As the definitive reference for clinical chemistry, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition offers the most current and authoritative guidance on selecting, performing, and evaluating results of new and established laboratory tests. Up-to-date encyclopedic coverage details everything you need to know, including: analytical criteria for the medical usefulness of laboratory procedures; new approaches for establishing reference ranges; variables that affect tests and results; the impact of modern analytical tools on lab management and costs; and applications of statistical methods. In addition to updated content throughout, this two-color edition also features a new chapter on hemostasis and the latest advances in molecular diagnostics. Section on Molecular Diagnostics and Genetics contains nine expanded chapters that focus on emerging issues and techniques, written by experts in field, including Y.M. Dennis Lo, Rossa W.K. Chiu, Carl Wittwer, Noriko Kusukawa, Cindy Vnencak-Jones, Thomas Williams, Victor Weedn, Malek Kamoun, Howard Baum, Angela Caliendo, Aaron Bossler, Gwendolyn McMillin, and Kojo S.J. Elenitoba-Johnson. Highly-respected author team includes three editors who are well known in the clinical chemistry world. Reference values in the appendix give you one location for comparing and evaluating test results. NEW! Two-color design throughout highlights important features, illustrations, and content for a quick reference. NEW! Chapter on hemostasis provides you with all the information you need to accurately conduct this type of clinical testing. NEW! Six associate editors lend even more expertise and insight to the reference. NEW! Reorganized chapters ensure that only the most current information is included.
Three amendments to the Foreign Intelligence Surveillance Act (FISA) are set to expire (sunset) on May 27, 2011. The three sun-setting amendments expanded the scope of federal intelligence gathering authority following the 9/11 terrorist attacks. Contents of this report: (1) Overview; (2) Background: Distinction Between FISA Court Orders and Warrants in Criminal Investigations; Distinction Between FISA Court Orders and National Security Letters; Expiring FISA Amendments; "Lone Wolf" Terrorists; Roving Wiretaps; Access to Business Records Under FISA; (3) Effect of Sunset Provisions; (4) Legislative Proposals in the 112th Congress. This is a print on demand edition of an important, hard-to-find publication.
The KRAS oncogene is believed to be the most common single nucleotide variant oncogene in human cancer. Historically, efforts to target KRAS and the other RAS GTPases have struggled. More recently, efforts have focused on identifying and exploiting features unique to specific oncogenic mutations. This has led to the first FDA approval for a RAS targeted therapy. This new agent is a covalent inhibitor that reacts with the cysteine residue created by a codon 12 glycine to cysteine (G12C) mutation within KRAS. Mutant-specific strategies may also exist for other KRAS single nucleotide variants, and recent studies provide examples and mechanisms.
This book introduces the exciting and fast-moving field of MOEMS to graduate students, scientists, and engineers by providing a foundation of both micro-optics and MEMS that will enable them to conduct future research in the field. Born from the relatively new fields of MEMS and micro-optics, MOEMS are proving to be an attractive and low-cost solution to a range of device problems requiring high optical functionality and high optical performance. MOEMS solutions include optical devices for telecommunication, sensing, and mobile systems such as v-grooves, gratings, shutters, scanners, filters, micromirrors, switches, alignment aids, lens arrays, and hermetic wafer-scale optical packaging. An international team of leading researchers contributed to this book, and it presents examples and problems employing cutting-edge MOEM devices. It will inspire researchers to further advance the design, fabrication, and analysis of MOEM systems.
Carbon materials have, in recent years, been attracting attention as potential supports in heterogeneous catalysis. In 2006, the number of articles dealing with various types of catalysts supported on carbon approached 1000, however only a fraction of those were devoted to hydroprocessing catalysts, despite the fact that interest in carbons as supports for hydroprocessing catalysts began more than two decades ago. This unique book is a comprehensive summary of recent research in the field and covers all areas of carbons and carbon materials. The potential application of carbon supports, partic.
Advanced Therapy in Cardiac Surgery - Second Edition This second edition of Advanced Therapy in Cardiac Surgery presents state-of-the-art techniques and an in-depth review of cardiac surgery from the leading authorities. Each of the 62 succinct chapters represents the personal treatment protocols of the experts. The Advanced ......
