Exploring one of the most dynamic and contested regions of the world, this series includes works on political, economic, cultural, and social changes in modern and contemporary Asia and the Pacific.
Principles of Animal Extrapolation addresses the conceptual basis for animal extrapolation and provides an abundance of documentation that illustrates how these principles may be applied in the selection of the more appropriate models and in the interpretation of toxicological studies. The book analyzes and documents each specific biological cause of interspecies differences in susceptibility to toxic agents, including differences in absorption, gut flora, tissue distribution, metabolism, mechanisms and efficiencies of repair, and excretion. The problem of the heterogenicity of the human population is addressed through several chapters that assess the availability and prospects of developing predictive animal models for normal humans, as well as selected potential high-risk groups. Other topics presented in this book include the biological basis of regulatory actions involving attempts to extrapolate from exceptionally high exposure levels to realistic values, especially carcinogens; an assessment of genotoxicity tests, their ability to predict carcinogenicity in whole animals, and the manner in which they should be used by regulatory agencies; birth defects; and predicting the risk of human teratogenesis. Principle of Animal Extrapolation is essential for environmental toxicologists. It also provides valuable information to biomedical scientists (especially those involved in drug development and testing) and regulatory personnel in agencies such as the EPA, the OSHA, the NIOSH, and the FDA.
When we think of "heaven," we generally conjure up positive, blissful images. Heaven is, after all, where God is and where good people go after death to receive their reward. But how and why did Western cultures come to imagine the heavenly realm in such terms? Why is heaven usually thought to be "up there," far beyond the visible sky? And what is the source of the idea that the post mortem abode of the righteous is in this heavenly realm with God? Seeking to discover the roots of these familiar notions, this volume traces the backgrounds, origin, and development of early Jewish and Christian speculation about the heavenly realm -- where it is, what it looks like, and who its inhabitants are. Wright begins his study with an examination of the beliefs of ancient Israel's neighbors Egypt and Mesopotamia, reconstructing the intellectual context in which the earliest biblical images of heaven arose. A detailed analysis of the Hebrew biblical texts themselves then reveals that the Israelites were deeply influenced by images drawn from the surrounding cultures. Wright goes on to examine Persian and Greco-Roman beliefs, thus setting the stage for his consideration of early Jewish and Christian images, which he shows to have been formed in the struggle to integrate traditional biblical imagery with the newer Hellenistic ideas about the cosmos. In a final chapter Wright offers a brief survey of how later Jewish, Christian, and Islamic traditions envisioned the heavenly realms. Accessible to a wide range of readers, this provocative book will interest anyone who is curious about the origins of this extraordinarily pervasive and influential idea.
In Projecting a Camera, film theorist Edward Branigan offers a groundbreaking approach to understanding film theory. Why, for example, does a camera move? What does a camera "know"? (And when does it know it?) What is the camera's relation to the subject during long static shots? What happens when the screen is blank? Through a wide-ranging engagement with Wittgenstein and theorists of film, he offers one of the most fully developed understandings of the ways in which the camera operates in film. With its thorough grounding in the philosophy of spectatorship and narrative, Projecting a Camera takes the study of film to a new level. With the care and precision that he brought to Narrative Comprehension and Film, Edward Branigan maps the ways in which we must understand the role of the camera, the meaning of the frame, the role of the spectator, and other key components of film-viewing. By analyzing how we think, discuss, and marvel about the films we see, Projecting a Camera, offers insights rich in implications for our understanding of film and film studies.
