but about the proper standards to use in evaluating his theory and therapy. This book develops epistemological standards for Freudian psychology and provides a comprehensive evaluation of, and possibly final, verdict on Freud's theory and therapy. Unlike any other evaluation published to date, it contains a systematic discussion of both the Freudian experimental and non-experimental evidence and the proper standards for interpreting the evidence. Part I considers the view that Freud's theory should be judged by special evidential standards deemed appropriate for judging hypotheses of commonsense psychology. Edward Erwin argues against this view and for the employment of standards applicable to causal hypotheses of both the natural and social sciences. Erwin also addresses other issues about standards such as the need for experimental evidence, the use of placebo controls, the proper goals of psychotherapy, and the use of meta-analysis in analyzing outcome data. The standards developed in part I of the book are used in part II in evaluating the best available Freudian evidence. A Bradford Book
Fully updated with completely updated content, exciting new authors, and commentary by national and international experts in the field, Rockwood and Matsen’s The Shoulder, 5th Edition continues its tradition of excellence as the cornerstone reference for effective management of shoulder disorders. This masterwork provides how-to guidance on the full range of both tried-and-true and recent surgical techniques, including both current arthroscopic methods and the latest approaches in arthroplasty. An outstanding editorial team headed by Drs. Charles A. Rockwood, Jr. and Frederick A. Matsen III ensures that you have the tools you need to achieve optimal patient outcomes for any shoulder challenge you encounter. Throughout the book the authors focus on the value of the procedures to patients, showing ways that expense and risk can be minimized. Combines the ‘how to’ for ‘tried and true’ shoulder procedures along with the latest arthroscopic methods for managing shoulder disorders. Focuses on the most challenging open procedures, including those often overlooked in training programs, yet thoroughly reviews the rationale for using minimally invasive arthroscopic techniques whenever possible. Offers scientifically based coverage of shoulder function and dysfunction to aid in the decision-making process. Features new commentaries from international authorities – including dissenting and alternative viewpoints -- and final comments by our editorial experts. Covers new approaches, including reverse total shoulder, the latest rotator cuff repair methods, and the "ream and run" procedure, as well as emerging imaging methods.
If you’re a breast cancer survivor, chances are you have renewed your commitment to maintaining your good health and taking care of your body. As one of the best preventative measures known to doctors and nutritionists today, a robust, cancer-fighting diet is vital to your personal plan for breast cancer prevention. The Whole-Food Guide for Breast Cancer Survivors is an essential guide for every woman seeking to understand the effect of nutritional deficiencies and environmental factors on her overall health and wellness. Based on Edward Bauman’s groundbreaking Eating for Health model, this highly comprehensive, practical approach can help you reduce the chance of breast cancer recurrence; rebuild your immune system; and enjoy a stronger, healthier body. Reduce the chance of breast cancer recurrence by: •Incorporating cancer-fighting foods into your diet •Indulging in safe, nontoxic cosmetics and body care products •Understanding the role of essential nutrients in maintaining your health •Managing your weight and balancing your blood sugar •Nourishing your immune, detoxification, and digestive systems
It is essential to minimize damage to normal tissues during radiation therapy and many strategies have been employed in finding the best methods for radioprotection. This book integrates chemical, biological, and clinical perspectives on these strategies and developments, providing a comprehensive treatise. It emphasizes new concepts in radioprotection, aiming to inspire further basic science and clinical progress in radioprotector research. Radioprotectors: Chemical, Biological, and Clinical Perspectives includes the following topics: Early research on radioprotectors WR-2721, an aminothiol prodrug, as a radioprotector New results with naturally occurring thiols Nitroxides as effective radioprotectors in vitro and in vivo Radioprotection observed with radical scavengers or antioxidants Bone marrow radioprotection with cytokines and biological modifiers Multiple mechanisms of altering radiation response by eicosanoids Vascular response to radiation and the importance of vascular damage to normal tissue Modifiers of radiation-induced apoptosis Survey of clinical trials with radioprotectors Radiation biologists and oncologists, cancer researchers, and toxicologists will benefit from the findings discussed and strategies for future research.
Three articles make up Volume 10 of Methods in Membrane Biology. In the first of these, Papahadjopoulos, Poste, and Vail extensively review much of the available data on the fusion of natural membranes, model membranes (liposomes), and natural membranes with liposomes. The authors are led by their review of the experimental methods and their interpretations of the results obtained to a general theory of membrane fusion which they believe is applicable to all systems that have been studied. Arguing that although protein and carbohydrate may serve, in some cases, to bring membranes into sufficiently close proximity for fusion to occur and, in other cases, to remove peripheral and integral proteins from the regions that are to undergo fusion, the authors conclude that membrane fusion per se is solely a property of the lipid bilayer. In their view, all the experimental observations to date can be subsumed under a unifying hypothesis in which membrane fusion is the result of a phase separation in one-half of the membrane bilayer brought about by the interaction - of calcium ions with acidic phospholipids, mostly phosphatidylserine. Where half-membranes already contain sufficient acidic phospholipids, a local increase in calcium ion concentration may suffice to induce fusion (examples might include exocytosis and fusion of intracellular membrane systems). In other cases, natural or experimentally induced events preceding fusion might be necessary to increase the local concentration of the acidic phospholipids in the half-membrane (virus-or fusogenic agent-induced cell-to-cell fusion, or endocytosis, for example).