PROFILES POTENTIAL TREATMENT APPROACHES FOR CARDIAC ARRHYTHMIAS Cardiac arrhythmias of ventricular origin are responsible for the deaths of nearly half a million Americans each year while atrial fibrillation accounts for about 2.3 million cases per year, a rate that is projected to increase 2.5 fold over the next half century. Effectively managing these cardiac rhythm disorders remains a major challenge for both caregivers and the pharmaceutical industry. Filling a gap in the current literature, Novel Therapeutic Targets for Antiarrhythmic Drugs presents the latest treatments for cardiac arrhythmias alongside comprehensive presentations of basic cardiac physiology and pharmacology. Written by leading experts in their research areas, this invaluable resource offers both practitioners and researchers a one-stop guide that brings together previously dispersed information. The text consists of four sections: Section One comprehensively reviews basic cardiac electrophysiology, the mechanisms responsible for arrhythmias in the setting of ischemia, and basic pharmacology of antiarrhythmic drugs. Section Two addresses safety pharmacology, including the concept of "repolarization reserve," safety challenges, and regulatory issues for the development of novel antiarrhythmic drugs. Section Three describes several novel pharmacological targets for antiarrhythmic drugs, including both ion channel and non-ion channel targets. Section Four describes promising non-pharmacological antiarrhythmic interventions including selective cardiac neural disruption or nerve stimulation, aerobic exercise training, and diet (omega-3 fatty acids). Offering an unparalleled look at the current state and future direction of cardiac arrhythmia treatment, Novel Therapeutic Targets for Antiarrhythmic Drugs provides an important resource to advanced students, working researchers, and busy professionals alike.
Authoritative, clinically oriented, and unique in the field,Computed Body Tomography with MRI Correlation, 5th Editionis your one-stop reference for current information on CT and MRI in all aspects of adult and pediatric congenital and acquired disorders. This comprehensive text uses an easy-to-navigate format to deliver complete, well-illustrated coverage of the most current CT and MRI techniques for thorax, abdomen, pelvis and musculoskeletal systems in both adult and pediatric populations. The fully revised 5th Edition is a complete reference for residents, fellows, and attending radiologists, as well as clinicians in other specialties who are interested in CT and MRI evaluation of both common and less common disorders encountered in daily practice.
The second edition of a bestseller, this book discusses an integrated product and process design that has been successfully used to conceptualize, design, and rapidly product competitively-priced quality products. It examines the overlapping, interacting, and iterative nature of the engineering aspects that impact the product realization process. A detailed introduction to the creation of high quality products, the new edition explores the role of innovation, requirements engineering, smart materials, different rapid prototyping methods, and life-cycle cost determination, to name just a few. The book delineates proven methods that have been used successfully to create products.
The state secrets privilege is a judicially created evidentiary privilege that allows the gov¿t. to resist court-ordered disclosure of info. during litigation, if there is a reasonable danger that such disclosure would harm the nat. security of the U.S. Contents of this report: (1) U.S. v. Reynolds: Asserting the Privilege; Evaluating the Validity of the Privilege; Effect of a Valid Privilege; (2) Totten v. U.S.: Special Case of Nonjusticiable Contracts for Espionage; (3) Classified Info. Procedures Act and Secret Evidence in Criminal Litigation:Withholding Classified Info. During Discovery; Confrontation Clause and the Use of Secret Evidence at Trial; (4) Legislative Modification of the State Secrets Privilege: Foreign Intell. Surveillance Act; State Secrets Protection Act.