The use of High Performance Liquid Chromatography (HPLC) techniques in the study of enzymatic reactions has grown significantly since the publication of the first edition of this highly successful book: the role of enzymes in biological research has expanded; the application of HPLC and enzymes has extended to more disciplines; advances in separation techniques and instrumentation have increased the capability of HPLC; and the discovery of new enzymes has spawned new methods of analysis. High Performance Liquid Chromatography in Enzymatic Analysis, Second Edition addresses these developments in its coverage of the refinements of HPLC methods and their use in a wide range of laboratory applications. It offers the same practical approach found in the first edition, incorporates a wealth of new information into existing chapters, and adds new chapters to deal with new applications, including capillary electrophoresis, forensic chemistry, microdialysis, and the polymerase chain reaction. Topics include: * Application of HPLC to the assay of enzymatic activities * Concepts and principles of HPLC, including the latest technological advances * Concepts and principles of capillary electrophoresis (CE) * Strategy for design of an HPLC/CE system for assay of enzyme activity * Preparation of enzymatic activities from tissues and single cells * Analysis of enzymatic activities in body fluids, including chromatobiosis * HPLC for the identification of new enzymatic activities * Fundamentals of the polymerase chain reaction * HPLC in forensics * Survey of enzymatic activities assayed by the HPLC method, including many new categories * Multienzyme systems, including many new examples * HPLC in the analysis of contaminated food "It is the ability of HPLC to accomplish separations completely and rapidly that led to its original application to problems in the life sciences, particularly those related to purification. An analysis of the literature revealed that this technique was used primarily for the purification of small molecules, macromolecules such as peptides and proteins, and more recently, antibodies. This application to purification has all but dominated the use of the method, and there has been a plethora of books, symposia, and conferences on the use of HPLC for these purposes. However, it was only a matter of time before others began to look beyond and to explore the possibilities that result from the capacity to make separations quickly and efficiently." --from the preface to the First Edition Easy to read and full of practical advice and hundreds of diagrams and examples, High Performance Liquid Chromatography in Enzymatic Analysis, Second Edition is an invaluable resource for students, researchers, and laboratory workers in analytical chemistry and biochemistry, molecular biology and cell biology, and for anyone interested in keeping up with this fast-growing field.
A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights. The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells. - Provides a complete review of the hypothesis-driven, controlled scientific experiments that have led to our current understanding of immunological principles - Explains the types of experiments that were performed and how the interpretation of the experiments altered the understanding of immunology - Presents concepts such as the division of lymphocytes into functionally different populations in their historical context - Includes fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, and the generation of diversity and mechanism of tolerance of T and B cells
Lavishly illustrated in color, this book presents a spectacular collection of archaeological and artistic treasures covering the extent of Egyptian art from the Predynastic Period of the fourth millennium B.C. to the Greco-Roman period of the fourth century A.D. The volume features more than 130 objects ranging from architectural elements of a royal palace and funerary chapel to delicate jewelry and textile fragments, and contains many objects never previously shown in print. In an introductory essay David P. Silverman documents major expeditions to sites in Egypt and Nubia and summarizes the new information gleaned about ancient Egyptian civilization. Donald B. Redford provides a general treatment of ancient Egypt history. The objects themselves are introduced with concise essays by recognized Egyptologists: Edward Brovarski, Rita E. Freed, Arielle P. Kozloff, David O'Connor, Edna R. Russmann, William K. Simpson, and Josef W. Wegner. Contributors-- Edward Brovarski, Museum of Fine Arts, Boston Rita Freed, Museum of Fine Arts, Boston Arielle Kozloff, Cleveland Museum of Art David O'Connor, Institute of Fine Arts, New York University Donald Redford, University of Toronto Edna. R. Russman, Brooklyn Museum of Art David Silverman, University of Pennsylvania William Kelly Simpson, Yale University Josef W. Wegner, University of Pennsylvania
First published in 1986. This book integrates current knowledge about the military, political, economic, and cultural roles of the armed forces in sixteen Asian countries, examining the interplay of these factors and their bearing on each society's civil-military relations. The authors explore the history, current status, and potential future course of each country. Analyzing all key Asian armed forces, they provide a comprehensive view of the military's domestic role-a crucial factor in assessing the foreign and defense policy options facing Asia as a whole.
Branigan effectively criticizes the communication model of narration, a task long overdue in Anglo-American circles. The book brings out the extent to which mainstream mimetic theories have relied upon the elastic notion of an invisible, idealized observer, a convenient spook whom critics can summon up whenever they desire to "naturalize" style. The book also makes distinctions among types of subjectivity; after this, we will have much more precise ways of tracing the fluctuations among a character's vision, dreams, wishes, and so forth. Branigan also explains the necessity of distinguishing levels of narration.
Was Gasoline, Texas, named in honor of a gas station? Nope, but the name does honor the town’s original claim to fame: a gasoline-powered cotton gin. Is Paris, Texas, a reference to Paris, France? Yes: Thomas Poteet, who donated land for the town site, thought it would be an improvement over “Pin Hook,” the original name of the Lamar County seat. Ding Dong’s story has a nice ring to it, derived from two store owners named Bell, who lived in Bell County, of course. Tracing the turning points, fascinating characters, and cultural crossroads that shaped Texas history, Texas Place Names provides the colorful stories behind these and more than three thousand other county, city, and community names. Drawing on in-depth research to present the facts behind the folklore, linguist Edward Callary also clarifies pronunciations (it’s NAY-chis for Neches, referring to a Caddoan people whose name was attached to the Neches River during a Spanish expedition). A great resource for road trippers and historians alike, Texas Place Names alphabetically charts centuries of humanity through the enduring words (and, occasionally, the fateful spelling gaffes) left behind by men and women from all walks of life.