In The Enslaved and Their Enslavers, Edward Pearson offers a sweeping history of slavery in South Carolina, from British settlement in 1670 to the dawn of the Civil War. For enslaved peoples, the shape of their daily lives depended primarily on the particular environment in which they lived and worked, and Pearson examines three distinctive settings in the province: the extensive rice and indigo plantations of the coastal plain; the streets, workshops, and wharves of Charleston; and the farms and estates of the upcountry. In doing so, he provides a fine-grained analysis of how enslaved laborers interacted with their enslavers in the workplace and other locations where they encountered one another as plantation agriculture came to dominate the colony. The Enslaved and Their Enslavers sets this portrait of early South Carolina against broader political events, economic developments, and social trends that also shaped the development of slavery in the region. For example, the outbreak of the American Revolution and the subsequent war against the British in the 1770s and early 1780s as well as the French and Haitian revolutions all had a profound impact on the institution's development, both in terms of what enslaved people drew from these events and how their enslavers responded to them. Throughout South Carolina's long history, enslaved people never accepted their enslavement passively and regularly demonstrated their fundamental opposition to the institution by engaging in acts of resistance, which ranged from vandalism to arson to escape, and, on rare occasions, organizing collectively against their oppression. Their attempts to subvert the institution in which they were held captive not only resulted in slaveowners tightening formal and informal mechanisms of control but also generated new forms of thinking about race and slavery among whites that eventually mutated into pro-slavery ideology and the myth of southern exceptionalism.
Surveys issues dealing with the process of aging, including the difference between generations in both physical and mental capacities and the treatment of the elderly.
Your days spent fruitlessly scouring textbooks and websites for credible vet information are over! Now you can get the whole story — the accurate story — all in one place. Introducing The Textbook of Veterinary Internal Medicine, Expert Consult, 8th Edition. Still the only comprehensive resource for veterinary internal medical problems, this faculty-and-student-favorite offers unparalleled coverage of pathophysiology, diagnosis, and disease treatments for dogs and cats. In addition to new chapters and discussions on the industry’s most topical issues, this "gold standard in vet medicine" comes with hundreds of original videos, algorithms, and learning tools to really bring all the information to life. There’s no better source to help you unlock the secrets of veterinary medicine than Ettinger’s! Fully searchable online text offers quick access to the most trusted information in the field. Complete library of over 500 original clinical videos you can believe in. Instead of fruitless YouTube searches, each video expertly breaks down veterinary procedures and important signs of diseases and disorders that are difficult or impossible to understand from written descriptions alone. In-depth coverage of timely issues includes expert explanations on topics such as the genome, clinical genomics, euthanasia, innocent heart murmurs, hyperbaric medicine, home prepared and raw diets, obesity, botulism, artificial pacing of the heart, and cancer vaccines. Thousands of references accessible from the printed book with the click of a QR code. 256 all-new client information sheets can be downloaded, customized, and printed as client handouts. 214 new and updated clinical algorithms aid in disease identification and decision-making. Exclusive access to Expert Consult Online website offers the complete library of original video clips, heart sounds, the full collection of client information sheets, and hyperlinking of references to their source abstracts in PubMed. NEW! In-depth coverage of the latest information and trends in small animal internal medicine. Completely new section on minimally-invasive interventional procedures includes techniques for treating respiratory, cardiovascular, gastrointestinal, urologic/nephrologic, and neoplastic disorders. 17 new chapters address the major clinicopathologic abnormalities that occur in canine and feline laboratory testing. Completely new section on management of mutually-antagonistic comorbidities spotlights concurrent cardiac and renal disease, concurrent infection in patients requiring immunosuppression, and concurrent diabetes mellitus and corticosteroid-dependent disease. Expert explanations on topics such as evidence-based medicine, distinguishing behavioral disorders from medical neurologic disorders, blood transfusion techniques, hyperadrenocorticism (Cushing’s disease), chronic kidney disease, respiratory and inhalant therapy, and many more.
This leading text reflects both the new direction and explosive growth of the field of hematology. Edited and written by practitioners who are the leaders in the field, the book covers basic scientific foundations of hematology while focusing on its clinical aspects. This edition has been thoroughly updated and includes ten new chapters on cellular biology, haploidentical transplantation, hematologic manifestations of parasitic diseases, and more. The table of contents itself has been thoroughly revised to reflect the rapidly changing nature of the molecular and cellular areas of the specialty. Over 1,000 vivid images, now all presented in full color for the first time, include a collection of detailed photomicrographs in every chapter, selected by a hematopathology image consultant. What's more, this Expert Consult Premium Edition includes access to the complete contents of the book online, fully searchable and updated quarterly by Dr. Hoffman himself. - Publisher.
Discusses the devastating effects of population growth and industry on air quality; the different types of pollutants that can be found in the atmosphere; the health and economical effects of pollution; and ways to clean up the air.
Includes free CD-ROM! Completely revised and updated for 2010, the Physicians' Cancer Chemotherapy Drug Manual is an up-to-date guide with the latest information on standard therapy and recent advances in chemotherapy. Written by world-class experts in the clinical cancer therapeutics, this essential reference provides a complete, easy-to-use catalogue of over 100 drugs and commonly used drug regimens - both on-and off-label - or the treatment of all major cancers. Special features include: * New drugs: Degarelix, Everolimius, and Nelarabine * Revised to reflect rapid advances in the field, incorporating new drug and treatment strategies * Diagrams of drug structures and pathways for each agent * Offers a comprehensive discussion of clinical pharmacology, special considerations, indications, and dosages * Covers toxicity and drug-drug interactions * Includes a section on osteogenic sarcoma and chemotherapy regimens for all major cancers * Provides an overview of the basic principles of cancer drug therapy * Contains an easy to load and use CD-ROM version PDA version of Physicians' Cancer Chemotherapy Drug Manual also available!
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