The book provides the most up-to-date information on testing and development of hydroprocessing catalysts with the aim to improve performance of the conventional and modified catalysts as well as to develop novel catalytic formulations. Besides diverse chemical composition, special attention is devoted to pore size and pore volume distribution of the catalysts. Properties of the catalysts are discussed in terms of their suitability for upgrading heavy feeds. For this purpose atmospheric residue was chosen as the base for defining other heavy feeds which comprise vacuum gas oil, deasphalted oil and vacuum residues in addition to topped heavy crude and bitumen. Attention is paid to deactivation with the aim to extent catalyst life during the operation. Into consideration is taken the loss of activity due to fouling, metal deposition, coke formed as the result of chemical reaction and poisoning by nitrogen bases. Mathematical models were reviewed focussing on those which can simulate performance of the commercial operations. Configurations of hydroprocessing reactors were compared in terms of their capability to upgrade various heavy feeds providing that a suitable catalyst was selected. Strategies for regeneration, utilization and disposal of spent hydroprocesing catalysts were evaluated. Potential of the non-conventional hydroprocessing involving soluble/dispersed catalysts and biocatalysts in comparison with conventional methods were assessed to identify issues which prevent commercial utilization of the former. A separate chapter is devoted to catalytic dewaxing because the structure of dewaxing catalysts is rather different than that of hydroprocessing catalysts, i.e., the objective of catalytic dewaxing is different than that of the conventional hydroprocessing, The relevant information in the scientific literature is complemented with the Patent literature covering the development of catalysts and novel reactor configurations.Separate chapter was added to distinguish upgrading capabilities of the residues catalytic cracking processes from those employing hydroprocessing. Upper limits on the content of carbon residue and metals in the feeds which can still be upgraded by the former processes differ markedly from those in the feeds which can be upgraded by hydroprocessing. It is necessary that the costs of modifications of catalytic cracking processes to accommodate heavier feeds are compared with that of hydroprocessing methods.Objective of the short chapter on upgrading by carbon rejecting processes was to identify limits of contaminants in heavy feeds beyond which catalytic upgrading via hydroprocessing becomes uneconomical because of the costs of catalyst inventory and that of reactors and equipment. - Comprehensive and most recent information on hydroprocessing catalysts for upgrading heavy petroleum feeds.- Compares conventional, modified and novel catalysts for upgrading a wide range of heavy petroleum feeds.- Comparison of conventional with non-conventional hydroprocessing, the latter involving soluble/dispersed catalysts and biocatalysts. - Development and comparison of mathematical models to simulate performance of catalytic reactors including most problematic feeds.- Residues upgrading by catalytic cracking in comparison to hydroprocessing.
A criminal prosecution involving CI may cause tension between the government¿s interest in protecting CI and the criminal defendant¿s right to a constitutionally valid trial. In some cases, a defendant may threaten to disclose CI in an effort to gain leverage. Concerns about this practice, referred to as ¿graymail,¿ led Congress to enact the Classified Info. Procedures Act (CIPA) to provide uniform procedures for prosecutions involving CI. Contents of this report: Background; The CIPA: Pretrial Conferences, Required Notice, and Appeals; Protective Orders and Security Clearances; Discovery: Brady and Jencks Material; Depositions; Admissibility of CI: Substitutions; Confrontation Clause and the Silent Witness Rule. A print on demand report.
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. Provides a comprehensive and valuable working handbook for scientists and students in medicinal chemistry Includes expanded coverage of pharmacokinetics fundamentals and effects Contains updates throughout, including the authors’ recent work in the importance of solubility in drug development; new and currently used property methods, with a reduction of seldom-used methods; and exploration of computational modeling methods
The second edition of Primary Immunodeficiency Diseases presents discussions of gene identification, mutation detection, and clinical and research applications for over 100 genetic immune disorders--disorders featuring an increased susceptibility to infections and, in certain conditions, an icreased rate of malignancies and autoimmune disorders. Since the publication of the first edition, a flurry of new disease entities has been defined and new treatment regimens have been introduced, the most spectacular being successful treatment by gene therapy for two genotypes of combined immunodeficiency. The first edition marked a historic turning point in the field of immunodeficiencies, demonstrating that many of the disorders of the immune systam could be understood at a molecular level. This new edition can proudly document the tremendous pace of progress in dissecting the complex immunologic networks responsible for protecting individuals from these disorders.
Study efficiently and effectively for high-stakes surgery exams with this superb review tool. Rush University Medical Center Review of Surgery, 6th Edition, has been thoroughly updated with new questions and answers in all chapters, and content has been revised to reflect what is most important on today’s exams. A broad range of surgical topics provide a complete review of the information you need to know. Comprehensive coverage of both general surgery and surgical subspecialties in a user-friendly question-and-answer format that mimics actual exams. More than 1,500 peer-reviewed questions mirror standardized test blueprints. Single best answer format provides a realistic exam simulation. Questions are followed by answers and explanations, with rationales backed up by references to leading texts and references. Ideal for residents in training, surgeons preparing for certification or recertification exams, and experienced clinicians who need to stay up to date with current practices and recent advances. Written by one of the premier general surgery departments in the U.S., with a new editorial team led by Dr. Jonathan A. Myers. Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
The Cervical Spine is the most comprehensive, current, and authoritative reference on the cervical spine. Prepared by internationally recognized members of The Cervical Spine Research Society Editorial Committee, the Fifth Edition presents new information, new technologies, and advances in clinical decision making. The text provides state-of-the-art coverage of basic and clinical research, diagnostic methods, and medical and surgical treatments, bringing together the latest thinking of the foremost orthopaedic surgeons, neurosurgeons, neurologists, rheumatologists, radiologists, anatomists, and bioengineers. Chapters cover anatomy, physiology, biomechanics, neurologic and functional evaluation, and radiographic evaluation and address the full range of pediatric problems, fractures, spinal cord injuries, tumors, infections, inflammatory conditions, degenerative disorders, and complications. Accompanying the text is a website with the fully searchable text plus a color image bank.
