In humans, the natural history of prostate cancer spans 30–40 years, which makes it a difficult disease to model in rodents. Furthermore, the molecular pathology of prostate cancer responsible for tumor initiation and progression is complex and often redundant. The sequential changes in oncogene and tumor suppressor gene expression during prostate cancer progression have not been fully delineated. Despite these issues, there are model systems, including carefully designed orthotopic xenograft models, that provide robust platforms for drug evaluation and studying the effects of diet and environmental stress on prostate carcinogenesis. Comprehensive transgenic and knockout models have also been developed that recapitulate individual steps in tumor initiation and metastatic progression and highlight the importance of the tumor microenvironment. While very few of the transgenic and knockout systems recapitulate the entire natural history of prostate cancer, individual model systems provide valuable genetic insight into the biological consequences of disrupting prostate homeostasis.
In the early twentieth century, China was on the brink of change. Different ideologies - those of radicalism, conservatism, liberalism, and social democracy - were much debated in political and intellectual circles. Whereas previous works have analyzed these trends in isolation, Edmund S. K. Fung shows how they related to one another and how intellectuals in China engaged according to their cultural and political persuasions. The author argues that it is this interrelatedness and interplay between different schools of thought that are central to the understanding of Chinese modernity, for many of the debates that began in the Republican era still resonate in China today. The book charts the development of these ideologies and explores the work and influence of the intellectuals who were associated with them. In its challenge to previous scholarship and the breadth of its approach, the book makes a major contribution to the study of Chinese political philosophy and intellectual history.
Chinese capital in Malaysia appears to have reasonable prospects for further growth in the immediate future. A review of the literature on Chinese business in Malaysia would indicate that although all studies acknowledge the dominant role of Chinese capital in the economy, there is a dearth of in-depth empirical research on its mode of development and styles of operation. This study, which covers the period from colonial times to the present day, fills that gap by identifying key issues pertaining to Chinese business operations in Malaysia: ownership and control patterns; style of growth; relations with the state, politicians, and other Chinese businessmen; and the manner of development of business abroad, at the same time debunking the theory that large-scale Chinese capital is not very entrepreneurial in nature.
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