Edward Emerson Barnard's Photographic Atlas of Selected Regions of the Milky Way was originally published in two volumes in 1927. Together, these volumes contained a wealth of information, including photographic plates of the most interesting portions of the Milky Way, descriptive text, charts and data. Only 700 copies were printed, making the original edition a collector's item. Reproduced in print for the first time, this edition combines both volumes of Barnard's Atlas. It directly replicates Barnard's text, and contains high-resolution images of the original photographic plates and charts, reordered so that they can be seen together. It also includes a biography of Barnard and his work, a Foreword and Addendum by Gerald Orin Dobek describing the importance of the Atlas and additions to this volume, and a pull-out section with a mosaic of all 50 plates combined in a single panorama.
A trainer and former triathlete shows you how to achieve the results you want with a new multidisciplinary approach Why does trying harder sometimes become an exercise in futility? Why does following "expert advice" often lead to little or no improvement? What if there were an efficient way of learning that could be applied to every area of human experience? Drawing from the principles of Bagua, Taichi, and Feldenkrais, Edward Yu presents an innovative approach to running: power, speed, and agility are more related to your ability to sense your own body than to willpower or raw talent. Centering the art of running as an explorative, creative, and somatic-based practice, Yu shows us how to run faster by learning to become more sensible--that is, more sense-able--through the playful and systematic exploration of movement.
When we think of "heaven," we generally conjure up positive, blissful images. Heaven is, after all, where God is and where good people go after death to receive their reward. But how and why did Western cultures come to imagine the heavenly realm in such terms? Why is heaven usually thought to be "up there," far beyond the visible sky? And what is the source of the idea that the post mortem abode of the righteous is in this heavenly realm with God? Seeking to discover the roots of these familiar notions, this volume traces the backgrounds, origin, and development of early Jewish and Christian speculation about the heavenly realm -- where it is, what it looks like, and who its inhabitants are. Wright begins his study with an examination of the beliefs of ancient Israel's neighbors Egypt and Mesopotamia, reconstructing the intellectual context in which the earliest biblical images of heaven arose. A detailed analysis of the Hebrew biblical texts themselves then reveals that the Israelites were deeply influenced by images drawn from the surrounding cultures. Wright goes on to examine Persian and Greco-Roman beliefs, thus setting the stage for his consideration of early Jewish and Christian images, which he shows to have been formed in the struggle to integrate traditional biblical imagery with the newer Hellenistic ideas about the cosmos. In a final chapter Wright offers a brief survey of how later Jewish, Christian, and Islamic traditions envisioned the heavenly realms. Accessible to a wide range of readers, this provocative book will interest anyone who is curious about the origins of this extraordinarily pervasive and influential idea.
Examines the commission of the Vatican tomb of Pope Alexander VIII Ottoboni by his great-nephew Cardinal Pietro Ottoboni. Although neglected for centuries, the Ottoboni monument occupies the most strategic liturgical position in the complex of tombs in the Vatican basilica. It is impressive in scale, & offers a commanding presence on the path from the papal entryway to the apse & main altar, with a majestic papal effigy, a visually compelling narrative relief carving, & symbolically important allegories. Using unpublished archival documents in the Vatican & Lateran archives, this study discusses in detail the 30-year campaign for the construction of the tomb & identifies the artists & artisans responsible for the project. The monograph is comprehensive in its stylistic analysis, exploration of iconography, discussion of liturgical practice, & consideration of studio procedures beginning with patron & artist, architect & sculptors, & sculptor & artisans. reveals why the project required three decades to complete. "A well-written, informative, & important monograph. And, in the process, he has expanded our understanding of contemporary workshop practice and art making in the Rome of the later Baroque period. There are sections where the author's meticulous care & insightful reconstruction of events gives the reader a sense of ""being there"" in the day-to-day process of work on the site. These parts make for especially exciting and engaging reading." -- "An absolutely wonderful piece of work.
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