New emerging diseases, new diagnostic modalities for resource-poor settings, new vaccine schedules ... all significant, recent developments in the fast-changing field of tropical medicine. Hunter’s Tropical Medicine and Emerging Infectious Diseases, 10th Edition, keeps you up to date with everything from infectious diseases and environmental issues through poisoning and toxicology, animal injuries, and nutritional and micronutrient deficiencies that result from traveling to tropical or subtropical regions. This comprehensive resource provides authoritative clinical guidance, useful statistics, and chapters covering organs, skills, and services, as well as traditional pathogen-based content. You’ll get a full understanding of how to recognize and treat these unique health issues, no matter how widespread or difficult to control. Includes important updates on malaria, leishmaniasis, tuberculosis and HIV, as well as coverage of Ebola, Zika virus, Chikungunya, and other emerging pathogens. Provides new vaccine schedules and information on implementation. Features five all-new chapters: Neglected Tropical Diseases: Public Health Control Programs and Mass Drug Administration; Health System and Health Care Delivery; Zika; Medical Entomology; and Vector Control – as well as 250 new images throughout. Presents the common characteristics and methods of transmission for each tropical disease, as well as the applicable diagnosis, treatment, control, and disease prevention techniques. Contains skills-based chapters such as dentistry, neonatal pediatrics and ICMI, and surgery in the tropics, and service-based chapters such as transfusion in resource-poor settings, microbiology, and imaging. Discusses maladies such as delusional parasitosis that are often seen in returning travelers, including those making international adoptions, transplant patients, medical tourists, and more.
Psychology 2ed will support you to develop the skills and knowledge needed for your career in psychology and within the professional discipline of psychology. This book will be an invaluable study resource during your introductory psychology course and it will be a helpful reference throughout your studies and your future career in psychology. Psychology 2ed provides you with local ideas and examples within the context of psychology as an international discipline. Rich cultural and indigenous coverage is integrated throughout the book to help your understanding. To support your learning online study tools with revision quizzes, games and additional content have been developed with this book.
This volume contains a collection of papers based on lectures delivered by distinguished mathematicians at Clay Mathematics Institute events over the past few years. It is intended to be the first in an occasional series of volumes of CMI lectures. Although not explicitly linked, the topics in this inaugural volume have a common flavour and a common appeal to all who are interested in recent developments in geometry. They are intended to be accessible to all who work in this general area, regardless of their own particular research interests.
Covering their production, modification and applications as a catalyst support this book reviews the current state-of-the art in using carbon nanomaterials for hydrogenation.
Infectious diseases are an ever present threat to humans. In recent years, the threat of these emerging viruses has been greater than ever before in human history, due in large part to global travel by larger numbers of people, and to a lesser extent to disruptions in the interface between developed and undeveloped areas. The emergence of new deadly viruses in human populations during recent decades has confirmed this risk. They remain the third leading cause of deaths in the US and the second world-wide. Emerging Viruses in Human Populations provides a comprehensive review of viruses that are emerging or that threaten to emerge among human populations in the twenty-first century. It discusses the apprehension over emerging viruses that has intensified due to concerns about bioterrorism. * Presents the history of emerging viruses * Includes chapters on SARS, Pandemic Threat of Avian Influenza Viruses, West Nile Virus, Monkeypox Virus, Hantavirus, Nipah Virus and Hendra Virus, Japanese Encephalitis Virus, Dengue and Crimean-Congo Hemorrhagic Fever Viruses * Discusses surveillance for newly emerging diseases
This book describes a circuit architecture for converting real analog signals into a digital format, suitable for digital signal processors. This architecture, referred to as multi-stage noise-shaping (MASH) Continuous-Time Sigma-Delta Modulators (CT-ΔΣM), has the potential to provide better digital data quality and achieve better data rate conversion with lower power consumption. The authors not only cover MASH continuous-time sigma delta modulator fundamentals, but also provide a literature review that will allow students, professors, and professionals to catch up on the latest developments in related technology.
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